JP2017508465A - 組換えイスファハンウイルスベクター - Google Patents

組換えイスファハンウイルスベクター Download PDF

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JP2017508465A
JP2017508465A JP2016555578A JP2016555578A JP2017508465A JP 2017508465 A JP2017508465 A JP 2017508465A JP 2016555578 A JP2016555578 A JP 2016555578A JP 2016555578 A JP2016555578 A JP 2016555578A JP 2017508465 A JP2017508465 A JP 2017508465A
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protein gene
virus
isfv
protein
risfv
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ファルーク ネイサー
ファルーク ネイサー
デメトリアス マタスソフ
デメトリアス マタスソフ
ロディオン ブイ. ゴルチャコフ
ロディオン ブイ. ゴルチャコフ
ステファン ハム
ステファン ハム
レベッカ ノヴァク
レベッカ ノヴァク
ロバート エル. セイモア
ロバート エル. セイモア
ジョン エイチ. エルドリッジ
ジョン エイチ. エルドリッジ
ロバート ビー. テシュ
ロバート ビー. テシュ
デビッド ケイ. クラーク
デビッド ケイ. クラーク
テレサ イー. ラザム
テレサ イー. ラザム
スコット ウィーバー
スコット ウィーバー
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University of Texas System
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University of Texas System
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Publication of JP2017508465A publication Critical patent/JP2017508465A/ja
Priority to JP2020015937A priority Critical patent/JP7454393B2/ja
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JP2016555578A 2014-03-01 2015-02-27 組換えイスファハンウイルスベクター Pending JP2017508465A (ja)

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JP2020015937A JP7454393B2 (ja) 2014-03-01 2020-02-03 組換えイスファハンウイルスベクター

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US201461946734P 2014-03-01 2014-03-01
US61/946,734 2014-03-01
PCT/US2015/018156 WO2015134332A2 (en) 2014-03-01 2015-02-27 Recombinant isfahan viral vectors

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JP2022095401A Pending JP2022126723A (ja) 2014-03-01 2022-06-14 組換えイスファハンウイルスベクター

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US (1) US9932564B2 (enExample)
EP (1) EP3113795B1 (enExample)
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KR (1) KR102416194B1 (enExample)
CN (1) CN106794240A (enExample)
AU (1) AU2015225553B2 (enExample)
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Cited By (1)

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JP2024525781A (ja) * 2021-07-14 2024-07-12 上海栄瑞医薬科技有限公司 腫瘍溶解性ウイルス及びその使用

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
US11364292B2 (en) 2015-07-21 2022-06-21 Modernatx, Inc. CHIKV RNA vaccines
WO2017070624A1 (en) 2015-10-22 2017-04-27 Modernatx, Inc. Tropical disease vaccines
EP3638215A4 (en) 2017-06-15 2021-03-24 Modernatx, Inc. RNA FORMULATIONS
CN111315359A (zh) 2017-08-31 2020-06-19 摩登纳特斯有限公司 制备脂质纳米颗粒的方法
US10653767B2 (en) 2017-09-14 2020-05-19 Modernatx, Inc. Zika virus MRNA vaccines
CA3075990A1 (en) * 2017-09-15 2019-03-21 Ohio State Innovation Foundation Vaccines and methods of making and using vaccines for prevention of respiratory syncytial virus (rsv) infections
US12274724B2 (en) 2018-07-17 2025-04-15 Yale University Methods for treatment of cancer using chikungunya-VSV chimeric virus
WO2020061457A1 (en) 2018-09-20 2020-03-26 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
WO2020190750A1 (en) 2019-03-15 2020-09-24 Modernatx, Inc. Hiv rna vaccines

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996034625A1 (en) * 1995-05-04 1996-11-07 Yale University Recombinant vesiculoviruses and their uses
JP2007535918A (ja) * 2004-04-09 2007-12-13 ワイス 水疱性口内炎ウイルスの相乗的弱毒化、そのベクター及びその免疫原性組成物
JP2010503660A (ja) * 2006-09-15 2010-02-04 オタワ ホスピタル リサーチ インスティテュート 腫瘍崩壊性ラブドウイルス
JP2010535495A (ja) * 2007-08-03 2010-11-25 インスティチュート・パスツール レンチウイルス遺伝子導入ベクター及びそれらの医薬品への適用
JP2011516040A (ja) * 2008-03-14 2011-05-26 サノフィ パスツール バイオロジクス カンパニー 複製欠損フラビウイルスワクチンおよびワクチンベクター
US20120014990A1 (en) * 2009-03-16 2012-01-19 Brian Lichty Vaccination methods

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004093906A1 (en) * 2003-03-26 2004-11-04 Wyeth Immunogenic composition and methods
CN101087886B (zh) * 2004-04-09 2013-07-17 惠氏公司 疱疹性口炎病毒、其载体和其免疫原性组合物的协同减毒
AU2010258047B2 (en) * 2009-06-08 2016-01-14 The University Of Western Ontario Different serotypes of vesicular stomatitis virus as expression vectors for immunization regimens
PL3333265T3 (pl) 2010-05-14 2020-08-10 Oregon Health & Science University Rekombinowane wektory HCMV i RHCMV kodujące heterologiczny antygen wyizolowany z wirusa zapalenia wątroby typu B oraz ich zastosowania
US20130095556A1 (en) * 2011-09-21 2013-04-18 International Aids Vaccine Initiative Novel vesicular stomatitis virus and virus rescue system

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996034625A1 (en) * 1995-05-04 1996-11-07 Yale University Recombinant vesiculoviruses and their uses
US6168943B1 (en) * 1995-05-04 2001-01-02 Yale University Methods for making modified recombinant vesiculoviruses
JP2007535918A (ja) * 2004-04-09 2007-12-13 ワイス 水疱性口内炎ウイルスの相乗的弱毒化、そのベクター及びその免疫原性組成物
JP2010503660A (ja) * 2006-09-15 2010-02-04 オタワ ホスピタル リサーチ インスティテュート 腫瘍崩壊性ラブドウイルス
JP2010535495A (ja) * 2007-08-03 2010-11-25 インスティチュート・パスツール レンチウイルス遺伝子導入ベクター及びそれらの医薬品への適用
JP2011516040A (ja) * 2008-03-14 2011-05-26 サノフィ パスツール バイオロジクス カンパニー 複製欠損フラビウイルスワクチンおよびワクチンベクター
US20120014990A1 (en) * 2009-03-16 2012-01-19 Brian Lichty Vaccination methods

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ARCH VIROL, vol. 150, JPN6018043103, 2005, pages 671 - 680, ISSN: 0004127163 *
PLOS ONE, vol. Volume 8, Issue 6, JPN6018043101, 2013, pages 67123, ISSN: 0004127164 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024525781A (ja) * 2021-07-14 2024-07-12 上海栄瑞医薬科技有限公司 腫瘍溶解性ウイルス及びその使用

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