JP2017507165A5 - - Google Patents
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- JP2017507165A5 JP2017507165A5 JP2016558550A JP2016558550A JP2017507165A5 JP 2017507165 A5 JP2017507165 A5 JP 2017507165A5 JP 2016558550 A JP2016558550 A JP 2016558550A JP 2016558550 A JP2016558550 A JP 2016558550A JP 2017507165 A5 JP2017507165 A5 JP 2017507165A5
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- Prior art keywords
- antigen
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000427 antigen Substances 0.000 claims description 31
- 102000036639 antigens Human genes 0.000 claims description 31
- 108091007433 antigens Proteins 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 22
- 229920000642 polymer Polymers 0.000 claims description 11
- 229940039227 diagnostic agent Drugs 0.000 claims description 7
- 239000000032 diagnostic agent Substances 0.000 claims description 7
- 230000028993 immune response Effects 0.000 claims description 7
- 230000000069 prophylactic effect Effects 0.000 claims description 7
- 239000003381 stabilizer Substances 0.000 claims description 7
- 235000000346 sugar Nutrition 0.000 claims description 7
- 230000001225 therapeutic effect Effects 0.000 claims description 7
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 238000001727 in vivo Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 241000894006 Bacteria Species 0.000 claims description 5
- 208000000474 Poliomyelitis Diseases 0.000 claims description 5
- 241000700605 Viruses Species 0.000 claims description 5
- 239000012678 infectious agent Substances 0.000 claims description 5
- 238000010146 3D printing Methods 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000001053 micromoulding Methods 0.000 claims description 4
- 239000002417 nutraceutical Substances 0.000 claims description 4
- 235000021436 nutraceutical agent Nutrition 0.000 claims description 4
- 201000005702 Pertussis Diseases 0.000 claims description 3
- 206010043376 Tetanus Diseases 0.000 claims description 3
- 206010013023 diphtheria Diseases 0.000 claims description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 2
- 201000006082 Chickenpox Diseases 0.000 claims description 2
- 241000233866 Fungi Species 0.000 claims description 2
- 201000005505 Measles Diseases 0.000 claims description 2
- 208000005647 Mumps Diseases 0.000 claims description 2
- 229920000954 Polyglycolide Polymers 0.000 claims description 2
- 241000702670 Rotavirus Species 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 230000005867 T cell response Effects 0.000 claims description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 2
- 206010046980 Varicella Diseases 0.000 claims description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
- 235000014633 carbohydrates Nutrition 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000011521 glass Substances 0.000 claims description 2
- 208000006454 hepatitis Diseases 0.000 claims description 2
- 231100000283 hepatitis Toxicity 0.000 claims description 2
- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- 206010022000 influenza Diseases 0.000 claims description 2
- 150000002632 lipids Chemical class 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 239000003094 microcapsule Substances 0.000 claims description 2
- 239000011859 microparticle Substances 0.000 claims description 2
- 239000004005 microsphere Substances 0.000 claims description 2
- 210000000214 mouth Anatomy 0.000 claims description 2
- 208000010805 mumps infectious disease Diseases 0.000 claims description 2
- 210000001331 nose Anatomy 0.000 claims description 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
- 210000000664 rectum Anatomy 0.000 claims description 2
- 201000005404 rubella Diseases 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 210000001215 vagina Anatomy 0.000 claims description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 2
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 claims 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims 1
- 235000021360 Myristic acid Nutrition 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 229910001629 magnesium chloride Inorganic materials 0.000 claims 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical group [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims 1
- 239000000347 magnesium hydroxide Substances 0.000 claims 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims 1
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 claims 1
- 235000013923 monosodium glutamate Nutrition 0.000 claims 1
- 239000004223 monosodium glutamate Substances 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 238000009472 formulation Methods 0.000 description 21
- 238000002360 preparation method Methods 0.000 description 9
- 229920000249 biocompatible polymer Polymers 0.000 description 3
- 150000008163 sugars Chemical class 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361916555P | 2013-12-16 | 2013-12-16 | |
| US61/916,555 | 2013-12-16 | ||
| PCT/US2014/070664 WO2015095230A1 (en) | 2013-12-16 | 2014-12-16 | Micromolded or 3-d printed pulsatile release vaccine formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019208044A Division JP2020055818A (ja) | 2013-12-16 | 2019-11-18 | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017507165A JP2017507165A (ja) | 2017-03-16 |
| JP2017507165A5 true JP2017507165A5 (https=) | 2018-02-01 |
Family
ID=52396804
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016558550A Withdrawn JP2017507165A (ja) | 2013-12-16 | 2014-12-16 | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| JP2019208044A Pending JP2020055818A (ja) | 2013-12-16 | 2019-11-18 | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| JP2021085890A Active JP7682019B2 (ja) | 2013-12-16 | 2021-05-21 | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| JP2023042995A Pending JP2023075311A (ja) | 2013-12-16 | 2023-03-17 | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019208044A Pending JP2020055818A (ja) | 2013-12-16 | 2019-11-18 | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| JP2021085890A Active JP7682019B2 (ja) | 2013-12-16 | 2021-05-21 | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| JP2023042995A Pending JP2023075311A (ja) | 2013-12-16 | 2023-03-17 | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US10300136B2 (https=) |
| EP (2) | EP3082852B1 (https=) |
| JP (4) | JP2017507165A (https=) |
| AU (1) | AU2014364930B2 (https=) |
| CA (1) | CA2933867A1 (https=) |
| WO (1) | WO2015095230A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2933867A1 (en) * | 2013-12-16 | 2015-06-25 | Massachusetts Institute Of Technology | Micromolded or 3-d printed pulsatile release vaccine formulations |
| AU2016272089B2 (en) | 2015-06-03 | 2021-02-18 | Triastek, Inc. | Dosage forms and use thereof |
| WO2018053300A1 (en) * | 2016-09-16 | 2018-03-22 | Auburn University | Biodegradable polymeric particles encapsulating an active agent, pharmaceutical compositions and uses thereof |
| US10150282B2 (en) | 2016-10-14 | 2018-12-11 | Xerox Corporation | System and method for additive manufacture of chemical delivery devices using halftone screening |
| EP3573602A4 (en) | 2017-01-26 | 2020-09-16 | Triastek, Inc. | DOSAGE FORMS OF CONTROLLED RELEASE AT SPECIFIC GASTROINTESTINAL SITES |
| US10933579B2 (en) | 2017-03-10 | 2021-03-02 | Prellis Biologics, Inc. | Methods and systems for printing biological material |
| US11085018B2 (en) | 2017-03-10 | 2021-08-10 | Prellis Biologics, Inc. | Three-dimensional printed organs, devices, and matrices |
| EP3595515A4 (en) | 2017-03-14 | 2020-12-30 | University of Connecticut | BIODEGRADABLE PRESSURE SENSOR |
| JP2020524483A (ja) | 2017-05-25 | 2020-08-20 | プレリス バイオロジクス，インク． | 三次元印刷された器官、デバイス、およびマトリックス |
| JP7358340B2 (ja) | 2017-05-26 | 2023-10-10 | インフィニット・マテリアル・ソリューションズ，エルエルシー | 水溶性ポリマー組成物 |
| CA3231455A1 (en) * | 2017-09-13 | 2019-03-21 | Massachusetts Institute Of Technology | Microdevices with complex geometries |
| CN116270513A (zh) | 2018-01-09 | 2023-06-23 | 南京三迭纪医药科技有限公司 | 一种包含固定剂量adhd非兴奋剂和adhd兴奋剂的复方口服药物剂型 |
| RU2020132467A (ru) | 2018-03-05 | 2022-04-05 | Юниверсити Оф Коннектикут | Микроигольная платформа со структурой типа сердцевина-оболочка для трансдермальной и пульсирующей доставки лекарств/вакцин и способ ее изготовления |
| CA3102755A1 (en) * | 2018-06-29 | 2020-01-02 | The Doshisha | Formulation containing emricasan |
| JP7355016B2 (ja) * | 2018-07-30 | 2023-10-03 | 三菱ケミカル株式会社 | 熱溶融型積層造形用材料 |
| GB2592486B (en) | 2018-07-31 | 2022-09-14 | Prellis Biologics Inc | Optically-induced auto-encapsulation |
| CN110882232B (zh) * | 2018-08-20 | 2026-02-24 | 中国科学院过程工程研究所 | 一种基于微囊的疫苗 |
| US11826495B2 (en) | 2019-03-01 | 2023-11-28 | University Of Connecticut | Biodegradable piezoelectric ultrasonic transducer system |
| US11678989B2 (en) | 2019-03-01 | 2023-06-20 | University Of Connecticut | Biodegradable piezoelectric nanofiber scaffold for bone or tissue regeneration |
| CN110420324B (zh) * | 2019-08-01 | 2022-07-12 | 临沂大学 | 含兔葡萄球菌抗原的免疫原性组合物及其制备方法和应用 |
| US11745001B2 (en) | 2020-03-10 | 2023-09-05 | University Of Connecticut | Therapeutic bandage |
| US12371581B2 (en) | 2020-03-25 | 2025-07-29 | Infinite Material Solutions, Llc | High performance water soluble polymer compositions |
| JP2023522244A (ja) * | 2020-04-20 | 2023-05-29 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 乾燥製剤を生成する方法 |
| MX2022014191A (es) * | 2020-05-13 | 2022-12-07 | Massachusetts Inst Technology | Composiciones de microdispositivos polimericos y su uso en la inmunoterapia de cancer. |
| US12491290B2 (en) | 2020-06-08 | 2025-12-09 | University Of Connecticut | Biodegradable piezoelectric composite materials |
| CN112370531B (zh) * | 2020-11-18 | 2022-09-23 | 金宇保灵生物药品有限公司 | 一种犬瘟热、犬细小、犬腺病毒、犬副流感四联活疫苗耐热保护剂及其制备方法和应用 |
| WO2022192361A2 (en) * | 2021-03-09 | 2022-09-15 | Board Of Regents Of The University Of Nebraska | Microparticle compositions and methods use thereof |
| EP4358944A4 (en) * | 2021-06-21 | 2025-03-12 | William Marsh Rice University | HIGH-YIELD PREPARATION OF PULSATILE-RELEASE MICROPARTICLES |
| CN113521263A (zh) * | 2021-08-03 | 2021-10-22 | 苏州大学 | 一种3d打印的肿瘤疫苗组合物及其制备方法与应用 |
| WO2024026039A2 (en) * | 2022-07-27 | 2024-02-01 | Board Of Regents, The University Of Texas System | Multi-channeled and guided inner controlling (magic) printheads |
| WO2024215759A2 (en) * | 2023-04-11 | 2024-10-17 | The Regents Of The University Of California | Biodegradable scaffolds for enhancing vaccine efficacy |
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| US4450150A (en) | 1973-05-17 | 1984-05-22 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery depots, and method for preparing and using the same |
| US5490962A (en) | 1993-10-18 | 1996-02-13 | Massachusetts Institute Of Technology | Preparation of medical devices by solid free-form fabrication methods |
| DE69431404T2 (de) | 1993-10-22 | 2003-04-30 | Genentech Inc., San Francisco | Verfahren zur mikroverkapselung von antigenen und verwendung der zusammensetzungen als impfstoffe |
| US6312731B1 (en) | 1997-08-29 | 2001-11-06 | Southern Research Institute | Rapid release encapsulated bioactive agents for inducing or potentiating an immune response and methods of using thereof |
| WO2001026708A1 (en) | 1999-10-12 | 2001-04-19 | The Ohio State University | Reactive polymeric valve, dispensing devices and methods using same |
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| CN103251941A (zh) * | 2012-02-16 | 2013-08-21 | 海南大学 | 动物病毒性疫苗脉冲释放系统、其制备方法及用途 |
| CA2875146C (en) | 2012-05-30 | 2022-03-22 | The Regents Of The University Of California | Bioactive agent delivery devices and methods of making and using the same |
| US20140200508A1 (en) | 2012-06-29 | 2014-07-17 | Isaac D. Cohen | Microneedles Comprising One Or More Cosmetic Ingredients |
| TWI554289B (zh) | 2012-06-29 | 2016-10-21 | 國立成功大學 | 鑲嵌式經皮藥物釋放貼片及其製造方法 |
| ITTO20130284A1 (it) | 2013-04-09 | 2014-10-10 | Fond Istituto Italiano Di Tecnologia | Procedimento per la produzione di microparticelle polimeriche sagomate |
| EP3021930B1 (en) | 2013-07-16 | 2020-10-07 | 3M Innovative Properties Company | Hollow microneedle with beveled tip |
| CA2933867A1 (en) * | 2013-12-16 | 2015-06-25 | Massachusetts Institute Of Technology | Micromolded or 3-d printed pulsatile release vaccine formulations |
-
2014
- 2014-12-16 CA CA2933867A patent/CA2933867A1/en active Pending
- 2014-12-16 JP JP2016558550A patent/JP2017507165A/ja not_active Withdrawn
- 2014-12-16 EP EP14830756.4A patent/EP3082852B1/en active Active
- 2014-12-16 WO PCT/US2014/070664 patent/WO2015095230A1/en not_active Ceased
- 2014-12-16 EP EP20177222.5A patent/EP3763383A1/en active Pending
- 2014-12-16 US US14/572,631 patent/US10300136B2/en active Active
- 2014-12-16 AU AU2014364930A patent/AU2014364930B2/en active Active
-
2019
- 2019-05-02 US US16/401,476 patent/US10960073B2/en active Active
- 2019-11-18 JP JP2019208044A patent/JP2020055818A/ja active Pending
-
2021
- 2021-01-07 US US17/143,871 patent/US11975069B2/en active Active
- 2021-05-21 JP JP2021085890A patent/JP7682019B2/ja active Active
-
2023
- 2023-03-17 JP JP2023042995A patent/JP2023075311A/ja active Pending
- 2023-12-29 US US18/400,533 patent/US20240181047A1/en active Pending
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