JP2017522579A - 液体クロマトグラフィーのための、新たな、超高効率の、表面多孔性粒子（ｓｐｐ）キラル相 - Google Patents

液体クロマトグラフィーのための、新たな、超高効率の、表面多孔性粒子（ｓｐｐ）キラル相 Download PDF

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JP2017522579A
JP2017522579A JP2017523195A JP2017523195A JP2017522579A JP 2017522579 A JP2017522579 A JP 2017522579A JP 2017523195 A JP2017523195 A JP 2017523195A JP 2017523195 A JP2017523195 A JP 2017523195A JP 2017522579 A JP2017522579 A JP 2017522579A
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chiral
spp
stationary phase
surface porous
derivatized
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JP2017522579A5 (enExample
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ダニエル ダブル アームストロング
ダニエル ダブル アームストロング
ザカリー エス ブライトバッハ
ザカリー エス ブライトバッハ
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Azyp LLC
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Azyp LLC
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    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3833—Chiral chromatography
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  • Chemical & Material Sciences (AREA)
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  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
JP2017523195A 2014-07-17 2015-07-17 液体クロマトグラフィーのための、新たな、超高効率の、表面多孔性粒子（ｓｐｐ）キラル相 Pending JP2017522579A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462025713P 2014-07-17 2014-07-17
US62/025,713 2014-07-17
PCT/US2015/041026 WO2016011425A1 (en) 2014-07-17 2015-07-17 New ultrahigh efficiency, superficially porous particle (spp) chiral phases for liquid chromatography

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JP2017522579A true JP2017522579A (ja) 2017-08-10
JP2017522579A5 JP2017522579A5 (enExample) 2018-11-22

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US (1) US10272364B2 (enExample)
EP (1) EP3169430B1 (enExample)
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US11237138B2 (en) * 2019-06-19 2022-02-01 The Wrangler Group Selection and design of columns for liquid chromatography
CN113717118B (zh) * 2021-09-06 2022-03-01 安徽美诺华药物化学有限公司 一种缬沙坦的合成工艺
CN116351399A (zh) * 2022-12-30 2023-06-30 厦门色谱分析仪器有限公司 一种键合型纤维素衍生物手性液相色谱柱及其制备方法和应用
CN119819277B (zh) * 2025-03-17 2025-05-27 昆明医科大学 一种基于BINAM的β-环糊精衍生物手性固定相及其制备方法和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10501727A (ja) * 1994-02-22 1998-02-17 キューレータズ オブ ディ ユニバーシティ オブ ミズーリ 分離剤としての大環状抗生物質
US20120226054A1 (en) * 2011-03-03 2012-09-06 Board Of Trustees Of The University Of Arkansas Multiple stationary phase matrix and uses thereof
JP2013501243A (ja) * 2009-08-04 2013-01-10 ウオーターズ・テクノロジーズ・コーポレイシヨン イオン性修飾剤を含有する高純度クロマトグラフィー材料
JP2013535544A (ja) * 2010-07-26 2013-09-12 ウオーターズ・テクノロジーズ・コーポレイシヨン 粒度分布の狭い実質的に非多孔質のハイブリッドコアを含む表面多孔質材料
JP2014029313A (ja) * 2012-07-20 2014-02-13 Mitsubishi Chemicals Corp クロマトグラフィー用分離剤
WO2014087937A1 (ja) * 2012-12-06 2014-06-12 株式会社ダイセル 分離剤

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10501727A (ja) * 1994-02-22 1998-02-17 キューレータズ オブ ディ ユニバーシティ オブ ミズーリ 分離剤としての大環状抗生物質
JP2013501243A (ja) * 2009-08-04 2013-01-10 ウオーターズ・テクノロジーズ・コーポレイシヨン イオン性修飾剤を含有する高純度クロマトグラフィー材料
JP2013535544A (ja) * 2010-07-26 2013-09-12 ウオーターズ・テクノロジーズ・コーポレイシヨン 粒度分布の狭い実質的に非多孔質のハイブリッドコアを含む表面多孔質材料
JP2013539016A (ja) * 2010-07-26 2013-10-17 ウオーターズ・テクノロジーズ・コーポレイシヨン 粒度分布の狭い実質的に非多孔質のコアを含む表面多孔質材料、その製造方法及びクロマトグラフィー分離用としてのその使用
US20120226054A1 (en) * 2011-03-03 2012-09-06 Board Of Trustees Of The University Of Arkansas Multiple stationary phase matrix and uses thereof
JP2014029313A (ja) * 2012-07-20 2014-02-13 Mitsubishi Chemicals Corp クロマトグラフィー用分離剤
WO2014087937A1 (ja) * 2012-12-06 2014-06-12 株式会社ダイセル 分離剤

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GYIMESI-FORRAS KRISZTINA ET AL.: "Liquid chromatographic enantiomer separations of novel quinazolone derivatives on quinine carbamate", JOURNAL OF CHROMATOGRAPHY A, vol. Vol.1047, Iss.1, JPN6019019868, 2004, pages 59 - 67, ISSN: 0004325059 *
REISCHL J. ROLAND ET AL.: "Chemoselective and enantioselective analysis of proteinogenic amino acids utilizing N-derivatization", JOURNAL OF CHROMATOGRAPHY A, vol. Vol.1218, Iss.46, JPN6019019867, 22 September 2011 (2011-09-22), pages 8379 - 8387, ISSN: 0004325058 *

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