JP2017512483A - 生体物質の単離のための改良された装置 - Google Patents

生体物質の単離のための改良された装置 Download PDF

Info

Publication number
JP2017512483A
JP2017512483A JP2016561352A JP2016561352A JP2017512483A JP 2017512483 A JP2017512483 A JP 2017512483A JP 2016561352 A JP2016561352 A JP 2016561352A JP 2016561352 A JP2016561352 A JP 2016561352A JP 2017512483 A JP2017512483 A JP 2017512483A
Authority
JP
Japan
Prior art keywords
electrode
conductive material
electrodes
array
nanoscale
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2016561352A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017512483A5 (https=
Inventor
シャーロット，デイビッド
サラザル，ホアン パブロ イネストローサ
サラザル，ホアン パブロ イネストローサ
ブイ． ドブロボルスカイア，イリーナ
ブイ． ドブロボルスカイア，イリーナ
ヤング，カイ
スワンソン，ポール
クリシュナン，ラジャラム
Original Assignee
バイオロジカル ダイナミクス，インク．
バイオロジカル ダイナミクス，インク．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by バイオロジカル ダイナミクス，インク．, バイオロジカル ダイナミクス，インク． filed Critical バイオロジカル ダイナミクス，インク．
Publication of JP2017512483A publication Critical patent/JP2017512483A/ja
Publication of JP2017512483A5 publication Critical patent/JP2017512483A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/005—Dielectrophoresis, i.e. dielectric particles migrating towards the region of highest field strength
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02—Separators
    • B03C5/022—Non-uniform field separators
    • B03C5/026—Non-uniform field separators using open-gradient differential dielectric separation, i.e. using electrodes of special shapes for non-uniform field creation, e.g. Fluid Integrated Circuit [FIC]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications

Landscapes

  • Engineering & Computer Science (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Sampling And Sample Adjustment (AREA)
  • External Artificial Organs (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2016561352A 2014-04-08 2015-04-07 生体物質の単離のための改良された装置 Pending JP2017512483A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461977006P 2014-04-08 2014-04-08
US61/977,006 2014-04-08
US201461977249P 2014-04-09 2014-04-09
US61/977,249 2014-04-09
PCT/US2015/024624 WO2015157217A1 (en) 2014-04-08 2015-04-07 Improved devices for separation of biological materials

Publications (2)

Publication Number Publication Date
JP2017512483A true JP2017512483A (ja) 2017-05-25
JP2017512483A5 JP2017512483A5 (https=) 2018-05-17

Family

ID=54208908

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016561352A Pending JP2017512483A (ja) 2014-04-08 2015-04-07 生体物質の単離のための改良された装置

Country Status (9)

Country Link
US (2) US9387489B2 (https=)
EP (1) EP3129481A4 (https=)
JP (1) JP2017512483A (https=)
KR (1) KR20160144428A (https=)
CN (1) CN106459966A (https=)
CA (1) CA2945146A1 (https=)
IL (1) IL248200A0 (https=)
MX (1) MX2016013216A (https=)
WO (1) WO2015157217A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021520218A (ja) * 2018-04-02 2021-08-19 バイオロジカル ダイナミクス，インク． 誘電体材料
US11731132B2 (en) 2017-12-19 2023-08-22 Biological Dynamics, Inc. Methods and devices for detection of multiple analytes from a biological sample
US12233412B2 (en) 2016-03-24 2025-02-25 Xzom, Inc. Disposable fluidic cartridge and components

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11198126B2 (en) 2011-10-31 2021-12-14 Fluid-Screen, Inc. Apparatus for pathogen detection
JP2015519886A (ja) 2012-04-16 2015-07-16 バイオロジカル ダイナミクス，インク． 核酸サンプル調製
US8932815B2 (en) 2012-04-16 2015-01-13 Biological Dynamics, Inc. Nucleic acid sample preparation
EP3129481A4 (en) 2014-04-08 2017-10-25 Biological Dynamics, Inc. Improved devices for separation of biological materials
EP3158088A4 (en) * 2014-06-20 2017-12-27 Biological Dynamics, Inc. Nucleic acid sample preparation
KR101701618B1 (ko) * 2015-06-23 2017-02-13 국립암센터 전도성 고분자를 이용한 세포 유리 ｄｎａ 검출용 구조체 및 이의 용도
PL3442711T3 (pl) * 2016-04-15 2021-11-15 Fluid-Screen, Inc. Sposoby wykrywania analitu oraz urządzenie wykorzystujące dielektroforezę i elektroosmozę
US9873129B1 (en) * 2016-12-19 2018-01-23 Charlot Biosciences, Inc. Multi-planar microelectrode array device and methods of making and using same
WO2018208820A1 (en) 2017-05-08 2018-11-15 Biological Dynamics, Inc. Methods and systems for analyte information processing
US12390810B2 (en) 2019-08-23 2025-08-19 The Regents Of The University Of California Electrokinetic microelectrode devices and methods for biomarker analysis
CA3161454A1 (en) 2019-11-13 2021-05-20 Fluid-Screen, Inc. Methods and apparatus for detection of bacteria in a sample using dielectrophoresis
EP4058055A4 (en) 2019-11-13 2023-12-13 Fluid-Screen, Inc. APPARATUS AND METHODS FOR RAPIDLY DETECTING, SEPARATING, PURIFYING AND QUANTIFYING VARIOUS VIRUSES CONTAINED IN CELLS, CULTURE MEDIUM AND OTHER LIQUIDS

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005501251A (ja) * 2001-08-24 2005-01-13 アプレラ コーポレイション 電場を使用する分析物の操作
US20090314644A1 (en) * 2006-04-10 2009-12-24 Technion Research & Development Foundation Ltd. Method and Device for Electrokinetic Manipulation
US20100155246A1 (en) * 2006-01-18 2010-06-24 Perkinelmer Cellular Technologies Germany Gmbh Electric field cage and associated operating method
JP2011516867A (ja) * 2008-04-03 2011-05-26 ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア 細胞、小胞、ナノ粒子およびバイオマーカーを分離および単離するためのエキソビボの多次元システム
WO2013158686A1 (en) * 2012-04-16 2013-10-24 Biological Dynamics, Inc. Nucleic acid sample preparation

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6149789A (en) 1990-10-31 2000-11-21 Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Process for manipulating microscopic, dielectric particles and a device therefor
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US6403367B1 (en) 1994-07-07 2002-06-11 Nanogen, Inc. Integrated portable biological detection system
US6071394A (en) 1996-09-06 2000-06-06 Nanogen, Inc. Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
US6641708B1 (en) 1996-01-31 2003-11-04 Board Of Regents, The University Of Texas System Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
GB9615775D0 (en) 1996-07-26 1996-09-04 British Tech Group Apparatus and method for characterising particles using dielectrophoresis
US6749736B1 (en) 1998-06-26 2004-06-15 Evotec Technologies Gmbh Electrode arrangement for the dielectrophoretic diversion of particles
US6203683B1 (en) 1998-11-09 2001-03-20 Princeton University Electrodynamically focused thermal cycling device
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
CN1181337C (zh) 2000-08-08 2004-12-22 清华大学 微流体系统中实体分子的操纵方法及相关试剂盒
US6824664B1 (en) 1999-11-04 2004-11-30 Princeton University Electrode-less dielectrophorises for polarizable particles
US6790330B2 (en) 2000-06-14 2004-09-14 Board Of Regents, The University Of Texas System Systems and methods for cell subpopulation analysis
CN100392384C (zh) 2000-10-09 2008-06-04 清华大学 芯片上分离实体分子的方法和样品溶液
WO2003052269A1 (en) * 2001-12-18 2003-06-26 Massachusetts Institute Of Technology Microfluidic pumps and mixers driven by induced-charge electro-osmosis
US6887362B2 (en) 2002-02-06 2005-05-03 Nanogen, Inc. Dielectrophoretic separation and immunoassay methods on active electronic matrix devices
GB2392977A (en) 2002-09-13 2004-03-17 Suisse Electronique Microtech A fluidic dielectrophoretic system and method for analysing biomolecules
US7105081B2 (en) 2002-12-20 2006-09-12 Board Of Regents, The University Of Texas System Methods and apparatus for electrosmear analysis
DE10311716A1 (de) 2003-03-17 2004-10-14 Evotec Oai Ag Verfahren und Vorrichtung zur Trennung von Partikeln in einer Flüssigkeitsströmung
AU2004262301A1 (en) 2003-07-25 2005-02-10 Platypus Technologies, Llc Liquid crystal based analyte detection
US7709262B2 (en) 2004-02-18 2010-05-04 Trustees Of Boston University Method for detecting and quantifying rare mutations/polymorphisms
US20070240495A1 (en) 2004-05-25 2007-10-18 Shuzo Hirahara Microfluidic Device and Analyzing/Sorting Apparatus Using The Same
ITBO20040420A1 (it) * 2004-07-07 2004-10-07 Type S R L Macchina per taglio e formatura di piattine metalliche
JP2006047153A (ja) 2004-08-05 2006-02-16 Sony Corp Ｄｎａチップの製造方法と製造システム、ハイブリダイゼーション検出方法と検出システム、並びに基板処理装置と基板処理方法
JP4645110B2 (ja) 2004-09-15 2011-03-09 ソニー株式会社 誘電泳動を利用するハイブリダイゼーション検出部と該検出部を備えるセンサーチップ、並びにハイブリダイゼーション検出方法
EP1764418B1 (en) 2005-09-14 2012-08-22 STMicroelectronics Srl Method and device for the treatment of biological samples using dielectrophoresis
US20070080062A1 (en) * 2005-10-03 2007-04-12 Harnett Cindy K Coated metal structures and methods of making and using thereof
WO2007102839A2 (en) 2005-10-27 2007-09-13 Applera Corporation Optoelectronic separation of biomolecules
TWI304752B (en) 2005-12-09 2009-01-01 Ind Tech Res Inst Multi-sample microfluidic dielectrophoresis separator
KR100745754B1 (ko) * 2005-12-29 2007-08-02 삼성전자주식회사 금속 기둥 전극 구조를 포함하는 유전 영동을 이용하여입자를 조작하기 위한 장치 및 그를 이용하여 빠른유속으로 유전 영동에 의하여 입자를 조작할 수 있는 방법
JP2009530634A (ja) 2006-03-21 2009-08-27 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ フィールド電極群を備えたマイクロエレクトロニクスデバイス
ITTO20060273A1 (it) * 2006-04-12 2007-10-13 Silicon Biosystem S P A Metodi ed apparati per la selezione e/o il processamento di particellle, in particolare per la lisi selettiva e/o ottimizzata di cellule
KR100813254B1 (ko) 2006-05-29 2008-03-13 삼성전자주식회사 유전 영동을 통하여 분극성 분석물을 분리하기 위한 장치및 그를 이용하여 시료 중의 분극성 물질을 분리하는 방법
JP2008298575A (ja) 2007-05-31 2008-12-11 Panasonic Corp 電極および製造方法とそれを用いた検出装置と検出方法
JP5306092B2 (ja) * 2009-07-17 2013-10-02 キヤノン株式会社 流体制御装置
DE102009028493B4 (de) * 2009-08-13 2023-08-24 Robert Bosch Gmbh Mikrofluidische Zelle
WO2011057347A1 (en) 2009-11-12 2011-05-19 Tgr Biosciences Pty Ltd Analyte detection
GB201102385D0 (en) 2011-02-10 2011-03-30 Biocule Scotland Ltd Two-dimensional gel electrophoresis apparatus and method
CN102320559B (zh) * 2011-09-14 2014-06-18 上海交通大学 一种中空结构的微阵列电极的制备方法
US8932815B2 (en) 2012-04-16 2015-01-13 Biological Dynamics, Inc. Nucleic acid sample preparation
US20150219618A1 (en) 2012-07-18 2015-08-06 Biological Dynamics, Inc. Manipulation of microparticles in low field dielectrophoretic regions
WO2014028222A1 (en) 2012-07-31 2014-02-20 Crown Bioscience, Inc. Biomarkers for identifying esophageal cancer patients for treatment with an anti-egfr drug
US20140066317A1 (en) 2012-09-04 2014-03-06 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US9551665B2 (en) 2012-10-01 2017-01-24 National Cheng Kung University Method for detecting mitochondria gene alterations
WO2015038797A1 (en) 2013-09-13 2015-03-19 The Board Of Trustees Of The Leland Stanford Junior University Plasmonic beads for multiplexed analysis by flow detection systems
EP3129481A4 (en) * 2014-04-08 2017-10-25 Biological Dynamics, Inc. Improved devices for separation of biological materials
EP3158088A4 (en) 2014-06-20 2017-12-27 Biological Dynamics, Inc. Nucleic acid sample preparation
US20160327549A1 (en) 2015-05-04 2016-11-10 Biological Dynamics, Inc. Particle based immunoassay with alternating current electrokinetics

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005501251A (ja) * 2001-08-24 2005-01-13 アプレラ コーポレイション 電場を使用する分析物の操作
US20100155246A1 (en) * 2006-01-18 2010-06-24 Perkinelmer Cellular Technologies Germany Gmbh Electric field cage and associated operating method
US20090314644A1 (en) * 2006-04-10 2009-12-24 Technion Research & Development Foundation Ltd. Method and Device for Electrokinetic Manipulation
JP2011516867A (ja) * 2008-04-03 2011-05-26 ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア 細胞、小胞、ナノ粒子およびバイオマーカーを分離および単離するためのエキソビボの多次元システム
WO2013158686A1 (en) * 2012-04-16 2013-10-24 Biological Dynamics, Inc. Nucleic acid sample preparation

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12233412B2 (en) 2016-03-24 2025-02-25 Xzom, Inc. Disposable fluidic cartridge and components
US11731132B2 (en) 2017-12-19 2023-08-22 Biological Dynamics, Inc. Methods and devices for detection of multiple analytes from a biological sample
US20230338956A1 (en) * 2017-12-19 2023-10-26 Biological Dynamics, Inc. Methods and devices for detection of multiple analytes from a biological sample
US12275010B2 (en) * 2017-12-19 2025-04-15 Xzom, Inc. Methods and devices for detection of multiple analytes from a biological sample
JP2021520218A (ja) * 2018-04-02 2021-08-19 バイオロジカル ダイナミクス，インク． 誘電体材料
US11883833B2 (en) 2018-04-02 2024-01-30 Biological Dynamics, Inc. Dielectric materials
JP2024037944A (ja) * 2018-04-02 2024-03-19 バイオロジカル ダイナミクス，インク． 誘電体材料

Also Published As

Publication number Publication date
KR20160144428A (ko) 2016-12-16
EP3129481A4 (en) 2017-10-25
US9682385B2 (en) 2017-06-20
CA2945146A1 (en) 2015-10-15
US20150283553A1 (en) 2015-10-08
US9387489B2 (en) 2016-07-12
MX2016013216A (es) 2017-05-01
EP3129481A1 (en) 2017-02-15
US20160271622A1 (en) 2016-09-22
IL248200A0 (en) 2016-11-30
WO2015157217A1 (en) 2015-10-15
CN106459966A (zh) 2017-02-22

Similar Documents

Publication Publication Date Title
JP7318975B2 (ja) 核酸サンプル調製
US9682385B2 (en) Devices for separation of biological materials
US20150219618A1 (en) Manipulation of microparticles in low field dielectrophoretic regions
US20140356877A1 (en) Nucleic acid sample preparation
JP2021509265A (ja) 生体サンプルからの複数の分析物の検出のための方法およびデバイス
WO2015196141A1 (en) Nucleic acid sample preparation

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161130

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180402

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20180403

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20190123

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190130

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190419

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20190924