JP2017526361A5 - - Google Patents

Info

Publication number

JP2017526361A5

JP2017526361A5 JP2017511182A JP2017511182A JP2017526361A5 JP 2017526361 A5 JP2017526361 A5 JP 2017526361A5 JP 2017511182 A JP2017511182 A JP 2017511182A JP 2017511182 A JP2017511182 A JP 2017511182A JP 2017526361 A5 JP2017526361 A5 JP 2017526361A5

Authority

JP

Japan

Prior art keywords

signaling

domain

binding domain

car

binding

Prior art date

2015-08-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 46
• 108020003175 receptors Proteins 0.000 claims description 34
• 102000005962 receptors Human genes 0.000 claims description 34
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• 239000003795 chemical substances by application Substances 0.000 claims description 20
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• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 4
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 4
• 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 4
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• 230000002265 prevention Effects 0.000 claims description 4
• SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims description 2
• FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 claims description 2
• 206010028980 Neoplasm Diseases 0.000 claims description 2
• 102000009661 Repressor Proteins Human genes 0.000 claims description 2
• 239000004098 Tetracycline Substances 0.000 claims description 2
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• 230000004068 intracellular signaling Effects 0.000 claims description 2
• 229960004023 minocycline Drugs 0.000 claims description 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
• 230000001177 retroviral effect Effects 0.000 claims description 2
• 229960002180 tetracycline Drugs 0.000 claims description 2
• 229930101283 tetracycline Natural products 0.000 claims description 2
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• 108700020534 tetracycline resistance-encoding transposon repressor Proteins 0.000 claims description 2
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• 108091007741 Chimeric antigen receptor T cells Proteins 0.000 description 1