KR20170046146A - 각막 동종이식 거부 및 신혈관 형성의 예방을 위한 글루코 코르티코이드-로딩된 나노입자 - Google Patents
각막 동종이식 거부 및 신혈관 형성의 예방을 위한 글루코 코르티코이드-로딩된 나노입자 Download PDFInfo
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- KR20170046146A KR20170046146A KR1020177006811A KR20177006811A KR20170046146A KR 20170046146 A KR20170046146 A KR 20170046146A KR 1020177006811 A KR1020177006811 A KR 1020177006811A KR 20177006811 A KR20177006811 A KR 20177006811A KR 20170046146 A KR20170046146 A KR 20170046146A
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- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
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- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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| US201562139561P | 2015-03-27 | 2015-03-27 | |
| US62/139,561 | 2015-03-27 | ||
| PCT/US2015/043478 WO2016025215A1 (en) | 2014-08-13 | 2015-08-03 | Glucocorticoid-loaded nanoparticles for prevention of corneal allograft rejection and neovascularization |
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| KR20170046146A true KR20170046146A (ko) | 2017-04-28 |
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| US8889193B2 (en) | 2010-02-25 | 2014-11-18 | The Johns Hopkins University | Sustained delivery of therapeutic agents to an eye compartment |
| EP3233098B1 (en) | 2014-12-15 | 2024-05-29 | The Johns Hopkins University | Cvs transplantation for treatment of bacterial vaginosis |
| CN107278151A (zh) | 2014-12-15 | 2017-10-20 | 约翰霍普金斯大学 | 舒尼替尼制剂及其在治疗青光眼中的使用方法 |
| CN107635545A (zh) | 2015-01-27 | 2018-01-26 | 约翰霍普金斯大学 | 用于增强粘膜表面处活性剂的输送的低渗水凝胶制剂 |
| KR20180058758A (ko) | 2015-09-22 | 2018-06-01 | 그레이버그 비젼, 인크. | 안구 장애의 치료를 위한 화합물 및 조성물 |
| BR112018009644A2 (pt) | 2015-11-12 | 2018-11-06 | Graybug Vision Inc | micropartículas agregantes sólidas modificadas na superfície, material injetável, processo para preparação de micropartículas agregantes sólidas modificadas na superfície, método para tratamento de um distúrbio ocular, e, uso de micropartículas agregantes sólidas modificadas na superfície |
| DE102017002454A1 (de) * | 2017-03-14 | 2018-09-20 | Friedrich-Schiller-Universität Jena | Organische Polymerpartikel enthaltend Poly(oxazolin)-Stabilisatoren und Verwendung von Poly(oxazolinen) zur Stabilisierung von organischen Polymerpartikeln |
| JP7217022B2 (ja) | 2017-03-23 | 2023-02-02 | グレイバグ ビジョン インコーポレイテッド | 眼障害の治療のための薬物及び組成物 |
| CA3057875A1 (en) | 2017-05-10 | 2018-11-15 | Graybug Vision, Inc. | Extended release microparticles and suspensions thereof for medical therapy |
| WO2019071275A1 (en) * | 2017-10-06 | 2019-04-11 | Aciont Inc. | DEVICES FOR DELIVERY OF NON-INVASIVE OCULAR MEDICINE |
| WO2020210805A1 (en) * | 2019-04-11 | 2020-10-15 | The Johns Hopkins University | Nanoparticles for drug delivery to brain |
| WO2021168239A1 (en) * | 2020-02-21 | 2021-08-26 | The Johns Hopkins University | Suprachoroidal delivery of drug particles to reduce toxicity |
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| US4432964A (en) * | 1981-08-24 | 1984-02-21 | Alza Corporation | Topical composition containing steroid in two forms released independently from polymeric carrier |
| US4888176A (en) | 1984-05-21 | 1989-12-19 | Massachusetts Institute Of Technology | Controlled drug delivery high molecular weight polyanhydrides |
| US4757128A (en) | 1986-08-01 | 1988-07-12 | Massachusetts Institute Of Technology | High molecular weight polyanhydride and preparation thereof |
| US4789724A (en) | 1986-10-17 | 1988-12-06 | Massachusetts Institute Of Technology | Preparation of anhydride copolymers |
| US4857311A (en) | 1987-07-31 | 1989-08-15 | Massachusetts Institute Of Technology | Polyanhydrides with improved hydrolytic degradation properties |
| US4997652A (en) | 1987-12-22 | 1991-03-05 | Visionex | Biodegradable ocular implants |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| WO2004084871A1 (en) * | 2003-03-26 | 2004-10-07 | Ltt Bio-Pharma Co., Ltd. | Intravenous nanoparticles for targenting drug delivery and sustained drug release |
| US20090148527A1 (en) * | 2007-12-07 | 2009-06-11 | Robinson Michael R | Intraocular formulation |
| US20050226814A1 (en) | 2004-04-13 | 2005-10-13 | Bausch & Lomb Incorporated | Diagnostic method and kit for implantation of a sustained release drug-delivery implant with a steroid |
| US20060089590A1 (en) * | 2004-10-27 | 2006-04-27 | John Higuchi | Methods and devices for sustained in-vivo release of an active agent |
| JP2007001926A (ja) * | 2005-06-24 | 2007-01-11 | Ltt Bio-Pharma Co Ltd | 吸入・噴霧用ステロイド製剤 |
| EP1985309B1 (en) * | 2005-12-26 | 2016-11-23 | LTT Bio-Pharma Co., Ltd. | Nanoparticles containing water-soluble non-peptide low-molecular weight drug |
| US20100129456A1 (en) * | 2007-05-14 | 2010-05-27 | Ltt Bio-Pharma Co., Ltd. | Sustained-release nanoparticle containing low-molecular-weight drug with negatively charged group |
| JP2011512903A (ja) * | 2008-02-25 | 2011-04-28 | アイゲート ファーマ エスエーエス | イオントフォレシスを介した眼組織への治療薬の向上した送達 |
| US20110206773A1 (en) * | 2008-05-20 | 2011-08-25 | Yale University | Sustained delivery of drugs from biodegradable polymeric microparticles |
| US9095506B2 (en) | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| WO2011041373A1 (en) | 2009-09-29 | 2011-04-07 | Eyegate Pharmaceuticals, Inc. | Positively-charged poly (d,l-lactide-co-glycolide) nanoparticles and fabrication methods of the same |
| CA2845673A1 (en) | 2011-09-13 | 2013-03-21 | Altacor Limited | Pharmaceutical nanoparticle compositions |
| AU2013209452B2 (en) | 2012-01-19 | 2015-11-05 | The Johns Hopkins University | Nanoparticle formulations with enhanced mucosal penetration |
| NZ741873A (en) * | 2012-05-03 | 2019-04-26 | Kala Pharmaceuticals Inc | Pharmaceutical nanoparticles showing improved mucosal transport |
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| EP3193827A1 (en) | 2017-07-26 |
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| US10195212B2 (en) | 2019-02-05 |
| JP2017524712A (ja) | 2017-08-31 |
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