JP2017515470A5 - - Google Patents
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- JP2017515470A5 JP2017515470A5 JP2016565168A JP2016565168A JP2017515470A5 JP 2017515470 A5 JP2017515470 A5 JP 2017515470A5 JP 2016565168 A JP2016565168 A JP 2016565168A JP 2016565168 A JP2016565168 A JP 2016565168A JP 2017515470 A5 JP2017515470 A5 JP 2017515470A5
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- JP
- Japan
- Prior art keywords
- antibody
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- antibody fragment
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 19
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 19
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 210000003719 b-lymphocyte Anatomy 0.000 claims 5
- 239000000611 antibody drug conjugate Substances 0.000 claims 4
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 230000001717 pathogenic effect Effects 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 210000004180 plasmocyte Anatomy 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 210000001806 memory b lymphocyte Anatomy 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000037914 B-cell disorder Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000007452 Plasmacytoma Diseases 0.000 claims 1
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 150000002482 oligosaccharides Polymers 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000031223 plasma cell leukemia Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000005945 translocation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14166729 | 2014-04-30 | ||
| EP14166729.5 | 2014-04-30 | ||
| PCT/EP2015/059562 WO2015166073A1 (en) | 2014-04-30 | 2015-04-30 | Humanized antibodies against cd269 (bcma) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020142486A Division JP7189913B2 (ja) | 2014-04-30 | 2020-08-26 | Ｃｄ２６９（ｂｃｍａ）に対するヒト化抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017515470A JP2017515470A (ja) | 2017-06-15 |
| JP2017515470A5 true JP2017515470A5 (cg-RX-API-DMAC7.html) | 2018-06-07 |
| JP6755805B2 JP6755805B2 (ja) | 2020-09-16 |
Family
ID=50677985
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016565168A Active JP6755805B2 (ja) | 2014-04-30 | 2015-04-30 | Ｃｄ２６９（ｂｃｍａ）に対するヒト化抗体 |
| JP2020142486A Active JP7189913B2 (ja) | 2014-04-30 | 2020-08-26 | Ｃｄ２６９（ｂｃｍａ）に対するヒト化抗体 |
| JP2022194533A Pending JP2023025202A (ja) | 2014-04-30 | 2022-12-05 | Ｃｄ２６９（ｂｃｍａ）に対するヒト化抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020142486A Active JP7189913B2 (ja) | 2014-04-30 | 2020-08-26 | Ｃｄ２６９（ｂｃｍａ）に対するヒト化抗体 |
| JP2022194533A Pending JP2023025202A (ja) | 2014-04-30 | 2022-12-05 | Ｃｄ２６９（ｂｃｍａ）に対するヒト化抗体 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10144782B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3137500A1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP6755805B2 (cg-RX-API-DMAC7.html) |
| KR (3) | KR102405492B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN106661109B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015254526B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112016024546A2 (cg-RX-API-DMAC7.html) |
| IL (2) | IL248257B2 (cg-RX-API-DMAC7.html) |
| MX (2) | MX375800B (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ725701A (cg-RX-API-DMAC7.html) |
| RU (2) | RU2749041C2 (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201608415QA (cg-RX-API-DMAC7.html) |
| UA (1) | UA121031C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015166073A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201607018B (cg-RX-API-DMAC7.html) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6694712B2 (ja) | 2012-11-01 | 2020-05-20 | マックス−デルブルック−セントラム フアー モレキュラーレ メデジン | Ｃｄ２６９（ｂｃｍａ）に対する抗体 |
| US10126301B2 (en) | 2013-02-08 | 2018-11-13 | Institute For Myeloma & Bone Cancer Research | Diagnostic, prognostic, and monitoring methods for multiple myeloma, chronic lymphocytic leukemia, and B-cell non-hodgkin lymphoma |
| MX375800B (es) * | 2014-04-30 | 2025-03-06 | Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft | Anticuerpos humanizados contra cd269 (bcma). |
| US10174095B2 (en) | 2014-07-21 | 2019-01-08 | Novartis Ag | Nucleic acid encoding a humanized anti-BCMA chimeric antigen receptor |
| SG11201707089WA (en) | 2015-04-13 | 2017-10-30 | Pfizer | Chimeric antigen receptors targeting b-cell maturation antigen |
| SG10201912819XA (en) | 2015-04-13 | 2020-02-27 | Pfizer | Therapeutic antibodies and their uses |
| US11698369B2 (en) | 2016-01-12 | 2023-07-11 | Oncotracker, Inc. | Methods for monitoring immune status of a subject |
| CA3011900A1 (en) | 2016-02-17 | 2017-08-24 | Seattle Genetics, Inc. | Bcma antibodies and use of same to treat cancer and immunological disorders |
| CA3026778A1 (en) | 2016-06-07 | 2017-12-14 | Max-Delbruck-Centrum Fur Molekulare Medizin In Der Helmholtz-Gemeinschaft | Chimeric antigen receptor and car-t cells that bind bcma |
| EA201891851A1 (ru) * | 2016-09-16 | 2019-04-30 | Сиэтл Дженетикс, Инк. | Антитела против bcma и их применение для лечения злокачественных новообразований и иммунологических нарушений |
| ES3000471T3 (en) | 2016-12-23 | 2025-02-28 | Heidelberg Pharma Res Gmbh | Amanitin antibody conjugates |
| CN108285489A (zh) * | 2017-01-09 | 2018-07-17 | 上海恒润达生生物科技有限公司 | 靶向BCMA-BBz-tEGFR的嵌合抗原受体及其用途 |
| CN110582509A (zh) | 2017-01-31 | 2019-12-17 | 诺华股份有限公司 | 使用具有多特异性的嵌合t细胞受体蛋白治疗癌症 |
| CN108395478A (zh) * | 2017-02-04 | 2018-08-14 | 上海恒润达生生物科技有限公司 | 靶向bcma的嵌合抗原受体并对其双重修饰的方法及其用途 |
| IL268349B2 (en) | 2017-02-17 | 2024-08-01 | Hutchinson Fred Cancer Res | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
| EP3615055A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| US20200179511A1 (en) | 2017-04-28 | 2020-06-11 | Novartis Ag | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
| US11635435B2 (en) | 2017-06-13 | 2023-04-25 | Oncotracker, Inc. | Diagnostic, prognostic, and monitoring methods for solid tumor cancers |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| CA3079407A1 (en) | 2017-10-18 | 2019-04-25 | Novartis Ag | Compositions and methods for selective protein degradation |
| TW201922774A (zh) | 2017-11-15 | 2019-06-16 | 瑞士商諾華公司 | 標靶bcma嵌合抗原受體、標靶cd19嵌合抗原受體及組合療法 |
| AU2018375738A1 (en) | 2017-11-30 | 2020-06-11 | Novartis Ag | BCMA-targeting chimeric antigen receptor, and uses thereof |
| CN112218651A (zh) | 2018-01-08 | 2021-01-12 | 诺华公司 | 用于与嵌合抗原受体疗法组合的免疫增强rna |
| EP3737692A4 (en) | 2018-01-09 | 2021-09-29 | Elstar Therapeutics, Inc. | CALRETICULIN AND MODIFIED T-LYMPHOCYTES BINDING CONSTRUCTIONS FOR THE TREATMENT OF DISEASES |
| AU2019215031B2 (en) | 2018-01-31 | 2025-10-09 | Novartis Ag | Combination therapy using a chimeric antigen receptor |
| TWI800854B (zh) * | 2018-02-01 | 2023-05-01 | 大陸商信達生物製藥（蘇州）有限公司 | 全人源的抗ｂ細胞成熟抗原（ｂｃｍａ）單鏈抗體及其應用 |
| WO2019160956A1 (en) | 2018-02-13 | 2019-08-22 | Novartis Ag | Chimeric antigen receptor therapy in combination with il-15r and il15 |
| JP2021514193A (ja) * | 2018-02-21 | 2021-06-10 | セルジーン コーポレイション | Ｂｃｍａ結合抗体及びその使用 |
| EP3765517A1 (en) | 2018-03-14 | 2021-01-20 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| BR112020024351A2 (pt) | 2018-06-01 | 2021-02-23 | Novartis Ag | moléculas de ligação contra bcma e usos das mesmas |
| MY208825A (en) | 2018-06-13 | 2025-05-30 | Novartis Ag | Bcma chimeric antigen receptors and uses thereof |
| US12252541B2 (en) * | 2018-06-26 | 2025-03-18 | Abl Bio Inc. | Anti-BCMA antibody and use thereof |
| EP3818083A2 (en) | 2018-07-03 | 2021-05-12 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| TWI838389B (zh) | 2018-07-19 | 2024-04-11 | 美商再生元醫藥公司 | 雙特異性抗-BCMAｘ抗-CD3抗體及其用途 |
| DK3823665T5 (da) | 2018-07-19 | 2024-08-19 | Regeneron Pharma | Kimæriske antigenreceptorer med BCMA-specificitet og anvendelser deraf |
| CN112639083A (zh) | 2018-08-31 | 2021-04-09 | 诺华股份有限公司 | 制备表达嵌合抗原受体的细胞的方法 |
| US20210171909A1 (en) | 2018-08-31 | 2021-06-10 | Novartis Ag | Methods of making chimeric antigen receptor?expressing cells |
| WO2020150339A1 (en) * | 2019-01-16 | 2020-07-23 | Caribou Biosciences, Inc. | Humanized bcma antibody and bcma-car-t cells |
| SG11202108955QA (en) | 2019-02-21 | 2021-09-29 | Marengo Therapeutics Inc | Antibody molecules that bind to nkp30 and uses thereof |
| CN119661722A (zh) | 2019-02-21 | 2025-03-21 | 马伦戈治疗公司 | 结合t细胞相关癌细胞的多功能分子及其用途 |
| TW202045207A (zh) | 2019-02-25 | 2020-12-16 | 瑞士商諾華公司 | 用於病毒遞送之介孔二氧化矽顆粒組成物 |
| US20230074800A1 (en) | 2019-03-21 | 2023-03-09 | Novartis Ag | Car-t cell therapies with enhanced efficacy |
| US20220168389A1 (en) | 2019-04-12 | 2022-06-02 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| WO2020219742A1 (en) | 2019-04-24 | 2020-10-29 | Novartis Ag | Compositions and methods for selective protein degradation |
| KR20220005058A (ko) * | 2019-05-03 | 2022-01-12 | 셀진 코포레이션 | 항-bcma 항체 접합체, 그를 포함하는 조성물, 및 그의 제조 및 사용 방법 |
| KR102878895B1 (ko) | 2019-05-21 | 2025-10-31 | 노파르티스 아게 | Cd19 결합 분자 및 이의 용도 |
| MX2022001065A (es) * | 2019-07-30 | 2022-02-14 | Shanghai Hansoh Biomedical Co Ltd | Anticuerpo anti-bcma, fragmento de union al antigeno y uso medico del mismo. |
| WO2021023721A1 (en) * | 2019-08-02 | 2021-02-11 | Fundacio Clinic Per A La Recerca Biomedica | Car t-cells against bcma for the treatment of multiple myeloma |
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| CN120775052A (zh) | 2019-10-10 | 2025-10-14 | 再凌生物医药(香港)有限公司 | 靶向bcma的具有人猴交叉的人源化单克隆抗体 |
| PH12022551291A1 (en) | 2019-11-26 | 2023-11-20 | Novartis Ag | Chimeric antigen receptors binding bcma and cd19 and uses thereof |
| WO2021121250A1 (zh) * | 2019-12-17 | 2021-06-24 | 深圳市菲鹏生物治疗股份有限公司 | Bcma结合抗体及其用途 |
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| AU2021225949A1 (en) | 2020-02-27 | 2022-09-15 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
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| CN113637073B (zh) * | 2020-05-11 | 2024-04-12 | 上海赛比曼生物科技有限公司 | Bcma抗体及其制备和应用 |
| US12043670B2 (en) | 2020-06-05 | 2024-07-23 | Eisai R&D Management Co., Ltd. | Anti-BCMA antibody-drug conjugates and methods of use |
| KR20230024967A (ko) | 2020-06-11 | 2023-02-21 | 노파르티스 아게 | Zbtb32 억제제 및 이의 용도 |
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| CN112614596B (zh) * | 2020-12-22 | 2023-01-10 | 厦门承葛生物科技有限公司 | 一种肠道菌群移植治疗溃疡性结肠炎的供受体配型方法 |
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| TW202309294A (zh) | 2021-04-27 | 2023-03-01 | 瑞士商諾華公司 | 病毒載體生產系統 |
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| EP4384189A1 (en) | 2021-08-11 | 2024-06-19 | Sana Biotechnology, Inc. | Genetically modified primary cells for allogeneic cell therapy |
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| CN117858901A (zh) | 2021-08-20 | 2024-04-09 | 诺华股份有限公司 | 制备表达嵌合抗原受体的细胞的方法 |
| JP2024543822A (ja) | 2021-11-03 | 2024-11-26 | アフィメド ゲーエムベーハー | 二重特異性ｃｄ１６ａバインダー |
| KR20240155390A (ko) | 2022-02-17 | 2024-10-28 | 사나 바이오테크놀로지, 인크. | 조작된 cd47 단백질 및 이의 용도 |
| WO2023215725A1 (en) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| CN120112650A (zh) | 2022-10-26 | 2025-06-06 | 诺华股份有限公司 | 慢病毒配制品 |
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| TW202440636A (zh) | 2023-03-21 | 2024-10-16 | 美商傳記５５有限公司 | Ｃｄ１９／ｃｄ３８多特異性抗體 |
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| EP1362061A2 (en) | 2001-02-20 | 2003-11-19 | ZymoGenetics, Inc. | Antibodies that bind both bcma and taci |
| AR039067A1 (es) * | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | Anticuerpos para cd40 |
| WO2003080672A1 (en) | 2002-03-22 | 2003-10-02 | Aprogen, Inc. | Humanized antibody and process for preparing same |
| US8303955B2 (en) * | 2005-05-26 | 2012-11-06 | Seattle Genetics, Inc. | Humanized anti-CD40 antibodies and their methods of use |
| US9382327B2 (en) * | 2006-10-10 | 2016-07-05 | Vaccinex, Inc. | Anti-CD20 antibodies and methods of use |
| WO2009070767A2 (en) * | 2007-11-28 | 2009-06-04 | Whitehead Institute For Biomedical Research | Systemic instigation systems to study tumor growth or metastasis |
| EP2321345A1 (en) * | 2008-07-28 | 2011-05-18 | Emergent Product Development Seattle, LLC | Multi-specific binding proteins targeting b cell disorders |
| MX341884B (es) * | 2009-03-10 | 2016-09-07 | Biogen Ma Inc | Anticuerpos anti-antigeno de maduracion de celulas b (bcma). |
| CN102361883A (zh) | 2009-04-07 | 2012-02-22 | 罗氏格黎卡特股份公司 | 双特异性抗-ErbB-1/抗-c-Met抗体 |
| EP3974453A3 (en) * | 2010-11-16 | 2022-08-03 | Amgen Inc. | Agents and methods for treating diseases that correlate with bcma expression |
| US20130101599A1 (en) * | 2011-04-21 | 2013-04-25 | Boehringer Ingelheim International Gmbh | Bcma-based stratification and therapy for multiple myeloma patients |
| WO2012163805A1 (en) * | 2011-05-27 | 2012-12-06 | Glaxo Group Limited | Bcma (cd269/tnfrsf17) -binding proteins |
| JP6694712B2 (ja) * | 2012-11-01 | 2020-05-20 | マックス−デルブルック−セントラム フアー モレキュラーレ メデジン | Ｃｄ２６９（ｂｃｍａ）に対する抗体 |
| MX375800B (es) | 2014-04-30 | 2025-03-06 | Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft | Anticuerpos humanizados contra cd269 (bcma). |
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2015
- 2015-04-30 MX MX2016013767A patent/MX375800B/es active IP Right Grant
- 2015-04-30 AU AU2015254526A patent/AU2015254526B2/en active Active
- 2015-04-30 IL IL248257A patent/IL248257B2/en unknown
- 2015-04-30 SG SG11201608415QA patent/SG11201608415QA/en unknown
- 2015-04-30 IL IL303667A patent/IL303667A/en unknown
- 2015-04-30 US US15/306,438 patent/US10144782B2/en active Active
- 2015-04-30 JP JP2016565168A patent/JP6755805B2/ja active Active
- 2015-04-30 UA UAA201612087A patent/UA121031C2/uk unknown
- 2015-04-30 KR KR1020167033409A patent/KR102405492B1/ko active Active
- 2015-04-30 WO PCT/EP2015/059562 patent/WO2015166073A1/en not_active Ceased
- 2015-04-30 CN CN201580021693.5A patent/CN106661109B/zh active Active
- 2015-04-30 RU RU2016146486A patent/RU2749041C2/ru active
- 2015-04-30 CN CN202110761923.9A patent/CN113491776B/zh active Active
- 2015-04-30 KR KR1020227018383A patent/KR102526945B1/ko active Active
- 2015-04-30 BR BR112016024546-6A patent/BR112016024546A2/pt not_active Application Discontinuation
- 2015-04-30 EP EP15720954.5A patent/EP3137500A1/en active Pending
- 2015-04-30 KR KR1020237013978A patent/KR102632731B1/ko active Active
- 2015-04-30 NZ NZ725701A patent/NZ725701A/en unknown
- 2015-04-30 RU RU2021115081A patent/RU2021115081A/ru unknown
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2016
- 2016-10-12 ZA ZA2016/07018A patent/ZA201607018B/en unknown
- 2016-10-20 MX MX2020010530A patent/MX2020010530A/es unknown
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2018
- 2018-10-25 US US16/170,575 patent/US10851172B2/en active Active
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2020
- 2020-08-26 JP JP2020142486A patent/JP7189913B2/ja active Active
- 2020-10-23 US US17/079,075 patent/US11820829B2/en active Active
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2022
- 2022-12-05 JP JP2022194533A patent/JP2023025202A/ja active Pending
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