JP2017525695A5 - - Google Patents

Download PDF

Info

Publication number
JP2017525695A5
JP2017525695A5 JP2017506886A JP2017506886A JP2017525695A5 JP 2017525695 A5 JP2017525695 A5 JP 2017525695A5 JP 2017506886 A JP2017506886 A JP 2017506886A JP 2017506886 A JP2017506886 A JP 2017506886A JP 2017525695 A5 JP2017525695 A5 JP 2017525695A5
Authority
JP
Japan
Prior art keywords
nucleotide
nucleoside
nucleic acid
formula
incorporated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017506886A
Other languages
English (en)
Japanese (ja)
Other versions
JP6563482B2 (ja
JP2017525695A (ja
Filing date
Publication date
Priority claimed from GBGB1414098.2A external-priority patent/GB201414098D0/en
Application filed filed Critical
Publication of JP2017525695A publication Critical patent/JP2017525695A/ja
Publication of JP2017525695A5 publication Critical patent/JP2017525695A5/ja
Application granted granted Critical
Publication of JP6563482B2 publication Critical patent/JP6563482B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017506886A 2014-08-08 2015-08-06 修飾ヌクレオチドリンカー Active JP6563482B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1414098.2A GB201414098D0 (en) 2014-08-08 2014-08-08 Modified nucleotide linkers
GB1414098.2 2014-08-08
PCT/GB2015/052282 WO2016020691A1 (en) 2014-08-08 2015-08-06 Modified nucleotide linkers

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019136261A Division JP2020015722A (ja) 2014-08-08 2019-07-24 修飾ヌクレオチドリンカー

Publications (3)

Publication Number Publication Date
JP2017525695A JP2017525695A (ja) 2017-09-07
JP2017525695A5 true JP2017525695A5 (cg-RX-API-DMAC7.html) 2018-06-28
JP6563482B2 JP6563482B2 (ja) 2019-08-21

Family

ID=51629525

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017506886A Active JP6563482B2 (ja) 2014-08-08 2015-08-06 修飾ヌクレオチドリンカー
JP2019136261A Pending JP2020015722A (ja) 2014-08-08 2019-07-24 修飾ヌクレオチドリンカー
JP2021148730A Active JP7726707B2 (ja) 2014-08-08 2021-09-13 修飾ヌクレオチドリンカー

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2019136261A Pending JP2020015722A (ja) 2014-08-08 2019-07-24 修飾ヌクレオチドリンカー
JP2021148730A Active JP7726707B2 (ja) 2014-08-08 2021-09-13 修飾ヌクレオチドリンカー

Country Status (19)

Country Link
US (3) US10190157B2 (cg-RX-API-DMAC7.html)
EP (2) EP3564252B1 (cg-RX-API-DMAC7.html)
JP (3) JP6563482B2 (cg-RX-API-DMAC7.html)
KR (2) KR102287718B1 (cg-RX-API-DMAC7.html)
CN (2) CN106604926B (cg-RX-API-DMAC7.html)
AU (2) AU2015298469B2 (cg-RX-API-DMAC7.html)
BR (2) BR112017002251B1 (cg-RX-API-DMAC7.html)
CA (1) CA2957382C (cg-RX-API-DMAC7.html)
DK (2) DK3177634T3 (cg-RX-API-DMAC7.html)
ES (2) ES2875557T3 (cg-RX-API-DMAC7.html)
GB (1) GB201414098D0 (cg-RX-API-DMAC7.html)
IL (1) IL250498B (cg-RX-API-DMAC7.html)
MX (2) MX377448B (cg-RX-API-DMAC7.html)
MY (1) MY195167A (cg-RX-API-DMAC7.html)
NZ (2) NZ728810A (cg-RX-API-DMAC7.html)
RU (1) RU2699993C2 (cg-RX-API-DMAC7.html)
SG (3) SG11201700880RA (cg-RX-API-DMAC7.html)
WO (1) WO2016020691A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201700838B (cg-RX-API-DMAC7.html)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201414098D0 (en) * 2014-08-08 2014-09-24 Illumina Cambridge Ltd Modified nucleotide linkers
CN106117288B (zh) * 2015-05-08 2019-10-15 生捷科技控股公司 二硫键连接的可逆终止子
US11085076B2 (en) 2015-09-28 2021-08-10 The Trustees Of Columbia University In The City Of New York Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
CN116656795A (zh) 2016-05-23 2023-08-29 纽约哥伦比亚大学董事会 核苷酸衍生物及其使用方法
IL267445B2 (en) * 2016-12-22 2023-10-01 Illumina Inc An array that includes a genetic tiling primer and a non tiling entity
WO2018165207A1 (en) 2017-03-06 2018-09-13 Singular Genomic Systems, Inc. Nucleic acid sequencing-by-synthesis (sbs) methods that combine sbs cycle steps
US12018325B2 (en) 2017-03-28 2024-06-25 The Trustees Of Columbia University In The City Of New York 3′-O-modified nucleotide analogues with different cleavable linkers for attaching fluorescent labels to the base for DNA sequencing by synthesis
CN110650968B (zh) * 2017-10-11 2022-07-05 深圳华大智造科技股份有限公司 修饰的核苷或核苷酸
US12215124B2 (en) 2018-02-21 2025-02-04 Singular Genomics Systems, Inc. Fluorinated nucleotides and uses thereof
CN112218640A (zh) 2018-03-15 2021-01-12 哥伦比亚大学董事会 核苷酸类似物及其在核酸测序和分析中的用途
US10738072B1 (en) 2018-10-25 2020-08-11 Singular Genomics Systems, Inc. Nucleotide analogues
EP3894598B1 (en) 2018-12-14 2024-01-03 Illumina Cambridge Limited Decreasing phasing with unlabeled nucleotides during sequencing
US11293061B2 (en) 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
JP2022516684A (ja) 2019-01-08 2022-03-01 シンギュラー・ゲノミクス・システムズ・インコーポレイテッド ヌクレオチドの開裂可能なリンカーおよびその使用
EP3931190A1 (en) 2019-03-01 2022-01-05 Illumina Cambridge Limited Tertiary amine substituted coumarin compounds and their uses as fluorescent labels
NL2023327B1 (en) 2019-03-01 2020-09-17 Illumina Inc Multiplexed fluorescent detection of analytes
US11390753B2 (en) 2019-03-01 2022-07-19 Illumina Cambridge Limited Exocyclic amine substituted coumarin compounds and uses as fluorescent labels
WO2020178231A1 (en) 2019-03-01 2020-09-10 Illumina, Inc. Multiplexed fluorescent detection of analytes
US11421271B2 (en) 2019-03-28 2022-08-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing using photoswitchable labels
WO2021104845A1 (en) 2019-11-27 2021-06-03 Illumina Cambridge Limited Cyclooctatetraene containing dyes and compositions
JP7287299B2 (ja) 2020-01-31 2023-06-06 トヨタ自動車株式会社 車両および車両制御インターフェース
BR112022026056A2 (pt) 2020-06-22 2023-03-07 Illumina Cambridge Ltd Nucleosídeos e nucleotídeos com grupo bloqueador 3? acetal
US11981964B2 (en) 2020-07-28 2024-05-14 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
US20220195517A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Long stokes shift chromenoquinoline dyes and uses in sequencing applications
US20220195196A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Alkylpyridinium coumarin dyes and uses in sequencing applications
US20220195516A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
US20220195518A1 (en) 2020-12-22 2022-06-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing
EP4334327A1 (en) 2021-05-05 2024-03-13 Illumina Cambridge Limited Fluorescent dyes containing bis-boron fused heterocycles and uses in sequencing
WO2022243480A1 (en) 2021-05-20 2022-11-24 Illumina, Inc. Compositions and methods for sequencing by synthesis
WO2022251032A1 (en) * 2021-05-26 2022-12-01 Illumina, Inc. Purifying and polymerizing 3'-blocked nucleotides
WO2023186815A1 (en) 2022-03-28 2023-10-05 Illumina Cambridge Limited Labeled avidin and methods for sequencing
US20230314322A1 (en) 2022-03-29 2023-10-05 Illumina, Inc. Systems and methods of sequencing polynucleotides
AU2023244351A1 (en) 2022-03-31 2024-01-18 Illumina, Inc. Nucleosides and nucleotides with 3' vinyl blocking group useful in sequencing by synthesis
WO2023186982A1 (en) 2022-03-31 2023-10-05 Illumina, Inc. Compositions and methods for improving sequencing signals
US20230383342A1 (en) 2022-05-31 2023-11-30 Illumina Cambridge Limited Compositions and methods for nucleic acid sequencing
CN119604513A (zh) 2022-06-28 2025-03-11 因美纳公司 含有稠合四环双硼杂环的荧光染料及其在测序中的用途
AU2023348238A1 (en) 2022-09-30 2024-10-03 Illumina, Inc. Compositions and methods for reducing photo damage during sequencing
CA3246536A1 (en) 2022-12-22 2024-06-27 Illumina, Inc. TRANSITION METAL CATALYST COMPOSITIONS AND SYNTHETIC SEQUENCE PROCESSES
US20240247311A1 (en) 2022-12-22 2024-07-25 Illumina, Inc. Palladium catalyst compositions and methods for sequencing by synthesis
AU2023419253A1 (en) 2022-12-27 2024-10-03 Illumina, Inc. Methods of sequencing using 3´ allyl blocked nucleotides
US20240327910A1 (en) 2023-03-29 2024-10-03 Illumina, Inc. Naphthalimide dyes and uses in nucleic acid sequencing
CA3257470A1 (en) 2023-03-30 2024-10-03 Illumina, Inc. NUCLEIC ACID COMPOSITIONS AND SEQUENCE METHODS
US20250075269A1 (en) 2023-08-31 2025-03-06 Illumina, Inc. Compositions and methods for nucleic acid sequencing
US20250137048A1 (en) 2023-10-26 2025-05-01 Illumina, Inc. 4,5-substituted naphthalimide dyes and uses in nucleic acid sequencing
WO2025106715A1 (en) 2023-11-17 2025-05-22 Illumina, Inc. Conjugated polymers or polymer dots as fluorescent labels
US20250197933A1 (en) 2023-12-18 2025-06-19 Illumina, Inc. Hydrogel nanoparticles as labeling scaffold in sequencing
US20250215493A1 (en) 2023-12-28 2025-07-03 Illumina, Inc. Nucleotides with enzymatically cleavable 3'-o-glycoside blocking groups for sequencing
US20250215494A1 (en) 2023-12-29 2025-07-03 Illumina, Inc. Tricyclic polymethine dyes for nucleic acid sequencing
WO2025184226A1 (en) 2024-02-28 2025-09-04 Illumina, Inc. Nucleotides with terminal phosphate capping
WO2025188906A1 (en) 2024-03-08 2025-09-12 Illumina, Inc. Modified adenosine nucleotides
WO2025221895A1 (en) 2024-04-19 2025-10-23 Illumina, Inc. Water soluble polymer scaffolds for dye labeling

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
DE3924454A1 (de) 1989-07-24 1991-02-07 Cornelis P Prof Dr Hollenberg Die anwendung von dna und dna-technologie fuer die konstruktion von netzwerken zur verwendung in der chip-konstruktion und chip-produktion (dna chips)
WO1991006678A1 (en) 1989-10-26 1991-05-16 Sri International Dna sequencing
EP0773227A1 (en) 1991-09-18 1997-05-14 Affymax Technologies N.V. Diverse collections of oligomers in use to prepare drugs, diagnostic reagents, pesticides or herbicides
ATE293011T1 (de) 1991-11-22 2005-04-15 Affymetrix Inc A Delaware Corp Kombinatorische strategien für die polymersynthese
ATE278807T1 (de) 1992-02-19 2004-10-15 New York Health Res Inst Neue anordnungen von oligonukleotiden und ihr nutzen zum sortieren, isolieren, sequenzierung und manipulieren von nukleinsäuren
US5583211A (en) 1992-10-29 1996-12-10 Beckman Instruments, Inc. Surface activated organic polymers useful for location - specific attachment of nucleic acids, peptides, proteins and oligosaccharides
US5472672A (en) 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
JPH09507121A (ja) 1993-10-26 1997-07-22 アフィマックス テクノロジーズ ナームロゼ ベノートスハップ 生物学的チップ上の核酸プローブアレー
US6156501A (en) 1993-10-26 2000-12-05 Affymetrix, Inc. Arrays of modified nucleic acid probes and methods of use
US5429807A (en) 1993-10-28 1995-07-04 Beckman Instruments, Inc. Method and apparatus for creating biopolymer arrays on a solid support surface
US5552278A (en) 1994-04-04 1996-09-03 Spectragen, Inc. DNA sequencing by stepwise ligation and cleavage
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
EP0852004B1 (en) 1995-10-11 2011-01-19 Luminex Corporation Multiplexed analysis of clinical specimens
US5658734A (en) 1995-10-17 1997-08-19 International Business Machines Corporation Process for synthesizing chemical compounds
US6458530B1 (en) 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
US6297006B1 (en) 1997-01-16 2001-10-02 Hyseq, Inc. Methods for sequencing repetitive sequences and for determining the order of sequence subfragments
US6087102A (en) 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6287776B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Method for detecting and classifying nucleic acid hybridization
JP3944996B2 (ja) 1998-03-05 2007-07-18 株式会社日立製作所 Dnaプローブアレー
US6031078A (en) 1998-06-16 2000-02-29 Millennium Pharmaceuticals, Inc. MTbx protein and nucleic acid molecules and uses therefor
US6277628B1 (en) 1998-10-02 2001-08-21 Incyte Genomics, Inc. Linear microarrays
WO2000036151A1 (en) * 1998-12-14 2000-06-22 Li-Cor, Inc. A heterogeneous assay for pyrophosphate detection
US6379698B1 (en) 1999-04-06 2002-04-30 Isis Pharmaceuticals, Inc. Fusogenic lipids and vesicles
CA2370976C (en) 1999-04-20 2009-10-20 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US20050244870A1 (en) 1999-04-20 2005-11-03 Illumina, Inc. Nucleic acid sequencing using microsphere arrays
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
CA2412567A1 (en) 2000-06-07 2001-12-13 Li-Cor, Inc. Charge-switch nucleotides
US6936702B2 (en) 2000-06-07 2005-08-30 Li-Cor, Inc. Charge-switch nucleotides
EP1368460B1 (en) 2000-07-07 2007-10-31 Visigen Biotechnologies, Inc. Real-time sequence determination
US7211414B2 (en) 2000-12-01 2007-05-01 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US20040259082A1 (en) * 2001-04-24 2004-12-23 Li-Cor, Inc. Polymerases with charge-switch activity and methods of generating such polymers
DE10120797B4 (de) 2001-04-27 2005-12-22 Genovoxx Gmbh Verfahren zur Analyse von Nukleinsäureketten
DE10120798B4 (de) * 2001-04-27 2005-12-29 Genovoxx Gmbh Verfahren zur Bestimmung der Genexpression
US7057026B2 (en) * 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
PT2119722T (pt) 2002-08-23 2016-12-12 Illumina Cambridge Ltd Nucleótidos marcados
US7414116B2 (en) * 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
WO2004018497A2 (en) * 2002-08-23 2004-03-04 Solexa Limited Modified nucleotides for polynucleotide sequencing
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
CA2521130C (en) * 2003-04-01 2013-05-14 Activx Biosciences, Inc. Acyl-phosphate and phosphonate probes and methods of their synthesis and use in proteomic analysis
WO2005044836A2 (de) * 2003-11-05 2005-05-19 Genovoxx Gmbh Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
US20070117104A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
AU2005296200B2 (en) 2004-09-17 2011-07-14 Pacific Biosciences Of California, Inc. Apparatus and method for analysis of molecules
WO2006097320A2 (de) * 2005-03-17 2006-09-21 Genovoxx Gmbh Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
US8212020B2 (en) 2005-03-11 2012-07-03 Steven Albert Benner Reagents for reversibly terminating primer extension
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
JP5122555B2 (ja) 2006-03-31 2013-01-16 ソレクサ・インコーポレイテッド 合成解析による配列決定システムおよび装置
EP2021415B1 (en) 2006-05-18 2017-03-15 Illumina Cambridge Limited Dye compounds and the use of their labelled conjugates
CA2662978A1 (en) * 2006-09-15 2008-03-20 Enzon Pharmaceuticals, Inc. Hindered ester-based biodegradable linkers for oligonucleotide delivery
CN101534861B (zh) 2006-09-15 2013-10-02 安佐制药股份有限公司 具有基于位阻酯的生物可降解连接基的聚环氧烷
BRPI0716808A2 (pt) * 2006-09-15 2013-11-05 Enzon Pharmaceuticals Inc Ligantes poliméricos baseados em lisina
US8110559B2 (en) 2006-09-15 2012-02-07 Enzon Pharmaceuticals, Inc. Hindered ester-based biodegradable linkers for oligonucleotide delivery
MX2009002855A (es) 2006-09-15 2009-03-30 Enzon Pharmaceuticals Inc Profarmacos polimericos dirigidos que contienen enlazadores multifuncionales.
US8399188B2 (en) * 2006-09-28 2013-03-19 Illumina, Inc. Compositions and methods for nucleotide sequencing
EP2089517A4 (en) 2006-10-23 2010-10-20 Pacific Biosciences California POLYMERASEENZYME AND REAGENTS FOR ADVANCED NUCKIC ACID SEQUENCING
NZ577303A (en) * 2006-12-05 2011-12-22 Lasergen Inc Nucleotides and nucleosides having derivitized bases including a dye and terminating group and uses in DNA sequencing
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
EP3285067B1 (en) 2006-12-14 2022-06-22 Life Technologies Corporation Apparatus for measuring analytes using fet arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US9163053B2 (en) * 2007-05-18 2015-10-20 Fluidigm Corporation Nucleotide analogs
US7678894B2 (en) * 2007-05-18 2010-03-16 Helicos Biosciences Corporation Nucleotide analogs
DK2725107T3 (da) * 2007-10-19 2019-01-02 Univ Columbia DNA-sekventering med ikke-fluorescerende nukleotidreversible terminatorer og ddNTP'er modificeret med spaltbart mærke og nukleinsyre omfattende inosin med reversible terminatorer
WO2009051807A1 (en) * 2007-10-19 2009-04-23 The Trustees Of Columbia University In The City Of New York Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US9206216B2 (en) * 2010-04-21 2015-12-08 Pierce Biotechnology, Inc. Modified nucleotides methods and kits
WO2012159072A2 (en) * 2011-05-18 2012-11-22 Cayman Chemical Company, Incorporated Fluorescent molecular probes for use in assays that measure test compound competitive binding with sam-utilizing proteins
PL3290528T3 (pl) * 2011-09-23 2020-03-31 Illumina, Inc. Sposoby i kompozycje do sekwencjonowania kwasów nukleinowych
EP2780031B1 (en) * 2011-11-17 2018-03-07 Indiana University Research and Technology Corporation Glucagon superfamily peptides exhibiting glucocorticoid receptor activity
WO2013101690A1 (en) * 2011-12-29 2013-07-04 modeRNA Therapeutics Modified mrnas encoding cell-penetrating polypeptides
CN103087131B (zh) * 2013-01-15 2015-07-08 上海交通大学 可逆终端及其合成和在dna合成测序中的用途
DK2964612T3 (en) 2013-03-08 2017-04-03 Illumina Cambridge Ltd POLYMETHIN COMPOUNDS AND USE THEREOF AS FLUORESCING LABELS
AU2013380647B2 (en) 2013-03-08 2017-05-04 Illumina Cambridge Ltd Rhodamine compounds and their use as fluorescent labels
CN103484106B (zh) 2013-09-05 2015-08-19 上海交通大学 四色荧光标记可逆终端及其在dna测序中的用途
CN103866010B (zh) 2014-02-28 2016-04-20 郭诚 一种基因测序的方法
GB201408077D0 (en) 2014-05-07 2014-06-18 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
GB201414098D0 (en) * 2014-08-08 2014-09-24 Illumina Cambridge Ltd Modified nucleotide linkers

Similar Documents

Publication Publication Date Title
JP2017525695A5 (cg-RX-API-DMAC7.html)
Cai et al. Phosphorothioated primers lead to loop-mediated isothermal amplification at low temperatures
KR102105236B1 (ko) 무효소 및 무증폭 시퀀싱
US11085079B2 (en) Universal Sanger sequencing from next-gen sequencing amplicons
JP2017520251A5 (cg-RX-API-DMAC7.html)
JP2014532430A5 (cg-RX-API-DMAC7.html)
JP2016526876A5 (cg-RX-API-DMAC7.html)
JP2017520580A5 (cg-RX-API-DMAC7.html)
JP2015156872A5 (cg-RX-API-DMAC7.html)
JP2012518421A5 (cg-RX-API-DMAC7.html)
JP2020508037A5 (ja) 親和性試薬を使用する核酸シークエンシング
JP2017535269A5 (cg-RX-API-DMAC7.html)
RU2017127990A (ru) Обнаружение посредством нанопоры полинуклеотидов-мишеней из фона образца
JP2013540423A5 (cg-RX-API-DMAC7.html)
JP2018531583A5 (cg-RX-API-DMAC7.html)
JP2013539970A5 (cg-RX-API-DMAC7.html)
JP2014223088A5 (cg-RX-API-DMAC7.html)
JP2010539940A5 (cg-RX-API-DMAC7.html)
RU2017101353A (ru) Набор или устройство для обнаружения рака пищевода и способ обнаружения
WO2016131030A4 (en) Methods for highly parallel and accurate measurement of nucleic acids
JP2017532980A5 (cg-RX-API-DMAC7.html)
WO2016187284A8 (en) Methods and composition for determining ph
JP2017521086A5 (cg-RX-API-DMAC7.html)
BR112017024688A2 (pt) métodos e composições para diagnóstico ou detecção de cânceres de pulmão
Li et al. Ultrasensitive detection of gastric cancer plasma microRNAs via magnetic beads-based chemiluminescent assay