JP2017513943A - 非結晶性ラロキシフェン塩酸塩の新規製造方法およびこれに用いられる新規中間体 - Google Patents

非結晶性ラロキシフェン塩酸塩の新規製造方法およびこれに用いられる新規中間体 Download PDF

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Publication number
JP2017513943A
JP2017513943A JP2017505431A JP2017505431A JP2017513943A JP 2017513943 A JP2017513943 A JP 2017513943A JP 2017505431 A JP2017505431 A JP 2017505431A JP 2017505431 A JP2017505431 A JP 2017505431A JP 2017513943 A JP2017513943 A JP 2017513943A
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JP
Japan
Prior art keywords
acid
chemical formula
crystalline
raloxifene
raloxifene hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2017505431A
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English (en)
Japanese (ja)
Inventor
チャン イ，ヨン
チャン イ，ヨン
キュン パク，サン
キュン パク，サン
ヨン イ，ハク
ヨン イ，ハク
ヨン イ，ソ
ヨン イ，ソ
ヒ キム，クヮン
ヒ キム，クヮン
グン チェ，テ
グン チェ，テ
Original Assignee
コーロン ライフ サイエンス，インク
コーロン ライフ サイエンス，インク
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Application filed by コーロン ライフ サイエンス，インク, コーロン ライフ サイエンス，インク filed Critical コーロン ライフ サイエンス，インク
Publication of JP2017513943A publication Critical patent/JP2017513943A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2017505431A 2014-04-08 2014-04-08 非結晶性ラロキシフェン塩酸塩の新規製造方法およびこれに用いられる新規中間体 Pending JP2017513943A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/KR2014/003024 WO2015156428A1 (fr) 2014-04-08 2014-04-08 Nouveau procédé de préparation de sel de chlorhydrate de raloxifène amorphe et nouvel intermédiaire utilisé à cet effet

Publications (1)

Publication Number Publication Date
JP2017513943A true JP2017513943A (ja) 2017-06-01

Family

ID=54287997

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017505431A Pending JP2017513943A (ja) 2014-04-08 2014-04-08 非結晶性ラロキシフェン塩酸塩の新規製造方法およびこれに用いられる新規中間体

Country Status (2)

Country Link
JP (1) JP2017513943A (fr)
WO (1) WO2015156428A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105753836A (zh) * 2016-02-03 2016-07-13 上海天慈生物谷生物工程有限公司 一种预防骨质疏松症药物的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009150669A1 (fr) * 2008-06-09 2009-12-17 Erregierre S.P.A. Procédé de régulation de la croissance d'un cristal de chlorhydrate de raloxifène

Also Published As

Publication number Publication date
WO2015156428A1 (fr) 2015-10-15

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