JP2017522046A - 生物可逆的および生物不可逆的基を有するポリヌクレオチド構築物 - Google Patents
生物可逆的および生物不可逆的基を有するポリヌクレオチド構築物 Download PDFInfo
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- JP2017522046A JP2017522046A JP2017516650A JP2017516650A JP2017522046A JP 2017522046 A JP2017522046 A JP 2017522046A JP 2017516650 A JP2017516650 A JP 2017516650A JP 2017516650 A JP2017516650 A JP 2017516650A JP 2017522046 A JP2017522046 A JP 2017522046A
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- 0 CCc([o]1)c(C)c(*)c1Br Chemical compound CCc([o]1)c(C)c(*)c1Br 0.000 description 14
- BVZFVTJMCZLZTR-UHFFFAOYSA-N CC(C)SSc1c(CCO)cccc1 Chemical compound CC(C)SSc1c(CCO)cccc1 BVZFVTJMCZLZTR-UHFFFAOYSA-N 0.000 description 1
- RWGFKTVRMDUZSP-UHFFFAOYSA-N CC(C)c1ccccc1 Chemical compound CC(C)c1ccccc1 RWGFKTVRMDUZSP-UHFFFAOYSA-N 0.000 description 1
- FLAHSSHSYCYJKU-UHFFFAOYSA-N CC(CCC(NCc1ccccc1)=O)SSCCCCO Chemical compound CC(CCC(NCc1ccccc1)=O)SSCCCCO FLAHSSHSYCYJKU-UHFFFAOYSA-N 0.000 description 1
- LFINOVGTZAMNRH-UHFFFAOYSA-N CC(c1ccccc1)SSCCCCO Chemical compound CC(c1ccccc1)SSCCCCO LFINOVGTZAMNRH-UHFFFAOYSA-N 0.000 description 1
- ALVSEZZLFXRSRZ-UHFFFAOYSA-N CCC1(CC)COC(c(cc2)ccc2C(O)=O)OC1 Chemical compound CCC1(CC)COC(c(cc2)ccc2C(O)=O)OC1 ALVSEZZLFXRSRZ-UHFFFAOYSA-N 0.000 description 1
- MFRQAHHMZZKCLP-UHFFFAOYSA-N Cc1c(CCO)c(S)ccc1 Chemical compound Cc1c(CCO)c(S)ccc1 MFRQAHHMZZKCLP-UHFFFAOYSA-N 0.000 description 1
- VSNHUQURADARHR-UHFFFAOYSA-N Cc1cc(OC(C2)=O)c2cc1 Chemical compound Cc1cc(OC(C2)=O)c2cc1 VSNHUQURADARHR-UHFFFAOYSA-N 0.000 description 1
- YABOHRWGTPOWPS-UHFFFAOYSA-N Cc1cccc(SSc2ncccc2)c1CCO Chemical compound Cc1cccc(SSc2ncccc2)c1CCO YABOHRWGTPOWPS-UHFFFAOYSA-N 0.000 description 1
- WGQKYBSKWIADBV-UHFFFAOYSA-N NCc1ccccc1 Chemical compound NCc1ccccc1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 1
- GOUHYARYYWKXHS-UHFFFAOYSA-N OC(c1ccc(C=O)cc1)=O Chemical compound OC(c1ccc(C=O)cc1)=O GOUHYARYYWKXHS-UHFFFAOYSA-N 0.000 description 1
- HAXFWIACAGNFHA-UHFFFAOYSA-N c1cc(SSc2ccccn2)ncc1 Chemical compound c1cc(SSc2ccccn2)ncc1 HAXFWIACAGNFHA-UHFFFAOYSA-N 0.000 description 1
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N2310/00—Structure or type of the nucleic acid
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462009123P | 2014-06-06 | 2014-06-06 | |
| US62/009,123 | 2014-06-06 | ||
| PCT/US2015/034749 WO2015188197A2 (en) | 2014-06-06 | 2015-06-08 | Polynucleotide constructs having bioreversible and non-bioreversible groups |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017522046A true JP2017522046A (ja) | 2017-08-10 |
| JP2017522046A5 JP2017522046A5 (enExample) | 2018-07-19 |
Family
ID=54767614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017516650A Pending JP2017522046A (ja) | 2014-06-06 | 2015-06-08 | 生物可逆的および生物不可逆的基を有するポリヌクレオチド構築物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20170114341A1 (enExample) |
| EP (1) | EP3152308A4 (enExample) |
| JP (1) | JP2017522046A (enExample) |
| CN (1) | CN107109405A (enExample) |
| AU (1) | AU2015269053A1 (enExample) |
| CA (1) | CA2950960A1 (enExample) |
| WO (1) | WO2015188197A2 (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2019039403A1 (ja) * | 2017-08-22 | 2020-11-26 | 国立大学法人東海国立大学機構 | 修飾ポリヌクレオチド |
| JP2021509402A (ja) * | 2017-12-29 | 2021-03-25 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッドSuzhou Ribo Life Science Co., Ltd. | 複合体及びその調製方法と使用 |
| JP2022515503A (ja) * | 2018-12-28 | 2022-02-18 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用 |
| JP2022546055A (ja) * | 2019-08-29 | 2022-11-02 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 化合物、薬物複合体及びその調製方法と使用 |
| WO2023113038A1 (ja) * | 2021-12-17 | 2023-06-22 | リードファーマ株式会社 | オリゴヌクレオチドの製造方法 |
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| TW201620526A (zh) | 2014-06-17 | 2016-06-16 | 愛羅海德研究公司 | 用於抑制α-1抗胰蛋白酶基因表現之組合物及方法 |
| US20180133327A1 (en) | 2015-03-16 | 2018-05-17 | Amal Therapeutics Sa | Cell Penetrating Peptides and Complexes Comprising the Same |
| KR102782598B1 (ko) | 2015-06-25 | 2025-03-14 | 로스웰 엠이 아이엔씨. | 바이오분자 센서들 및 방법들 |
| WO2017100461A1 (en) * | 2015-12-08 | 2017-06-15 | Solstice Biologics, Ltd. | Polynucleotide constructs having an auxiliary moiety non-bioreversibly linked to an internucleoside phosphate or phosphorothioate |
| KR20250022239A (ko) | 2016-01-28 | 2025-02-14 | 로스웰 엠이 아이엔씨. | 대량 병렬 dna 시퀀싱 장치 |
| CN109071212A (zh) | 2016-01-28 | 2018-12-21 | 罗斯韦尔生物技术股份有限公司 | 使用大规模分子电子传感器阵列测量分析物的方法和装置 |
| JP6854532B2 (ja) | 2016-02-09 | 2021-04-07 | ロズウェル バイオテクノロジーズ,インコーポレイテッド | 電子的、標識フリーのdnaおよびゲノムシークエンシング |
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| RU2769314C1 (ru) | 2016-03-16 | 2022-03-30 | Амаль Терапьютикс Са | Комбинация модулятора иммунных контрольных точек и комплекса, содержащего проникающий в клетку пептид, карго-молекулу и пептидный агонист tlr, для применения в медицине |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120040459A1 (en) * | 2008-09-22 | 2012-02-16 | Rxi Pharmaceuticals Corporation | Reduced size self-delivering rnai compounds |
| US20120142763A1 (en) * | 2009-06-01 | 2012-06-07 | The Regents Of The University Of California | Nucleic acid delivery compositions and methods of use thereof |
| WO2014031575A1 (en) * | 2012-08-20 | 2014-02-27 | The Regents Of The University Of California | Polynucleotides having bioreversible groups |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2651453C (en) * | 2006-05-11 | 2014-10-14 | Isis Pharmaceuticals, Inc. | 5'-modified bicyclic nucleic acid analogs |
| CN106061981A (zh) * | 2013-11-06 | 2016-10-26 | 索尔斯蒂斯生物有限公司 | 具有二硫化物基团的多核苷酸构建体 |
-
2015
- 2015-06-08 EP EP15803887.7A patent/EP3152308A4/en not_active Withdrawn
- 2015-06-08 US US15/315,608 patent/US20170114341A1/en not_active Abandoned
- 2015-06-08 CN CN201580041889.0A patent/CN107109405A/zh active Pending
- 2015-06-08 AU AU2015269053A patent/AU2015269053A1/en not_active Abandoned
- 2015-06-08 CA CA2950960A patent/CA2950960A1/en not_active Abandoned
- 2015-06-08 WO PCT/US2015/034749 patent/WO2015188197A2/en not_active Ceased
- 2015-06-08 JP JP2017516650A patent/JP2017522046A/ja active Pending
-
2020
- 2020-02-03 US US16/780,204 patent/US20200392498A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120040459A1 (en) * | 2008-09-22 | 2012-02-16 | Rxi Pharmaceuticals Corporation | Reduced size self-delivering rnai compounds |
| US20120142763A1 (en) * | 2009-06-01 | 2012-06-07 | The Regents Of The University Of California | Nucleic acid delivery compositions and methods of use thereof |
| WO2014031575A1 (en) * | 2012-08-20 | 2014-02-27 | The Regents Of The University Of California | Polynucleotides having bioreversible groups |
Non-Patent Citations (1)
| Title |
|---|
| CURR. PROTOC. NUCLEIC ACID CHEM., 2008, VOL.35, 4.33.1-4.33.21, JPN6019028553, ISSN: 0004082367 * |
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| JPWO2019039403A1 (ja) * | 2017-08-22 | 2020-11-26 | 国立大学法人東海国立大学機構 | 修飾ポリヌクレオチド |
| JP7282379B2 (ja) | 2017-08-22 | 2023-05-29 | 国立大学法人東海国立大学機構 | 修飾ポリヌクレオチド |
| JP2021509402A (ja) * | 2017-12-29 | 2021-03-25 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッドSuzhou Ribo Life Science Co., Ltd. | 複合体及びその調製方法と使用 |
| JP7436030B2 (ja) | 2017-12-29 | 2024-02-21 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 複合体及びその調製方法と使用 |
| JP2022515503A (ja) * | 2018-12-28 | 2022-02-18 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用 |
| JP7507495B2 (ja) | 2018-12-28 | 2024-06-28 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用 |
| JP2022546055A (ja) * | 2019-08-29 | 2022-11-02 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 化合物、薬物複合体及びその調製方法と使用 |
| WO2023113038A1 (ja) * | 2021-12-17 | 2023-06-22 | リードファーマ株式会社 | オリゴヌクレオチドの製造方法 |
Also Published As
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|---|---|
| CA2950960A1 (en) | 2015-12-10 |
| EP3152308A2 (en) | 2017-04-12 |
| AU2015269053A1 (en) | 2016-12-22 |
| WO2015188197A3 (en) | 2016-02-25 |
| EP3152308A4 (en) | 2017-12-27 |
| WO2015188197A2 (en) | 2015-12-10 |
| US20200392498A1 (en) | 2020-12-17 |
| US20170114341A1 (en) | 2017-04-27 |
| CN107109405A (zh) | 2017-08-29 |
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