JP2015500864A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015500864A5 JP2015500864A5 JP2014548063A JP2014548063A JP2015500864A5 JP 2015500864 A5 JP2015500864 A5 JP 2015500864A5 JP 2014548063 A JP2014548063 A JP 2014548063A JP 2014548063 A JP2014548063 A JP 2014548063A JP 2015500864 A5 JP2015500864 A5 JP 2015500864A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- immunogenic composition
- composition
- item
- stabilizing additive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 25
- 239000000427 antigen Substances 0.000 claims description 18
- 102000036639 antigens Human genes 0.000 claims description 18
- 108091007433 antigens Proteins 0.000 claims description 18
- 230000002163 immunogen Effects 0.000 claims description 17
- 229920001184 polypeptide Polymers 0.000 claims description 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 239000000654 additive Substances 0.000 claims description 6
- 230000000996 additive effect Effects 0.000 claims description 6
- 230000000087 stabilizing effect Effects 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 3
- 241000124008 Mammalia Species 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
- 108020001507 fusion proteins Proteins 0.000 claims description 2
- 102000037865 fusion proteins Human genes 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 description 2
- 238000010845 search algorithm Methods 0.000 description 2
- PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161580191P | 2011-12-23 | 2011-12-23 | |
| US61/580,191 | 2011-12-23 | ||
| PCT/EP2012/076609 WO2013092985A1 (en) | 2011-12-23 | 2012-12-21 | Stable compositions for immunising against staphylococcus aureus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015500864A JP2015500864A (ja) | 2015-01-08 |
| JP2015500864A5 true JP2015500864A5 (OSRAM) | 2015-12-10 |
Family
ID=47520086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548063A Pending JP2015500864A (ja) | 2011-12-23 | 2012-12-21 | 黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ）に対して免疫するための安定な組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20150044251A1 (OSRAM) |
| EP (1) | EP2793939A1 (OSRAM) |
| JP (1) | JP2015500864A (OSRAM) |
| CN (1) | CN104023744A (OSRAM) |
| WO (1) | WO2013092985A1 (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014507142A (ja) | 2011-02-08 | 2014-03-27 | インテグレイテッド バイオセラピューティクス，インコーポレイテッド | α溶血素オリゴペプチドを含む免疫原性組成物 |
| BR112014026861A2 (pt) * | 2012-04-26 | 2018-05-15 | Univ Chicago | antígenos de estafilococos coagulase e métodos de seu uso |
| JP6435261B2 (ja) | 2012-08-31 | 2018-12-05 | ノバルティス アーゲー | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓに対する免疫化のための安定化されたタンパク質 |
| EP3077820B1 (en) * | 2013-12-03 | 2025-02-26 | Evaxion Biotech A/S | Proteins and nucleic acids useful in vaccines targeting staphylococcus aureus |
| CN112521464A (zh) | 2014-03-26 | 2021-03-19 | 葛兰素史密丝克莱恩生物有限公司 | 突变型葡萄球菌抗原 |
| CN104147599B (zh) * | 2014-06-24 | 2017-03-01 | 华中科技大学 | 一种疫苗佐剂、其制备方法及应用 |
| WO2016095832A1 (en) * | 2014-12-18 | 2016-06-23 | The University Of Hong Kong | Immunotherapeutic targets against staphylococcus aureus |
| WO2017144523A1 (en) * | 2016-02-22 | 2017-08-31 | Evaxion Biotech Aps | Proteins and nucleic acids useful in vaccines targeting staphylococcus aureus |
| CN113893340B (zh) * | 2021-09-30 | 2024-10-22 | 中牧实业股份有限公司 | 双相油佐剂口蹄疫疫苗的稳定剂及其应用 |
| AU2022457212A1 (en) * | 2022-05-04 | 2024-11-14 | Evaxion Biotech A/S | Staphylococcal protein variants and truncates |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK331087A (da) * | 1986-06-30 | 1987-12-31 | Smith Kline Rit | Stabilisator for levende vaccine |
| HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| WO1995011700A1 (en) | 1993-10-29 | 1995-05-04 | Pharmos Corp. | Submicron emulsions as vaccine adjuvants |
| CN1188171C (zh) * | 1994-06-02 | 2005-02-09 | 廓德伦特控股剑桥有限公司 | 防止各种特质在再水化或熔化时聚集的方法以及由此获得的组合物 |
| US6080725A (en) | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| CA2330610A1 (en) | 1998-05-07 | 1999-11-11 | Corixa Corporation | Adjuvant composition and methods for its use |
| PL201482B1 (pl) | 1998-10-16 | 2009-04-30 | Smithkline Beecham Biolog | Sposoby wytwarzania kompozycji szczepionki oraz kompozycja szczepionki |
| PT1150918E (pt) | 1999-02-03 | 2005-01-31 | Biosante Pharmaceuticals Inc | Metodo de fabrico de particulas terapeuticas de fosfato de calcio |
| AU5731200A (en) * | 1999-06-11 | 2001-01-02 | Endorex Corporation | Adjuvant-containing polymerized liposomes for oral, mucosal or intranasal vaccination |
| DK1233784T3 (da) * | 1999-12-02 | 2008-09-01 | Novartis Vaccines & Diagnostic | Præparater og fremgangsmåder til stabilisering af biologiske molekyler efter lyofilisering |
| CA2399321C (en) * | 2000-03-07 | 2013-04-30 | Robert K. Evans | Adenovirus formulations |
| AU2003247337B2 (en) * | 2002-04-11 | 2007-09-06 | Medimmune, Llc | Preservation of bioactive materials by freeze dried foam |
| CN101804202B (zh) * | 2003-02-25 | 2014-06-18 | 米迪缪尼有限公司 | 制备流感疫苗组合物的方法 |
| WO2005042016A2 (en) * | 2003-10-23 | 2005-05-12 | Chiron Corporation | Stabilised compositions |
| KR20110132416A (ko) | 2004-04-05 | 2011-12-07 | 화이자 프로덕츠 인코포레이티드 | 미세유체화된 수중유 유화액 및 백신 조성물 |
| WO2006078294A2 (en) * | 2004-05-21 | 2006-07-27 | Novartis Vaccines And Diagnostics Inc. | Alphavirus vectors for respiratory pathogen vaccines |
| US20080193478A1 (en) * | 2004-08-27 | 2008-08-14 | Rajesh Jain | Inactivated Poliomyelitis Vaccine Derived From Sabin Strain Of Polio Virus |
| US20060228369A1 (en) | 2005-04-11 | 2006-10-12 | Program For Appropriate Technology In Health | Stabilization and preservation of temperature-sensitive vaccines |
| US7691368B2 (en) | 2005-04-15 | 2010-04-06 | Merial Limited | Vaccine formulations |
| WO2006125763A1 (en) * | 2005-05-25 | 2006-11-30 | Novo Nordisk A/S | Stabilized polypeptide formulations |
| US8703095B2 (en) | 2005-07-07 | 2014-04-22 | Sanofi Pasteur S.A. | Immuno-adjuvant emulsion |
| BRPI0520505B1 (pt) * | 2005-09-01 | 2015-03-31 | José Luis Nuño Ayalá | Fórmula estabilizadora de vacinas com antígenos vivos para uso em sistemas de vacinação em massa |
| US8784843B2 (en) * | 2005-09-16 | 2014-07-22 | Merial Limited | Stabilizers for freeze-dried vaccines |
| FR2896162B1 (fr) | 2006-01-13 | 2008-02-15 | Sanofi Pasteur Sa | Emulsion huile dans eau thermoreversible |
| WO2008019162A2 (en) | 2006-01-18 | 2008-02-14 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
| WO2007145689A1 (en) | 2006-06-12 | 2007-12-21 | Nabi Biopharmaceuticals | Use of alpha-toxin for treating and preventing staphylococcus infections |
| CN100460013C (zh) * | 2006-09-05 | 2009-02-11 | 重庆康卫生物科技有限公司 | 口服重组幽门螺杆菌疫苗及其制备方法 |
| US20100183667A1 (en) | 2006-10-12 | 2010-07-22 | Glaxo Smithkline Biologicals S.A. | Vaccine Comprising an Oil in Water Emulsion Adjuvant |
| JP5658564B2 (ja) | 2007-08-31 | 2015-01-28 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | ブドウ球菌肺疾患および状態に対する免疫に関連した方法および組成物 |
| GB0821806D0 (en) * | 2008-11-28 | 2009-01-07 | Circassia Ltd | Compositions with reduced dimer formation |
| NZ612315A (en) * | 2009-04-14 | 2014-10-31 | Novartis Ag | Compositions for immunising against staphylococcus aureus |
| NZ598654A (en) | 2009-09-02 | 2014-05-30 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
| CN102258537B (zh) * | 2011-07-15 | 2012-07-04 | 骆延波 | 鸡传染性法氏囊病特异性转移因子的制备方法 |
-
2012
- 2012-12-21 WO PCT/EP2012/076609 patent/WO2013092985A1/en not_active Ceased
- 2012-12-21 EP EP12812257.9A patent/EP2793939A1/en not_active Withdrawn
- 2012-12-21 JP JP2014548063A patent/JP2015500864A/ja active Pending
- 2012-12-21 CN CN201280063615.8A patent/CN104023744A/zh active Pending
- 2012-12-21 US US14/366,362 patent/US20150044251A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015500864A5 (OSRAM) | ||
| JP2016510983A5 (OSRAM) | ||
| WO2018109220A3 (en) | Novel recombinant prefusion rsv f proteins and uses thereof | |
| WO2014018858A3 (en) | Multimeric fusion protein vaccine and immunotherapeutic | |
| JP2015525217A5 (OSRAM) | ||
| JP2012523246A5 (OSRAM) | ||
| HRP20191902T1 (hr) | Antigeni virusa ljudske imunodeficijencije, vektori, pripravci, i postupci njihove upotrebe | |
| IL288541B (en) | Vaccine against rsv | |
| JP2015214545A5 (OSRAM) | ||
| AR072796A1 (es) | ESTABILIZADOR Y COMPOSICION DE VACUNA QUE COMPRENDE UNO O MAS FLAVIVIRUS VIVOS ATENUADOS O QUIMÉRICOS. MÉTODO DE ESTABILIZACIoN. KIT. | |
| BR112015022617A2 (pt) | polipeptídeo recombinante termoestável, composição imunogênica, vetor de expressão recombinante e uso de um polipeptídeo recombinante termoestável | |
| MX340735B (es) | Proteinas multimericas recombinantes de la influenza. | |
| JP2015524422A5 (OSRAM) | ||
| PE20140986A1 (es) | Proteinas de fusion y vacunas de combinacion que comprenden proteina e y pilina a de haemophilus influenzae | |
| RU2014117068A (ru) | Вакцина на основе рекомбинантных наночастиц f из rsv против респираторно-синцитиального вируса | |
| WO2014136064A3 (en) | Immunogenic fusion polypeptides | |
| JP2015500827A5 (OSRAM) | ||
| JP2013504556A5 (OSRAM) | ||
| MX2016007429A (es) | Mezcla de peptidos. | |
| WO2012046061A3 (en) | Clostridium difficile antigens | |
| HRP20191166T1 (hr) | Stabilizirani proteini, namijenjeni imuniziranju protiv bakterije staphylococcus aureus | |
| MX2021000030A (es) | Metodos y composiciones que utilizan polipeptidos variantes klotho. | |
| MX2015007421A (es) | Proteinas de tipo espiral enrollada modificadas que tienen propiedades mejoradas. | |
| EA201892735A1 (ru) | Состав вакцины против hiv | |
| JP2017522877A5 (OSRAM) |