JP2017527566A5 - - Google Patents
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- JP2017527566A5 JP2017527566A5 JP2017512974A JP2017512974A JP2017527566A5 JP 2017527566 A5 JP2017527566 A5 JP 2017527566A5 JP 2017512974 A JP2017512974 A JP 2017512974A JP 2017512974 A JP2017512974 A JP 2017512974A JP 2017527566 A5 JP2017527566 A5 JP 2017527566A5
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- protein
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- capsule
- assembly
- proteins
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- 235000018102 proteins Nutrition 0.000 claims 38
- 102000004169 proteins and genes Human genes 0.000 claims 38
- 108090000623 proteins and genes Proteins 0.000 claims 38
- 239000002775 capsule Substances 0.000 claims 24
- 239000012071 phase Substances 0.000 claims 24
- 238000001338 self-assembly Methods 0.000 claims 13
- 238000000034 method Methods 0.000 claims 12
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 8
- 108010000912 Egg Proteins Proteins 0.000 claims 8
- 102000002322 Egg Proteins Human genes 0.000 claims 8
- 229940098773 bovine serum albumin Drugs 0.000 claims 8
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 8
- 239000000463 material Substances 0.000 claims 8
- 102100033468 Lysozyme C Human genes 0.000 claims 6
- 108010014251 Muramidase Proteins 0.000 claims 6
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims 6
- 235000010335 lysozyme Nutrition 0.000 claims 6
- 229960000274 lysozyme Drugs 0.000 claims 6
- 239000004325 lysozyme Substances 0.000 claims 6
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 claims 4
- 101800001288 Atrial natriuretic factor Proteins 0.000 claims 4
- 102400001282 Atrial natriuretic peptide Human genes 0.000 claims 4
- 101800001890 Atrial natriuretic peptide Proteins 0.000 claims 4
- 102000051325 Glucagon Human genes 0.000 claims 4
- 108060003199 Glucagon Proteins 0.000 claims 4
- 102000001554 Hemoglobins Human genes 0.000 claims 4
- 108010054147 Hemoglobins Proteins 0.000 claims 4
- 102000004877 Insulin Human genes 0.000 claims 4
- 108090001061 Insulin Proteins 0.000 claims 4
- 102000008192 Lactoglobulins Human genes 0.000 claims 4
- 108010060630 Lactoglobulins Proteins 0.000 claims 4
- 102000036675 Myoglobin Human genes 0.000 claims 4
- 108010062374 Myoglobin Proteins 0.000 claims 4
- 108010058846 Ovalbumin Proteins 0.000 claims 4
- 102000029797 Prion Human genes 0.000 claims 4
- 108091000054 Prion Proteins 0.000 claims 4
- 235000014103 egg white Nutrition 0.000 claims 4
- 210000000969 egg white Anatomy 0.000 claims 4
- 210000002969 egg yolk Anatomy 0.000 claims 4
- 235000013345 egg yolk Nutrition 0.000 claims 4
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 4
- 229960004666 glucagon Drugs 0.000 claims 4
- 229940125396 insulin Drugs 0.000 claims 4
- 229940092253 ovalbumin Drugs 0.000 claims 4
- -1 silk Proteins 0.000 claims 4
- 239000008346 aqueous phase Substances 0.000 claims 3
- NSQLIUXCMFBZME-MPVJKSABSA-N carperitide Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 NSQLIUXCMFBZME-MPVJKSABSA-N 0.000 claims 3
- 241000894007 species Species 0.000 claims 3
- 102000007469 Actins Human genes 0.000 claims 2
- 108010085238 Actins Proteins 0.000 claims 2
- 108050001786 Alpha-s2 casein Proteins 0.000 claims 2
- 102100026882 Alpha-synuclein Human genes 0.000 claims 2
- 108010059886 Apolipoprotein A-I Proteins 0.000 claims 2
- 102000005666 Apolipoprotein A-I Human genes 0.000 claims 2
- 108010087614 Apolipoprotein A-II Proteins 0.000 claims 2
- 102000009081 Apolipoprotein A-II Human genes 0.000 claims 2
- 108010071619 Apolipoproteins Proteins 0.000 claims 2
- 102000007592 Apolipoproteins Human genes 0.000 claims 2
- 102000007372 Ataxin-1 Human genes 0.000 claims 2
- 108010032963 Ataxin-1 Proteins 0.000 claims 2
- 102000055006 Calcitonin Human genes 0.000 claims 2
- 108060001064 Calcitonin Proteins 0.000 claims 2
- 108010076119 Caseins Proteins 0.000 claims 2
- 102000011632 Caseins Human genes 0.000 claims 2
- 108010061642 Cystatin C Proteins 0.000 claims 2
- 102100026897 Cystatin-C Human genes 0.000 claims 2
- 102000018832 Cytochromes Human genes 0.000 claims 2
- 108010052832 Cytochromes Proteins 0.000 claims 2
- 201000008163 Dentatorubral pallidoluysian atrophy Diseases 0.000 claims 2
- 102000008857 Ferritin Human genes 0.000 claims 2
- 108050000784 Ferritin Proteins 0.000 claims 2
- 238000008416 Ferritin Methods 0.000 claims 2
- 102400000524 Fibrinogen alpha chain Human genes 0.000 claims 2
- 101710137044 Fibrinogen alpha chain Proteins 0.000 claims 2
- 108010058643 Fungal Proteins Proteins 0.000 claims 2
- 108090001064 Gelsolin Proteins 0.000 claims 2
- 102000004878 Gelsolin Human genes 0.000 claims 2
- 101000912191 Homo sapiens Cystatin-B Proteins 0.000 claims 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 2
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 2
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 2
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 2
- 102000004407 Lactalbumin Human genes 0.000 claims 2
- 108090000942 Lactalbumin Proteins 0.000 claims 2
- 102000010445 Lactoferrin Human genes 0.000 claims 2
- 108010063045 Lactoferrin Proteins 0.000 claims 2
- 101710181812 Methionine aminopeptidase Proteins 0.000 claims 2
- 102100037591 Neuroserpin Human genes 0.000 claims 2
- 102000011755 Phosphoglycerate Kinase Human genes 0.000 claims 2
- 108010071690 Prealbumin Proteins 0.000 claims 2
- 108010057464 Prolactin Proteins 0.000 claims 2
- 102000003946 Prolactin Human genes 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 102100037550 Semenogelin-1 Human genes 0.000 claims 2
- 101710089345 Semenogelin-1 Proteins 0.000 claims 2
- 241000700584 Simplexvirus Species 0.000 claims 2
- 108010029389 Simplexvirus glycoprotein B Proteins 0.000 claims 2
- 101001099217 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) Triosephosphate isomerase Proteins 0.000 claims 2
- 102100021398 Transforming growth factor-beta-induced protein ig-h3 Human genes 0.000 claims 2
- 102000009190 Transthyretin Human genes 0.000 claims 2
- 108090000185 alpha-Synuclein Proteins 0.000 claims 2
- 108010080146 androgen receptors Proteins 0.000 claims 2
- 102000001307 androgen receptors Human genes 0.000 claims 2
- 108010073614 apolipoprotein A-IV Proteins 0.000 claims 2
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims 2
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims 2
- 108700006666 betaIG-H3 Proteins 0.000 claims 2
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims 2
- 229960004015 calcitonin Drugs 0.000 claims 2
- 239000005482 chemotactic factor Substances 0.000 claims 2
- 102000006834 complement receptors Human genes 0.000 claims 2
- 108010047295 complement receptors Proteins 0.000 claims 2
- 210000003298 dental enamel Anatomy 0.000 claims 2
- 102000048843 human CSTB Human genes 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims 2
- 235000021242 lactoferrin Nutrition 0.000 claims 2
- 229940078795 lactoferrin Drugs 0.000 claims 2
- 210000000265 leukocyte Anatomy 0.000 claims 2
- 108010080874 neuroserpin Proteins 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 229940097325 prolactin Drugs 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 238000013268 sustained release Methods 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- 102000013498 tau Proteins Human genes 0.000 claims 2
- 108010026424 tau Proteins Proteins 0.000 claims 2
- 235000021241 α-lactalbumin Nutrition 0.000 claims 2
- 108700026758 Adenovirus hexon capsid Proteins 0.000 claims 1
- 108010041872 Islet Amyloid Polypeptide Proteins 0.000 claims 1
- 102100027670 Islet amyloid polypeptide Human genes 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 238000005538 encapsulation Methods 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- BABRMHJHAGFVGO-BRTFOEFASA-N peptide, atrial natriuretic Chemical compound C([C@@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C1=CC=CC=C1 BABRMHJHAGFVGO-BRTFOEFASA-N 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1415681.4 | 2014-09-04 | ||
| GBGB1415681.4A GB201415681D0 (en) | 2014-09-04 | 2014-09-04 | Protien Capsules |
| PCT/EP2015/070300 WO2016034728A1 (en) | 2014-09-04 | 2015-09-04 | Protein capsules |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017527566A JP2017527566A (ja) | 2017-09-21 |
| JP2017527566A5 true JP2017527566A5 (cg-RX-API-DMAC10.html) | 2018-09-27 |
| JP7117845B2 JP7117845B2 (ja) | 2022-08-15 |
Family
ID=51796212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512974A Active JP7117845B2 (ja) | 2014-09-04 | 2015-09-04 | タンパク質カプセル |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11878080B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP3188719B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP7117845B2 (cg-RX-API-DMAC10.html) |
| GB (1) | GB201415681D0 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2016034728A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201415681D0 (en) | 2014-09-04 | 2014-10-22 | Cambridge Entpr Ltd And President And Fellows Of Harvard College | Protien Capsules |
| SE541260C2 (en) * | 2016-05-17 | 2019-05-21 | Benjamin Schmuck | Antibody binding nanofibrils |
| US20210154359A1 (en) * | 2017-07-14 | 2021-05-27 | Hi-Aspect Limited | Fibrillar-protein based compositions and uses thereof |
| CN109044987A (zh) * | 2018-09-17 | 2018-12-21 | 青海清华博众生物技术有限公司 | 一种羟丙基淀粉空心胶囊及其制备方法 |
| CN111939312B (zh) * | 2020-07-03 | 2022-04-12 | 中国科学院大学温州研究院(温州生物材料与工程研究所) | 一种双重交联的多功能水凝胶敷料及其制备和用途 |
| CN115193496B (zh) * | 2022-07-18 | 2024-02-27 | 南昌大学 | 一种微流道装置和该装置制备的高载油微胶囊及其方法 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5196183A (en) * | 1991-12-04 | 1993-03-23 | Sterling Winthrop Inc. | Contrast agents for ultrasound imaging |
| GB0028710D0 (en) * | 2000-11-24 | 2001-01-10 | Isis Innovation | Mixed fibrils |
| CN101018816A (zh) | 2004-04-23 | 2007-08-15 | 尤金妮亚·库马切瓦 | 生产具有选定尺寸、形状、形态和组成的聚合物颗粒的方法 |
| ATE503465T1 (de) * | 2004-10-25 | 2011-04-15 | Celonova Biosciences Germany Gmbh | Beladbare polyphosphazenhaltige teilchen für therapeutische und/oder diagnostische anwendungen sowie herstellungs- und verwendungsverfahren dafür |
| US9039273B2 (en) | 2005-03-04 | 2015-05-26 | President And Fellows Of Harvard College | Method and apparatus for forming multiple emulsions |
| US20090273105A1 (en) * | 2005-05-23 | 2009-11-05 | Cornell Research Foundation | Method and system for performing an interfacial reaction in a microfluidic device |
| PL1757276T3 (pl) * | 2005-08-01 | 2008-02-29 | Amsilk Gmbh | Sposób otrzymywania nano-i mikrokapsułek z białka pajęczego jedwabiu |
| FR2893501B1 (fr) | 2005-11-21 | 2014-03-14 | Oreal | Compositions topiques pour favoriser l'homeostasie de la peau |
| US20070259382A1 (en) | 2005-11-22 | 2007-11-08 | The University Of Iowa Research Foundation | Rapid localized cell trapping on biodegradable polymers |
| WO2007082923A2 (de) * | 2006-01-20 | 2007-07-26 | Basf Se | Verwendung von protein-microbeads in der kosmetik |
| WO2007141131A1 (en) * | 2006-06-08 | 2007-12-13 | Technische Universitaet Muenchen | Microfluidic device for controlled aggregation of spider silk |
| US20100028451A1 (en) * | 2006-09-26 | 2010-02-04 | Trustees Of Tufts College | Silk microspheres for encapsulation and controlled release |
| WO2008108838A2 (en) | 2006-11-21 | 2008-09-12 | Charles Stark Draper Laboratory, Inc. | Microfluidic devices and methods for fabricating the same |
| WO2008106485A2 (en) | 2007-02-27 | 2008-09-04 | Trustees Of Tufts College | Tissue-engineered silk organs |
| CA2689427C (en) | 2007-06-05 | 2015-12-29 | Eugenia Kumacheva | Multiple continuous microfluidic reactors for the scaled up synthesis of gel or polymer particles |
| WO2009026448A1 (en) | 2007-08-21 | 2009-02-26 | Affomix Corporation | Interaction screening methods, systems and devices |
| WO2009039458A2 (en) | 2007-09-19 | 2009-03-26 | Massachusetts Institute Of Technology | Virus/nanowire encapsulation within polymer microgels for 2d and 3d devices for energy and electronics |
| EP2307054A4 (en) | 2008-06-18 | 2013-02-06 | Tufts College | EDIBLE HOLOGRAPHIC SILK PRODUCTS |
| JP2011530491A (ja) * | 2008-08-08 | 2011-12-22 | ビーエーエスエフ ソシエタス・ヨーロピア | バイオポリマーに基づいた活性物質含有連続繊維層、その使用、およびその生産のための方法 |
| WO2010036992A2 (en) | 2008-09-26 | 2010-04-01 | Trustees Of Tufts College | Active silk muco-adhesives, silk electrogelation process, and devices |
| US8501172B2 (en) | 2008-09-26 | 2013-08-06 | Trustees Of Tufts College | pH-induced silk gels and uses thereof |
| US9603243B2 (en) | 2010-04-12 | 2017-03-21 | Tufts University | Silk electronic components |
| US8940858B2 (en) * | 2010-05-17 | 2015-01-27 | Northwestern University | Fibrous microcapsules and methods of assembly and use thereof |
| CA2839719A1 (en) | 2010-06-17 | 2011-12-22 | Tufts University / Trustees Of Tufts College | Silk optical particles and uses thereof |
| KR20140048067A (ko) * | 2010-08-26 | 2014-04-23 | 바스프 에스이 | 자기-조립형 단백질의 고 농축 용액의 제조 방법 |
| JP5937092B2 (ja) | 2010-10-19 | 2016-06-22 | トラスティーズ オブ タフツ カレッジ | シルクフィブロインベースのマイクロニードルおよびその製造方法 |
| US8546338B2 (en) * | 2010-12-08 | 2013-10-01 | Johnson & Johnson Consumer Companies, Inc. | Self-assembling hydrogels based on dicephalic peptide amphiphiles |
| WO2012145652A1 (en) | 2011-04-20 | 2012-10-26 | Trustees Of Tufts College | Dynamic silk coatings for implantable devices |
| BR112014001868B1 (pt) * | 2011-07-26 | 2022-01-11 | Cambridge Enterprise Limited | Cápsulas supramoleculares, método para preparação das referidas cápsulas e método não-terapêutico de distribuir um componente a um local |
| WO2013103424A2 (en) | 2011-10-11 | 2013-07-11 | Tufts University | Silk-based multifunctional biomedical platform |
| US20140370094A1 (en) | 2011-11-08 | 2014-12-18 | Tufts University | Silk-based scaffold platform for engineering tissue constructs |
| ES2953309T3 (es) | 2011-11-09 | 2023-11-10 | Tufts College | Partículas de fibroína de seda inyectables y usos de las mismas |
| WO2013071123A1 (en) | 2011-11-09 | 2013-05-16 | Trustees Of Tufts College | Injectable silk fibroin foams and uses thereof |
| CA2865796A1 (en) | 2011-12-29 | 2013-07-04 | Trustees Of Tufts College | Functionalization of biomaterials to control regeneration and inflammation responses |
| EP2625966A1 (en) * | 2012-02-13 | 2013-08-14 | Bionanoplus, S.L. | Nanoparticles comprising a vegetable hydrophobic protein and a water miscible non-volatile organic solvent and uses thereof |
| GB201301648D0 (en) * | 2013-01-30 | 2013-03-13 | Cambridge Entpr Ltd | Nested supramolecular capsules |
| WO2013142119A1 (en) * | 2012-03-20 | 2013-09-26 | Trustees Of Tufts College | Silk reservoirs for drug delivery |
| WO2014012105A1 (en) * | 2012-07-13 | 2014-01-16 | Tufts University | Encapsulation of immiscible phases in silk fibroin biomaterials |
| US20140023688A1 (en) | 2012-07-13 | 2014-01-23 | Firmenich Sa | Encapsulated oils |
| CN105979938A (zh) * | 2013-12-09 | 2016-09-28 | 香港大学 | 用于包封粒子、胶体和细胞的芯-壳胶囊 |
| GB201415681D0 (en) | 2014-09-04 | 2014-10-22 | Cambridge Entpr Ltd And President And Fellows Of Harvard College | Protien Capsules |
-
2014
- 2014-09-04 GB GBGB1415681.4A patent/GB201415681D0/en not_active Ceased
-
2015
- 2015-09-04 EP EP15775633.9A patent/EP3188719B1/en active Active
- 2015-09-04 JP JP2017512974A patent/JP7117845B2/ja active Active
- 2015-09-04 US US15/508,876 patent/US11878080B2/en active Active
- 2015-09-04 WO PCT/EP2015/070300 patent/WO2016034728A1/en not_active Ceased
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