JP6670763B2 - 治療用途のための一酸化炭素放出分子ならびにその作製および使用の方法 - Google Patents
治療用途のための一酸化炭素放出分子ならびにその作製および使用の方法 Download PDFInfo
- Publication number
- JP6670763B2 JP6670763B2 JP2016571722A JP2016571722A JP6670763B2 JP 6670763 B2 JP6670763 B2 JP 6670763B2 JP 2016571722 A JP2016571722 A JP 2016571722A JP 2016571722 A JP2016571722 A JP 2016571722A JP 6670763 B2 JP6670763 B2 JP 6670763B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- aryl
- heteroaryl
- cycloalkyl
- moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CC1(C=CC(I*c2ccccc2C)=C(C)C=C1)I(=C)=Cl=C1C=C1 Chemical compound CC1(C=CC(I*c2ccccc2C)=C(C)C=C1)I(=C)=Cl=C1C=C1 0.000 description 2
- AEZGUNVVMJOPTN-UHFFFAOYSA-N C#CCOc(cccc1)c1C1=C(c2cccc3cccc4c23)C4=C(C(N2CCOCC2)=O)C1=O Chemical compound C#CCOc(cccc1)c1C1=C(c2cccc3cccc4c23)C4=C(C(N2CCOCC2)=O)C1=O AEZGUNVVMJOPTN-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B32/00—Carbon; Compounds thereof
- C01B32/40—Carbon monoxide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B37/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
- C07B37/10—Cyclisation
- C07B37/12—Diels-Alder reactions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Carbon And Carbon Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462009451P | 2014-06-09 | 2014-06-09 | |
| US62/009,451 | 2014-06-09 | ||
| PCT/US2015/034948 WO2015191616A1 (en) | 2014-06-09 | 2015-06-09 | Carbon monoxide-releasing molecules for therapeutic applications and methods of making and using thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017528416A JP2017528416A (ja) | 2017-09-28 |
| JP2017528416A5 JP2017528416A5 (enExample) | 2018-07-19 |
| JP6670763B2 true JP6670763B2 (ja) | 2020-03-25 |
Family
ID=54834205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016571722A Active JP6670763B2 (ja) | 2014-06-09 | 2015-06-09 | 治療用途のための一酸化炭素放出分子ならびにその作製および使用の方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10300069B2 (enExample) |
| EP (1) | EP3151919B1 (enExample) |
| JP (1) | JP6670763B2 (enExample) |
| KR (1) | KR20170007857A (enExample) |
| CN (1) | CN106794362B (enExample) |
| AU (1) | AU2015274767B2 (enExample) |
| CA (1) | CA2950007A1 (enExample) |
| WO (1) | WO2015191616A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106794362B (zh) | 2014-06-09 | 2021-07-06 | 乔治亚州立大学研究基金会股份有限公司 | 用于治疗应用的一氧化碳-释放分子及其制备和使用方法 |
| WO2018093924A1 (en) * | 2016-11-16 | 2018-05-24 | Georgia State University Research Foundation, Inc. | Carbon monoxide-releasing molecules and therapeutic applications thereof |
| KR102373273B1 (ko) * | 2017-04-18 | 2022-03-15 | 기초과학연구원 | 고분자형 젤과 이의 제조방법, 및 이를 포함하는 물품 |
| CN110944629B (zh) * | 2017-06-12 | 2024-04-09 | 乔治亚州立大学研究基金会股份有限公司 | 酶触发的一氧化碳释放分子 |
| US20180369278A1 (en) * | 2017-06-23 | 2018-12-27 | The Regents Of The University Of Michigan | Carbon monoxide-based therapies and implantable devices for the treatment of vascular disease |
| WO2019032879A1 (en) * | 2017-08-09 | 2019-02-14 | Georgia State University Research Foundation, Inc. | CARBON MONOXIDE RELEASE MOLECULES DISCHARGED BY PHYSIOLOGICAL STIMULI |
| WO2019084323A1 (en) * | 2017-10-25 | 2019-05-02 | Georgia State University Research Foundation, Inc. | CHEMICAL RELEASE SYSTEM DELIVERED BY ENRICHMENT |
| CN109306049B (zh) * | 2018-09-28 | 2020-12-01 | 中国热带农业科学院农产品加工研究所 | 植物油-壳聚糖基可生物降解pua及其制备方法和应用 |
| WO2020081723A1 (en) | 2018-10-16 | 2020-04-23 | Georgia State University Research Foundation, Inc. | Carbon monoxide prodrugs for the treatment of medical disorders |
| CN113559071B (zh) * | 2021-08-18 | 2022-12-27 | 苏州大学 | 一种co靶向递送系统及其构建方法与应用 |
| EP4275682A1 (en) * | 2022-05-12 | 2023-11-15 | Institut National De La Sante Et De La Recherche Medicale - Inserm | Carbon monoxide-releasing molecule (corm) or composition thereof for use in the treatment or the prevention of an intestinal dysbiosis in a subject |
| WO2025090901A1 (en) * | 2023-10-26 | 2025-05-01 | Georgia State University Research Foundation, Inc. | Ros-activated co prodrugs for cancer treatment |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5670664A (en) * | 1995-09-08 | 1997-09-23 | University Of Maryland Biotechnology Institute | Photosensitive organic compounds that release carbon monoxide upon illumination |
| JP2005519928A (ja) | 2002-02-04 | 2005-07-07 | ハース,ベルナー | Co放出能力を有する化合物の投与によって哺乳動物を治療する方法と、co放出能力を有する化合物ならびにその医薬組成物 |
| PT1812031E (pt) | 2004-11-01 | 2015-10-01 | Univ California | Composições e métodos para modificação de biomoléculas |
| US8519122B2 (en) | 2010-02-12 | 2013-08-27 | The Regents Of The University Of California | Compositions and methods for modification of biomolecules |
| CN106794362B (zh) | 2014-06-09 | 2021-07-06 | 乔治亚州立大学研究基金会股份有限公司 | 用于治疗应用的一氧化碳-释放分子及其制备和使用方法 |
-
2015
- 2015-06-09 CN CN201580042734.9A patent/CN106794362B/zh active Active
- 2015-06-09 EP EP15807244.7A patent/EP3151919B1/en active Active
- 2015-06-09 WO PCT/US2015/034948 patent/WO2015191616A1/en not_active Ceased
- 2015-06-09 JP JP2016571722A patent/JP6670763B2/ja active Active
- 2015-06-09 KR KR1020177000227A patent/KR20170007857A/ko not_active Withdrawn
- 2015-06-09 AU AU2015274767A patent/AU2015274767B2/en not_active Ceased
- 2015-06-09 US US15/317,705 patent/US10300069B2/en active Active
- 2015-06-09 CA CA2950007A patent/CA2950007A1/en not_active Abandoned
-
2019
- 2019-05-27 US US16/423,094 patent/US10751344B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015191616A1 (en) | 2015-12-17 |
| CN106794362B (zh) | 2021-07-06 |
| US10751344B2 (en) | 2020-08-25 |
| EP3151919A4 (en) | 2018-02-21 |
| US20170128456A1 (en) | 2017-05-11 |
| AU2015274767A1 (en) | 2017-01-05 |
| EP3151919B1 (en) | 2023-08-30 |
| US10300069B2 (en) | 2019-05-28 |
| CA2950007A1 (en) | 2015-12-17 |
| EP3151919A1 (en) | 2017-04-12 |
| AU2015274767B2 (en) | 2020-04-16 |
| JP2017528416A (ja) | 2017-09-28 |
| KR20170007857A (ko) | 2017-01-20 |
| CN106794362A (zh) | 2017-05-31 |
| US20190350937A1 (en) | 2019-11-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6670763B2 (ja) | 治療用途のための一酸化炭素放出分子ならびにその作製および使用の方法 | |
| US11420994B2 (en) | Carbon-monoxide-releasing molecules and therapeutic applications thereof | |
| RU2675270C2 (ru) | Сокристаллы и содержащие их фармацевтические композиции | |
| AU2011377440B2 (en) | Hydroxamic acid compound containing quinolyl and preparation method thereof, and pharmaceutical composition containing this compound and use thereof | |
| WO2006097625A1 (fr) | NOUVEAUX DÉRIVÉS D'IMIDAZO[1,5-a]PYRIDINES, LEUR PROCÉDÉ DE PRÉPARATION ET LES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT. | |
| KR20210102887A (ko) | 말초 세로토닌과 관련된 질병 또는 장애를 치료하기 위한 트립토판 하이드록실라제 1 (tph1)의 결정질 스피로사이클릭 화합물 억제제 | |
| RU2650682C2 (ru) | Пирролзамещенное производное индолона, способ его получения, включающая его композиция и применение | |
| CN111566113B (zh) | 大环化合物及其用途 | |
| CA3144201A1 (en) | Ep2 antagonist | |
| JP2025501287A (ja) | Menin阻害剤及びその用途 | |
| CN109922834B (zh) | 用于治疗癌症的卟啉化合物和组合物 | |
| US11730712B2 (en) | Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and derivatives thereof, and their use for the prevention or treatment of disease | |
| AU2016226083A1 (en) | Cyclic peptide analogs and conjugates thereof | |
| US9771344B2 (en) | Peloruside analogs | |
| WO2004080455A1 (ja) | 抗菌剤と抗ガン剤 | |
| EP4435060A1 (en) | Silicon phthalocyanine and tribenzophthalocyanine dyes and their use in diagnosis and therapy | |
| CN115340526B (zh) | 邻二甲酰亚胺类化合物及其药物组合物、制备方法和用途 | |
| EP3237015B1 (fr) | Derives hydroxybisphosphoniques hydrosolubles de la doxorubicine | |
| JP2019516725A (ja) | がんを処置するためのプロパルギル基を含む生体直交型化合物 | |
| TWI881296B (zh) | 包含抑制前列腺素e2受體之新穎化合物與抗癌藥物的用於治療癌症之藥學組成物 | |
| JP6281901B2 (ja) | 水溶性ポルフィリン誘導体とそれらの製造方法 | |
| JP2022531612A (ja) | がん治療のための新規治療用ベクター及びプロドラッグ | |
| CN111995629A (zh) | 大根香叶衍生物及其药物组合物和其在医药中的用途 | |
| HK1247906A1 (en) | Hydrogen sulfide precursors and conjugates thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180608 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20180608 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190527 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190827 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20200131 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20200302 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6670763 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |