JP2017524712A - 角膜同種移植片拒絶および新血管形成を予防するためのグルココルチコイドを負荷したナノ粒子 - Google Patents

角膜同種移植片拒絶および新血管形成を予防するためのグルココルチコイドを負荷したナノ粒子 Download PDF

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JP2017524712A
JP2017524712A JP2017507390A JP2017507390A JP2017524712A JP 2017524712 A JP2017524712 A JP 2017524712A JP 2017507390 A JP2017507390 A JP 2017507390A JP 2017507390 A JP2017507390 A JP 2017507390A JP 2017524712 A JP2017524712 A JP 2017524712A
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dsp
injection
nanoparticles
polymer
particles
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JP2017507390A
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JP2017524712A5 (enExample
Inventor
ジャスティン スコット ヘインズ，
ジャスティン スコット ヘインズ，
チン パン，
チン パン，
チングオ シュー，
チングオ シュー，
ニコラス ジェイ． ボイラン，
ニコラス ジェイ． ボイラン，
ウォルター ジェイ． スターク，
ウォルター ジェイ． スターク，
ビン ワン，
ビン ワン，
リシア ルオ，
リシア ルオ，
Original Assignee
ザ・ジョンズ・ホプキンス・ユニバーシティー
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Publication of JP2017524712A publication Critical patent/JP2017524712A/ja
Publication of JP2017524712A5 publication Critical patent/JP2017524712A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
JP2017507390A 2014-08-13 2015-08-03 角膜同種移植片拒絶および新血管形成を予防するためのグルココルチコイドを負荷したナノ粒子 Pending JP2017524712A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462037000P 2014-08-13 2014-08-13
US62/037,000 2014-08-13
US201562139561P 2015-03-27 2015-03-27
US62/139,561 2015-03-27
PCT/US2015/043478 WO2016025215A1 (en) 2014-08-13 2015-08-03 Glucocorticoid-loaded nanoparticles for prevention of corneal allograft rejection and neovascularization

Publications (2)

Publication Number Publication Date
JP2017524712A true JP2017524712A (ja) 2017-08-31
JP2017524712A5 JP2017524712A5 (enExample) 2018-08-16

Family

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JP2017507390A Pending JP2017524712A (ja) 2014-08-13 2015-08-03 角膜同種移植片拒絶および新血管形成を予防するためのグルココルチコイドを負荷したナノ粒子

Country Status (8)

Country Link
US (1) US10195212B2 (enExample)
EP (1) EP3193827A1 (enExample)
JP (1) JP2017524712A (enExample)
KR (1) KR20170046146A (enExample)
CN (1) CN106794152A (enExample)
CA (1) CA2957764C (enExample)
MX (1) MX2017001863A (enExample)
WO (1) WO2016025215A1 (enExample)

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US8889193B2 (en) 2010-02-25 2014-11-18 The Johns Hopkins University Sustained delivery of therapeutic agents to an eye compartment
EP3233098B1 (en) 2014-12-15 2024-05-29 The Johns Hopkins University Cvs transplantation for treatment of bacterial vaginosis
CN107278151A (zh) 2014-12-15 2017-10-20 约翰霍普金斯大学 舒尼替尼制剂及其在治疗青光眼中的使用方法
CN107635545A (zh) 2015-01-27 2018-01-26 约翰霍普金斯大学 用于增强粘膜表面处活性剂的输送的低渗水凝胶制剂
KR20180058758A (ko) 2015-09-22 2018-06-01 그레이버그 비젼, 인크. 안구 장애의 치료를 위한 화합물 및 조성물
BR112018009644A2 (pt) 2015-11-12 2018-11-06 Graybug Vision Inc micropartículas agregantes sólidas modificadas na superfície, material injetável, processo para preparação de micropartículas agregantes sólidas modificadas na superfície, método para tratamento de um distúrbio ocular, e, uso de micropartículas agregantes sólidas modificadas na superfície
DE102017002454A1 (de) * 2017-03-14 2018-09-20 Friedrich-Schiller-Universität Jena Organische Polymerpartikel enthaltend Poly(oxazolin)-Stabilisatoren und Verwendung von Poly(oxazolinen) zur Stabilisierung von organischen Polymerpartikeln
JP7217022B2 (ja) 2017-03-23 2023-02-02 グレイバグ ビジョン インコーポレイテッド 眼障害の治療のための薬物及び組成物
CA3057875A1 (en) 2017-05-10 2018-11-15 Graybug Vision, Inc. Extended release microparticles and suspensions thereof for medical therapy
WO2019071275A1 (en) * 2017-10-06 2019-04-11 Aciont Inc. DEVICES FOR DELIVERY OF NON-INVASIVE OCULAR MEDICINE
WO2020210805A1 (en) * 2019-04-11 2020-10-15 The Johns Hopkins University Nanoparticles for drug delivery to brain
WO2021168239A1 (en) * 2020-02-21 2021-08-26 The Johns Hopkins University Suprachoroidal delivery of drug particles to reduce toxicity

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WO2007074604A1 (ja) * 2005-12-26 2007-07-05 Ltt Bio-Pharma Co., Ltd. 水溶性非ペプチド性低分子薬物含有ナノ粒子
JP2008518038A (ja) * 2004-10-27 2008-05-29 アシオント・インコーポレーテッド 活性剤の持続性ｉｎ−ｖｉｖｏ送達のための方法及びデバイス
WO2008139804A1 (ja) * 2007-05-14 2008-11-20 Ltt Bio-Pharma Co., Ltd. 徐放性の陰荷電基を持つ低分子薬物含有ナノ粒子
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Also Published As

Publication number Publication date
US20170157147A1 (en) 2017-06-08
CA2957764C (en) 2019-07-02
CN106794152A (zh) 2017-05-31
MX2017001863A (es) 2017-07-17
CA2957764A1 (en) 2016-02-18
EP3193827A1 (en) 2017-07-26
WO2016025215A1 (en) 2016-02-18
US10195212B2 (en) 2019-02-05
KR20170046146A (ko) 2017-04-28

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