JP2017513927A5 - - Google Patents
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- JP2017513927A5 JP2017513927A5 JP2016575314A JP2016575314A JP2017513927A5 JP 2017513927 A5 JP2017513927 A5 JP 2017513927A5 JP 2016575314 A JP2016575314 A JP 2016575314A JP 2016575314 A JP2016575314 A JP 2016575314A JP 2017513927 A5 JP2017513927 A5 JP 2017513927A5
- Authority
- JP
- Japan
- Prior art keywords
- solution
- item
- self
- target area
- assembling peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000243 solution Substances 0.000 claims description 126
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 98
- 238000000034 method Methods 0.000 claims description 95
- 235000002639 sodium chloride Nutrition 0.000 claims description 38
- 210000004072 lung Anatomy 0.000 claims description 33
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 31
- 239000000872 buffer Substances 0.000 claims description 28
- 150000003839 salts Chemical class 0.000 claims description 27
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 22
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 20
- 239000001110 calcium chloride Substances 0.000 claims description 20
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 20
- 150000001413 amino acids Chemical class 0.000 claims description 18
- 230000004888 barrier function Effects 0.000 claims description 17
- 239000000017 hydrogel Substances 0.000 claims description 17
- -1 ammonium ions Chemical class 0.000 claims description 16
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 14
- 230000002685 pulmonary effect Effects 0.000 claims description 14
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 12
- 239000001103 potassium chloride Substances 0.000 claims description 11
- 235000011164 potassium chloride Nutrition 0.000 claims description 11
- 239000011780 sodium chloride Substances 0.000 claims description 11
- 230000004962 physiological condition Effects 0.000 claims description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 8
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 8
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 8
- 230000003872 anastomosis Effects 0.000 claims description 8
- 239000002872 contrast media Substances 0.000 claims description 8
- 229910001414 potassium ion Inorganic materials 0.000 claims description 8
- 229910001415 sodium ion Inorganic materials 0.000 claims description 8
- 239000012266 salt solution Substances 0.000 claims description 7
- 238000001356 surgical procedure Methods 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 4
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 4
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims description 4
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims description 4
- 239000013543 active substance Substances 0.000 claims description 4
- 150000001450 anions Chemical class 0.000 claims description 4
- 235000011148 calcium chloride Nutrition 0.000 claims description 4
- 229910001424 calcium ion Inorganic materials 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
- 229910052742 iron Inorganic materials 0.000 claims description 4
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 4
- 229910001425 magnesium ion Inorganic materials 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 4
- 229910002651 NO3 Inorganic materials 0.000 claims description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 206010050456 Anastomotic leak Diseases 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 46
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 6
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 5
- 239000007853 buffer solution Substances 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 description 3
- 125000001453 quaternary ammonium group Chemical group 0.000 description 3
- 230000007547 defect Effects 0.000 description 2
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 239000002121 nanofiber Substances 0.000 description 1
- 229940006477 nitrate ion Drugs 0.000 description 1
- 229940005654 nitrite ion Drugs 0.000 description 1
- 229940085991 phosphate ion Drugs 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461950529P | 2014-03-10 | 2014-03-10 | |
| US61/950,529 | 2014-03-10 | ||
| US201461953221P | 2014-03-14 | 2014-03-14 | |
| US61/953,221 | 2014-03-14 | ||
| PCT/US2015/019738 WO2015138473A1 (en) | 2014-03-10 | 2015-03-10 | Autoassembling peptides for the treatment of pulmonary leakage |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019194312A Division JP2020011125A (ja) | 2014-03-10 | 2019-10-25 | 肺の漏出を治療するための自発組織化ペプチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017513927A JP2017513927A (ja) | 2017-06-01 |
| JP2017513927A5 true JP2017513927A5 (cg-RX-API-DMAC7.html) | 2018-07-26 |
Family
ID=52737413
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016575314A Pending JP2017513927A (ja) | 2014-03-10 | 2015-03-10 | 肺の漏出を治療するための自発組織化ペプチド |
| JP2019194312A Pending JP2020011125A (ja) | 2014-03-10 | 2019-10-25 | 肺の漏出を治療するための自発組織化ペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019194312A Pending JP2020011125A (ja) | 2014-03-10 | 2019-10-25 | 肺の漏出を治療するための自発組織化ペプチド |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20170173105A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3116522B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2017513927A (cg-RX-API-DMAC7.html) |
| ES (1) | ES2729214T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015138473A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101670099B1 (ko) | 2008-10-06 | 2016-10-27 | 가부시끼가이샤 쓰리디 매트릭스 | 조직 폐색제 |
| EP2869903B1 (en) | 2012-07-06 | 2018-11-28 | 3-D Matrix Ltd. | Fill-finish process for peptide solutions |
| CN117138022A (zh) * | 2014-03-10 | 2023-12-01 | 三维矩阵有限责任公司 | 自组装肽组合物 |
| EP3116524B1 (en) | 2014-03-10 | 2018-11-28 | 3-D Matrix Ltd. | Autoassembling peptides for the treatment of pulmonary bulla |
| BR112016019510A2 (pt) | 2014-03-10 | 2017-10-24 | 3 D Matrix Ltd | esterilização e filtração de composições de peptídeos |
| US10814038B2 (en) | 2016-01-06 | 2020-10-27 | 3-D Matrix, Ltd. | Combination compositions |
| CN111712230B (zh) | 2017-12-15 | 2024-04-26 | 立美基股份有限公司 | 表面活性剂肽纳米结构及在药物递送中的用途 |
| WO2020008377A2 (en) | 2018-07-03 | 2020-01-09 | 3-D Matrix, Ltd. | Ionic self-assembling peptides |
| IL304283B2 (en) | 2020-03-31 | 2024-12-01 | 3 D Matrix Ltd | Sterilization of self-assembling peptides by irradiation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003517889A (ja) * | 1999-12-22 | 2003-06-03 | サージカル シーランツ， インコーポレイテッド | 組織の漏出を封止するための方法および組成物 |
| AU2003249606A1 (en) * | 2002-05-13 | 2003-12-02 | Massachusetts Institute Of Technology | Angiogenesis and cardiac tissue engineering with peptide hydrogels and related compositions and methods of use thereof |
| DE602005027862D1 (de) * | 2004-10-07 | 2011-06-16 | Du Pont | Polymer auf basis von polysaccharide für gewebekleber zur medizinischen verwendung |
| KR20110091019A (ko) * | 2006-04-25 | 2011-08-10 | 메사추세츠 인스티튜트 오브 테크놀로지 | 오염물, 체액 또는 다른 실재물의 이동 및/또는 다른 생리학적 상태에 영향을 주기 위한 조성물 및 방법 |
| KR101670099B1 (ko) * | 2008-10-06 | 2016-10-27 | 가부시끼가이샤 쓰리디 매트릭스 | 조직 폐색제 |
| JP6034868B2 (ja) * | 2011-09-02 | 2016-11-30 | 株式会社スリー・ディー・マトリックス | 胸部の空気漏れ閉塞のための両親媒性ペプチド |
-
2015
- 2015-03-10 EP EP15712231.8A patent/EP3116522B1/en active Active
- 2015-03-10 WO PCT/US2015/019738 patent/WO2015138473A1/en not_active Ceased
- 2015-03-10 ES ES15712231T patent/ES2729214T3/es active Active
- 2015-03-10 JP JP2016575314A patent/JP2017513927A/ja active Pending
- 2015-03-10 US US15/124,638 patent/US20170173105A1/en not_active Abandoned
-
2019
- 2019-10-25 JP JP2019194312A patent/JP2020011125A/ja active Pending
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