JP2017519784A5 - - Google Patents
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- JP2017519784A5 JP2017519784A5 JP2016575488A JP2016575488A JP2017519784A5 JP 2017519784 A5 JP2017519784 A5 JP 2017519784A5 JP 2016575488 A JP2016575488 A JP 2016575488A JP 2016575488 A JP2016575488 A JP 2016575488A JP 2017519784 A5 JP2017519784 A5 JP 2017519784A5
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- hydrogen
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- 239000008194 pharmaceutical composition Substances 0.000 claims 86
- 229910052739 hydrogen Inorganic materials 0.000 claims 31
- 239000001257 hydrogen Substances 0.000 claims 31
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 27
- 150000001875 compounds Chemical class 0.000 claims 26
- 150000003839 salts Chemical class 0.000 claims 25
- -1 α-amino acid ester Chemical class 0.000 claims 24
- 235000008206 alpha-amino acids Nutrition 0.000 claims 17
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 16
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 10
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 10
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 10
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 10
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 10
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 10
- 235000004279 alanine Nutrition 0.000 claims 10
- 229960000310 isoleucine Drugs 0.000 claims 10
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- 239000004474 valine Substances 0.000 claims 10
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 claims 9
- 239000004475 Arginine Substances 0.000 claims 8
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 8
- 239000004471 Glycine Substances 0.000 claims 8
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 8
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 8
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 8
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 8
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 8
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 8
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 8
- 239000004472 Lysine Substances 0.000 claims 8
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 8
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 8
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 8
- 239000004473 Threonine Substances 0.000 claims 8
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 8
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 8
- 235000009582 asparagine Nutrition 0.000 claims 8
- 229960001230 asparagine Drugs 0.000 claims 8
- 235000018417 cysteine Nutrition 0.000 claims 8
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 8
- 229930195712 glutamate Natural products 0.000 claims 8
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 8
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 8
- 229930182817 methionine Natural products 0.000 claims 8
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 8
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 8
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 6
- 241000700605 Viruses Species 0.000 claims 6
- 125000005907 alkyl ester group Chemical group 0.000 claims 6
- 229940009098 aspartate Drugs 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 229940024606 amino acid Drugs 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 150000007860 aryl ester derivatives Chemical class 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 4
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 2
- 241000711573 Coronaviridae Species 0.000 claims 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 229910052805 deuterium Inorganic materials 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 241001502567 Chikungunya virus Species 0.000 claims 1
- 241001122120 Hepeviridae Species 0.000 claims 1
- 241000127282 Middle East respiratory syndrome-related coronavirus Species 0.000 claims 1
- 102220587413 N-acetylserotonin O-methyltransferase-like protein_R23A_mutation Human genes 0.000 claims 1
- 102220587418 N-acetylserotonin O-methyltransferase-like protein_R24A_mutation Human genes 0.000 claims 1
- 102220479492 NAD(+) hydrolase SARM1_R22A_mutation Human genes 0.000 claims 1
- 241000150350 Peribunyaviridae Species 0.000 claims 1
- 241000315672 SARS coronavirus Species 0.000 claims 1
- 241000710924 Togaviridae Species 0.000 claims 1
- 241000710959 Venezuelan equine encephalitis virus Species 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- FYGSULGPSNHJFD-LUTQBAROSA-N C#C[C@@]([C@@H]1O)([C@H]([n]2c(N=C(N)NC3=O)c3nc2)O[C@@]1(COP(O)(OP(O)(OP(O)(O)=O)=O)=O)F)F Chemical compound C#C[C@@]([C@@H]1O)([C@H]([n]2c(N=C(N)NC3=O)c3nc2)O[C@@]1(COP(O)(OP(O)(OP(O)(O)=O)=O)=O)F)F FYGSULGPSNHJFD-LUTQBAROSA-N 0.000 description 1
- MAYPBRYPGCIUGY-FPQZTECRSA-N CC([C@@]([C@@H]1F)([C@H]([n]2c(N=C(N)NC3=O)c3nc2)O[C@@]1(COP(O)(OP(O)(OP(O)(O)=O)=O)=O)F)O)=C Chemical compound CC([C@@]([C@@H]1F)([C@H]([n]2c(N=C(N)NC3=O)c3nc2)O[C@@]1(COP(O)(OP(O)(OP(O)(O)=O)=O)=O)F)O)=C MAYPBRYPGCIUGY-FPQZTECRSA-N 0.000 description 1
- GRVAKIGJYFCAOR-LGVRLFTQSA-N CCOc1c2nc[n]([C@@H]([C@]3(C)F)OCC3(COP(NC(C)C(OC(C)C)=O)(Oc3ccccc3)=O)O)c2nc(N)n1 Chemical compound CCOc1c2nc[n]([C@@H]([C@]3(C)F)OCC3(COP(NC(C)C(OC(C)C)=O)(Oc3ccccc3)=O)O)c2nc(N)n1 GRVAKIGJYFCAOR-LGVRLFTQSA-N 0.000 description 1
- POYJEGXPYNEDOC-OUVAMTEUSA-N CCOc1nc(N)nc2c1nc[n]2[C@@H]([C@@](C)([C@@H]1F)O)O[C@@]1(COP(OCOC(OC(C)C)=O)(OCOC(OC(C)C)=O)=O)F Chemical compound CCOc1nc(N)nc2c1nc[n]2[C@@H]([C@@](C)([C@@H]1F)O)O[C@@]1(COP(OCOC(OC(C)C)=O)(OCOC(OC(C)C)=O)=O)F POYJEGXPYNEDOC-OUVAMTEUSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462016232P | 2014-06-24 | 2014-06-24 | |
| US62/016,232 | 2014-06-24 | ||
| US201462061770P | 2014-10-09 | 2014-10-09 | |
| US62/061,770 | 2014-10-09 | ||
| PCT/US2015/037001 WO2015200219A1 (en) | 2014-06-24 | 2015-06-22 | Substituted nucleosides, nucleotides and analogs thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020114136A Division JP7080928B2 (ja) | 2014-06-24 | 2020-07-01 | 置換ヌクレオシド、ヌクレオチドおよびその類似体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017519784A JP2017519784A (ja) | 2017-07-20 |
| JP2017519784A5 true JP2017519784A5 (OSRAM) | 2018-09-13 |
| JP6728075B2 JP6728075B2 (ja) | 2020-07-22 |
Family
ID=54868668
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016575488A Active JP6728075B2 (ja) | 2014-06-24 | 2015-06-22 | 置換ヌクレオシド、ヌクレオチドおよびその類似体 |
| JP2020114136A Active JP7080928B2 (ja) | 2014-06-24 | 2020-07-01 | 置換ヌクレオシド、ヌクレオチドおよびその類似体 |
| JP2022085181A Active JP7449978B2 (ja) | 2014-06-24 | 2022-05-25 | 置換ヌクレオシド、ヌクレオチドおよびその類似体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020114136A Active JP7080928B2 (ja) | 2014-06-24 | 2020-07-01 | 置換ヌクレオシド、ヌクレオチドおよびその類似体 |
| JP2022085181A Active JP7449978B2 (ja) | 2014-06-24 | 2022-05-25 | 置換ヌクレオシド、ヌクレオチドおよびその類似体 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9603864B2 (OSRAM) |
| EP (2) | EP3160476B1 (OSRAM) |
| JP (3) | JP6728075B2 (OSRAM) |
| CN (2) | CN117379452A (OSRAM) |
| AU (2) | AU2015280248B2 (OSRAM) |
| CA (2) | CA3207106A1 (OSRAM) |
| DK (1) | DK3160476T3 (OSRAM) |
| EA (1) | EA201692535A1 (OSRAM) |
| ES (1) | ES2841310T3 (OSRAM) |
| HR (1) | HRP20202014T1 (OSRAM) |
| HU (1) | HUE051986T2 (OSRAM) |
| IL (1) | IL249628A0 (OSRAM) |
| LT (1) | LT3160476T (OSRAM) |
| MX (1) | MX2016017383A (OSRAM) |
| PH (1) | PH12016502564A1 (OSRAM) |
| SG (1) | SG11201610599TA (OSRAM) |
| SI (1) | SI3160476T1 (OSRAM) |
| SM (1) | SMT202000716T1 (OSRAM) |
| TW (1) | TW201613612A (OSRAM) |
| WO (1) | WO2015200219A1 (OSRAM) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013096680A1 (en) | 2011-12-22 | 2013-06-27 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
| EP2794627B1 (en) | 2011-12-22 | 2018-09-26 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US8916538B2 (en) | 2012-03-21 | 2014-12-23 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US9598457B2 (en) | 2012-12-21 | 2017-03-21 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| EP2935303B1 (en) | 2012-12-21 | 2021-02-17 | Janssen BioPharma, Inc. | 4'-fluoro-nucleosides, 4'-fluoro-nucleotides and analogs thereof for the treatment of hcv |
| CA2908313A1 (en) | 2013-04-05 | 2014-10-09 | Alios Biopharma, Inc. | Hepatitis c viral infection treatment using a combination of compounds |
| TWI655199B (zh) | 2013-06-26 | 2019-04-01 | 美商艾洛斯生物製藥公司 | 經取代之核苷、核苷酸及其類似物 |
| HK1224229A1 (zh) | 2013-06-26 | 2017-08-18 | Alios Biopharma, Inc. | 取代的核苷，核苷酸及其类似物 |
| AU2014331863C1 (en) | 2013-10-11 | 2019-05-16 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| EP3160475B1 (en) | 2014-06-24 | 2024-01-03 | Janssen Pharmaceuticals, Inc. | Substituted nucleosides and nucleotides to treat filoviridae infections |
| US9603864B2 (en) | 2014-06-24 | 2017-03-28 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US10358458B2 (en) | 2014-09-26 | 2019-07-23 | Riboscience Llc | 4′-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus RNA replication |
| US9908914B2 (en) | 2014-10-28 | 2018-03-06 | Alios Biopharma, Inc. | Methods of preparing substituted nucleoside analogs |
| MA41213A (fr) | 2014-12-19 | 2017-10-24 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| MA41441A (fr) | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| CN118286245A (zh) | 2014-12-26 | 2024-07-05 | 埃莫里大学 | N4-羟基胞苷和衍生物及与其相关的抗病毒用途 |
| HK1247829A1 (zh) | 2015-03-06 | 2018-10-05 | Atea Pharmaceuticals, Inc. | 用於治疗HCV的β-D-2'-脱氧-2'Α-氟-2'-β-C-取代-2-改性N6-取代的嘌呤核苷酸 |
| HK1246780A1 (zh) | 2015-03-11 | 2018-09-14 | Janssen Biopharma, Inc. | 氮杂-吡啶酮化合物及其用途 |
| CN105503787A (zh) * | 2015-12-31 | 2016-04-20 | 阜阳欣奕华材料科技有限公司 | 一种索非布韦中间体的纯化方法 |
| CN109311885A (zh) * | 2016-03-24 | 2019-02-05 | 诺华股份有限公司 | 炔基核苷类似物作为人类鼻病毒的抑制剂 |
| CA3022119A1 (en) * | 2016-04-28 | 2017-11-02 | Emory University | Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
| US10202412B2 (en) | 2016-07-08 | 2019-02-12 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections |
| EP3512863B1 (en) | 2016-09-07 | 2021-12-08 | ATEA Pharmaceuticals, Inc. | 2'-substituted-n6-substituted purine nucleotides for rna virus treatment |
| WO2018049145A1 (en) | 2016-09-09 | 2018-03-15 | Calithera Biosciences, Inc. | Ectonucleotidase inhibitors and methods of use thereof |
| US11643432B2 (en) | 2016-12-16 | 2023-05-09 | National University Corporation Tokai National Higher Education And Research System | Nucleoside derivative and use thereof |
| EP4450129A3 (en) | 2017-02-01 | 2025-03-19 | ATEA Pharmaceuticals, Inc. | Nucleotide hemi-sulfate salt for the treatment of hepatitis c virus |
| KR20190141747A (ko) | 2017-05-01 | 2019-12-24 | 길리애드 사이언시즈, 인코포레이티드 | (S)-2-에틸부틸 2-(((S)-(((2R,3S,4R,5R)-5-(4-아미노피롤로[2,1-f] [1,2,4]트리아진-7-일)-5-시아노-3,4-디히드록시테트라히드로푸란-2-일)메톡시)(페녹시) 포스포릴)아미노)프로파노에이트의 결정질 형태 |
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| WO2019027905A1 (en) | 2017-07-31 | 2019-02-07 | January Therapeutics, Inc. | ORGANOPHOSPHATE DERIVATIVES |
| EP3684782A1 (en) * | 2017-09-18 | 2020-07-29 | Janssen BioPharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| WO2019088179A1 (ja) | 2017-10-31 | 2019-05-09 | ヤマサ醤油株式会社 | ヌクレオシド誘導体及びその利用 |
| US11331331B2 (en) | 2017-12-07 | 2022-05-17 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| CN112218533A (zh) * | 2018-03-02 | 2021-01-12 | 詹纽瑞治疗公司 | 纳米颗粒组合物 |
| WO2019173602A1 (en) * | 2018-03-07 | 2019-09-12 | Emory University | 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
| TW202012001A (zh) | 2018-04-10 | 2020-04-01 | 美商亞堤製藥公司 | C型肝炎病毒(hcv)感染硬化之患者的治療 |
| MX2021010700A (es) | 2019-03-06 | 2021-10-01 | Glaxosmithkline Ip No 2 Ltd | Compuestos utiles en la terapia del vih. |
| CN119874793A (zh) * | 2019-04-05 | 2025-04-25 | 株式会社日本触媒 | 交联型人工核苷的制备 |
| CN118477090A (zh) * | 2019-10-08 | 2024-08-13 | 埃默里大学 | 含4'-卤素的核苷酸和核苷治疗组合物以及其相关用途 |
| CN118766947A (zh) | 2020-01-27 | 2024-10-15 | 吉利德科学公司 | 用于治疗SARS CoV-2感染的方法 |
| CA3171648A1 (en) * | 2020-02-18 | 2021-08-26 | Gilead Sciences, Inc. | Antiviral compounds |
| TWI883391B (zh) | 2020-02-18 | 2025-05-11 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI775313B (zh) | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| CN113387954B (zh) * | 2020-03-11 | 2024-03-19 | 上海特化医药科技有限公司 | 一种瑞德西韦中间体的制备方法 |
| CA3169340A1 (en) | 2020-03-12 | 2021-09-16 | Pavel R. Badalov | Methods of preparing 1'-cyano nucleosides |
| CN115605493A (zh) | 2020-03-20 | 2023-01-13 | 吉利德科学公司（Us） | 4′-c-取代的-2-卤代-2′-脱氧腺苷核苷的前药及其制备和使用方法 |
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