JP2017512479A5 - - Google Patents
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- JP2017512479A5 JP2017512479A5 JP2016560744A JP2016560744A JP2017512479A5 JP 2017512479 A5 JP2017512479 A5 JP 2017512479A5 JP 2016560744 A JP2016560744 A JP 2016560744A JP 2016560744 A JP2016560744 A JP 2016560744A JP 2017512479 A5 JP2017512479 A5 JP 2017512479A5
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- JP
- Japan
- Prior art keywords
- antibody
- seq
- amino acid
- lgr5
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461975589P | 2014-04-04 | 2014-04-04 | |
| US61/975,589 | 2014-04-04 | ||
| US201462081497P | 2014-11-18 | 2014-11-18 | |
| US62/081,497 | 2014-11-18 | ||
| PCT/US2015/024162 WO2015153916A1 (en) | 2014-04-04 | 2015-04-02 | Humanized antibodies that bind lgr5 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017512479A JP2017512479A (ja) | 2017-05-25 |
| JP2017512479A5 true JP2017512479A5 (https=) | 2018-05-17 |
| JP6614582B2 JP6614582B2 (ja) | 2019-12-04 |
Family
ID=54241299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016560744A Active JP6614582B2 (ja) | 2014-04-04 | 2015-04-02 | Ｌｇｒ５に結合するヒト化抗体 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US9546214B2 (https=) |
| EP (1) | EP3126397B1 (https=) |
| JP (1) | JP6614582B2 (https=) |
| KR (1) | KR102352573B1 (https=) |
| CN (1) | CN106536556B (https=) |
| AU (1) | AU2015240599B2 (https=) |
| CA (1) | CA2944649C (https=) |
| MX (1) | MX2016012873A (https=) |
| NZ (1) | NZ724815A (https=) |
| WO (1) | WO2015153916A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10598653B2 (en) | 2011-11-01 | 2020-03-24 | Bionomics Inc. | Methods of blocking cancer stem cell growth |
| JP6771385B2 (ja) | 2014-02-28 | 2020-10-21 | メルス ナムローゼ フェンノートシャップ | 二重特異性抗体および医薬組成物 |
| CA2944649C (en) | 2014-04-04 | 2022-06-21 | Bionomics, Inc. | Humanized antibodies that bind lgr5 |
| SMT202100230T1 (it) | 2015-10-23 | 2021-07-12 | Fundacio Inst De Recerca Biomedica Irb Barcelona | Molecole di legame che inibiscono la crescita tumorale |
| WO2017161414A1 (en) * | 2016-03-22 | 2017-09-28 | Bionomics Limited | Administration of an anti-lgr5 monoclonal antibody |
| WO2018049474A1 (en) | 2016-09-16 | 2018-03-22 | Bionomics Limited | Antibody and checkpoint inhibitor combination therapy |
| IL269656B2 (en) | 2017-03-31 | 2024-06-01 | Merus Nv | Bispecific antibodies that bind ERBB-2 and ERBB3 for use in the treatment of cells with NRG1 fusion gene |
| JP7296891B2 (ja) | 2017-05-17 | 2023-06-23 | メルス ナムローゼ フェンノートシャップ | 乳癌のためのＥｒｂＢ－２／ＥｒｂＢ－３二重特異性抗体と内分泌療法との組み合わせ |
| US20200114017A1 (en) * | 2017-06-16 | 2020-04-16 | Bionomics Limited | Antibody drug conjugates that bind lgr5 |
| JP2020524527A (ja) * | 2017-06-23 | 2020-08-20 | スージョウ ボジュホワ バイオメディカル デクノロジー カンパニー リミテッドＳｕｚｈｏｕ Ｂｏｊｕｈｕａ Ｂｉｏｍｅｄｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ． Ｌｔｄ | ヒト腫瘍幹細胞をターゲティングするモノクローナル抗体及びその使用 |
| SG11202001050PA (en) | 2017-08-09 | 2020-03-30 | Merus Nv | Antibodies that bind egfr and cmet |
| WO2019113306A2 (en) * | 2017-12-07 | 2019-06-13 | National Health Research Institutes | Anti-rspo3 antibodies |
| CN108273070B (zh) * | 2018-02-11 | 2020-10-16 | 上海交通大学 | 细胞和药物靶向转接结构及其制备与应用 |
| KR102500434B1 (ko) * | 2019-10-01 | 2023-02-16 | 가톨릭대학교 산학협력단 | 위암의 복강 전이 진단용 펩타이드 프로브 |
| KR102883390B1 (ko) | 2020-06-15 | 2025-11-07 | 주식회사 엘지에너지솔루션 | 리튬 금속 전극의 제조 방법 및 리튬 금속 이차전지 |
| EP4247856A4 (en) * | 2020-11-18 | 2024-10-30 | Carina Biotech Pty Ltd | CHIMERIC ANTIGEN RECEPTOR T CELL AND METHODS |
| US20240207457A1 (en) * | 2021-05-11 | 2024-06-27 | The Catholic University Of Korea Industry-Academic Cooperation Foundation | Cancer-specific polypeptide and use thereof |
| KR102838739B1 (ko) * | 2021-05-11 | 2025-07-25 | 가톨릭대학교 산학협력단 | 암 특이적인 폴리펩티드 및 이의 용도 |
| AU2023367766A1 (en) * | 2022-10-26 | 2025-05-01 | Research Development Foundation | Cell targeting constructs and uses thereof |
| KR20240150629A (ko) * | 2023-04-06 | 2024-10-16 | 가톨릭대학교 산학협력단 | 위암 특이적 원형 폴리펩타이드 프로브 및 이의 활용안 |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
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|---|---|---|---|---|
| US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
| US4714681A (en) | 1981-07-01 | 1987-12-22 | The Board Of Reagents, The University Of Texas System Cancer Center | Quadroma cells and trioma cells and methods for the production of same |
| US4474893A (en) | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
| US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
| US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| EP0216846B2 (en) | 1985-04-01 | 1995-04-26 | Celltech Limited | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
| US5981216A (en) | 1985-04-01 | 1999-11-09 | Alusuisse Holdings A.G. | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
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- 2015-04-02 MX MX2016012873A patent/MX2016012873A/es unknown
- 2015-04-02 AU AU2015240599A patent/AU2015240599B2/en active Active
- 2015-04-02 CN CN201580026619.2A patent/CN106536556B/zh active Active
- 2015-04-02 US US14/677,815 patent/US9546214B2/en active Active
- 2015-04-02 EP EP15774211.5A patent/EP3126397B1/en active Active
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