JP7117845B2 - タンパク質カプセル - Google Patents

タンパク質カプセル Download PDF

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Publication number
JP7117845B2
JP7117845B2 JP2017512974A JP2017512974A JP7117845B2 JP 7117845 B2 JP7117845 B2 JP 7117845B2 JP 2017512974 A JP2017512974 A JP 2017512974A JP 2017512974 A JP2017512974 A JP 2017512974A JP 7117845 B2 JP7117845 B2 JP 7117845B2
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Japan
Prior art keywords
capsule
proteins
protein
phase
shell
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JP2017512974A
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English (en)
Japanese (ja)
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JP2017527566A5 (cg-RX-API-DMAC10.html
JP2017527566A (ja
Inventor
ツォーマス ノールズ
ウリヤナ シマノヴィッチ
クリストファー ドブソン
デイヴィッド ワイツ
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Cambridge Enterprise Ltd
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Cambridge Enterprise Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
JP2017512974A 2014-09-04 2015-09-04 タンパク質カプセル Active JP7117845B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1415681.4 2014-09-04
GBGB1415681.4A GB201415681D0 (en) 2014-09-04 2014-09-04 Protien Capsules
PCT/EP2015/070300 WO2016034728A1 (en) 2014-09-04 2015-09-04 Protein capsules

Publications (3)

Publication Number Publication Date
JP2017527566A JP2017527566A (ja) 2017-09-21
JP2017527566A5 JP2017527566A5 (cg-RX-API-DMAC10.html) 2018-09-27
JP7117845B2 true JP7117845B2 (ja) 2022-08-15

Family

ID=51796212

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017512974A Active JP7117845B2 (ja) 2014-09-04 2015-09-04 タンパク質カプセル

Country Status (5)

Country Link
US (1) US11878080B2 (cg-RX-API-DMAC10.html)
EP (1) EP3188719B1 (cg-RX-API-DMAC10.html)
JP (1) JP7117845B2 (cg-RX-API-DMAC10.html)
GB (1) GB201415681D0 (cg-RX-API-DMAC10.html)
WO (1) WO2016034728A1 (cg-RX-API-DMAC10.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201415681D0 (en) 2014-09-04 2014-10-22 Cambridge Entpr Ltd And President And Fellows Of Harvard College Protien Capsules
SE541260C2 (en) * 2016-05-17 2019-05-21 Benjamin Schmuck Antibody binding nanofibrils
US20210154359A1 (en) * 2017-07-14 2021-05-27 Hi-Aspect Limited Fibrillar-protein based compositions and uses thereof
CN109044987A (zh) * 2018-09-17 2018-12-21 青海清华博众生物技术有限公司 一种羟丙基淀粉空心胶囊及其制备方法
CN111939312B (zh) * 2020-07-03 2022-04-12 中国科学院大学温州研究院(温州生物材料与工程研究所) 一种双重交联的多功能水凝胶敷料及其制备和用途
CN115193496B (zh) * 2022-07-18 2024-02-27 南昌大学 一种微流道装置和该装置制备的高载油微胶囊及其方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008535644A (ja) 2005-03-04 2008-09-04 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ 多重エマルジョンの形成のための方法および装置
JP2009502492A (ja) 2005-08-01 2009-01-29 テッヒニシェ・ウニヴェルジテート・ミュンヘン スパイダーシルクタンパク質からなるナノおよびマイクロカプセルの製造方法
JP2010536381A (ja) 2007-08-21 2010-12-02 アフォミックス コーポレイション 相互作用スクリーニングの方法、システムおよび装置
US20110280944A1 (en) 2010-05-17 2011-11-17 Samuel Stupp Fibrous microcapsules and methods of assembly and use thereof
WO2014118553A1 (en) 2013-01-30 2014-08-07 Cambridge Enterprise Limited Nested supramolecular capsules

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196183A (en) * 1991-12-04 1993-03-23 Sterling Winthrop Inc. Contrast agents for ultrasound imaging
GB0028710D0 (en) * 2000-11-24 2001-01-10 Isis Innovation Mixed fibrils
CN101018816A (zh) 2004-04-23 2007-08-15 尤金妮亚·库马切瓦 生产具有选定尺寸、形状、形态和组成的聚合物颗粒的方法
ATE503465T1 (de) * 2004-10-25 2011-04-15 Celonova Biosciences Germany Gmbh Beladbare polyphosphazenhaltige teilchen für therapeutische und/oder diagnostische anwendungen sowie herstellungs- und verwendungsverfahren dafür
US20090273105A1 (en) * 2005-05-23 2009-11-05 Cornell Research Foundation Method and system for performing an interfacial reaction in a microfluidic device
FR2893501B1 (fr) 2005-11-21 2014-03-14 Oreal Compositions topiques pour favoriser l'homeostasie de la peau
US20070259382A1 (en) 2005-11-22 2007-11-08 The University Of Iowa Research Foundation Rapid localized cell trapping on biodegradable polymers
WO2007082923A2 (de) * 2006-01-20 2007-07-26 Basf Se Verwendung von protein-microbeads in der kosmetik
WO2007141131A1 (en) * 2006-06-08 2007-12-13 Technische Universitaet Muenchen Microfluidic device for controlled aggregation of spider silk
US20100028451A1 (en) * 2006-09-26 2010-02-04 Trustees Of Tufts College Silk microspheres for encapsulation and controlled release
WO2008108838A2 (en) 2006-11-21 2008-09-12 Charles Stark Draper Laboratory, Inc. Microfluidic devices and methods for fabricating the same
WO2008106485A2 (en) 2007-02-27 2008-09-04 Trustees Of Tufts College Tissue-engineered silk organs
CA2689427C (en) 2007-06-05 2015-12-29 Eugenia Kumacheva Multiple continuous microfluidic reactors for the scaled up synthesis of gel or polymer particles
WO2009039458A2 (en) 2007-09-19 2009-03-26 Massachusetts Institute Of Technology Virus/nanowire encapsulation within polymer microgels for 2d and 3d devices for energy and electronics
EP2307054A4 (en) 2008-06-18 2013-02-06 Tufts College EDIBLE HOLOGRAPHIC SILK PRODUCTS
JP2011530491A (ja) * 2008-08-08 2011-12-22 ビーエーエスエフ ソシエタス・ヨーロピア バイオポリマーに基づいた活性物質含有連続繊維層、その使用、およびその生産のための方法
WO2010036992A2 (en) 2008-09-26 2010-04-01 Trustees Of Tufts College Active silk muco-adhesives, silk electrogelation process, and devices
US8501172B2 (en) 2008-09-26 2013-08-06 Trustees Of Tufts College pH-induced silk gels and uses thereof
US9603243B2 (en) 2010-04-12 2017-03-21 Tufts University Silk electronic components
CA2839719A1 (en) 2010-06-17 2011-12-22 Tufts University / Trustees Of Tufts College Silk optical particles and uses thereof
KR20140048067A (ko) * 2010-08-26 2014-04-23 바스프 에스이 자기-조립형 단백질의 고 농축 용액의 제조 방법
JP5937092B2 (ja) 2010-10-19 2016-06-22 トラスティーズ オブ タフツ カレッジ シルクフィブロインベースのマイクロニードルおよびその製造方法
US8546338B2 (en) * 2010-12-08 2013-10-01 Johnson & Johnson Consumer Companies, Inc. Self-assembling hydrogels based on dicephalic peptide amphiphiles
WO2012145652A1 (en) 2011-04-20 2012-10-26 Trustees Of Tufts College Dynamic silk coatings for implantable devices
BR112014001868B1 (pt) * 2011-07-26 2022-01-11 Cambridge Enterprise Limited Cápsulas supramoleculares, método para preparação das referidas cápsulas e método não-terapêutico de distribuir um componente a um local
WO2013103424A2 (en) 2011-10-11 2013-07-11 Tufts University Silk-based multifunctional biomedical platform
US20140370094A1 (en) 2011-11-08 2014-12-18 Tufts University Silk-based scaffold platform for engineering tissue constructs
ES2953309T3 (es) 2011-11-09 2023-11-10 Tufts College Partículas de fibroína de seda inyectables y usos de las mismas
WO2013071123A1 (en) 2011-11-09 2013-05-16 Trustees Of Tufts College Injectable silk fibroin foams and uses thereof
CA2865796A1 (en) 2011-12-29 2013-07-04 Trustees Of Tufts College Functionalization of biomaterials to control regeneration and inflammation responses
EP2625966A1 (en) * 2012-02-13 2013-08-14 Bionanoplus, S.L. Nanoparticles comprising a vegetable hydrophobic protein and a water miscible non-volatile organic solvent and uses thereof
WO2013142119A1 (en) * 2012-03-20 2013-09-26 Trustees Of Tufts College Silk reservoirs for drug delivery
WO2014012105A1 (en) * 2012-07-13 2014-01-16 Tufts University Encapsulation of immiscible phases in silk fibroin biomaterials
US20140023688A1 (en) 2012-07-13 2014-01-23 Firmenich Sa Encapsulated oils
CN105979938A (zh) * 2013-12-09 2016-09-28 香港大学 用于包封粒子、胶体和细胞的芯-壳胶囊
GB201415681D0 (en) 2014-09-04 2014-10-22 Cambridge Entpr Ltd And President And Fellows Of Harvard College Protien Capsules

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008535644A (ja) 2005-03-04 2008-09-04 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ 多重エマルジョンの形成のための方法および装置
JP2009502492A (ja) 2005-08-01 2009-01-29 テッヒニシェ・ウニヴェルジテート・ミュンヘン スパイダーシルクタンパク質からなるナノおよびマイクロカプセルの製造方法
JP2010536381A (ja) 2007-08-21 2010-12-02 アフォミックス コーポレイション 相互作用スクリーニングの方法、システムおよび装置
US20110280944A1 (en) 2010-05-17 2011-11-17 Samuel Stupp Fibrous microcapsules and methods of assembly and use thereof
WO2014118553A1 (en) 2013-01-30 2014-08-07 Cambridge Enterprise Limited Nested supramolecular capsules

Also Published As

Publication number Publication date
GB201415681D0 (en) 2014-10-22
EP3188719B1 (en) 2022-10-05
US20170202779A1 (en) 2017-07-20
US11878080B2 (en) 2024-01-23
WO2016034728A1 (en) 2016-03-10
JP2017527566A (ja) 2017-09-21
EP3188719A1 (en) 2017-07-12

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