JP2017515466A5 - - Google Patents

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Publication number
JP2017515466A5
JP2017515466A5 JP2016562248A JP2016562248A JP2017515466A5 JP 2017515466 A5 JP2017515466 A5 JP 2017515466A5 JP 2016562248 A JP2016562248 A JP 2016562248A JP 2016562248 A JP2016562248 A JP 2016562248A JP 2017515466 A5 JP2017515466 A5 JP 2017515466A5
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JP
Japan
Prior art keywords
lactamase
residue
polarity
alanine
cephalosporin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2016562248A
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English (en)
Japanese (ja)
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JP2017515466A (ja
JP6685925B2 (ja
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Priority claimed from PCT/US2015/026457 external-priority patent/WO2015161243A2/en
Publication of JP2017515466A publication Critical patent/JP2017515466A/ja
Publication of JP2017515466A5 publication Critical patent/JP2017515466A5/ja
Application granted granted Critical
Publication of JP6685925B2 publication Critical patent/JP6685925B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2016562248A 2014-04-17 2015-04-17 治療用として改善された特性を有するβ−ラクタマーゼ Expired - Fee Related JP6685925B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461980844P 2014-04-17 2014-04-17
US61/980,844 2014-04-17
US201462046627P 2014-09-05 2014-09-05
US62/046,627 2014-09-05
PCT/US2015/026457 WO2015161243A2 (en) 2014-04-17 2015-04-17 Beta-lactamases with improved properties for therapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019220462A Division JP7038094B2 (ja) 2014-04-17 2019-12-05 治療用として改善された特性を有するβ－ラクタマーゼ

Publications (3)

Publication Number Publication Date
JP2017515466A JP2017515466A (ja) 2017-06-15
JP2017515466A5 true JP2017515466A5 (https=) 2018-05-31
JP6685925B2 JP6685925B2 (ja) 2020-04-22

Family

ID=54321063

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016562248A Expired - Fee Related JP6685925B2 (ja) 2014-04-17 2015-04-17 治療用として改善された特性を有するβ−ラクタマーゼ
JP2019220462A Expired - Fee Related JP7038094B2 (ja) 2014-04-17 2019-12-05 治療用として改善された特性を有するβ－ラクタマーゼ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019220462A Expired - Fee Related JP7038094B2 (ja) 2014-04-17 2019-12-05 治療用として改善された特性を有するβ－ラクタマーゼ

Country Status (10)

Country Link
US (14) US9290754B2 (https=)
EP (1) EP3132033B1 (https=)
JP (2) JP6685925B2 (https=)
KR (1) KR102360582B1 (https=)
CN (1) CN106163546B (https=)
AU (1) AU2015247382B2 (https=)
BR (1) BR112016023360B1 (https=)
CA (1) CA2942971C (https=)
RU (1) RU2678124C2 (https=)
WO (1) WO2015161243A2 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016057744A1 (en) 2014-10-08 2016-04-14 Synthetic Biologics, Inc. Beta-lactamase formulations and uses thereof
EP3265119B1 (en) * 2015-03-06 2023-10-11 Theriva Biologics, Inc. Safe and effective beta-lactamase dosing for microbiome protection
JP6845258B6 (ja) * 2016-02-23 2021-04-28 ダ・ボルテラ ベータ−ラクタマーゼ変異体
WO2017144495A1 (en) * 2016-02-23 2017-08-31 Da Volterra Beta-lactamase variants
CN109562147B (zh) 2016-06-28 2023-09-01 特里瓦生物制剂有限公司 保护微生物组免受口服抗生素
US20210290741A1 (en) 2018-08-05 2021-09-23 Da Volterra Compositions for the treatment of graft versus host disease
AU2019317986A1 (en) 2018-08-05 2021-02-11 Da Volterra Method for improving anticancer agent efficacy
CN109576250B (zh) * 2018-12-26 2025-04-15 广州白云山拜迪生物医药有限公司 一种酶活提高的头孢菌素酶突变体及其构建方法
CN109337889B (zh) * 2018-12-26 2020-10-02 广州白云山拜迪生物医药有限公司 一种酶活提高的金属β-内酰胺酶突变体及其构建方法
CA3136833A1 (en) * 2019-05-06 2020-11-12 Synthetic Biologics, Inc. Beta-lactamase compositions for treatment of graft versus host disease
EP4148136A1 (en) 2021-09-08 2023-03-15 Da Volterra An engineered yeast cell for the delivery of antibiotic-inactivating enzymes
WO2024012487A1 (en) * 2022-07-14 2024-01-18 The Hong Kong Polytechnic University Biosensor comprising a modified beta-lactamase and uses thereof
CN115433701B (zh) * 2022-11-08 2023-03-17 南京农业大学 一株变形杆菌及其菌剂和在降解头孢类抗生素中的应用
CN117701543A (zh) * 2023-12-15 2024-03-15 四川省固体废物与化学品管理中心 一种b家族内酰胺酶突变体及其固定化方法与应用

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL89987C (https=) 1954-05-29
US2941995A (en) 1957-08-02 1960-06-21 Beecham Res Lab Recovery of solid 6-aminopenicillanic acid
US2982696A (en) 1959-05-01 1961-05-02 Schenley Ind Inc Ion-exchange procedures for the purification of penicillinase
US3070511A (en) 1960-02-10 1962-12-25 Lepetit Spa Process for preparing 6-aminopenicillanic acid
US3150059A (en) 1962-12-26 1964-09-22 Lilly Co Eli Penicillin deacylation via actinoplanaceae fermentation
US3239394A (en) 1964-06-15 1966-03-08 Merck & Co Inc Process for producing 7-amino-cephalosporanic acid
US3499909A (en) 1966-05-18 1970-03-10 Koninklijke Gist Spiritus Process for production of 6-aminopenicillanic acid
US3488729A (en) 1966-08-22 1970-01-06 Lilly Co Eli Cephalothin ester
GB1241844A (en) 1968-08-23 1971-08-04 Beecham Group Ltd Penicillins
FI59265C (fi) 1974-08-13 1981-07-10 Beecham Group Ltd Foerfarande foer framstaellning av 6-aminopenicillansyra
GB1463513A (en) 1974-08-13 1977-02-02 Beecham Group Ltd Enzymes
GB2199582A (en) 1987-01-07 1988-07-13 Bayer Ag Analogues of pancreatic secretory trypsin inhibitor
FR2613624B1 (fr) 1987-04-10 1990-11-23 Roussy Inst Gustave Composition pharmaceutique, administrable par voie orale, destinee a reduire les effets des b-lactamines
CA2007083A1 (en) 1989-01-09 1990-07-09 Nobuhiko Katunuma Pharmaceutical use of trypstatin
CS275231B2 (en) 1989-09-29 1992-02-19 Ustav Makormolekularni Chemie Medicine bottle
FI920206A0 (fi) 1992-01-17 1992-01-17 Pekka Untamo Heino Medicinsk anvaendning, medicinskt foerfarande och preparat.
CN1190434A (zh) 1995-07-07 1998-08-12 诺沃挪第克公司 用不能形成芽孢的芽孢杆菌生产蛋白质的方法
CN1363680A (zh) * 2001-01-05 2002-08-14 上海博德基因开发有限公司 一种新的多肽——β内酰胺酶20.24和编码这种多肽的多核苷酸
US7585674B2 (en) 2001-05-29 2009-09-08 Kao Corporation Host microorganisms
FI112666B (fi) 2001-11-06 2003-12-31 Ipsat Therapies Oy Itiöimätön Bacillus subtilis, sen valmistus ja käyttö
FR2843302B1 (fr) 2002-08-09 2004-10-22 Centre Nat Rech Scient Forme galenique pour la delivrance colique de principes actifs
EP2284185A3 (en) * 2004-01-09 2011-05-18 Novozymes A/S Bacillus protein inactivation
EP1564286A1 (en) * 2004-02-11 2005-08-17 Université de Liège Hybrid proteins of beta-lactamase class A
DE102004032995A1 (de) * 2004-07-08 2006-03-30 Henkel Kgaa Neue, sekretierte Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren
ES2429095T3 (es) 2005-05-18 2013-11-13 Da Volterra Aporte colónico de adsorbentes
FI119190B (fi) * 2006-06-21 2008-08-29 Ipsat Therapies Oy Modifioitu beta-laktamaasi ja menetelmä sen valmistamiseksi
CN101104858A (zh) * 2006-07-10 2008-01-16 温州医学院 一种体外定向进化获取高活力超广谱β-内酰胺酶的方法
FI119678B (fi) 2006-11-28 2009-02-13 Ipsat Therapies Oy Beta-laktamaasin käyttö
US20100064393A1 (en) * 2006-11-29 2010-03-11 Novozymes, Inc. Bacillus liceniformis chromosome
CN101647022B (zh) * 2007-01-31 2012-07-18 麦科罗医药科技(武汉)有限公司 描述蛋白质的构象和根据折叠、整体形状与结构序列对其进行评价的方法、系统及装置
FI20105572A0 (fi) 2010-05-24 2010-05-24 Prevab R Lcc Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt
US9347057B2 (en) * 2012-06-12 2016-05-24 The Johns Hopkins University Methods for efficient, expansive user-defined DNA mutagenesis

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