JP2017514812A5 - - Google Patents
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- JP2017514812A5 JP2017514812A5 JP2016563404A JP2016563404A JP2017514812A5 JP 2017514812 A5 JP2017514812 A5 JP 2017514812A5 JP 2016563404 A JP2016563404 A JP 2016563404A JP 2016563404 A JP2016563404 A JP 2016563404A JP 2017514812 A5 JP2017514812 A5 JP 2017514812A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410174890.8 | 2014-04-29 | ||
| CN201410174890 | 2014-04-29 | ||
| PCT/CN2015/077887 WO2015165413A1 (zh) | 2014-04-29 | 2015-04-29 | 一种新型的稳定型抗体药物耦联物及其制备方法和用途 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019215918A Division JP7100617B2 (ja) | 2014-04-29 | 2019-11-29 | 新規安定型抗体薬物複合体の作製およびその応用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017514812A JP2017514812A (ja) | 2017-06-08 |
| JP2017514812A5 true JP2017514812A5 (OSRAM) | 2017-07-20 |
| JP6666264B2 JP6666264B2 (ja) | 2020-03-13 |
Family
ID=54358190
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016563404A Active JP6666264B2 (ja) | 2014-04-29 | 2015-04-29 | 新規安定型抗体薬物複合体の作製およびその応用 |
| JP2019215918A Active JP7100617B2 (ja) | 2014-04-29 | 2019-11-29 | 新規安定型抗体薬物複合体の作製およびその応用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019215918A Active JP7100617B2 (ja) | 2014-04-29 | 2019-11-29 | 新規安定型抗体薬物複合体の作製およびその応用 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US11040084B2 (OSRAM) |
| EP (2) | EP3517114A1 (OSRAM) |
| JP (2) | JP6666264B2 (OSRAM) |
| KR (1) | KR102511249B1 (OSRAM) |
| CN (2) | CN106856656B (OSRAM) |
| AU (2) | AU2015252518B2 (OSRAM) |
| ES (1) | ES2736505T3 (OSRAM) |
| WO (1) | WO2015165413A1 (OSRAM) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3517114A1 (en) | 2014-04-29 | 2019-07-31 | Genequantum Healthcare (Suzhou) Co., Ltd. | New stable antibody-drug conjugate, preparation method and use thereof |
| KR102590454B1 (ko) | 2016-07-07 | 2023-10-17 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 항체-애쥬번트 접합체 |
| JP2022525594A (ja) | 2019-03-15 | 2022-05-18 | ボルト バイオセラピューティクス、インコーポレーテッド | Ｈｅｒ２を標的とする免疫結合体 |
| WO2021136475A1 (en) * | 2019-12-31 | 2021-07-08 | Genequantum Healthcare (Suzhou) Co., Ltd. | A drug conjugate and applications thereof |
| CN114901694A (zh) * | 2019-12-31 | 2022-08-12 | 启德医药科技（苏州）有限公司 | 抗trop2抗体、抗体-药物缀合物及其应用 |
| CN116547000A (zh) * | 2020-10-30 | 2023-08-04 | 西湖生物医药科技(杭州)有限公司 | 经修饰的红细胞及其在递送活性剂中的用途 |
| CN115867283A (zh) * | 2020-12-23 | 2023-03-28 | 启德医药科技（苏州）有限公司 | 包含开环硫代琥珀酰亚胺基团、寡肽片段和手性部分的新型异构化合物 |
| AU2021423664B2 (en) | 2021-01-28 | 2026-02-05 | Genequantum Healthcare (Suzhou) Co., Ltd. | Ligase fusion proteins and applications thereof |
| EP4304661A1 (en) * | 2021-03-08 | 2024-01-17 | Genequantum Healthcare (Suzhou) Co., Ltd. | Anti-her2 antibody-immune agonist conjugate and applications thereof |
| CN117042806A (zh) | 2021-03-08 | 2023-11-10 | 启德医药科技（苏州）有限公司 | 抗体-免疫激动剂缀合物及其应用 |
| AU2022259314A1 (en) * | 2021-04-14 | 2023-11-30 | Genequantum Healthcare (Suzhou) Co., Ltd. | Linkers, conjugates and applications thereof |
| CN117337195A (zh) * | 2021-04-29 | 2024-01-02 | 上海汇连生物医药有限公司 | 抗体偶联药物的制备方法及应用 |
| US11814394B2 (en) | 2021-11-16 | 2023-11-14 | Genequantum Healthcare (Suzhou) Co., Ltd. | Exatecan derivatives, linker-payloads, and conjugates and thereof |
| EP4444759A4 (en) * | 2021-12-09 | 2025-11-26 | Genequantum Healthcare Suzhou Co Ltd | ANTIBODY-CYTOKINE FUSION PROTEINS AND THEIR APPLICATIONS |
| CN118946369A (zh) * | 2022-03-29 | 2024-11-12 | 启德医药科技（苏州）有限公司 | Adc的冷冻干燥工艺 |
| EP4534090A1 (en) | 2022-06-02 | 2025-04-09 | Genequantum Healthcare (Suzhou) Co., Ltd. | Oligosaccharide linker, linker-supported material comprising oligosaccharide linker, antibody-drug conjugate having sugar chain remodeling, preparation method therefor and use thereof |
| KR20250068592A (ko) * | 2022-06-28 | 2025-05-16 | 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. | 항-fgfr3 항체 접합체 및 이의 의학적 용도 |
| AU2023296781A1 (en) | 2022-07-01 | 2025-02-13 | Genequantum Healthcare (Suzhou) Co., Ltd. | Immobilized endoglycosidase fusion protein and use thereof |
| WO2024012566A2 (en) | 2022-07-15 | 2024-01-18 | Genequantum Healthcare (Suzhou) Co., Ltd. | Antibody, linkers, payload, conjugates and applications thereof |
| EP4554956A1 (en) * | 2022-07-15 | 2025-05-21 | Genequantum Healthcare (Suzhou) Co., Ltd. | Linkers, conjugates and applications thereof |
| WO2024041587A1 (zh) | 2022-08-25 | 2024-02-29 | 启德医药科技（苏州）有限公司 | 抗体偶联药物的药物组合物 |
| KR20250084935A (ko) * | 2022-10-14 | 2025-06-11 | 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. | 링커-페이로드 화합물, 접합체 및 이의 응용 분야 |
| CN120957726A (zh) * | 2023-03-21 | 2025-11-14 | 启德医药科技（苏州）有限公司 | 抗体-药物偶联物与癌症疗法的组合及其用途 |
| KR20250162918A (ko) * | 2023-03-30 | 2025-11-19 | 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. | 부위 특이적 직교 생체접합체 모달리티 및 이의 응용 |
| WO2024213091A1 (en) | 2023-04-13 | 2024-10-17 | Genequantum Healthcare (Suzhou) Co., Ltd. | Combination of antibody-drug conjugate and anti-pd-1 antibody, and use thereof |
| WO2025149014A1 (en) | 2024-01-12 | 2025-07-17 | Genequantum Healthcare (Suzhou) Co., Ltd. | Pharmaceutical composition |
| WO2025255054A1 (en) * | 2024-06-03 | 2025-12-11 | Darbix Llc | Methods and compositions for oligonucleotide bioconjugation |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3434275A1 (en) | 2003-11-06 | 2019-01-30 | Seattle Genetics, Inc. | Assay for cancer cells based on the use of auristatin conjugates with antibodies |
| US7241020B2 (en) * | 2003-11-20 | 2007-07-10 | Mirror Lite | High definition vehicular mirror |
| MXPA06014065A (es) * | 2004-06-01 | 2007-01-31 | Genentech Inc | Conjugados de droga-anticuerpo y metodos. |
| RU2487877C2 (ru) * | 2008-04-30 | 2013-07-20 | Иммьюноджен, Инк. | Высокоэффективные конъюгаты и гидрофильные сшивающие агенты (линкеры) |
| WO2010087994A2 (en) | 2009-01-30 | 2010-08-05 | Whitehead Institute For Biomedical Research | Methods for ligation and uses thereof |
| US9504756B2 (en) | 2012-05-15 | 2016-11-29 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
| RU2661083C2 (ru) * | 2012-10-04 | 2018-07-11 | Иммуноджен, Инк. | Использование пвдф-мембраны для очистки конъюгатов клеточно-связывающий агент - цитотоксический агент |
| EP2777714A1 (en) | 2013-03-15 | 2014-09-17 | NBE-Therapeutics LLC | Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme |
| GB2529356B (en) * | 2013-04-28 | 2020-12-23 | Genequantum Healthcare Co Ltd | Novel linkers, coupling intermediates, conjugates, preparation method and application thereof |
| EP3517114A1 (en) | 2014-04-29 | 2019-07-31 | Genequantum Healthcare (Suzhou) Co., Ltd. | New stable antibody-drug conjugate, preparation method and use thereof |
| CN107828351B (zh) | 2016-09-15 | 2021-07-27 | E·I·内穆尔杜邦公司 | 用于粘合的导电糊料 |
| EP3821005A4 (en) | 2018-07-09 | 2022-10-26 | Genequantum Healthcare (Suzhou) Co., Ltd. | AGAINST TROPHOBLAST ANTIGEN 2 (TROP2) SPECIFIC ANTIBODIES |
| CN114901694A (zh) | 2019-12-31 | 2022-08-12 | 启德医药科技（苏州）有限公司 | 抗trop2抗体、抗体-药物缀合物及其应用 |
| AU2021423664B2 (en) | 2021-01-28 | 2026-02-05 | Genequantum Healthcare (Suzhou) Co., Ltd. | Ligase fusion proteins and applications thereof |
| KR102942648B1 (ko) | 2021-02-09 | 2026-03-20 | 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. | 결합 장치 및 결합 화합물을 생성하는 방법 |
| CN117042806A (zh) | 2021-03-08 | 2023-11-10 | 启德医药科技（苏州）有限公司 | 抗体-免疫激动剂缀合物及其应用 |
| AU2022259314A1 (en) | 2021-04-14 | 2023-11-30 | Genequantum Healthcare (Suzhou) Co., Ltd. | Linkers, conjugates and applications thereof |
-
2015
- 2015-04-29 EP EP19157398.9A patent/EP3517114A1/en not_active Withdrawn
- 2015-04-29 ES ES15786402T patent/ES2736505T3/es active Active
- 2015-04-29 WO PCT/CN2015/077887 patent/WO2015165413A1/zh not_active Ceased
- 2015-04-29 EP EP15786402.6A patent/EP3138568B1/en active Active
- 2015-04-29 AU AU2015252518A patent/AU2015252518B2/en active Active
- 2015-04-29 JP JP2016563404A patent/JP6666264B2/ja active Active
- 2015-04-29 KR KR1020167033391A patent/KR102511249B1/ko active Active
- 2015-04-29 US US15/307,738 patent/US11040084B2/en active Active
- 2015-04-29 CN CN201580023609.3A patent/CN106856656B/zh active Active
- 2015-10-09 CN CN202110225700.0A patent/CN112999362B/zh active Active
-
2019
- 2019-11-29 JP JP2019215918A patent/JP7100617B2/ja active Active
-
2020
- 2020-02-11 AU AU2020200975A patent/AU2020200975B2/en active Active
-
2021
- 2021-02-19 US US17/180,412 patent/US11911434B2/en active Active
- 2021-02-19 US US17/180,645 patent/US11911435B2/en active Active
-
2024
- 2024-01-10 US US18/408,826 patent/US20240156894A1/en active Pending
- 2024-01-11 US US18/410,200 patent/US20240165192A1/en active Pending
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