JP2017513928A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017513928A5 JP2017513928A5 JP2016575316A JP2016575316A JP2017513928A5 JP 2017513928 A5 JP2017513928 A5 JP 2017513928A5 JP 2016575316 A JP2016575316 A JP 2016575316A JP 2016575316 A JP2016575316 A JP 2016575316A JP 2017513928 A5 JP2017513928 A5 JP 2017513928A5
- Authority
- JP
- Japan
- Prior art keywords
- solution
- item
- self
- ion
- assembling peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000243 solution Substances 0.000 claims description 137
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 121
- 238000000034 method Methods 0.000 claims description 106
- 210000004072 lung Anatomy 0.000 claims description 53
- 235000002639 sodium chloride Nutrition 0.000 claims description 41
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 36
- 239000000872 buffer Substances 0.000 claims description 33
- 150000003839 salts Chemical class 0.000 claims description 28
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 26
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 22
- 150000001413 amino acids Chemical class 0.000 claims description 22
- 239000001110 calcium chloride Substances 0.000 claims description 22
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 22
- 230000004888 barrier function Effects 0.000 claims description 20
- 239000000017 hydrogel Substances 0.000 claims description 20
- -1 ammonium ions Chemical class 0.000 claims description 16
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 15
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 15
- 239000001103 potassium chloride Substances 0.000 claims description 13
- 235000011164 potassium chloride Nutrition 0.000 claims description 13
- 239000011780 sodium chloride Substances 0.000 claims description 13
- 239000012266 salt solution Substances 0.000 claims description 12
- 230000004962 physiological condition Effects 0.000 claims description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 10
- 239000002872 contrast media Substances 0.000 claims description 10
- 229910001414 potassium ion Inorganic materials 0.000 claims description 10
- 229910001415 sodium ion Inorganic materials 0.000 claims description 10
- 210000003456 pulmonary alveoli Anatomy 0.000 claims description 9
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 8
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 claims description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 5
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 5
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims description 5
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims description 5
- 239000013543 active substance Substances 0.000 claims description 5
- 150000001450 anions Chemical class 0.000 claims description 5
- 229910001424 calcium ion Inorganic materials 0.000 claims description 5
- 150000001768 cations Chemical class 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 5
- 229910052742 iron Inorganic materials 0.000 claims description 5
- 229910001425 magnesium ion Inorganic materials 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 4
- 210000000621 bronchi Anatomy 0.000 claims description 4
- 235000011148 calcium chloride Nutrition 0.000 claims description 4
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 4
- 230000002685 pulmonary effect Effects 0.000 claims description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 claims description 4
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 3
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 3
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims description 3
- 229940005654 nitrite ion Drugs 0.000 claims description 3
- 238000001356 surgical procedure Methods 0.000 claims description 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 2
- 206010014561 Emphysema Diseases 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- 210000003123 bronchiole Anatomy 0.000 claims description 2
- 230000009172 bursting Effects 0.000 claims description 2
- 229940006477 nitrate ion Drugs 0.000 claims description 2
- 229940085991 phosphate ion Drugs 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 46
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 239000007853 buffer solution Substances 0.000 description 4
- 241000124008 Mammalia Species 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 229910002651 NO3 Inorganic materials 0.000 description 2
- 239000002121 nanofiber Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461950529P | 2014-03-10 | 2014-03-10 | |
| US61/950,529 | 2014-03-10 | ||
| US201461953049P | 2014-03-14 | 2014-03-14 | |
| US61/953,049 | 2014-03-14 | ||
| PCT/US2015/019743 WO2015138478A1 (en) | 2014-03-10 | 2015-03-10 | Autoassembling peptides for the treatment of pulmonary bulla |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017513928A JP2017513928A (ja) | 2017-06-01 |
| JP2017513928A5 true JP2017513928A5 (cg-RX-API-DMAC7.html) | 2018-07-26 |
| JP6545727B2 JP6545727B2 (ja) | 2019-07-17 |
Family
ID=52737415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016575316A Expired - Fee Related JP6545727B2 (ja) | 2014-03-10 | 2015-03-10 | 肺大気胞を治療するための自発組織化ペプチド |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10245299B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3116524B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6545727B2 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2712608T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015138478A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101670099B1 (ko) | 2008-10-06 | 2016-10-27 | 가부시끼가이샤 쓰리디 매트릭스 | 조직 폐색제 |
| EP2869903B1 (en) | 2012-07-06 | 2018-11-28 | 3-D Matrix Ltd. | Fill-finish process for peptide solutions |
| EP3116524B1 (en) | 2014-03-10 | 2018-11-28 | 3-D Matrix Ltd. | Autoassembling peptides for the treatment of pulmonary bulla |
| CN117138022A (zh) | 2014-03-10 | 2023-12-01 | 三维矩阵有限责任公司 | 自组装肽组合物 |
| EP3116523B1 (en) * | 2014-03-10 | 2018-10-17 | 3-D Matrix, Ltd. | Self-assembling peptides as bronchial obstruction agents |
| BR112016019510A2 (pt) | 2014-03-10 | 2017-10-24 | 3 D Matrix Ltd | esterilização e filtração de composições de peptídeos |
| US10814038B2 (en) | 2016-01-06 | 2020-10-27 | 3-D Matrix, Ltd. | Combination compositions |
| CN106539561B (zh) * | 2016-12-09 | 2023-08-11 | 中国科学院西安光学精密机械研究所 | 一种肺大泡破裂部位定位装置 |
| CN111712230B (zh) | 2017-12-15 | 2024-04-26 | 立美基股份有限公司 | 表面活性剂肽纳米结构及在药物递送中的用途 |
| WO2020008377A2 (en) | 2018-07-03 | 2020-01-09 | 3-D Matrix, Ltd. | Ionic self-assembling peptides |
| IL304283B2 (en) | 2020-03-31 | 2024-12-01 | 3 D Matrix Ltd | Sterilization of self-assembling peptides by irradiation |
| WO2022035782A2 (en) * | 2020-08-10 | 2022-02-17 | Gel4Med, Inc. | Antimicrobial matrix formed from peptide hydrogels |
| JP2023538536A (ja) * | 2020-08-10 | 2023-09-08 | ジェルフォーメッド，インク． | 自己組織化両親媒性ペプチドハイドロゲルの局所的および非経口的な使用および投与 |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4582640A (en) | 1982-03-08 | 1986-04-15 | Collagen Corporation | Injectable cross-linked collagen implant material |
| US4466641A (en) | 1982-08-04 | 1984-08-21 | The Lockformer Company | Duct connecting system |
| US4642117A (en) | 1985-03-22 | 1987-02-10 | Collagen Corporation | Mechanically sheared collagen implant material and method |
| US4947840A (en) | 1987-08-21 | 1990-08-14 | Massachusetts Institute Of Technology | Biodegradable templates for the regeneration of tissues |
| US5236903A (en) | 1988-06-24 | 1993-08-17 | Ichiro Azuma | Polypeptide comprising repeated cell-adhesive core sequences |
| US5110604A (en) | 1988-06-30 | 1992-05-05 | Collagen Corporation | Processes for producing collagen matrixes and methods of using same |
| US5126141A (en) | 1988-11-16 | 1992-06-30 | Mediventures Incorporated | Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides |
| US5550187A (en) | 1988-11-21 | 1996-08-27 | Collagen Corporation | Method of preparing crosslinked biomaterial compositions for use in tissue augmentation |
| US5629291A (en) | 1992-01-31 | 1997-05-13 | La Jolla Cancer Research Foundation | Methods of modulating fibronectin extracellular matrix assembly |
| US5292514A (en) | 1992-06-24 | 1994-03-08 | Minnesota Mining And Manufacturing Company | Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof |
| US5955343A (en) | 1992-12-28 | 1999-09-21 | Massachusetts Institute Of Technology | Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor |
| US5670483A (en) | 1992-12-28 | 1997-09-23 | Massachusetts Insititute Of Technology | Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor |
| GB2274988A (en) | 1993-02-10 | 1994-08-17 | Mcconn Stern Rita | Iodine containing wound-healing preparations |
| US5709854A (en) | 1993-04-30 | 1998-01-20 | Massachusetts Institute Of Technology | Tissue formation by injecting a cell-polymeric solution that gels in vivo |
| US5773577A (en) | 1994-03-03 | 1998-06-30 | Protein Polymer Technologies | Products comprising substrates capable of enzymatic cross-linking |
| US5527610A (en) | 1994-05-20 | 1996-06-18 | The Uab Research Foundation | Elastomeric polypeptide matrices for preventing adhesion of biological materials |
| US5510102A (en) | 1995-01-23 | 1996-04-23 | The Regents Of The University Of California | Plasma and polymer containing surgical hemostatic adhesives |
| WO1996040033A1 (en) | 1995-06-07 | 1996-12-19 | Clarion Pharmaceuticals Inc. | Non-biological patch for hemostasis |
| EP0891193B1 (en) | 1996-04-04 | 2003-08-20 | Baxter Aktiengesellschaft | Hemostatic sponge based on collagen |
| US6489446B1 (en) | 1996-08-07 | 2002-12-03 | Hsc Research And Development Limited Partnership | Self-aligning peptides modeled on human elastin and other fibrous proteins |
| AU6019898A (en) | 1997-01-09 | 1998-08-03 | Cohesion Technologies, Inc. | Devices for tissue repair and methods for preparation and use thereof |
| US6224893B1 (en) | 1997-04-11 | 2001-05-01 | Massachusetts Institute Of Technology | Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering |
| US6187555B1 (en) | 1998-04-16 | 2001-02-13 | 3M Innovative Properties Company | Spores with increased sensitivity to sterilants using additives that bind to sterilant-sensitive sites |
| KR100661413B1 (ko) | 1998-07-06 | 2006-12-27 | 나노박 오와이 | 나노박테리아 박멸 방법 |
| US6046160A (en) | 1999-07-22 | 2000-04-04 | Deroyal Industries, Inc. | Composition and method for enhancing wound healing |
| WO2001087323A2 (en) | 2000-05-16 | 2001-11-22 | Genentech, Inc. | Method for treating cartilage disorders |
| EE05587B1 (et) | 2001-01-25 | 2012-10-15 | Nycomed Pharma As | Meetod kollageenksna valmistamiseks |
| ATE419333T1 (de) | 2001-02-06 | 2009-01-15 | Massachusetts Inst Technology | Peptidgerüstverkapselung von gewebszellen und verwendungen davon |
| US7449180B2 (en) | 2001-02-06 | 2008-11-11 | John Kisiday | Macroscopic scaffold containing amphiphilic peptides encapsulating cells |
| AU2003222167A1 (en) | 2002-04-02 | 2003-10-20 | Northwestern University | Peptide amphiphile solutions and self assembled peptide nanofiber networks |
| AU2003249606A1 (en) | 2002-05-13 | 2003-12-02 | Massachusetts Institute Of Technology | Angiogenesis and cardiac tissue engineering with peptide hydrogels and related compositions and methods of use thereof |
| GB0216286D0 (en) | 2002-07-15 | 2002-08-21 | Univ Leeds | Network |
| EP1542709A2 (en) | 2002-08-06 | 2005-06-22 | EPIX Pharmaceuticals, Inc. | Peptide aggregates |
| WO2005014615A2 (en) | 2003-06-25 | 2005-02-17 | Massachusetts Institute Of Technology | Self-assembling peptides incorporating modifications and methods of use thereof |
| US7713923B2 (en) | 2003-06-25 | 2010-05-11 | Massachusetts Institute Of Technology | Self-assembling peptides incorporating modifications and methods of use thereof |
| US7846891B2 (en) | 2003-10-17 | 2010-12-07 | Massachusetts Institute Of Technology | Self-assembling peptides for regeneration and repair of neural tissue |
| GB0404374D0 (en) | 2004-02-27 | 2004-03-31 | Univ Manchester | Treatment of bacterial infections |
| CA2572964C (en) * | 2004-07-06 | 2018-03-06 | 3D Matrix, Inc. | Purified amphiphilic peptide compositions and uses thereof |
| US7429567B2 (en) | 2005-01-04 | 2008-09-30 | The Brigham And Women's Hospital, Inc. | Sustained delivery of PDGF using self-assembling peptide nanofibers |
| WO2006116524A1 (en) | 2005-04-25 | 2006-11-02 | Massachusetts Institute Of Technology | Compositions and methods for promoting hemostasis and other physiological activities |
| US9162005B2 (en) | 2005-04-25 | 2015-10-20 | Arch Biosurgery, Inc. | Compositions for prevention of adhesions and other barrier applications |
| US20060293243A1 (en) | 2005-06-17 | 2006-12-28 | Navneet Puri | Stable, buffered, pharmaceutical compositions including motilin-like peptides |
| JP2008546689A (ja) | 2005-06-17 | 2008-12-25 | バクスター・インターナショナル・インコーポレイテッド | モチリン様ペプチドを含む、安定に緩衝化された薬学的組成物 |
| JP4982841B2 (ja) | 2005-10-12 | 2012-07-25 | 国立大学法人名古屋大学 | 再生医療骨組成物 |
| KR20110091019A (ko) | 2006-04-25 | 2011-08-10 | 메사추세츠 인스티튜트 오브 테크놀로지 | 오염물, 체액 또는 다른 실재물의 이동 및/또는 다른 생리학적 상태에 영향을 주기 위한 조성물 및 방법 |
| WO2008039483A2 (en) | 2006-09-26 | 2008-04-03 | Massachusetts Institute Of Technology | Modified self-assembling peptides |
| WO2008073392A2 (en) | 2006-12-11 | 2008-06-19 | 3D Matrix, Inc. | Compositions and methods for cardiac tissue protection and regeneration |
| WO2008113030A2 (en) | 2007-03-14 | 2008-09-18 | Arch Therapeutics, Inc | Treatment of leaky or damaged tight junctions and enhancing extracellular matrix |
| US20110002880A1 (en) | 2007-12-05 | 2011-01-06 | 3-D Matrix, Ltd. | Material For Wound Healing and Skin Reconstruction |
| KR101670099B1 (ko) | 2008-10-06 | 2016-10-27 | 가부시끼가이샤 쓰리디 매트릭스 | 조직 폐색제 |
| CN101514225B (zh) | 2008-10-13 | 2011-09-14 | 西安蓝晶生物科技有限公司 | 自聚体多肽及其制备方法和应用 |
| WO2011072482A1 (en) | 2009-12-14 | 2011-06-23 | The University Of Hong Kong | Nano cancer barrier device(ncbd) to immobilize and inhibit the division of metastic cancer stem cells |
| JP6034868B2 (ja) * | 2011-09-02 | 2016-11-30 | 株式会社スリー・ディー・マトリックス | 胸部の空気漏れ閉塞のための両親媒性ペプチド |
| EP2823830A4 (en) | 2012-03-09 | 2015-11-18 | 3 D Matrix Ltd | MESH-HIGHNESS MEDIUM |
| EP2869903B1 (en) | 2012-07-06 | 2018-11-28 | 3-D Matrix Ltd. | Fill-finish process for peptide solutions |
| EP2919826B1 (en) | 2012-11-14 | 2025-06-11 | 3-D Matrix Ltd. | Vascular embolic system |
| CN103251690B (zh) * | 2013-02-26 | 2015-10-28 | 中国人民解放军新疆军区联勤部药品仪器检验所 | 维药瘤果黑种草子挥发油在制备治疗慢性阻塞性肺病药物的应用 |
| CN112402587A (zh) | 2013-03-06 | 2021-02-26 | 三维矩阵有限责任公司 | 使用纯化的两亲性多肽组合物的外科手术方法 |
| AU2014229273B2 (en) | 2013-03-14 | 2016-12-01 | 3-D Matrix, Ltd. | Materials for gastrointestinal obstruction prevention |
| JP2016513523A (ja) | 2013-03-14 | 2016-05-16 | 株式会社スリー・ディー・マトリックス | 胆汁漏の処置 |
| JP6502352B2 (ja) | 2013-08-22 | 2019-04-17 | アーチ・バイオサージェリー・インコーポレイテッド | 流体の移動を制御するための移植可能なメッシュ |
| JP6837280B2 (ja) | 2013-09-02 | 2021-03-03 | 大成化工株式会社 | シリンジセット |
| CN117138022A (zh) | 2014-03-10 | 2023-12-01 | 三维矩阵有限责任公司 | 自组装肽组合物 |
| EP3116522B1 (en) | 2014-03-10 | 2019-05-08 | 3-D Matrix Ltd. | Autoassembling peptides for the treatment of pulmonary leakage |
| EP3116524B1 (en) | 2014-03-10 | 2018-11-28 | 3-D Matrix Ltd. | Autoassembling peptides for the treatment of pulmonary bulla |
| EP3116523B1 (en) | 2014-03-10 | 2018-10-17 | 3-D Matrix, Ltd. | Self-assembling peptides as bronchial obstruction agents |
| BR112016019510A2 (pt) | 2014-03-10 | 2017-10-24 | 3 D Matrix Ltd | esterilização e filtração de composições de peptídeos |
| MX2016016832A (es) | 2014-06-20 | 2017-09-05 | 3-D Matrix Ltd | Materiales y metodos para llenar cavidades oseas. |
| US10814038B2 (en) | 2016-01-06 | 2020-10-27 | 3-D Matrix, Ltd. | Combination compositions |
-
2015
- 2015-03-10 EP EP15712233.4A patent/EP3116524B1/en not_active Not-in-force
- 2015-03-10 US US15/124,636 patent/US10245299B2/en not_active Expired - Fee Related
- 2015-03-10 ES ES15712233T patent/ES2712608T3/es active Active
- 2015-03-10 JP JP2016575316A patent/JP6545727B2/ja not_active Expired - Fee Related
- 2015-03-10 WO PCT/US2015/019743 patent/WO2015138478A1/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017513928A5 (cg-RX-API-DMAC7.html) | ||
| JP2017510400A5 (cg-RX-API-DMAC7.html) | ||
| JP2017513927A5 (cg-RX-API-DMAC7.html) | ||
| US10952961B2 (en) | Implants and constructs including hollow fibers | |
| JP6554121B2 (ja) | 気管支閉鎖剤としての自己組織化ペプチド | |
| JP6545727B2 (ja) | 肺大気胞を治療するための自発組織化ペプチド | |
| JP7146011B2 (ja) | ＰＴＨｒＰ類似体の製剤、その経皮パッチ、およびその使用 | |
| JP6920341B2 (ja) | アバロパラチドの製剤、その経皮パッチ、およびその使用 | |
| JP2016515113A5 (cg-RX-API-DMAC7.html) | ||
| ES2729214T3 (es) | Péptidos de autoensamblaje para el tratamiento de la fuga pulmonar | |
| JP2019528320A5 (cg-RX-API-DMAC7.html) | ||
| RS49764B (sr) | Farmaceutski preparat za primenu na mukozu | |
| JP2013501224A5 (cg-RX-API-DMAC7.html) | ||
| JP2017537124A5 (cg-RX-API-DMAC7.html) | ||
| JP2020527545A5 (cg-RX-API-DMAC7.html) | ||
| JP2022023249A (ja) | 内視鏡的剥離術後の食道狭窄を予防するための自己集合性ペプチドマトリックス | |
| RU2020109705A (ru) | Соединения и их фармацевтические композиции для применения в лечении фиброзных заболеваний | |
| HRP20161634T1 (hr) | Novi pripravak alfentanila za liječenje akutne boli | |
| JP7668481B2 (ja) | 薬物送達用担体及び医薬組成物 | |
| WO2020071448A1 (ja) | 吸入粉末剤、その評価方法及びその用途 | |
| Djani et al. | Congestive heart failure caused by transvenous pacemaker lead prolapse and associated right ventricular outflow tract obstruction in a dog | |
| Calenda et al. | Duration of pain after a combination of peribulbar anesthesia and local anesthetic in the ball after enucleation or evisceration: 115 cases | |
| WO2025264889A1 (en) | Nebulizer kits and uses thereof | |
| Kim | Diagnosis and treatment of idiopathic pulmonary arterial hypertension | |
| CN118526697A (zh) | 鼻腔给药系统 |