JP2017522877A5 - - Google Patents
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- JP2017522877A5 JP2017522877A5 JP2017503089A JP2017503089A JP2017522877A5 JP 2017522877 A5 JP2017522877 A5 JP 2017522877A5 JP 2017503089 A JP2017503089 A JP 2017503089A JP 2017503089 A JP2017503089 A JP 2017503089A JP 2017522877 A5 JP2017522877 A5 JP 2017522877A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- fhbp
- variant
- substitution
- acid substitution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001413 amino acids Chemical class 0.000 claims description 94
- 101710186862 Factor H binding protein Proteins 0.000 claims description 93
- 238000006467 substitution reaction Methods 0.000 claims description 84
- 235000001014 amino acid Nutrition 0.000 claims description 74
- 229940024606 amino acid Drugs 0.000 claims description 17
- 230000005875 antibody response Effects 0.000 claims description 11
- 230000002163 immunogen Effects 0.000 claims description 10
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 9
- 230000000844 anti-bacterial effect Effects 0.000 claims description 9
- 101000737574 Homo sapiens Complement factor H Proteins 0.000 claims description 7
- 241000124008 Mammalia Species 0.000 claims description 7
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 7
- 102000045512 human CFH Human genes 0.000 claims description 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 6
- 239000004471 Glycine Substances 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 125000003607 serino group Chemical class [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims description 5
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 4
- 241000588650 Neisseria meningitidis Species 0.000 claims description 4
- 239000013604 expression vector Substances 0.000 claims description 4
- 235000013922 glutamic acid Nutrition 0.000 claims description 4
- 239000004220 glutamic acid Substances 0.000 claims description 4
- 125000000291 glutamic acid group Chemical class N[C@@H](CCC(O)=O)C(=O)* 0.000 claims description 4
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims description 4
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 4
- 125000000487 histidyl group Chemical class [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims description 4
- 238000003259 recombinant expression Methods 0.000 claims description 4
- 102200128616 rs121908751 Human genes 0.000 claims description 4
- 102220466919 Runt-related transcription factor 1_R80A_mutation Human genes 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 3
- 239000004475 Arginine Substances 0.000 claims description 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims description 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
- 102000018697 Membrane Proteins Human genes 0.000 claims description 2
- 108010052285 Membrane Proteins Proteins 0.000 claims description 2
- 241000588653 Neisseria Species 0.000 claims description 2
- 102220534532 Protein quaking_Q38K_mutation Human genes 0.000 claims description 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 2
- 239000004473 Threonine Substances 0.000 claims description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 2
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical group O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 2
- 229960001230 asparagine Drugs 0.000 claims description 2
- 235000009582 asparagine Nutrition 0.000 claims description 2
- 235000003704 aspartic acid Nutrition 0.000 claims description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 2
- 102220481542 eIF5-mimic protein 2_R41A_mutation Human genes 0.000 claims description 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 2
- 125000000404 glutamine group Chemical class N[C@@H](CCC(N)=O)C(=O)* 0.000 claims description 2
- 150000002333 glycines Chemical class 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 229960000310 isoleucine Drugs 0.000 claims description 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 2
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims description 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 102220279362 rs1554893806 Human genes 0.000 claims description 2
- 102220056952 rs730880947 Human genes 0.000 claims description 2
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims description 2
- 239000004474 valine Substances 0.000 claims description 2
- 125000002987 valine group Chemical class [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462028123P | 2014-07-23 | 2014-07-23 | |
| US62/028,123 | 2014-07-23 | ||
| PCT/US2015/041616 WO2016014719A1 (en) | 2014-07-23 | 2015-07-22 | Factor h binding protein variants and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020158515A Division JP7221917B2 (ja) | 2014-07-23 | 2020-09-23 | Ｈ因子結合タンパク質変異体及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017522877A JP2017522877A (ja) | 2017-08-17 |
| JP2017522877A5 true JP2017522877A5 (OSRAM) | 2018-08-30 |
| JP6796057B2 JP6796057B2 (ja) | 2020-12-02 |
Family
ID=55163727
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017503089A Active JP6796057B2 (ja) | 2014-07-23 | 2015-07-22 | Ｈ因子結合タンパク質変異体及びその使用方法 |
| JP2020158515A Active JP7221917B2 (ja) | 2014-07-23 | 2020-09-23 | Ｈ因子結合タンパク質変異体及びその使用方法 |
| JP2022180069A Active JP7719046B2 (ja) | 2014-07-23 | 2022-11-10 | Ｈ因子結合タンパク質変異体及びその使用方法 |
| JP2025071948A Pending JP2025108722A (ja) | 2014-07-23 | 2025-04-24 | Ｈ因子結合タンパク質変異体及びその使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020158515A Active JP7221917B2 (ja) | 2014-07-23 | 2020-09-23 | Ｈ因子結合タンパク質変異体及びその使用方法 |
| JP2022180069A Active JP7719046B2 (ja) | 2014-07-23 | 2022-11-10 | Ｈ因子結合タンパク質変異体及びその使用方法 |
| JP2025071948A Pending JP2025108722A (ja) | 2014-07-23 | 2025-04-24 | Ｈ因子結合タンパク質変異体及びその使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (10) | US10266572B2 (OSRAM) |
| EP (2) | EP3172224B1 (OSRAM) |
| JP (4) | JP6796057B2 (OSRAM) |
| KR (2) | KR102752259B1 (OSRAM) |
| CN (3) | CN112851768A (OSRAM) |
| AU (5) | AU2015292615B2 (OSRAM) |
| BR (1) | BR112017001417B1 (OSRAM) |
| CA (2) | CA2955802C (OSRAM) |
| CO (1) | CO2017000558A2 (OSRAM) |
| CR (1) | CR20170020A (OSRAM) |
| ES (1) | ES2922554T3 (OSRAM) |
| MX (3) | MX382409B (OSRAM) |
| NZ (2) | NZ766005A (OSRAM) |
| RU (1) | RU2714248C2 (OSRAM) |
| WO (1) | WO2016014719A1 (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110845585A (zh) | 2010-03-30 | 2020-02-28 | 奥克兰儿童医院及研究中心 | 改性的h因子结合蛋白（fhbp）及其使用方法 |
| EP3172224B1 (en) * | 2014-07-23 | 2022-06-29 | Children's Hospital & Research Center at Oakland | Factor h binding protein variants and methods of use thereof |
| GB201614687D0 (en) * | 2016-08-31 | 2016-10-12 | Univ Oxford Innovation Ltd | fHbp scaffold |
| KR101855133B1 (ko) | 2016-11-16 | 2018-05-08 | 주식회사 케이엠더블유 | 적층구조의 mimo 안테나 어셈블리 |
| WO2018093176A2 (ko) | 2016-11-16 | 2018-05-24 | 주식회사 케이엠더블유 | 적층구조의 mimo 안테나 어셈블리 |
| RU2020122024A (ru) * | 2017-12-04 | 2022-01-10 | Де Стат Дер Недерланден, Верт. Дор Де Министер Ван Ввс, Министери Ван Волксгезондхейд, Велзейн Ен Спорт | Улучшенный способ получения везикул внешней мембраны |
| EP3607967A1 (en) * | 2018-08-09 | 2020-02-12 | GlaxoSmithKline Biologicals S.A. | Modified meningococcal fhbp polypeptides |
| GB202016604D0 (en) | 2020-10-20 | 2020-12-02 | Univ Of Oxford | Compositions and methods for inducing an immune response |
| MX2023009728A (es) | 2021-02-19 | 2023-08-30 | Sanofi Pasteur Inc | Vacuna recombinante meningococica b. |
| TW202423477A (zh) | 2022-08-03 | 2024-06-16 | 美商賽諾菲巴斯德公司 | 針對腦膜炎奈瑟氏菌b的含佐劑免疫原性組成物 |
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| EA201692552A1 (ru) * | 2014-07-17 | 2017-06-30 | Глаксосмитклайн Байолоджикалс С.А. | МОДИФИЦИРОВАННЫЕ МЕНИНГОКОККОВЫЕ ПОЛИПЕПТИДЫ fHbp |
| EP3172224B1 (en) * | 2014-07-23 | 2022-06-29 | Children's Hospital & Research Center at Oakland | Factor h binding protein variants and methods of use thereof |
| EP3607967A1 (en) * | 2018-08-09 | 2020-02-12 | GlaxoSmithKline Biologicals S.A. | Modified meningococcal fhbp polypeptides |
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