JP2017513897A5 - - Google Patents
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- JP2017513897A5 JP2017513897A5 JP2016564122A JP2016564122A JP2017513897A5 JP 2017513897 A5 JP2017513897 A5 JP 2017513897A5 JP 2016564122 A JP2016564122 A JP 2016564122A JP 2016564122 A JP2016564122 A JP 2016564122A JP 2017513897 A5 JP2017513897 A5 JP 2017513897A5
- Authority
- JP
- Japan
- Prior art keywords
- substituents
- optionally substituted
- optionally
- heteroaryl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000001424 substituent group Chemical group 0.000 claims 78
- 125000000217 alkyl group Chemical group 0.000 claims 35
- 150000001875 compounds Chemical class 0.000 claims 20
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 19
- 125000000623 heterocyclic group Chemical group 0.000 claims 18
- 125000001072 heteroaryl group Chemical group 0.000 claims 17
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 16
- 229910052760 oxygen Inorganic materials 0.000 claims 16
- 229910052717 sulfur Inorganic materials 0.000 claims 16
- 125000003118 aryl group Chemical group 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 15
- 125000005842 heteroatom Chemical group 0.000 claims 14
- 229910052757 nitrogen Inorganic materials 0.000 claims 14
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 14
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 125000000304 alkynyl group Chemical group 0.000 claims 8
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- -1 5-[(3aS, 4S, 6aR) -2-oxohexahydro-1H-thieno [3,4-d] imidazol-4-yl] pentanoyl Chemical group 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 125000005724 cycloalkenylene group Chemical group 0.000 claims 4
- 125000002993 cycloalkylene group Chemical group 0.000 claims 4
- 230000009033 hematopoietic malignancy Effects 0.000 claims 4
- 208000018706 hematopoietic system disease Diseases 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 208000003669 immune deficiency disease Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000004450 alkenylene group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000004419 alkynylene group Chemical group 0.000 claims 2
- 208000007502 anemia Diseases 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 210000001185 bone marrow Anatomy 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 210000004700 fetal blood Anatomy 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 229920000936 Agarose Polymers 0.000 claims 1
- 208000032467 Aplastic anaemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 1
- 206010049466 Erythroblastosis Diseases 0.000 claims 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 1
- 208000015872 Gaucher disease Diseases 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 208000001019 Inborn Errors Metabolism Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 208000014767 Myeloproliferative disease Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 206010043395 Thalassaemia sickle cell Diseases 0.000 claims 1
- 208000002903 Thalassemia Diseases 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 208000015322 bone marrow disease Diseases 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 229910052805 deuterium Inorganic materials 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 201000001505 hemoglobinuria Diseases 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000016245 inborn errors of metabolism Diseases 0.000 claims 1
- 208000015978 inherited metabolic disease Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 208000028529 primary immunodeficiency disease Diseases 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 208000007056 sickle cell anemia Diseases 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461982445P | 2014-04-22 | 2014-04-22 | |
| US61/982,445 | 2014-04-22 | ||
| PCT/CA2015/050330 WO2015161373A1 (en) | 2014-04-22 | 2015-04-21 | Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017513897A JP2017513897A (ja) | 2017-06-01 |
| JP2017513897A5 true JP2017513897A5 (https=) | 2018-06-07 |
| JP6762233B2 JP6762233B2 (ja) | 2020-09-30 |
Family
ID=54331531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016564122A Active JP6762233B2 (ja) | 2014-04-22 | 2015-04-21 | 化合物および造血幹細胞および／または造血前駆細胞の増大におけるその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10647718B2 (https=) |
| EP (1) | EP3134409B1 (https=) |
| JP (1) | JP6762233B2 (https=) |
| CN (2) | CN106414445B (https=) |
| CA (1) | CA2946446C (https=) |
| ES (1) | ES2788977T3 (https=) |
| WO (1) | WO2015161373A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107208111B (zh) | 2014-09-18 | 2021-07-06 | 蒙特利尔大学 | 用于增强病毒基因转移至人造血细胞的化合物和方法 |
| CA3024273A1 (en) * | 2016-06-01 | 2017-12-07 | Universite De Montreal | Selection of human hematopoetic stem cells using epcr |
| US20180002344A1 (en) | 2016-06-16 | 2018-01-04 | Genentech, Inc. | Heteroaryl estrogen receptor modulators and uses thereof |
| JP7018026B2 (ja) * | 2016-06-16 | 2022-02-09 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | ヘテロアリールエストロゲン受容体モジュレーター及びその使用 |
| KR102522572B1 (ko) * | 2016-08-18 | 2023-04-17 | 내셔널 유니버시티 오브 싱가포르 | 조혈 줄기 및 전구 세포의 생성, 증식 및 분화를 위한 치환된 아졸 유도체 |
| CN106727541A (zh) * | 2017-02-20 | 2017-05-31 | 刘金涛 | 一种治疗耳肿胀的药物组合物 |
| CN107353288B (zh) * | 2017-06-23 | 2019-10-18 | 吉林大学 | 4-乙胺(2-羧基)-9H-嘧啶并[4,5-b]吲哚及其制备方法 |
| AU2018354418B2 (en) * | 2017-10-27 | 2025-09-11 | Immunebridge Inc. | Compositions and methods of making expanded hematopoietic stem cells using derivatives of fluorene |
| US12011460B2 (en) | 2018-02-20 | 2024-06-18 | Universite De Montreal | Expansion of NK and DC cells in vivo mediating immune response |
| KR102329235B1 (ko) * | 2018-11-21 | 2021-11-22 | 한국화학연구원 | Irak4 저해제로서 신규의 삼중고리 화합물 |
| WO2020106059A1 (ko) * | 2018-11-21 | 2020-05-28 | 한국화학연구원 | Irak4 저해제로서 신규의 삼중고리 화합물 |
| AU2020409437A1 (en) * | 2019-12-18 | 2022-07-14 | Universite De Montreal | Modulators of Cullin 3 adaptor KBTBD4 as anti-cancer compounds |
| MX2022008715A (es) * | 2020-01-24 | 2022-07-21 | Univ Tokyo | Medio libre de suero y metodo de cultivo adecuado para el cultivo de celulas sanguineas, incluidas celulas madre hematopoyeticas humanas. |
| EP4146797A1 (en) | 2020-05-06 | 2023-03-15 | Orchard Therapeutics (Europe) Limited | Treatment for neurodegenerative diseases |
| US12129265B2 (en) | 2020-07-21 | 2024-10-29 | Ankh Life Sciences Limited | Therapeutic agents and uses thereof |
| US11851430B1 (en) * | 2023-09-06 | 2023-12-26 | King Faisal University | Pyrido[4,3-B]indole-7-carboxylic acid compounds as CK2 inhibitors |
| US11945818B1 (en) | 2023-09-06 | 2024-04-02 | King Faisal University | Pyrrolo[3,2-c]quinoline compounds as CK2 inhibitors |
| CN120157613A (zh) * | 2023-12-15 | 2025-06-17 | 山东诚创蓝海医药科技有限公司 | 多拉韦林中间体及其应用和合成方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2595701B1 (fr) | 1986-03-17 | 1988-07-01 | Sanofi Sa | Derives du pyrido-indole, leur application a titre de medicaments et les compositions les renfermant |
| JP2002529502A (ja) | 1998-11-17 | 2002-09-10 | スミスクライン・ビーチャム・コーポレイション | 血小板減少症の治療法 |
| GC0000177A (en) | 1998-12-17 | 2006-03-29 | Smithkline Beecham | Thrombopoietin mimetics |
| AU4692400A (en) | 1999-05-03 | 2000-11-17 | Smithkline Beecham Corporation | Cxcr-4 receptor antagonists - thrombopoietin mimetics |
| EP1213965B1 (en) | 1999-09-10 | 2006-01-18 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
| ATE350044T1 (de) | 1999-09-24 | 2007-01-15 | Smithkline Beecham Corp | Thrombopoietinmimetika |
| WO2001034585A1 (en) | 1999-11-05 | 2001-05-17 | Smithkline Beecham Corporation | Semicarbazone derivatives and their use as thrombopoietin mimetics |
| AU2079901A (en) | 1999-12-06 | 2001-06-12 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
| CY2010012I2 (el) | 2000-05-25 | 2020-05-29 | Novartis Ag | Μιμητικα θρομβοποιητινης |
| WO2002049413A2 (en) | 2000-12-19 | 2002-06-27 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
| WO2002085343A1 (en) | 2001-03-01 | 2002-10-31 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
| EP1442039A1 (en) * | 2001-10-31 | 2004-08-04 | Bayer HealthCare AG | Pyrimido (4,5-b) indole derivatives |
| AU2003248630A1 (en) | 2002-06-06 | 2003-12-22 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
| EP1581527A4 (en) | 2002-12-13 | 2006-11-22 | Smithkline Beecham Corp | MIMETICS OF THROMBOPOIETINE |
| ATE478863T1 (de) | 2005-07-14 | 2010-09-15 | Irm Llc | Heterotetracyclische verbindungen als tpo- mimetica |
| US7816542B2 (en) | 2005-08-15 | 2010-10-19 | Irm Llc | Compounds and compositions as TPO mimetics |
| US8518964B2 (en) * | 2005-11-22 | 2013-08-27 | Merck Sharp & Dohme Corp. | Tricyclic compounds useful as inhibitors of kinases |
| KR20090021217A (ko) | 2006-06-14 | 2009-02-27 | 추가이 세이야쿠 가부시키가이샤 | 조혈 줄기세포 증가 촉진제 |
| JP2008050355A (ja) * | 2006-08-21 | 2008-03-06 | Eisai R & D Management Co Ltd | 造血幹細胞を増殖、分化および／または循環系内に動員させる医薬組成物および方法 |
| WO2008028645A1 (en) | 2006-09-05 | 2008-03-13 | Aplagen Gmbh | Peptides binding the tpo receptor |
| US9394520B2 (en) | 2006-12-08 | 2016-07-19 | University Of Rochester | Expansion of hematopoietic stem cells |
| JP2010525836A (ja) * | 2007-05-04 | 2010-07-29 | ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ | ヒト造血幹細胞のｅｘｖｉｖｏ増殖 |
| CA2707491A1 (en) | 2007-12-13 | 2009-06-18 | Merck Sharp & Dohme Corp. | Inhibitors of janus kinases |
| CN101423517B (zh) * | 2008-11-28 | 2011-09-14 | 浙江大学 | γ-咔啉类衍生物及其制备方法和用途 |
| JP2010193879A (ja) | 2009-01-27 | 2010-09-09 | Jms Co Ltd | 臍帯血造血幹細胞の増殖制御方法およびその用途 |
| US20120157500A1 (en) | 2009-08-24 | 2012-06-21 | Weikang Tao | Jak inhibition blocks rna interference associated toxicities |
| US8685969B2 (en) | 2010-06-16 | 2014-04-01 | Bristol-Myers Squibb Company | Carboline carboxamide compounds useful as kinase inhibitors |
| US9198900B2 (en) | 2011-11-10 | 2015-12-01 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Treatment of peritoneal injury using JAK inhibitors |
| PT2807165T (pt) * | 2012-01-27 | 2019-07-12 | Univ Montreal | Derivados de pirimido[4,5-b]indole e sua utilização na expansão de células estaminais hematopoiéticas |
| CN107011342A (zh) | 2012-05-22 | 2017-08-04 | 伊莱利利公司 | 用于检测神经功能障碍的基于咔啉和咔唑的成像剂 |
| EP2970312B1 (en) | 2013-03-11 | 2017-11-15 | The Regents of The University of Michigan | Bet bromodomain inhibitors and therapeutic methods using the same |
-
2015
- 2015-04-21 CA CA2946446A patent/CA2946446C/en active Active
- 2015-04-21 WO PCT/CA2015/050330 patent/WO2015161373A1/en not_active Ceased
- 2015-04-21 EP EP15782744.5A patent/EP3134409B1/en active Active
- 2015-04-21 CN CN201580026051.4A patent/CN106414445B/zh active Active
- 2015-04-21 CN CN202010516927.6A patent/CN111620870B/zh active Active
- 2015-04-21 JP JP2016564122A patent/JP6762233B2/ja active Active
- 2015-04-21 US US15/305,409 patent/US10647718B2/en active Active
- 2015-04-21 ES ES15782744T patent/ES2788977T3/es active Active
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