CN106794152A - 用于预防角膜同种异体移植物排斥和新生血管形成的载有糖皮质激素的纳米颗粒 - Google Patents

用于预防角膜同种异体移植物排斥和新生血管形成的载有糖皮质激素的纳米颗粒 Download PDF

Info

Publication number
CN106794152A
CN106794152A CN201580053822.9A CN201580053822A CN106794152A CN 106794152 A CN106794152 A CN 106794152A CN 201580053822 A CN201580053822 A CN 201580053822A CN 106794152 A CN106794152 A CN 106794152A
Authority
CN
China
Prior art keywords
dsp
injection
nanoparticles
particles
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580053822.9A
Other languages
English (en)
Chinese (zh)
Inventor
J·S·汉斯
潘青
徐庆国
N·J·博兰
W·J·斯塔克
王冰
罗莉霞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of CN106794152A publication Critical patent/CN106794152A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
CN201580053822.9A 2014-08-13 2015-08-03 用于预防角膜同种异体移植物排斥和新生血管形成的载有糖皮质激素的纳米颗粒 Pending CN106794152A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462037000P 2014-08-13 2014-08-13
US62/037,000 2014-08-13
US201562139561P 2015-03-27 2015-03-27
US62/139,561 2015-03-27
PCT/US2015/043478 WO2016025215A1 (en) 2014-08-13 2015-08-03 Glucocorticoid-loaded nanoparticles for prevention of corneal allograft rejection and neovascularization

Publications (1)

Publication Number Publication Date
CN106794152A true CN106794152A (zh) 2017-05-31

Family

ID=54011072

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580053822.9A Pending CN106794152A (zh) 2014-08-13 2015-08-03 用于预防角膜同种异体移植物排斥和新生血管形成的载有糖皮质激素的纳米颗粒

Country Status (8)

Country Link
US (1) US10195212B2 (enExample)
EP (1) EP3193827A1 (enExample)
JP (1) JP2017524712A (enExample)
KR (1) KR20170046146A (enExample)
CN (1) CN106794152A (enExample)
CA (1) CA2957764C (enExample)
MX (1) MX2017001863A (enExample)
WO (1) WO2016025215A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2538929A4 (en) 2010-02-25 2014-07-09 Univ Johns Hopkins DELAYED RELEASE OF THERAPIES IN A PART OF THE EYE
KR20170094793A (ko) 2014-12-15 2017-08-21 더 존스 홉킨스 유니버시티 수니티닙 제제 및 녹내장의 치료에서의 그의 사용 방법
WO2016100086A1 (en) 2014-12-15 2016-06-23 The Johns Hopkins University Cvs transplantation for treatment of bacterial vaginosis
US10485757B2 (en) 2015-01-27 2019-11-26 The Johns Hopkins University Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces
KR20180058758A (ko) 2015-09-22 2018-06-01 그레이버그 비젼, 인크. 안구 장애의 치료를 위한 화합물 및 조성물
MX2018005932A (es) 2015-11-12 2019-05-20 Graybug Vision Inc Microparticulas aglomerantes para terapia medica.
DE102017002454A1 (de) * 2017-03-14 2018-09-20 Friedrich-Schiller-Universität Jena Organische Polymerpartikel enthaltend Poly(oxazolin)-Stabilisatoren und Verwendung von Poly(oxazolinen) zur Stabilisierung von organischen Polymerpartikeln
EP3600324A4 (en) 2017-03-23 2020-12-09 Graybug Vision, Inc. COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF EYE DISORDERS
MX2019013363A (es) 2017-05-10 2020-01-13 Graybug Vision Inc Microparticulas de liberacion extendida y suspensiones de las mismas para terapia medica.
WO2019071275A1 (en) * 2017-10-06 2019-04-11 Aciont Inc. DEVICES FOR DELIVERY OF NON-INVASIVE OCULAR MEDICINE
US12496279B2 (en) 2019-04-11 2025-12-16 The Johns Hopkins University Nanoparticles for drug delivery to brain
US20230081539A1 (en) * 2020-02-21 2023-03-16 The Johns Hopkins University Suprachoroidal delivery of drug particles to reduce toxicity

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4432964A (en) * 1981-08-24 1984-02-21 Alza Corporation Topical composition containing steroid in two forms released independently from polymeric carrier
US20090148527A1 (en) * 2007-12-07 2009-06-11 Robinson Michael R Intraocular formulation
US20110206773A1 (en) * 2008-05-20 2011-08-25 Yale University Sustained delivery of drugs from biodegradable polymeric microparticles
WO2013110028A1 (en) * 2012-01-19 2013-07-25 The Johns Hopkins University Nanoparticle formulations with enhanced mucosal penetration
WO2013166436A1 (en) * 2012-05-03 2013-11-07 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4757128A (en) 1986-08-01 1988-07-12 Massachusetts Institute Of Technology High molecular weight polyanhydride and preparation thereof
US4888176A (en) 1984-05-21 1989-12-19 Massachusetts Institute Of Technology Controlled drug delivery high molecular weight polyanhydrides
US4789724A (en) 1986-10-17 1988-12-06 Massachusetts Institute Of Technology Preparation of anhydride copolymers
US4857311A (en) 1987-07-31 1989-08-15 Massachusetts Institute Of Technology Polyanhydrides with improved hydrolytic degradation properties
US4997652A (en) 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
WO2004084871A1 (en) * 2003-03-26 2004-10-07 Ltt Bio-Pharma Co., Ltd. Intravenous nanoparticles for targenting drug delivery and sustained drug release
US20050226814A1 (en) 2004-04-13 2005-10-13 Bausch & Lomb Incorporated Diagnostic method and kit for implantation of a sustained release drug-delivery implant with a steroid
US20060089590A1 (en) * 2004-10-27 2006-04-27 John Higuchi Methods and devices for sustained in-vivo release of an active agent
JP2007001926A (ja) * 2005-06-24 2007-01-11 Ltt Bio-Pharma Co Ltd 吸入・噴霧用ステロイド製剤
US8916206B2 (en) * 2005-12-26 2014-12-23 Ltt Bio-Pharma Co., Ltd. Nanoparticles containing water-soluble non-peptide low-molecular weight drug
EP2156848A4 (en) * 2007-05-14 2012-11-28 Ltt Bio Pharma Co Ltd NANOPARTICLE CONTAINING A LOW MOLECULAR WEIGHT DRUG HAVING A NEGATIVELY PROLONGED RELEASE GROUP
CN101970042A (zh) * 2008-02-25 2011-02-09 眼门药品公司 经由离子电渗法增强递送治疗药物至眼部组织
US9095506B2 (en) 2008-11-17 2015-08-04 Allergan, Inc. Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof
EP2482818A4 (en) 2009-09-29 2014-04-09 Eyegate Pharmaceuticals Inc POSITIVELY CHARGED POLY (D, L-LACTIDE-CO-GLYCOLIDE) NANOPARTICLES AND METHODS OF MAKING SAME
WO2013038195A2 (en) 2011-09-13 2013-03-21 Altacor Limited Pharmaceutical nanoparticle compositions

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4432964A (en) * 1981-08-24 1984-02-21 Alza Corporation Topical composition containing steroid in two forms released independently from polymeric carrier
US20090148527A1 (en) * 2007-12-07 2009-06-11 Robinson Michael R Intraocular formulation
US20110206773A1 (en) * 2008-05-20 2011-08-25 Yale University Sustained delivery of drugs from biodegradable polymeric microparticles
WO2013110028A1 (en) * 2012-01-19 2013-07-25 The Johns Hopkins University Nanoparticle formulations with enhanced mucosal penetration
WO2013166436A1 (en) * 2012-05-03 2013-11-07 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CAROLINA ET AL: "Encapsulation of dexamethasone into biodegradable polymeric nanoparticles", 《INTERNATIONAL JOURNAL OF PHARMACEUTICS》 *
ISHIHARA ET AL: "Role of zinc in formulation of PLGA/PLA nanoparticles encapsulating betamethasone phosphate and its release profile", 《JOURNAL OF CONTROLLED RELEASE》 *
JARASWEKIN ET AL: "Effect of poly(lactide-co-glycolide) molecular weight on the release of dexamethasone sodium phosphate from microparticles", 《JOURNAL OF MICROENCAPSULATION》 *
PERACCHIA ET AL: "PEG-coated nanospheres from amphiphilic diblock and multiblock copolymers: Investigation of their drug encapsulation and release characteristics", 《JOURNAL OF CONTROLLED RELEASE》 *
QINGGUO XU ET AL: "Nanotechnology Approaches for Ocular Drug Delivery", 《MIDDLE EAST AFRICAN JOURNAL OF OPHTHALMOLOGY》 *
陶自珍: "《临床眼科治疗学》", 31 July 2006 *

Also Published As

Publication number Publication date
US10195212B2 (en) 2019-02-05
CA2957764A1 (en) 2016-02-18
MX2017001863A (es) 2017-07-17
CA2957764C (en) 2019-07-02
US20170157147A1 (en) 2017-06-08
JP2017524712A (ja) 2017-08-31
WO2016025215A1 (en) 2016-02-18
KR20170046146A (ko) 2017-04-28
EP3193827A1 (en) 2017-07-26

Similar Documents

Publication Publication Date Title
US10195212B2 (en) Glucocorticoid-loaded nanoparticles for prevention of corneal allograft rejection and neovascularization
US11660349B2 (en) Non-linear multiblock copolymer-drug conjugates for the delivery of active agents
CN104363924B (zh) 用于递送hif‑1抑制剂的控制释放调配物
Pan et al. Corticosteroid-loaded biodegradable nanoparticles for prevention of corneal allograft rejection in rats
JP6570513B2 (ja) 持続的眼内放出のためのマイクロスフェア薬剤送達システム
JP2022001582A (ja) 眼において薬物徐放を達成する方法及び生体適合性組成物
JP2018515529A (ja) ハイドロゲルからの薬物送達
Desai et al. Ophthalmic and otic drug administration: novel approaches and challenges
KR20210013339A (ko) 개선된 점막 수송을 나타내는 제약 나노입자
JP2015013863A (ja) 増大した前眼部クリアランス速度を有するα−２アドレナリン受容体アゴニストを用いる眼科治療
Paliwal et al. Chitosan-based nanocarriers for ophthalmic applications
EP4433076A1 (en) Compositions and methods for the treatment of ocular diseases and injuries
US11369575B2 (en) PPARα agonist compositions and methods of use
Sha et al. In situ gels: The next new frontier in ophthalmic drug delivery system
US20240197740A1 (en) Methotrexate treatment methods
Kundu et al. Emerging drug delivery strategies for glaucoma therapy: focus on nanoparticles and stimuli-responsive systems
Pillay et al. Intraocular drug delivery technologies: advancing treatment of posterior segment disorders of the eye
US20190022016A1 (en) Compositions for sustained release of anti-glaucoma agents to control intraocular pressure
Ramesh Ocular barriers and ocular drug delivery: Bridging the gap using nanomicelles as drug carriers
Khodakiya et al. Implants and Inserts in Diagnosis and Treatment of Macular Degeneration
Virmani et al. Eyes on the Future: Nano-medicine Innovations in Enhancing Ocular Bioavailability
Virmani et al. An overview of ocular drug delivery systemsdconventional and novel drug delivery systems
WO2024129979A1 (en) Methotrexate treatment methods
HK40003833A (en) Methods and biocompatible compositions to achieve sustained drug release in the eye

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20170531

WD01 Invention patent application deemed withdrawn after publication