KR102416194B1 - 재조합 이스파한 바이러스 벡터 - Google Patents

재조합 이스파한 바이러스 벡터 Download PDF

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KR102416194B1
KR102416194B1 KR1020167027395A KR20167027395A KR102416194B1 KR 102416194 B1 KR102416194 B1 KR 102416194B1 KR 1020167027395 A KR1020167027395 A KR 1020167027395A KR 20167027395 A KR20167027395 A KR 20167027395A KR 102416194 B1 KR102416194 B1 KR 102416194B1
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KR20160135740A (ko
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파루크 나사르
데메트리우스 마타쏘브
로디온 브이. 고르차코브
스테판 함므
레베카 노왁
로버트 엘. 세이모르
존 에이치. 엘드리지
로버트 비. 테쉬
데이비드 케이. 클라크
테레사 이. 라담
스콧 위버
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프로펙츄스 바이오사이언스, 인크.
더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템
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KR1020167027395A 2014-03-01 2015-02-27 재조합 이스파한 바이러스 벡터 Active KR102416194B1 (ko)

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US201461946734P 2014-03-01 2014-03-01
US61/946,734 2014-03-01
PCT/US2015/018156 WO2015134332A2 (en) 2014-03-01 2015-02-27 Recombinant isfahan viral vectors

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KR102416194B1 true KR102416194B1 (ko) 2022-07-04

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US11364292B2 (en) 2015-07-21 2022-06-21 Modernatx, Inc. CHIKV RNA vaccines
WO2017070624A1 (en) 2015-10-22 2017-04-27 Modernatx, Inc. Tropical disease vaccines
EP3638215A4 (en) 2017-06-15 2021-03-24 Modernatx, Inc. RNA FORMULATIONS
CN111315359A (zh) 2017-08-31 2020-06-19 摩登纳特斯有限公司 制备脂质纳米颗粒的方法
US10653767B2 (en) 2017-09-14 2020-05-19 Modernatx, Inc. Zika virus MRNA vaccines
CA3075990A1 (en) * 2017-09-15 2019-03-21 Ohio State Innovation Foundation Vaccines and methods of making and using vaccines for prevention of respiratory syncytial virus (rsv) infections
US12274724B2 (en) 2018-07-17 2025-04-15 Yale University Methods for treatment of cancer using chikungunya-VSV chimeric virus
WO2020061457A1 (en) 2018-09-20 2020-03-26 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
WO2020190750A1 (en) 2019-03-15 2020-09-24 Modernatx, Inc. Hiv rna vaccines
CN115612674A (zh) * 2021-07-14 2023-01-17 上海荣瑞医药科技有限公司 一种溶瘤病毒及其用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005098009A2 (en) 2004-04-09 2005-10-20 Wyeth Synergistic attenutation of vesicular stomatitis virus, vectors thereof and immunogenic compositions thereof
WO2010142030A1 (en) 2009-06-08 2010-12-16 The University Of Western Ontario Different serotypes of vesicular stomatitis virus as expression vectors for immunization regimens
US20130095556A1 (en) 2011-09-21 2013-04-18 International Aids Vaccine Initiative Novel vesicular stomatitis virus and virus rescue system

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7153510B1 (en) * 1995-05-04 2006-12-26 Yale University Recombinant vesiculoviruses and their uses
WO2004093906A1 (en) * 2003-03-26 2004-11-04 Wyeth Immunogenic composition and methods
CN101087886B (zh) * 2004-04-09 2013-07-17 惠氏公司 疱疹性口炎病毒、其载体和其免疫原性组合物的协同减毒
CA2921063C (en) * 2006-09-15 2020-01-28 Ottawa Hospital Research Institute Oncolytic rhabdovirus
EP2185192B1 (en) * 2007-08-03 2018-10-31 Institut Pasteur Lentiviral gene transfer vectors and their medicinal applications
CA2717499A1 (en) * 2008-03-14 2009-09-17 Sanofi Pasteur Biologics Co. Replication-defective flavivirus vaccines and vaccine vectors
ES2576036T3 (es) * 2009-03-16 2016-07-05 Mcmaster University Métodos de vacunación
PL3333265T3 (pl) 2010-05-14 2020-08-10 Oregon Health & Science University Rekombinowane wektory HCMV i RHCMV kodujące heterologiczny antygen wyizolowany z wirusa zapalenia wątroby typu B oraz ich zastosowania

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005098009A2 (en) 2004-04-09 2005-10-20 Wyeth Synergistic attenutation of vesicular stomatitis virus, vectors thereof and immunogenic compositions thereof
WO2010142030A1 (en) 2009-06-08 2010-12-16 The University Of Western Ontario Different serotypes of vesicular stomatitis virus as expression vectors for immunization regimens
US20130095556A1 (en) 2011-09-21 2013-04-18 International Aids Vaccine Initiative Novel vesicular stomatitis virus and virus rescue system

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CN106794240A (zh) 2017-05-31
EP3113795B1 (en) 2019-07-10
US20170067027A1 (en) 2017-03-09
WO2015134332A3 (en) 2016-01-28
JP2022126723A (ja) 2022-08-30
IL290258A (en) 2022-04-01
WO2015134332A2 (en) 2015-09-11
MX369776B (es) 2019-11-21
EP3113795A2 (en) 2017-01-11
DK3113795T3 (da) 2019-10-21
JP2017508465A (ja) 2017-03-30
ES2749381T3 (es) 2020-03-20
MX2016011300A (es) 2017-05-08
EP3113795A4 (en) 2017-07-26
KR20160135740A (ko) 2016-11-28
US9932564B2 (en) 2018-04-03
JP7454393B2 (ja) 2024-03-22
ZA201606036B (en) 2020-02-26
IL247545A0 (en) 2016-11-30
AU2015225553B2 (en) 2020-02-27
SG11201607287XA (en) 2016-09-29
CA2941261A1 (en) 2015-09-11
IL247545B (en) 2022-03-01
JP2020078318A (ja) 2020-05-28
AU2015225553A1 (en) 2016-09-15

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