JP2017509335A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017509335A5 JP2017509335A5 JP2016555472A JP2016555472A JP2017509335A5 JP 2017509335 A5 JP2017509335 A5 JP 2017509335A5 JP 2016555472 A JP2016555472 A JP 2016555472A JP 2016555472 A JP2016555472 A JP 2016555472A JP 2017509335 A5 JP2017509335 A5 JP 2017509335A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- residue
- multimeric fusion
- region
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020001507 fusion proteins Proteins 0.000 claims 18
- 102000037865 fusion proteins Human genes 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 239000000178 monomer Substances 0.000 claims 5
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 5
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 4
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 238000010367 cloning Methods 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
- WLKSPGHQGFFKGE-UHFFFAOYSA-N 1-chloropropan-2-yl n-(3-chlorophenyl)carbamate Chemical compound ClCC(C)OC(=O)NC1=CC=CC(Cl)=C1 WLKSPGHQGFFKGE-UHFFFAOYSA-N 0.000 claims 1
- 230000004931 aggregating effect Effects 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000013599 cloning vector Substances 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201403914A GB201403914D0 (en) | 2014-03-05 | 2014-03-05 | Proteins |
| GB1403915.0 | 2014-03-05 | ||
| GB1403914.3 | 2014-03-05 | ||
| GB201403915A GB201403915D0 (en) | 2014-03-05 | 2014-03-05 | Proteins |
| GBGB1405955.4A GB201405955D0 (en) | 2014-04-02 | 2014-04-02 | Proteins |
| GB1405955.4 | 2014-04-02 | ||
| GB1412648.6 | 2014-07-16 | ||
| GB201412648A GB201412648D0 (en) | 2014-07-16 | 2014-07-16 | Proteins |
| PCT/EP2015/054688 WO2015132365A1 (en) | 2014-03-05 | 2015-03-05 | Multimeric fc proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017509335A JP2017509335A (ja) | 2017-04-06 |
| JP2017509335A5 true JP2017509335A5 (OSRAM) | 2018-04-12 |
| JP6851199B2 JP6851199B2 (ja) | 2021-03-31 |
Family
ID=52697365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555472A Expired - Fee Related JP6851199B2 (ja) | 2014-03-05 | 2015-03-05 | 多量体Ｆｃタンパク質 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20170081406A1 (OSRAM) |
| EP (1) | EP3114137A1 (OSRAM) |
| JP (1) | JP6851199B2 (OSRAM) |
| KR (1) | KR20160127821A (OSRAM) |
| CN (1) | CN106132994A (OSRAM) |
| AU (1) | AU2015226101B2 (OSRAM) |
| BR (1) | BR112016020377A2 (OSRAM) |
| CA (1) | CA2939201A1 (OSRAM) |
| IL (1) | IL247246A0 (OSRAM) |
| MX (1) | MX2016010953A (OSRAM) |
| RU (1) | RU2016139022A (OSRAM) |
| SG (1) | SG11201606596PA (OSRAM) |
| WO (1) | WO2015132365A1 (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112016020368A2 (pt) | 2014-03-05 | 2018-01-23 | Ucb Biopharma Sprl | proteínas fc multiméricas |
| CN106661125B (zh) | 2014-05-02 | 2021-10-01 | 动量制药公司 | 涉及工程化Fc构建体的组合物和方法 |
| GB201511787D0 (en) * | 2015-07-06 | 2015-08-19 | Ucb Biopharma Sprl | Proteins |
| GB201513033D0 (en) * | 2015-07-23 | 2015-09-09 | Ucb Biopharma Sprl | Proteins |
| MX394116B (es) | 2015-07-24 | 2025-03-19 | Gliknik Inc | Proteinas de fusion de fragmentos de proteina humana para crear composiciones de fc de inmunoglobulina multimerizada de forma ordenada con union al complemento aumentada. |
| CA3012037A1 (en) * | 2016-01-27 | 2017-08-03 | Csl Behring Recombinant Facility Ag | Recombinant igg fc multimers |
| US12391759B2 (en) | 2016-03-02 | 2025-08-19 | Momenta Pharmaceuticals, Inc. | Methods related to engineered Fc constructs |
| KR102635635B1 (ko) | 2016-05-23 | 2024-02-14 | 모멘타 파머슈티컬스 인코포레이티드 | 유전자 조작 Fc 작제물에 관한 조성물 및 방법 |
| EP3464347B1 (en) | 2016-06-07 | 2023-05-31 | Gliknik Inc. | Cysteine-optimized stradomers |
| CN109641048A (zh) | 2016-07-22 | 2019-04-16 | 格利克尼克股份有限公司 | 产生具有增强的Fc受体结合的经有序多聚化的免疫球蛋白Fc组合物的人蛋白片段的融合蛋白 |
| AU2017371182B2 (en) | 2016-12-09 | 2024-03-28 | Gliknik Inc. | Methods of treating inflammatory disorders with multivalent Fc compounds |
| CN110650748B (zh) | 2017-01-06 | 2024-01-02 | 动量制药公司 | 与经工程改造的Fc构建体相关的组合物和方法 |
| CN113336849A (zh) * | 2017-03-28 | 2021-09-03 | 礼进生物医药科技（上海）有限公司 | 用于增强肿瘤微环境中免疫应答的治疗剂和方法 |
| CA3085385A1 (en) * | 2017-12-14 | 2019-06-20 | CSL Behring Lengnau AG | Recombinant igg fc multimers for the treatment of neuromyelitis optica |
| CN113271972B (zh) | 2018-11-14 | 2025-06-17 | Jn生物科学有限责任公司 | 用于替代IVIG的多聚体杂交Fc蛋白 |
| GB201903767D0 (en) * | 2019-03-19 | 2019-05-01 | Quadrucept Bio Ltd | Multimers, tetramers & octamers |
| KR20220062084A (ko) | 2019-09-13 | 2022-05-13 | 체에스엘 베링 렝나우 아게 | 면역 복합체 매개된 콩팥 장애의 치료를 위한 재조합 IgG Fc 다량체 |
| JP2023505493A (ja) * | 2019-12-06 | 2023-02-09 | ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト | Ｆｃ多量体の安定組成物 |
| CN115724985A (zh) * | 2021-08-27 | 2023-03-03 | 三生国健药业（上海）股份有限公司 | 一种cdc平台抗体 |
| CN120060370A (zh) * | 2023-11-29 | 2025-05-30 | 上海科锐克医药科技有限公司 | 用于递送人vegf受体融合蛋白的基因递送载体及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE028958T2 (en) * | 2008-02-08 | 2017-01-30 | Medimmune Llc | Anti-ifnar1 antibodies with reduced fc ligand affinity |
| JP5604311B2 (ja) * | 2008-03-13 | 2014-10-08 | バイオテスト・アクチエンゲゼルシヤフト | 疾患治療剤 |
| AU2010206681A1 (en) * | 2009-01-23 | 2011-09-01 | Biogen Idec Ma Inc. | Stabilized Fc polypeptides with reduced effector function and methods of use |
| WO2013049254A1 (en) * | 2011-09-26 | 2013-04-04 | Jn Biosciences Llc | Hybrid constant regions |
| EP2880057A4 (en) * | 2012-08-02 | 2016-03-23 | Jn Biosciences Llc | MULTIMERIZED FUSION ANTIBODIES OR PROTEINS THROUGH THE MUTATION OF A CYSTEINE AND A PIECE OF TAIL |
-
2015
- 2015-03-05 AU AU2015226101A patent/AU2015226101B2/en not_active Ceased
- 2015-03-05 KR KR1020167027644A patent/KR20160127821A/ko not_active Withdrawn
- 2015-03-05 WO PCT/EP2015/054688 patent/WO2015132365A1/en not_active Ceased
- 2015-03-05 JP JP2016555472A patent/JP6851199B2/ja not_active Expired - Fee Related
- 2015-03-05 MX MX2016010953A patent/MX2016010953A/es unknown
- 2015-03-05 CA CA2939201A patent/CA2939201A1/en not_active Abandoned
- 2015-03-05 US US15/123,066 patent/US20170081406A1/en not_active Abandoned
- 2015-03-05 RU RU2016139022A patent/RU2016139022A/ru not_active Application Discontinuation
- 2015-03-05 CN CN201580011852.3A patent/CN106132994A/zh active Pending
- 2015-03-05 SG SG11201606596PA patent/SG11201606596PA/en unknown
- 2015-03-05 BR BR112016020377A patent/BR112016020377A2/pt not_active Application Discontinuation
- 2015-03-05 EP EP15711066.9A patent/EP3114137A1/en not_active Withdrawn
-
2016
- 2016-08-11 IL IL247246A patent/IL247246A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017509335A5 (OSRAM) | ||
| JP2017512063A5 (OSRAM) | ||
| JP2018502572A5 (OSRAM) | ||
| RU2010122053A (ru) | Иммуносупрессорные полипептиды и нуклеиновые кислоты | |
| JP2016526909A5 (OSRAM) | ||
| RU2016139006A (ru) | Мультимерные fc-белки | |
| JP2019516665A5 (OSRAM) | ||
| JP2019522465A5 (OSRAM) | ||
| RU2016139022A (ru) | МУЛЬТИМЕРНЫЕ Fc-БЕЛКИ | |
| JP2021020905A5 (OSRAM) | ||
| RU2015129640A (ru) | Связанные дисульфидом мультивалентные многофункциональные белки, содержащие молекулы гкгс класса 1 | |
| JP2020500015A5 (OSRAM) | ||
| JP2014506790A5 (OSRAM) | ||
| JP2005120106A5 (OSRAM) | ||
| FI3998285T3 (fi) | Cd38:aan ja pd-l1:een sitoutuvia molekyylejä | |
| RU2013140685A (ru) | ВАРИАНТЫ Fc, СПОСОБЫ ИХ ПОЛУЧЕНИЯ | |
| JP2020529841A5 (OSRAM) | ||
| JP2019512222A5 (OSRAM) | ||
| IL309260B1 (en) | Fusion proteins of human protein fragments to create orderly multimerized immunoglobulin fc compositions with enhanced complement binding | |
| IL276286B2 (en) | FC variants with improved binding to FCRN and extended half-life | |
| NZ606427A (en) | Extended recombinant polypeptides and compositions comprising same | |
| FI2968461T3 (fi) | Fuusioproteiineja, jotka käsittävät pdgf:ää ja vegf:ää sitovia osia, ja menetelmiä niiden käyttämiseksi | |
| MX2009012319A (es) | Polipeptidos que se unen a receptores fc con funciones efectoras modificadas. | |
| JP2016525100A5 (OSRAM) | ||
| JP2016533174A5 (OSRAM) |