MX2017001863A - Nanoparticulas cargadas con glucocorticoides para prevencion de rechazo de aloinjerto corneal y neovascularizacion. - Google Patents
Nanoparticulas cargadas con glucocorticoides para prevencion de rechazo de aloinjerto corneal y neovascularizacion.Info
- Publication number
- MX2017001863A MX2017001863A MX2017001863A MX2017001863A MX2017001863A MX 2017001863 A MX2017001863 A MX 2017001863A MX 2017001863 A MX2017001863 A MX 2017001863A MX 2017001863 A MX2017001863 A MX 2017001863A MX 2017001863 A MX2017001863 A MX 2017001863A
- Authority
- MX
- Mexico
- Prior art keywords
- glucocorticoid
- neovascularization
- prevention
- allograft rejection
- loaded nanoparticles
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
Partículas que encapsulan un glucocorticoide tal como fosfato de sodio dexametasona (DSP) en una matriz tal como poli(ácido láctico-co-glicólico) (PLGA) biodegradable que se recubre densamente con polímero hidrofílico tal como PEG o PLURONIC(r) F127, exhiben liberación sostenida de DSP por hasta 7 días in vitro. Estas nanopartículas se pueden utilizar para prevenir el rechazo de injerto corneal o la neovascularización corneal.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462037000P | 2014-08-13 | 2014-08-13 | |
US201562139561P | 2015-03-27 | 2015-03-27 | |
PCT/US2015/043478 WO2016025215A1 (en) | 2014-08-13 | 2015-08-03 | Glucocorticoid-loaded nanoparticles for prevention of corneal allograft rejection and neovascularization |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017001863A true MX2017001863A (es) | 2017-07-17 |
Family
ID=54011072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017001863A MX2017001863A (es) | 2014-08-13 | 2015-08-03 | Nanoparticulas cargadas con glucocorticoides para prevencion de rechazo de aloinjerto corneal y neovascularizacion. |
Country Status (8)
Country | Link |
---|---|
US (1) | US10195212B2 (es) |
EP (1) | EP3193827A1 (es) |
JP (1) | JP2017524712A (es) |
KR (1) | KR20170046146A (es) |
CN (1) | CN106794152A (es) |
CA (1) | CA2957764C (es) |
MX (1) | MX2017001863A (es) |
WO (1) | WO2016025215A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3233056B1 (en) | 2014-12-15 | 2023-11-15 | The Johns Hopkins University | Sunitinib formulations and methods for use thereof in treatment of ocular disorders |
AU2016211696B2 (en) | 2015-01-27 | 2018-05-10 | The Johns Hopkins University | Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces |
KR20180058758A (ko) | 2015-09-22 | 2018-06-01 | 그레이버그 비젼, 인크. | 안구 장애의 치료를 위한 화합물 및 조성물 |
EA038755B1 (ru) | 2015-11-12 | 2021-10-14 | Грейбаг Вижн, Инк. | Агрегирующие микрочастицы для обеспечения замедленного высвобождения терапевтического агента для внутриглазной доставки |
DE102017002454A1 (de) * | 2017-03-14 | 2018-09-20 | Friedrich-Schiller-Universität Jena | Organische Polymerpartikel enthaltend Poly(oxazolin)-Stabilisatoren und Verwendung von Poly(oxazolinen) zur Stabilisierung von organischen Polymerpartikeln |
AU2018240462C1 (en) | 2017-03-23 | 2022-12-08 | Graybug Vision, Inc. | Drugs and compositions for the treatment of ocular disorders |
CN111201040A (zh) | 2017-05-10 | 2020-05-26 | 灰色视觉公司 | 用于医学疗法的缓释微粒及其悬浮液 |
WO2019071275A1 (en) * | 2017-10-06 | 2019-04-11 | Aciont Inc. | DEVICES FOR DELIVERY OF NON-INVASIVE OCULAR MEDICINE |
WO2021168239A1 (en) * | 2020-02-21 | 2021-08-26 | The Johns Hopkins University | Suprachoroidal delivery of drug particles to reduce toxicity |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4432964A (en) * | 1981-08-24 | 1984-02-21 | Alza Corporation | Topical composition containing steroid in two forms released independently from polymeric carrier |
US4757128A (en) | 1986-08-01 | 1988-07-12 | Massachusetts Institute Of Technology | High molecular weight polyanhydride and preparation thereof |
US4888176A (en) | 1984-05-21 | 1989-12-19 | Massachusetts Institute Of Technology | Controlled drug delivery high molecular weight polyanhydrides |
US4789724A (en) | 1986-10-17 | 1988-12-06 | Massachusetts Institute Of Technology | Preparation of anhydride copolymers |
US4857311A (en) | 1987-07-31 | 1989-08-15 | Massachusetts Institute Of Technology | Polyanhydrides with improved hydrolytic degradation properties |
US4997652A (en) | 1987-12-22 | 1991-03-05 | Visionex | Biodegradable ocular implants |
US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
US20060233883A1 (en) * | 2003-03-26 | 2006-10-19 | Tsutomu Ishihara | Intravenous nanoparticles for targeting drug delivery and sustained drug release |
US20090148527A1 (en) * | 2007-12-07 | 2009-06-11 | Robinson Michael R | Intraocular formulation |
US20050226814A1 (en) | 2004-04-13 | 2005-10-13 | Bausch & Lomb Incorporated | Diagnostic method and kit for implantation of a sustained release drug-delivery implant with a steroid |
US8246949B2 (en) * | 2004-10-27 | 2012-08-21 | Aciont, Inc. | Methods and devices for sustained in-vivo release of an active agent |
JP2007001926A (ja) * | 2005-06-24 | 2007-01-11 | Ltt Bio-Pharma Co Ltd | 吸入・噴霧用ステロイド製剤 |
US8916206B2 (en) * | 2005-12-26 | 2014-12-23 | Ltt Bio-Pharma Co., Ltd. | Nanoparticles containing water-soluble non-peptide low-molecular weight drug |
US20100129456A1 (en) * | 2007-05-14 | 2010-05-27 | Ltt Bio-Pharma Co., Ltd. | Sustained-release nanoparticle containing low-molecular-weight drug with negatively charged group |
CN101970042A (zh) * | 2008-02-25 | 2011-02-09 | 眼门药品公司 | 经由离子电渗法增强递送治疗药物至眼部组织 |
US20110206773A1 (en) * | 2008-05-20 | 2011-08-25 | Yale University | Sustained delivery of drugs from biodegradable polymeric microparticles |
US9095506B2 (en) | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
US20120177741A1 (en) | 2009-09-29 | 2012-07-12 | Eyegate Pharmaceuticals, Inc. | Positively-charged poly (d,l-lactide-co-glycolide) nanoparticles and fabrication methods of the same |
EP2755659A2 (en) | 2011-09-13 | 2014-07-23 | Altacor Limited | Pharmaceutical nanoparticle compositions |
KR101811917B1 (ko) * | 2012-01-19 | 2017-12-22 | 더 존스 홉킨스 유니버시티 | 점액 침투 강화를 나타내는 나노 입자 제형 |
US20130316001A1 (en) * | 2012-05-03 | 2013-11-28 | Kala Pharmaceuticals, Inc. | Particles, compositions and methods for ophthalmic and/or other applications |
-
2015
- 2015-08-03 CN CN201580053822.9A patent/CN106794152A/zh active Pending
- 2015-08-03 JP JP2017507390A patent/JP2017524712A/ja active Pending
- 2015-08-03 EP EP15756267.9A patent/EP3193827A1/en not_active Withdrawn
- 2015-08-03 WO PCT/US2015/043478 patent/WO2016025215A1/en active Application Filing
- 2015-08-03 US US15/502,732 patent/US10195212B2/en active Active
- 2015-08-03 KR KR1020177006811A patent/KR20170046146A/ko unknown
- 2015-08-03 MX MX2017001863A patent/MX2017001863A/es unknown
- 2015-08-03 CA CA2957764A patent/CA2957764C/en active Active
Also Published As
Publication number | Publication date |
---|---|
US10195212B2 (en) | 2019-02-05 |
KR20170046146A (ko) | 2017-04-28 |
CA2957764C (en) | 2019-07-02 |
CA2957764A1 (en) | 2016-02-18 |
JP2017524712A (ja) | 2017-08-31 |
CN106794152A (zh) | 2017-05-31 |
US20170157147A1 (en) | 2017-06-08 |
WO2016025215A1 (en) | 2016-02-18 |
EP3193827A1 (en) | 2017-07-26 |
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