JP2017509585A5 - - Google Patents

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Publication number
JP2017509585A5
JP2017509585A5 JP2016541595A JP2016541595A JP2017509585A5 JP 2017509585 A5 JP2017509585 A5 JP 2017509585A5 JP 2016541595 A JP2016541595 A JP 2016541595A JP 2016541595 A JP2016541595 A JP 2016541595A JP 2017509585 A5 JP2017509585 A5 JP 2017509585A5
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JP
Japan
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formula
salt
compound
providing
crystal
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JP2016541595A
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English (en)
Japanese (ja)
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JP2017509585A (ja
JP6425727B2 (ja
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Priority claimed from PCT/US2014/071319 external-priority patent/WO2015100145A1/en
Publication of JP2017509585A publication Critical patent/JP2017509585A/ja
Publication of JP2017509585A5 publication Critical patent/JP2017509585A5/ja
Application granted granted Critical
Publication of JP6425727B2 publication Critical patent/JP6425727B2/ja
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JP2016541595A 2013-12-23 2014-12-18 大環状hcv ns3阻害トリペプチド Active JP6425727B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361920446P 2013-12-23 2013-12-23
US61/920,446 2013-12-23
PCT/US2014/071319 WO2015100145A1 (en) 2013-12-23 2014-12-18 Synthesis of a macrocyclic hcv ns3 inhibiting tripeptide

Publications (3)

Publication Number Publication Date
JP2017509585A JP2017509585A (ja) 2017-04-06
JP2017509585A5 true JP2017509585A5 (https=) 2018-01-18
JP6425727B2 JP6425727B2 (ja) 2018-11-21

Family

ID=52278856

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016541595A Active JP6425727B2 (ja) 2013-12-23 2014-12-18 大環状hcv ns3阻害トリペプチド

Country Status (20)

Country Link
US (2) US9440991B2 (https=)
EP (1) EP3087085B1 (https=)
JP (1) JP6425727B2 (https=)
KR (1) KR102366697B1 (https=)
CN (3) CN111320610B (https=)
AR (1) AR098959A1 (https=)
AU (1) AU2014370125B2 (https=)
CA (1) CA2934537C (https=)
EA (1) EA201691031A1 (https=)
ES (1) ES2724460T3 (https=)
IL (1) IL246064A0 (https=)
MX (1) MX2016008452A (https=)
NZ (1) NZ720745A (https=)
PL (1) PL3087085T3 (https=)
PT (1) PT3087085T (https=)
SG (1) SG11201604482QA (https=)
SI (1) SI3087085T1 (https=)
TR (1) TR201906413T4 (https=)
TW (3) TWI710547B (https=)
WO (1) WO2015100145A1 (https=)

Families Citing this family (15)

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PE20160605A1 (es) 2013-07-30 2016-07-20 Gilead Connecticut Inc Formulaciones de inhibidores de la syk
KR101810798B1 (ko) 2013-07-30 2017-12-19 질레드 코네티컷 인코포레이티드 Syk 억제제의 다형체
TWI735853B (zh) 2013-12-23 2021-08-11 美商克洛諾斯生技有限公司 脾酪胺酸激酶抑制劑
AU2014370125B2 (en) 2013-12-23 2017-11-16 Gilead Sciences, Inc. Synthesis of a macrocyclic HCV NS3 inhibiting tripeptide
US9809576B1 (en) 2014-07-18 2017-11-07 Abbvie Inc. Synthetic route to anti-viral agents
US9809534B1 (en) 2014-07-21 2017-11-07 Abbvie Inc. Difluoroalkylcyclopropyl amino acids and esters, and syntheses thereof
US10059969B1 (en) 2014-10-03 2018-08-28 Abbvie Inc. Process for the preparation of (S)-2-amino-non-8-enoic acid
US10316338B1 (en) 2015-01-30 2019-06-11 Abb Vie Inc. Enzymatic process for the preparation of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropanecarboxylic acid
CN107709309B (zh) * 2015-06-29 2020-10-09 中央硝子株式会社 含氟环丙烷羧酸类的制造方法
EP3577100A4 (en) 2017-02-01 2021-03-10 Abbvie Inc. ENZYMATIC PROCESS FOR THE PRODUCTION OF (±) -2- (DIFLUOROMETHYL) -1- (ALCOXYCARBONYL) -CYCLOPROPANECARBONIC ACID AND (±) -2- (VINYL) -1- (ALCOXYCARBONYLURE) -CYCLOPROPANEC
CN107739319A (zh) * 2017-10-31 2018-02-27 上海同昌生物医药科技有限公司 一种Glecaprevir合成中间体及其胺盐的制备方法
WO2019084740A1 (zh) * 2017-10-31 2019-05-09 上海同昌生物医药科技有限公司 一种Glecaprevir合成中间体及其胺盐的制备方法
CN107827748A (zh) * 2017-11-14 2018-03-23 安徽华胜医药科技有限公司 一种乙酸2‑烯丙基环丙酯消旋体的合成方法
KR102519417B1 (ko) 2018-11-28 2023-04-10 삼성디스플레이 주식회사 스트레처블 표시 장치
US11339168B2 (en) 2019-02-22 2022-05-24 Kronos Bio, Inc. Crystalline forms of 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as Syk inhibitors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005058808A1 (en) * 2003-12-15 2005-06-30 Japan Tobacco Inc. N-substituted-n-sulfonylaminocyclopropane compounds and pharmaceutical use thereof
CL2008003384A1 (es) * 2007-11-14 2009-12-11 Enanta Pharm Inc Compuestos derivados de quinoxalina macrocíclica, inhibidores de serina proteasa; composicion farmaceutica que los comprende; y su uso en el tratamiento de la hepatitis c.
WO2009134987A1 (en) 2008-04-30 2009-11-05 Enanta Pharmaceuticals, Inc. Difluoromethyl-containing macrocyclic compounds as hepatitis c virus inhibitors
PT2540350E (pt) * 2008-07-22 2014-08-27 Merck Sharp & Dohme Combinações de um composto de quinoxalina macrocílico o qual é um inibidor da protease ns3 do hcv com outros agentes do hcv
US8283310B2 (en) 2008-12-15 2012-10-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2289880A1 (en) * 2009-07-08 2011-03-02 Bayer CropScience AG 2-Pyridinylcyclopropylbenzamide fungicides
JP5857053B2 (ja) * 2010-09-21 2016-02-10 エナンタ ファーマシューティカルズ インコーポレイテッド 大環式プロリン由来hcvセリンプロテアーゼ阻害剤
EP2618665A4 (en) 2010-09-21 2014-08-20 Merck Sharp & Dohme HCV NS3 proteinase inhibitor
PY1153144A (es) * 2010-12-10 2015-01-01 Gilead Sciences Inc Inhibidores macrocíclicos de virus flaviviridae
UA119315C2 (uk) * 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
WO2015095430A1 (en) * 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. Methods and intermediates for the preparation of macrolactams
AU2014370125B2 (en) 2013-12-23 2017-11-16 Gilead Sciences, Inc. Synthesis of a macrocyclic HCV NS3 inhibiting tripeptide
JP6568541B2 (ja) 2013-12-23 2019-08-28 ギリアド ファーマセット エルエルシー 大環状hcv ns3阻害トリペプチドの結晶形態

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