JP2017514866A - Ｂｒａｆ阻害剤を使用する創傷治癒 - Google Patents

Ｂｒａｆ阻害剤を使用する創傷治癒 Download PDF

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Publication number
JP2017514866A
JP2017514866A JP2016566754A JP2016566754A JP2017514866A JP 2017514866 A JP2017514866 A JP 2017514866A JP 2016566754 A JP2016566754 A JP 2016566754A JP 2016566754 A JP2016566754 A JP 2016566754A JP 2017514866 A JP2017514866 A JP 2017514866A
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JP
Japan
Prior art keywords
dressing
group
braf inhibitor
wound
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2016566754A
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English (en)
Japanese (ja)
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JP2017514866A5 (OSRAM
Inventor
リバス アントニー
リバス アントニー
エスクイン オーディナス ヘレナ
エスクイン オーディナス ヘレナ
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University of California
University of California Berkeley
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University of California San Diego UCSD
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Publication of JP2017514866A publication Critical patent/JP2017514866A/ja
Publication of JP2017514866A5 publication Critical patent/JP2017514866A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
JP2016566754A 2014-05-06 2015-05-06 Ｂｒａｆ阻害剤を使用する創傷治癒 Pending JP2017514866A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461989398P 2014-05-06 2014-05-06
US61/989,398 2014-05-06
PCT/US2015/029562 WO2015171833A1 (en) 2014-05-06 2015-05-06 Wound healing using braf inhibitors

Publications (2)

Publication Number Publication Date
JP2017514866A true JP2017514866A (ja) 2017-06-08
JP2017514866A5 JP2017514866A5 (OSRAM) 2018-06-21

Family

ID=54392978

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016566754A Pending JP2017514866A (ja) 2014-05-06 2015-05-06 Ｂｒａｆ阻害剤を使用する創傷治癒

Country Status (5)

Country Link
US (1) US20170100345A1 (OSRAM)
EP (1) EP3139927A4 (OSRAM)
JP (1) JP2017514866A (OSRAM)
CN (1) CN106535900A (OSRAM)
WO (1) WO2015171833A1 (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020530457A (ja) * 2017-08-08 2020-10-22 メモリアル スローン ケタリング キャンサー センター Ｍｅｋ阻害剤治療によって惹起される皮膚反応を治療するｂｒａｆ阻害剤の使用
JP2022519675A (ja) * 2019-02-12 2022-03-24 ルトリス ファーマ エル ティー ディー． 放射線皮膚炎の治療のための局所用ｂｒａｆ阻害剤組成物の使用

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20231036T1 (hr) * 2016-03-10 2023-12-22 Lutris Pharma Ltd. Upotreba braf inhibitora za liječenje kožnih reakcija
KR20190021351A (ko) * 2016-06-21 2019-03-05 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Braf 억제제를 이용한 상처 치유
JP7300394B2 (ja) 2017-01-17 2023-06-29 ヘパリジェニックス ゲーエムベーハー 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害
US11998550B2 (en) 2017-04-20 2024-06-04 Thomas Jefferson University Trametinib prevents mesothelial-mesenchymal transition and ameliorates abdominal adhesion and pulmonary fibrosis formation
HRP20220609T1 (hr) * 2017-07-29 2022-06-24 Lutris Pharma Ltd. Novi braf inhibitori i njihovo korištenje za tretiranje kožnih reakcija
US20200325543A1 (en) * 2017-11-20 2020-10-15 Tolremo Therapeutics Ag Diagnostic method
TW202039481A (zh) 2018-12-21 2020-11-01 美商西建公司 Ripk2之噻吩并吡啶抑制劑
DE102019129444A1 (de) * 2019-10-31 2021-05-06 Lts Lohmann Therapie-Systeme Ag Lagtime-Verkürzung/Eisspray

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001506908A (ja) * 1996-12-20 2001-05-29 プロサイト コーポレイション 吸収性ヒドロゲル粒子および創傷用ドレッシングにおけるその使用
JP2003192598A (ja) * 2001-12-27 2003-07-09 Mikasa Seiyaku Co Ltd 創傷治療用製剤
JP2008546797A (ja) * 2005-06-22 2008-12-25 プレキシコン，インコーポレーテッド キナーゼ調節のための化合物および方法，およびその適応症
JP2009519917A (ja) * 2005-12-17 2009-05-21 パウル ハルトマン アクチェンゲゼルシャフト 有効成分を含む医薬組成物、及び組成物を含む創傷接触層
JP2012524058A (ja) * 2009-04-15 2012-10-11 フォンダツィオーネ アイアールシーシーエス イスティトゥト ナツィオナーレ デイ トゥモリ 血管透過性亢進の治療におけるマルチキナーゼ阻害剤の使用
JP2013523614A (ja) * 2010-03-26 2013-06-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｂ−ｒａｆキナーゼインヒビター

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2425739T3 (es) * 2002-02-11 2013-10-17 Bayer Healthcare Llc Sorafenib-tosilato para el tratamiento de enfermedades caracterizadas por angiogénesis anormal
US20080044439A1 (en) * 2004-03-11 2008-02-21 David Nathaniel E Compositions and Methods for Preventing and Treating Skin and Hair Conditions
US20050214325A1 (en) * 2004-03-26 2005-09-29 Vvii Newco 2003, Inc. Compositions and methods to increase the effect of a neurotoxin treatment
PT2947072T (pt) * 2008-03-17 2016-12-06 Ambit Biosciences Corp 1-(3-(6,7-dimetoxiquinazolin-4-iloxi)fenil)-3-(5-(1,1,1-trifluoro-2-metilpropan-2-il)isoxazol-3-il)ureia como modulador da cinase raf no tratamento de doenças oncológicas
US20100222371A1 (en) * 2008-11-20 2010-09-02 Children's Medical Center Corporation Prevention of surgical adhesions
EP2519517B1 (en) * 2009-12-29 2015-03-25 Dana-Farber Cancer Institute, Inc. Type ii raf kinase inhibitors
US20120010229A1 (en) * 2010-07-08 2012-01-12 Macdougall John R Therapeutic regimens for hedgehog-associated cancers
US20130336899A1 (en) * 2010-10-11 2013-12-19 Purdue Research Foundation Antimicrobial formulations that aid in wound healing
CA2818544A1 (en) * 2010-11-19 2012-05-24 Glaxosmithkline Intellectual Property (No.2) Limited Method of treatment with braf inhibitor
AU2012253525B2 (en) * 2011-05-10 2016-09-22 Brunangelo Falini Hairy cell leukemia biomarkers and methods of using same
CA2883807A1 (en) * 2012-09-28 2014-04-03 Boehringer Ingelheim International Gmbh Pharmaceutical combinations comprising dual angiopoietin-2 / dll4 binders and anti-vegf-r agents
CN103520162B (zh) * 2013-10-15 2015-11-18 中国科学院上海药物研究所 达拉菲尼抑制程序性坏死和保护肝脏的应用

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001506908A (ja) * 1996-12-20 2001-05-29 プロサイト コーポレイション 吸収性ヒドロゲル粒子および創傷用ドレッシングにおけるその使用
JP2003192598A (ja) * 2001-12-27 2003-07-09 Mikasa Seiyaku Co Ltd 創傷治療用製剤
JP2008546797A (ja) * 2005-06-22 2008-12-25 プレキシコン，インコーポレーテッド キナーゼ調節のための化合物および方法，およびその適応症
JP2009519917A (ja) * 2005-12-17 2009-05-21 パウル ハルトマン アクチェンゲゼルシャフト 有効成分を含む医薬組成物、及び組成物を含む創傷接触層
JP2012524058A (ja) * 2009-04-15 2012-10-11 フォンダツィオーネ アイアールシーシーエス イスティトゥト ナツィオナーレ デイ トゥモリ 血管透過性亢進の治療におけるマルチキナーゼ阻害剤の使用
JP2013523614A (ja) * 2010-03-26 2013-06-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｂ−ｒａｆキナーゼインヒビター

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
高水 勝: "ドレッシング材を４つの視点で整理する", 薬局, vol. 第６４巻，第１２号, JPN6019008079, 2013, pages 2984 - 2994, ISSN: 0004159168 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020530457A (ja) * 2017-08-08 2020-10-22 メモリアル スローン ケタリング キャンサー センター Ｍｅｋ阻害剤治療によって惹起される皮膚反応を治療するｂｒａｆ阻害剤の使用
JP2023021241A (ja) * 2017-08-08 2023-02-10 メモリアル スローン ケタリング キャンサー センター Ｍｅｋ阻害剤治療によって惹起される皮膚反応を治療するｂｒａｆ阻害剤の使用
JP7520093B2 (ja) 2017-08-08 2024-07-22 メモリアル スローン ケタリング キャンサー センター Ｍｅｋ阻害剤治療によって惹起される皮膚反応を治療するｂｒａｆ阻害剤の使用
JP2022519675A (ja) * 2019-02-12 2022-03-24 ルトリス ファーマ エル ティー ディー． 放射線皮膚炎の治療のための局所用ｂｒａｆ阻害剤組成物の使用

Also Published As

Publication number Publication date
EP3139927A4 (en) 2017-12-13
CN106535900A (zh) 2017-03-22
WO2015171833A1 (en) 2015-11-12
EP3139927A1 (en) 2017-03-15
US20170100345A1 (en) 2017-04-13

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