JP2017512786A - TrkAキナーゼ阻害薬、その組成物および方法 - Google Patents
TrkAキナーゼ阻害薬、その組成物および方法 Download PDFInfo
- Publication number
- JP2017512786A JP2017512786A JP2016558347A JP2016558347A JP2017512786A JP 2017512786 A JP2017512786 A JP 2017512786A JP 2016558347 A JP2016558347 A JP 2016558347A JP 2016558347 A JP2016558347 A JP 2016558347A JP 2017512786 A JP2017512786 A JP 2017512786A
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- trifluoromethyl
- benzamide
- fluoro
- pyrimidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 0 C**1C(*)=C(C=CC=C2)C2=*1 Chemical compound C**1C(*)=C(C=CC=C2)C2=*1 0.000 description 4
- BPFZJCPKQKKFEO-XRQDTVIWSA-N CC(CO)(c1cc2n[n](/C(/C=C\C)=C/C)c(NC(c3ccc(C(F)(F)F)c(-c4n[n](C)cc4)c3)=O)c2cc1)O Chemical compound CC(CO)(c1cc2n[n](/C(/C=C\C)=C/C)c(NC(c3ccc(C(F)(F)F)c(-c4n[n](C)cc4)c3)=O)c2cc1)O BPFZJCPKQKKFEO-XRQDTVIWSA-N 0.000 description 1
- CXZGGQRFVODNEZ-UHFFFAOYSA-N COC(c(cnc1c2N)cc1n[n]2-c1ccccc1)=O Chemical compound COC(c(cnc1c2N)cc1n[n]2-c1ccccc1)=O CXZGGQRFVODNEZ-UHFFFAOYSA-N 0.000 description 1
- HJTABPHXEPPCQJ-NXIFLTDJSA-N COC(c1cccc(N/C(/N)=C2/N=CC=CC2=N)c1)=O Chemical compound COC(c1cccc(N/C(/N)=C2/N=CC=CC2=N)c1)=O HJTABPHXEPPCQJ-NXIFLTDJSA-N 0.000 description 1
- FVMSFSQVAGKVOX-UHFFFAOYSA-N Cc1c2ncccc2n[n]1-c1cc(C#N)ccc1 Chemical compound Cc1c2ncccc2n[n]1-c1cc(C#N)ccc1 FVMSFSQVAGKVOX-UHFFFAOYSA-N 0.000 description 1
- VZFPSCNTFBJZHB-UHFFFAOYSA-N N#Cc1ncccc1F Chemical compound N#Cc1ncccc1F VZFPSCNTFBJZHB-UHFFFAOYSA-N 0.000 description 1
- TXLCUPGXOIFFIH-UHFFFAOYSA-N NCc(c[n]c1c2NC(c(cc(c(C(F)(F)F)c3)-c4ncccn4)c3F)=O)cc1n[n]2-c1ccccc1 Chemical compound NCc(c[n]c1c2NC(c(cc(c(C(F)(F)F)c3)-c4ncccn4)c3F)=O)cc1n[n]2-c1ccccc1 TXLCUPGXOIFFIH-UHFFFAOYSA-N 0.000 description 1
- PESJTQQZJJTNOC-UHFFFAOYSA-N NNc1cc(Br)ccc1 Chemical compound NNc1cc(Br)ccc1 PESJTQQZJJTNOC-UHFFFAOYSA-N 0.000 description 1
- XTLWVPYKAFDBDX-UHFFFAOYSA-N Nc1c(cnc(C#N)c2)c2n[n]1-c1ccccc1 Chemical compound Nc1c(cnc(C#N)c2)c2n[n]1-c1ccccc1 XTLWVPYKAFDBDX-UHFFFAOYSA-N 0.000 description 1
- MUJBXLUIFCHDRH-UHFFFAOYSA-N Nc1c2ncccc2n[n]1-c1cc(Br)ccc1 Chemical compound Nc1c2ncccc2n[n]1-c1cc(Br)ccc1 MUJBXLUIFCHDRH-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2014/074143 WO2015143652A1 (en) | 2014-03-26 | 2014-03-26 | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
CNPCT/CN2014/074143 | 2014-03-26 | ||
PCT/US2015/021952 WO2015148354A2 (en) | 2014-03-26 | 2015-03-23 | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2017512786A true JP2017512786A (ja) | 2017-05-25 |
JP2017512786A5 JP2017512786A5 (hu) | 2018-05-10 |
Family
ID=54193893
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016558339A Pending JP2017508766A (ja) | 2014-03-26 | 2015-03-23 | TrkAキナーゼ阻害薬、その組成物および方法 |
JP2016558347A Pending JP2017512786A (ja) | 2014-03-26 | 2015-03-23 | TrkAキナーゼ阻害薬、その組成物および方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016558339A Pending JP2017508766A (ja) | 2014-03-26 | 2015-03-23 | TrkAキナーゼ阻害薬、その組成物および方法 |
Country Status (10)
Country | Link |
---|---|
US (2) | US9862716B2 (hu) |
EP (2) | EP3122344B1 (hu) |
JP (2) | JP2017508766A (hu) |
KR (2) | KR20160132114A (hu) |
CN (2) | CN106456581A (hu) |
AU (2) | AU2015236363A1 (hu) |
CA (2) | CA2942957A1 (hu) |
MX (2) | MX2016012483A (hu) |
RU (2) | RU2016141645A (hu) |
WO (3) | WO2015143652A1 (hu) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105418615B (zh) * | 2015-12-09 | 2018-02-02 | 北京工业大学 | 苯甲酰胺衍生物及制备和应用 |
WO2018236856A1 (en) * | 2017-06-19 | 2018-12-27 | University Of Maryland, Baltimore | CAR ACTIVATING AGENTS FOR THE TREATMENT OF CANCER BASED ON CYCLOPHOSPHAMIDE |
AU2018346331B2 (en) | 2017-10-04 | 2023-08-24 | Dana-Farber Cancer Institute, Inc. | Small molecule inhibition of transcription factor SALL4 and uses thereof |
JOP20180094A1 (ar) | 2017-10-18 | 2019-04-18 | Hk Inno N Corp | مركب حلقي غير متجانس كمثبط بروتين كيناز |
HRP20220464T1 (hr) * | 2017-12-15 | 2022-05-27 | Pyramid Biosciences, Inc. | Derivati 5-(2-(2,5-difluorfenil)pirolidin-1-il)-3-(1h-pirazol-1-il)pirazolo[1,5-a]pririmidina i srodni spojevi kao inhibitori trk kinaze za liječenje raka |
IL277777B2 (en) | 2018-04-12 | 2023-10-01 | Bayer Ag | N-(cyclopropylmethyl)-5-(methylsulfonyl)-N-{1-[1-(pyrimidin-2-yl)-H1-1, 2, 4-triazol-5-yl]ethyl}benzamide derivatives and pyridinecarboxamide derivatives Compatible as pest killers |
KR102129114B1 (ko) * | 2018-07-26 | 2020-07-02 | 주식회사 온코파마텍 | TrkA 저해 활성을 갖는 화합물 및 이를 유효성분으로 함유하는 통증의 예방 또는 치료용 약학적 조성물 |
US11969472B2 (en) | 2018-08-22 | 2024-04-30 | Cullgen (Shanghai), Inc. | Tropomyosin receptor kinase (TRK) degradation compounds and methods of use |
JP7472103B2 (ja) | 2018-08-22 | 2024-04-22 | クルゲン(シャンハイ),インク. | トロポミオシン受容体キナーゼ(trk)分解化合物とその使用方法 |
CN111269233A (zh) * | 2018-12-05 | 2020-06-12 | 上海轶诺药业有限公司 | 一类咪唑并芳环类化合物的制备和应用 |
EP3942045A1 (en) | 2019-03-21 | 2022-01-26 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
CN117567338A (zh) | 2019-10-09 | 2024-02-20 | 拜耳公司 | 作为农药的新的杂芳基三唑化合物 |
JP2023500906A (ja) | 2019-11-08 | 2023-01-11 | インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
TW202134226A (zh) | 2019-11-18 | 2021-09-16 | 德商拜耳廠股份有限公司 | 作為殺蟲劑之新穎雜芳基-三唑化合物 |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
CN115916771A (zh) * | 2020-04-02 | 2023-04-04 | 浙江华海药业股份有限公司 | 多靶点的抗肿瘤化合物及其制备方法和应用 |
TW202210467A (zh) | 2020-05-28 | 2022-03-16 | 美商美國禮來大藥廠 | TrkA抑制劑 |
CN113666862B (zh) * | 2021-08-18 | 2024-05-31 | 山东大学 | 一种通过镍催化不对称硝化反应制备手性3-硝基吲哚类化合物的方法 |
Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB599834A (en) * | 1943-04-08 | 1948-03-22 | Francolor Sa | Improvements in or relating to the manufacture of azodyestuffs |
WO2003028720A1 (en) * | 2001-09-26 | 2003-04-10 | Pharmacia Italia S.P.A. | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them |
WO2003068773A1 (en) * | 2002-02-12 | 2003-08-21 | Glaxo Group Limited | Pyrazolopyridine derivatives |
JP2004513882A (ja) * | 2000-07-31 | 2004-05-13 | シグナル ファーマシューティカルズ, インコーポレイテッド | Jnk阻害剤としてのインダゾール誘導体 |
JP2005527544A (ja) * | 2002-03-25 | 2005-09-15 | インダストリアル リサーチ リミテッド | ヌクレオシドホスホリラーゼ及びヌクレオシダーゼのインヒビター |
JP2007526324A (ja) * | 2004-03-02 | 2007-09-13 | スミスクライン・ビーチャム・コーポレイション | Akt活性のある阻害剤 |
JP2009501236A (ja) * | 2005-07-14 | 2009-01-15 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
KR20100057433A (ko) * | 2008-11-21 | 2010-05-31 | 한국화학연구원 | 신규 피라졸로[4,3-b]피리딘 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물 |
JP2010529137A (ja) * | 2007-06-08 | 2010-08-26 | アボット・ラボラトリーズ | キナーゼ阻害薬としての5−ヘテロアリール置換インダゾール類 |
JP2011502959A (ja) * | 2007-07-20 | 2011-01-27 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | キナーゼ阻害剤として活性な置換インダゾール誘導体 |
WO2011014775A1 (en) * | 2009-07-31 | 2011-02-03 | The Brigham And Women's Hospital, Inc. | Modulation of sgk1 expression in th17 cells to modulate th17-mediated immune responses |
WO2014016433A1 (en) * | 2012-07-27 | 2014-01-30 | Pierre Fabre Medicament | Derivatives of azaindazole or diazaindazole type for treating pain |
WO2015038503A1 (en) * | 2013-09-13 | 2015-03-19 | E. I. Du Pont De Nemours And Company | Heterocycle-substituted bicyclic azole pesticides |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995035298A1 (fr) * | 1994-06-21 | 1995-12-28 | Otsuka Pharmaceutical Factory, Inc. | DERIVE DE PYRAZOLO[1,5-a]PYRIMIDINE |
IT1306704B1 (it) | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
DE19946322A1 (de) | 1999-09-28 | 2001-03-29 | Bayer Ag | Verfahren zur Konditionierung von Ionenaustauscherharzen |
FR2807660A1 (fr) | 2000-04-13 | 2001-10-19 | Warner Lambert Co | Utilisation d'antagonistes du ngf pour la prevention ou le traitement de douleurs viscerales chroniques |
AU4878601A (en) * | 2000-04-20 | 2001-11-07 | Mitsubishi Corporation | Aromatic amide compounds |
US20050009876A1 (en) * | 2000-07-31 | 2005-01-13 | Bhagwat Shripad S. | Indazole compounds, compositions thereof and methods of treatment therewith |
KR100713137B1 (ko) * | 2001-06-28 | 2007-05-02 | 동화약품공업주식회사 | 신규의 2,4-디플루오로벤즈아미드 유도체 |
US20030144518A1 (en) * | 2001-12-07 | 2003-07-31 | The Procter & Gamble Company | Process for preparing 3-acylamino-imidazo[1,2-a]pyridines |
JP2003231687A (ja) * | 2002-02-04 | 2003-08-19 | Japan Tobacco Inc | ピラゾリル縮合環化合物及びその医薬用途 |
EP1388341A1 (en) | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals |
UA80447C2 (en) | 2002-10-08 | 2007-09-25 | Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic | |
EP1575517B1 (en) | 2002-12-24 | 2012-04-11 | Rinat Neuroscience Corp. | Anti-ngf antibodies and methods using same |
NZ543375A (en) | 2003-05-01 | 2009-05-31 | Bristol Myers Squibb Co | Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors |
JP4489077B2 (ja) | 2003-07-15 | 2010-06-23 | アムジェン インコーポレイテッド | 選択的ngf経路インヒビターとしてのヒト抗ngf中和抗体 |
US20060281803A1 (en) | 2003-09-23 | 2006-12-14 | Lindsley Craig W | Pyrazole modulators of metabotropic glutamate receptors |
US20050143384A1 (en) | 2003-10-30 | 2005-06-30 | Eric Sartori | Amide thiadiazole inhibitors of plasminogen activator inhibitor-1 |
ITRM20030601A1 (it) | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
EP2295426A1 (en) | 2004-04-30 | 2011-03-16 | Bayer HealthCare, LLC | Substituted pyrazolyl urea derivatives useful in the treatment of cancer |
BRPI0608160A2 (pt) | 2005-02-16 | 2010-11-09 | Astrazeneca Ab | anticorpo isolado, célula hospedeira, método de inibir o crescimento de células psma+, e, uso de um anticorpo anti-psma defucosilado |
JP2008540335A (ja) | 2005-04-27 | 2008-11-20 | アストラゼネカ・アクチエボラーグ | ピラゾリル・ピリミジン誘導体の疼痛治療における使用 |
EP1899323A2 (en) | 2005-05-16 | 2008-03-19 | AstraZeneca AB | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors |
ITRM20050290A1 (it) | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
ITRM20050332A1 (it) | 2005-06-24 | 2006-12-25 | Lay Line Genomics Spa | Uso di molecole in grado di bloccare l'attivita' di trka per potenziare gli effetti di analgesici oppiacei sul dolore. |
US20100216798A1 (en) | 2005-07-29 | 2010-08-26 | Astellas Pharma Inc | Fused heterocycles as lck inhibitors |
DE102005042742A1 (de) | 2005-09-02 | 2007-03-08 | Schering Ag | Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
WO2007042321A2 (en) | 2005-10-13 | 2007-04-19 | Devgen N.V. | Kinase inhibitors |
JP2009519208A (ja) | 2005-12-15 | 2009-05-14 | 塩野義製薬株式会社 | アミド誘導体を含有する医薬組成物 |
PE20080401A1 (es) | 2006-07-07 | 2008-06-23 | Boehringer Ingelheim Int | DERIVADOS DE HETEROARIL-FENIL SUSTITUIDOS COMO INHIBIDORES DE B-Raf-QUINASAS |
WO2008016131A1 (fr) * | 2006-08-04 | 2008-02-07 | Takeda Pharmaceutical Company Limited | Composé hétérocyclique à cycles fusionnés |
BRPI0718266A2 (pt) | 2006-10-30 | 2014-01-07 | Novartis Ag | Compostos heterocíclicos como agentes anti-inflamatórios. |
EA017029B1 (ru) | 2007-04-06 | 2012-09-28 | Ньюрокрайн Байосайенсиз, Инк. | Антагонисты рецептора гонадотропин-рилизинг-фактора и способы их применения |
GB0708188D0 (en) * | 2007-04-27 | 2007-06-06 | Merck Sharp & Dohme | Therapeutic compounds |
WO2009003998A2 (en) | 2007-07-02 | 2009-01-08 | Boehringer Ingelheim International Gmbh | Antiproliferative compounds based on 5-membered heterocycles |
CL2008001943A1 (es) | 2007-07-02 | 2009-09-11 | Boehringer Ingelheim Int | Compuestos derivados de fenil-triazol, inhibidores de enzimas de señales especificas que participan del control de la proliferacion celular; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cancer, infecciones, enfermedades inflamatorias y autoinmunes. |
WO2009046802A1 (en) | 2007-10-09 | 2009-04-16 | Merck Patent Gmbh | N- ( pyrazole- 3 -yl) -benzamide derivatives as glucokinase activators |
PL2350075T3 (pl) | 2008-09-22 | 2014-07-31 | Array Biopharma Inc | Podstawione związki imidazo[1,2b]pirydazynowe jako inhibitory kinaz Trk |
US8703962B2 (en) | 2008-10-24 | 2014-04-22 | Purdue Pharma L.P. | Monocyclic compounds and their use as TRPV1 ligands |
BRPI0922224A2 (pt) | 2008-12-08 | 2016-08-02 | Vm Pharma Llc | composições de inibidores de proteína tirosina quiinase receptora. |
JP2012522013A (ja) | 2009-03-27 | 2012-09-20 | ザ ユーエービー リサーチ ファウンデーション | 調節ires媒介翻訳 |
US9309238B2 (en) * | 2009-11-05 | 2016-04-12 | University Of Notre Dame Du Lac | Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same |
US8440665B2 (en) | 2010-07-02 | 2013-05-14 | Gilead Sciences, Inc. | Apoptosis signal-regulating kinase inhibitors |
BR112013002879A2 (pt) * | 2010-08-05 | 2016-05-31 | Amgen Inc | compostos de benizmidazol e azabenzimidazol que inibem a quinase de linfoma anaplásico |
BR112013005070B1 (pt) | 2010-09-01 | 2018-04-03 | Bayer Intellectual Property Gmbh | Compostos n-(tetrazol-5-il)- e n-(triazol-5-il) arilcarboxamidas, composição herbicida, seus usos como herbicidas e método para controlar plantas indesejadas |
KR20130141500A (ko) * | 2010-09-29 | 2013-12-26 | 크리스탈지노믹스(주) | 단백질 키나제 억제 활성을 갖는 신규한 아미노퀴나졸린 화합물 |
US9079859B2 (en) | 2011-01-21 | 2015-07-14 | Auckland Uniservices Limited | Synthetic lethal targeting of glucose transport |
MX2013009067A (es) | 2011-02-09 | 2013-10-01 | Syngenta Participations Ag | Compuestos insecticidas. |
NZ618795A (en) | 2011-05-13 | 2015-07-31 | Array Biopharma Inc | Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as trka kinase inhibitors |
RS56084B1 (sr) | 2011-05-23 | 2017-10-31 | Merck Patent Gmbh | Tiazol derivati |
CN102796103A (zh) | 2011-05-23 | 2012-11-28 | 南京英派药业有限公司 | 6-(芳基甲酰)咪唑并[1,2-a]嘧啶和6-(芳基甲酰)[1,2,4]三唑并[4,3-a]嘧啶作为Hedgehog抑制剂及其应用 |
WO2013009582A1 (en) * | 2011-07-12 | 2013-01-17 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
US20150306086A1 (en) * | 2011-11-14 | 2015-10-29 | Tesaro, Inc. | Modulating certain tyrosine kinases |
KR20140105508A (ko) * | 2011-12-12 | 2014-09-01 | 닥터 레디스 레보러터리즈 리미티드 | 트로포미오신 수용체 키나제(Trk) 억제제인 치환된 피라졸로[1,5-a]피리딘 |
EP2689779A1 (en) * | 2012-07-27 | 2014-01-29 | Pierre Fabre Medicament | Derivatives of azaindazole or diazaindazole type for treating a cancer overexpressing trk |
-
2014
- 2014-03-26 WO PCT/CN2014/074143 patent/WO2015143652A1/en active Application Filing
-
2015
- 2015-03-23 KR KR1020167029495A patent/KR20160132114A/ko unknown
- 2015-03-23 US US15/129,206 patent/US9862716B2/en active Active
- 2015-03-23 MX MX2016012483A patent/MX2016012483A/es unknown
- 2015-03-23 CA CA2942957A patent/CA2942957A1/en not_active Abandoned
- 2015-03-23 CN CN201580027483.7A patent/CN106456581A/zh active Pending
- 2015-03-23 EP EP15769051.2A patent/EP3122344B1/en active Active
- 2015-03-23 CN CN201580027484.1A patent/CN106456582A/zh active Pending
- 2015-03-23 AU AU2015236363A patent/AU2015236363A1/en not_active Abandoned
- 2015-03-23 KR KR1020167029497A patent/KR20160131119A/ko unknown
- 2015-03-23 MX MX2016012481A patent/MX2016012481A/es unknown
- 2015-03-23 US US15/128,793 patent/US9862707B2/en active Active
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- 2015-03-23 RU RU2016141647A patent/RU2016141647A/ru not_active Application Discontinuation
- 2015-03-23 WO PCT/US2015/022004 patent/WO2015148373A2/en active Application Filing
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB599834A (en) * | 1943-04-08 | 1948-03-22 | Francolor Sa | Improvements in or relating to the manufacture of azodyestuffs |
JP2004513882A (ja) * | 2000-07-31 | 2004-05-13 | シグナル ファーマシューティカルズ, インコーポレイテッド | Jnk阻害剤としてのインダゾール誘導体 |
WO2003028720A1 (en) * | 2001-09-26 | 2003-04-10 | Pharmacia Italia S.P.A. | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them |
WO2003068773A1 (en) * | 2002-02-12 | 2003-08-21 | Glaxo Group Limited | Pyrazolopyridine derivatives |
JP2005527544A (ja) * | 2002-03-25 | 2005-09-15 | インダストリアル リサーチ リミテッド | ヌクレオシドホスホリラーゼ及びヌクレオシダーゼのインヒビター |
JP2007526324A (ja) * | 2004-03-02 | 2007-09-13 | スミスクライン・ビーチャム・コーポレイション | Akt活性のある阻害剤 |
JP2009501236A (ja) * | 2005-07-14 | 2009-01-15 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
JP2010529137A (ja) * | 2007-06-08 | 2010-08-26 | アボット・ラボラトリーズ | キナーゼ阻害薬としての5−ヘテロアリール置換インダゾール類 |
JP2011502959A (ja) * | 2007-07-20 | 2011-01-27 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | キナーゼ阻害剤として活性な置換インダゾール誘導体 |
KR20100057433A (ko) * | 2008-11-21 | 2010-05-31 | 한국화학연구원 | 신규 피라졸로[4,3-b]피리딘 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물 |
WO2011014775A1 (en) * | 2009-07-31 | 2011-02-03 | The Brigham And Women's Hospital, Inc. | Modulation of sgk1 expression in th17 cells to modulate th17-mediated immune responses |
WO2014016433A1 (en) * | 2012-07-27 | 2014-01-30 | Pierre Fabre Medicament | Derivatives of azaindazole or diazaindazole type for treating pain |
WO2015038503A1 (en) * | 2013-09-13 | 2015-03-19 | E. I. Du Pont De Nemours And Company | Heterocycle-substituted bicyclic azole pesticides |
Non-Patent Citations (4)
Title |
---|
DATABASE REGISTRY (STN) RN 670246-35-2, [ONLINE], JPN7018003923, 2 April 2004 (2004-04-02), ISSN: 0004077170 * |
JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 6, JPN6018045176, 2013, pages 2256 - 2269, ISSN: 0004077168 * |
JOURNAL OF THE CHINESE CHEMICAL SOCIETY, vol. 49, no. 6, JPN6018045178, 2002, pages 1069 - 1072, ISSN: 0004077169 * |
QATAR UNIVERSITY SCIENCE JOURNAL, vol. 14, JPN7018003922, 1994, pages 114 - 122, ISSN: 0004077167 * |
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JP2017508766A (ja) | 2017-03-30 |
WO2015148354A3 (en) | 2015-12-03 |
US20170107204A1 (en) | 2017-04-20 |
CN106456582A (zh) | 2017-02-22 |
WO2015143652A8 (en) | 2015-12-10 |
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MX2016012481A (es) | 2016-12-16 |
RU2016141645A3 (hu) | 2018-10-26 |
EP3122345A2 (en) | 2017-02-01 |
CA2942817A1 (en) | 2015-10-01 |
EP3122345B1 (en) | 2020-12-16 |
WO2015148373A2 (en) | 2015-10-01 |
EP3122344B1 (en) | 2022-04-27 |
WO2015148373A3 (en) | 2015-11-26 |
MX2016012483A (es) | 2016-12-16 |
RU2016141645A (ru) | 2018-04-27 |
US9862707B2 (en) | 2018-01-09 |
KR20160132114A (ko) | 2016-11-16 |
WO2015148354A2 (en) | 2015-10-01 |
EP3122345A4 (en) | 2017-10-04 |
CN106456581A (zh) | 2017-02-22 |
WO2015143652A1 (en) | 2015-10-01 |
AU2015236438A1 (en) | 2016-09-01 |
KR20160131119A (ko) | 2016-11-15 |
EP3122344A4 (en) | 2017-09-06 |
AU2015236363A1 (en) | 2016-09-01 |
US9862716B2 (en) | 2018-01-09 |
EP3122344A2 (en) | 2017-02-01 |
CA2942957A1 (en) | 2015-10-01 |
RU2016141647A (ru) | 2018-04-27 |
US20170114056A1 (en) | 2017-04-27 |
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