JP2017515854A - カスパーゼ阻害剤による慢性肝疾患の合併症の治療 - Google Patents

カスパーゼ阻害剤による慢性肝疾患の合併症の治療 Download PDF

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JP2017515854A
JP2017515854A JP2016567605A JP2016567605A JP2017515854A JP 2017515854 A JP2017515854 A JP 2017515854A JP 2016567605 A JP2016567605 A JP 2016567605A JP 2016567605 A JP2016567605 A JP 2016567605A JP 2017515854 A JP2017515854 A JP 2017515854A
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caspase inhibitor
pharmaceutically acceptable
acceptable derivative
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JP2017515854A5 (OSRAM
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ピー．スパダ アルフレド
ピー．スパダ アルフレド
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クオナトウス ファーマシューティカルズ，インコーポレイテッド
クオナトウス ファーマシューティカルズ，インコーポレイテッド
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2016567605A 2014-05-12 2015-05-11 カスパーゼ阻害剤による慢性肝疾患の合併症の治療 Pending JP2017515854A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461992169P 2014-05-12 2014-05-12
US61/992,169 2014-05-12
PCT/US2015/030101 WO2015175381A1 (en) 2014-05-12 2015-05-11 Treatment of the complications of chronic liver disease with caspase inhibitors

Publications (2)

Publication Number Publication Date
JP2017515854A true JP2017515854A (ja) 2017-06-15
JP2017515854A5 JP2017515854A5 (OSRAM) 2018-06-21

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JP2016567605A Pending JP2017515854A (ja) 2014-05-12 2015-05-11 カスパーゼ阻害剤による慢性肝疾患の合併症の治療

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US (2) US20170100448A1 (OSRAM)
EP (2) EP3444011A1 (OSRAM)
JP (1) JP2017515854A (OSRAM)
KR (1) KR20170015312A (OSRAM)
CN (1) CN106470679A (OSRAM)
AU (1) AU2015259471A1 (OSRAM)
BR (1) BR112016026560A2 (OSRAM)
CA (1) CA2948540A1 (OSRAM)
ES (1) ES2751652T3 (OSRAM)
IL (1) IL248882A0 (OSRAM)
MX (1) MX2016014731A (OSRAM)
RU (1) RU2016148364A (OSRAM)
SG (1) SG11201609256SA (OSRAM)
WO (1) WO2015175381A1 (OSRAM)
ZA (1) ZA201607740B (OSRAM)

Cited By (3)

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WO2020004652A1 (ja) * 2018-06-29 2020-01-02 学校法人同志社 エムリカサンを含む製剤
JP2022524049A (ja) * 2019-03-07 2022-04-27 クオナトウス ファーマシューティカルズ，インコーポレイテッド カスパーゼ阻害剤及びその使用方法
JP2023522339A (ja) * 2020-04-14 2023-05-30 アメリミューン リミテッド ライアビリティ カンパニー Ｒｎａウイルスによって引き起こされる疾患の処置

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WO2017079566A1 (en) * 2015-11-05 2017-05-11 Conatus Pharmaceuticals, Inc. Caspase inhibitors for use in the treatment of liver cancer
CN108697663A (zh) * 2015-12-31 2018-10-23 科内图斯医药公司 在肝病治疗中使用胱天蛋白酶抑制剂的方法
FR3050112B1 (fr) 2016-04-15 2020-09-04 Soc Civ Immobiliere Gecinq Utilisation de l'acide fenofibrique dans le traitement des maladies hepatiques
TW201739734A (zh) * 2016-05-11 2017-11-16 Chia Tai Tianqing Pharmaceutical Group Co Ltd Caspase抑制劑及其藥物組合物、用途和治療方法
US20190351003A1 (en) * 2017-02-07 2019-11-21 The Regents Of The University Of California Methods for inhibiting nonalcoholic steatohepatitis, nonalcoholic fatty liver disease, and/or de novo lipogenesis
EP3717006A1 (en) * 2017-09-13 2020-10-07 Novartis AG Use of il-1b binding antibodies for the treatment of alcoholic hepatitis
CN109748843B (zh) * 2017-11-06 2022-11-11 正大天晴药业集团股份有限公司 Caspase抑制剂及其药物组合物、用途和治疗方法
CA3105352A1 (en) 2018-06-29 2020-01-02 Histogen, Inc. (s)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases
WO2020222541A1 (ko) * 2019-04-30 2020-11-05 주식회사 엘지화학 캐스파제 저해제의 프로드럭
MX2022013549A (es) 2020-05-01 2023-01-16 Medstar Health Inc Metodos para tratar la covid-19.
US20250288547A1 (en) * 2021-06-22 2025-09-18 Amerimmune Llc Treatment of diseases caused by rna viruses

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