JP2016510983A5 - - Google Patents
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- Publication number
- JP2016510983A5 JP2016510983A5 JP2015562115A JP2015562115A JP2016510983A5 JP 2016510983 A5 JP2016510983 A5 JP 2016510983A5 JP 2015562115 A JP2015562115 A JP 2015562115A JP 2015562115 A JP2015562115 A JP 2015562115A JP 2016510983 A5 JP2016510983 A5 JP 2016510983A5
- Authority
- JP
- Japan
- Prior art keywords
- recombinant polypeptide
- thermostable
- polypeptide according
- immunogenic composition
- thermostable recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 230000002163 immunogen Effects 0.000 claims 7
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 4
- 241000725643 Respiratory syncytial virus Species 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 238000005829 trimerization reaction Methods 0.000 claims 3
- 102000004961 Furin Human genes 0.000 claims 2
- 108090001126 Furin Proteins 0.000 claims 2
- 230000000890 antigenic effect Effects 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 108010011170 Ala-Trp-Arg-His-Pro-Gln-Phe-Gly-Gly Proteins 0.000 claims 1
- 101100107610 Arabidopsis thaliana ABCF4 gene Proteins 0.000 claims 1
- 102100024365 Arf-GAP domain and FG repeat-containing protein 1 Human genes 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 claims 1
- 108010013639 Peptidoglycan Proteins 0.000 claims 1
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims 1
- 101100068078 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GCN4 gene Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 230000001086 cytosolic effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000003259 recombinant expression Methods 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 210000003660 reticulum Anatomy 0.000 claims 1
- 239000013638 trimer Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/828,667 US9060975B2 (en) | 2013-03-14 | 2013-03-14 | Heat-stable respiratory syncytial virus F protein oligomers and their use in immunological compositions |
| US13/828,667 | 2013-03-14 | ||
| PCT/EP2014/054804 WO2014140083A1 (en) | 2013-03-14 | 2014-03-12 | Heat-stable respiratory syncytial virus prefusion f protein oligomers and their use in immunological compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016510983A JP2016510983A (ja) | 2016-04-14 |
| JP2016510983A5 true JP2016510983A5 (OSRAM) | 2017-02-23 |
| JP6285469B2 JP6285469B2 (ja) | 2018-02-28 |
Family
ID=50241453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015562115A Expired - Fee Related JP6285469B2 (ja) | 2013-03-14 | 2014-03-12 | 呼吸器合胞体ウイルスの熱安定な融合前ｆタンパク質オリゴマーおよび免疫組成物におけるその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9060975B2 (OSRAM) |
| EP (2) | EP2970393B1 (OSRAM) |
| JP (1) | JP6285469B2 (OSRAM) |
| CN (2) | CN107029227A (OSRAM) |
| AU (1) | AU2014230822B2 (OSRAM) |
| BR (1) | BR112015022617A2 (OSRAM) |
| CA (1) | CA2905571A1 (OSRAM) |
| WO (1) | WO2014140083A1 (OSRAM) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014212268B2 (en) | 2013-02-01 | 2018-07-19 | Medimmune, Llc | Respiratory Syncytial Virus F protein epitopes |
| ES2854673T3 (es) | 2013-03-14 | 2021-09-22 | Univ Emory | VSR recombinante con mutaciones silenciosas, vacunas y métodos relacionados con ello |
| WO2017075125A1 (en) * | 2015-10-29 | 2017-05-04 | Emory University | Chimeric RSV, Immunogenic Compositions, and Methods of Use |
| EP3439672B1 (en) * | 2016-04-05 | 2020-11-25 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion rsv f protein for use in the prophylaxis of rsv infection |
| IL264119B2 (en) * | 2016-05-30 | 2023-04-01 | Janssen Vaccines Prevention B V | f proteins of rsv are stabilized before fusion |
| CN113832116B (zh) * | 2017-01-12 | 2024-09-13 | 厦门大学 | 稳定呼吸道合胞病毒融合蛋白的方法 |
| PL3601367T3 (pl) | 2017-03-30 | 2025-03-31 | The University Of Queensland | Cząsteczki chimeryczne i ich zastosowania |
| AU2018249533C1 (en) | 2017-04-04 | 2023-10-12 | Institute For Research In Biomedicine | Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus f proteins and their use |
| WO2019063844A1 (en) * | 2017-09-29 | 2019-04-04 | Universiteit Antwerpen | VACCINATION AGAINST SYNCYTIAL RESPIRATORY VIRUS |
| CN110684747B (zh) * | 2018-07-06 | 2024-05-24 | 厦门大学 | 灭活及保存呼吸道合胞病毒的方法 |
| KR102725189B1 (ko) * | 2018-11-01 | 2024-10-31 | 에스케이바이오사이언스(주) | 재조합 호흡기 세포융합 바이러스 f 단백질 및 이를 포함하는 백신 조성물 |
| CN109694400A (zh) * | 2019-01-31 | 2019-04-30 | 苏州高泓利康生物科技有限公司 | 一种表达呼吸道合胞病毒f蛋白及其制备方法 |
| WO2020205986A1 (en) | 2019-04-02 | 2020-10-08 | Sanofi | Antigenic multimeric respiratory syncytial virus polypeptides |
| CN110054668B (zh) * | 2019-04-25 | 2021-09-10 | 北京交通大学 | 一种呼吸道合胞病毒融合前f蛋白及其应用 |
| EP4025587A1 (en) | 2019-09-04 | 2022-07-13 | University of Washington | Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus f proteins and their use |
| CN111303245B (zh) * | 2020-02-21 | 2023-06-27 | 成都奥达生物科技有限公司 | 一种抗合胞病毒膜融合抑制剂 |
| EP4141121A4 (en) * | 2020-04-22 | 2024-07-10 | POSTECH Research and Business Development Foundation | RECOMBINANT HEMAGGLUTININ PROTEIN DERIVED FROM TRIMER-FORMING INFLUENZA VIRUS SURFACE PROTEIN AND USE THEREOF |
| CA3179246A1 (en) * | 2020-05-19 | 2021-11-25 | Yves Durocher | Use of resistin as a trimerization partner for expression of trimeric proteins |
| CN112480217B (zh) * | 2020-11-30 | 2022-04-08 | 广州阿格纳生物医药制造有限公司 | 基于SARS-CoV-2的S抗原蛋白的疫苗和组合物 |
| KR20250140099A (ko) * | 2023-02-03 | 2025-09-24 | 노바백스, 인코포레이티드 | Rsv f 백신 제형 |
| WO2024192698A1 (zh) * | 2023-03-22 | 2024-09-26 | 中科牧维(南京)生物科技有限公司 | 靶向人呼吸道合胞病毒融合糖蛋白的多肽拮抗剂 |
| WO2024251281A1 (zh) * | 2023-06-07 | 2024-12-12 | 四川三叶草生物制药有限公司 | Rsv疫苗组合物、方法及其用途 |
| US12383614B2 (en) | 2023-12-21 | 2025-08-12 | Yikang Biotech (Suzhou) Co., Ltd. | Mutants of respiratory syncytial virus fusion proteins |
| CN117886902B (zh) * | 2023-12-21 | 2024-11-26 | 易康生物(苏州)有限公司 | 改良的呼吸道合胞病毒融合f蛋白突变体及其应用 |
| CN120329390A (zh) * | 2025-03-03 | 2025-07-18 | 中国医学科学院医学生物学研究所 | 基于异源三聚体基序的蛋白的改造及应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0916726A1 (en) | 1997-11-13 | 1999-05-19 | Rijksuniversiteit te Groningen | Attaching substances to micro-organisms |
| CA2450318C (en) | 2001-06-11 | 2011-08-02 | Applied Nanosystems B.V. | Improved methods for binding acma-type protein anchor fusions to cell-wall material of micro-organisms |
| EP1997830A1 (en) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV specific binding molecules and means for producing them |
| AU2010264686A1 (en) | 2009-06-24 | 2012-01-19 | Glaxosmithkline Biologicals S.A. | Vaccine |
| WO2010149745A1 (en) | 2009-06-24 | 2010-12-29 | Glaxosmithkline Biologicals S.A. | Recombinant rsv antigens |
| EP4218799A1 (en) * | 2009-07-15 | 2023-08-02 | GlaxoSmithKline Biologicals S.A. | Rsv f protein compositions and methods for making same |
| US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
| CN103547676B (zh) | 2011-03-22 | 2016-11-16 | 缪科西斯私人有限公司 | 颗粒形式的免疫原性组合物和用于产生其的方法 |
| WO2012158613A1 (en) | 2011-05-13 | 2012-11-22 | Novartis Ag | Pre-fusion rsv f antigens |
-
2013
- 2013-03-14 US US13/828,667 patent/US9060975B2/en not_active Ceased
-
2014
- 2014-03-12 CN CN201710040168.9A patent/CN107029227A/zh active Pending
- 2014-03-12 WO PCT/EP2014/054804 patent/WO2014140083A1/en not_active Ceased
- 2014-03-12 EP EP14709318.1A patent/EP2970393B1/en not_active Not-in-force
- 2014-03-12 CA CA2905571A patent/CA2905571A1/en not_active Abandoned
- 2014-03-12 CN CN201480022815.8A patent/CN105246910A/zh active Pending
- 2014-03-12 BR BR112015022617A patent/BR112015022617A2/pt not_active IP Right Cessation
- 2014-03-12 AU AU2014230822A patent/AU2014230822B2/en not_active Ceased
- 2014-03-12 JP JP2015562115A patent/JP6285469B2/ja not_active Expired - Fee Related
- 2014-03-12 EP EP16200916.1A patent/EP3178840A1/en not_active Withdrawn
-
2016
- 2016-03-26 US US15/081,854 patent/USRE47471E1/en not_active Expired - Fee Related
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