JP2017524366A5 - - Google Patents

Info

Publication number

JP2017524366A5

JP2017524366A5 JP2017507848A JP2017507848A JP2017524366A5 JP 2017524366 A5 JP2017524366 A5 JP 2017524366A5 JP 2017507848 A JP2017507848 A JP 2017507848A JP 2017507848 A JP2017507848 A JP 2017507848A JP 2017524366 A5 JP2017524366 A5 JP 2017524366A5

Authority

JP

Japan

Prior art keywords

protein

factor

furin

transformed

transformed cell

Prior art date

2015-08-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000013604 expression vector Substances 0.000 claims 10
• 102000004169 proteins and genes Human genes 0.000 claims 10
• 108090000623 proteins and genes Proteins 0.000 claims 10
• 239000012228 culture supernatant Substances 0.000 claims 9
• 238000000034 method Methods 0.000 claims 9
• 101001022148 Homo sapiens Furin Proteins 0.000 claims 8
• 108010014173 Factor X Proteins 0.000 claims 7
• 108090001126 Furin Proteins 0.000 claims 6
• 102000004961 Furin Human genes 0.000 claims 6
• 239000002773 nucleotide Substances 0.000 claims 6
• 125000003729 nucleotide group Chemical group 0.000 claims 6
• 238000004519 manufacturing process Methods 0.000 claims 3
• 102100022641 Coagulation factor IX Human genes 0.000 claims 2
• 108010076282 Factor IX Proteins 0.000 claims 2
• 125000001176 L-lysyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C([H])([H])C([H])([H])C(N([H])[H])([H])[H] 0.000 claims 2
• 101800004937 Protein C Proteins 0.000 claims 2
• 102000017975 Protein C Human genes 0.000 claims 2
• 229940096437 Protein S Drugs 0.000 claims 2
• 108010066124 Protein S Proteins 0.000 claims 2
• 102000029301 Protein S Human genes 0.000 claims 2
• 108010094028 Prothrombin Proteins 0.000 claims 2
• 101800001700 Saposin-D Proteins 0.000 claims 2
• AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 229960004222 factor ix Drugs 0.000 claims 2
• 229940012426 factor x Drugs 0.000 claims 2
• 108010025221 plasma protein Z Proteins 0.000 claims 2
• 229960000856 protein c Drugs 0.000 claims 2
• 108010047303 von Willebrand Factor Proteins 0.000 claims 2
• 102100036537 von Willebrand factor Human genes 0.000 claims 2
• 229960001134 von willebrand factor Drugs 0.000 claims 2
• 230000001747 exhibiting effect Effects 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 230000003248 secreting effect Effects 0.000 claims 1
• 239000013598 vector Substances 0.000 claims 1