JP2017507165A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017507165A5 JP2017507165A5 JP2016558550A JP2016558550A JP2017507165A5 JP 2017507165 A5 JP2017507165 A5 JP 2017507165A5 JP 2016558550 A JP2016558550 A JP 2016558550A JP 2016558550 A JP2016558550 A JP 2016558550A JP 2017507165 A5 JP2017507165 A5 JP 2017507165A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- group
- agent
- item
- released
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000427 antigen Substances 0.000 claims description 31
- 102000036639 antigens Human genes 0.000 claims description 31
- 108091007433 antigens Proteins 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 22
- 229920000642 polymer Polymers 0.000 claims description 11
- 229940039227 diagnostic agent Drugs 0.000 claims description 7
- 239000000032 diagnostic agent Substances 0.000 claims description 7
- 230000028993 immune response Effects 0.000 claims description 7
- 230000000069 prophylactic effect Effects 0.000 claims description 7
- 239000003381 stabilizer Substances 0.000 claims description 7
- 235000000346 sugar Nutrition 0.000 claims description 7
- 230000001225 therapeutic effect Effects 0.000 claims description 7
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 238000001727 in vivo Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 241000894006 Bacteria Species 0.000 claims description 5
- 208000000474 Poliomyelitis Diseases 0.000 claims description 5
- 241000700605 Viruses Species 0.000 claims description 5
- 239000012678 infectious agent Substances 0.000 claims description 5
- 238000010146 3D printing Methods 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000001053 micromoulding Methods 0.000 claims description 4
- 239000002417 nutraceutical Substances 0.000 claims description 4
- 235000021436 nutraceutical agent Nutrition 0.000 claims description 4
- 201000005702 Pertussis Diseases 0.000 claims description 3
- 206010043376 Tetanus Diseases 0.000 claims description 3
- 206010013023 diphtheria Diseases 0.000 claims description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 2
- 201000006082 Chickenpox Diseases 0.000 claims description 2
- 241000233866 Fungi Species 0.000 claims description 2
- 201000005505 Measles Diseases 0.000 claims description 2
- 208000005647 Mumps Diseases 0.000 claims description 2
- 229920000954 Polyglycolide Polymers 0.000 claims description 2
- 241000702670 Rotavirus Species 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 230000005867 T cell response Effects 0.000 claims description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 2
- 206010046980 Varicella Diseases 0.000 claims description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
- 235000014633 carbohydrates Nutrition 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000011521 glass Substances 0.000 claims description 2
- 208000006454 hepatitis Diseases 0.000 claims description 2
- 231100000283 hepatitis Toxicity 0.000 claims description 2
- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- 206010022000 influenza Diseases 0.000 claims description 2
- 150000002632 lipids Chemical class 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 239000003094 microcapsule Substances 0.000 claims description 2
- 239000011859 microparticle Substances 0.000 claims description 2
- 239000004005 microsphere Substances 0.000 claims description 2
- 210000000214 mouth Anatomy 0.000 claims description 2
- 208000010805 mumps infectious disease Diseases 0.000 claims description 2
- 210000001331 nose Anatomy 0.000 claims description 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
- 210000000664 rectum Anatomy 0.000 claims description 2
- 201000005404 rubella Diseases 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 210000001215 vagina Anatomy 0.000 claims description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 2
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 claims 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims 1
- 235000021360 Myristic acid Nutrition 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 229910001629 magnesium chloride Inorganic materials 0.000 claims 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical group [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims 1
- 239000000347 magnesium hydroxide Substances 0.000 claims 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims 1
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 claims 1
- 235000013923 monosodium glutamate Nutrition 0.000 claims 1
- 239000004223 monosodium glutamate Substances 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 238000009472 formulation Methods 0.000 description 21
- 238000002360 preparation method Methods 0.000 description 9
- 229920000249 biocompatible polymer Polymers 0.000 description 3
- 150000008163 sugars Chemical class 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361916555P | 2013-12-16 | 2013-12-16 | |
| US61/916,555 | 2013-12-16 | ||
| PCT/US2014/070664 WO2015095230A1 (en) | 2013-12-16 | 2014-12-16 | Micromolded or 3-d printed pulsatile release vaccine formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019208044A Division JP2020055818A (ja) | 2013-12-16 | 2019-11-18 | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017507165A JP2017507165A (ja) | 2017-03-16 |
| JP2017507165A5 true JP2017507165A5 (cg-RX-API-DMAC7.html) | 2018-02-01 |
Family
ID=52396804
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016558550A Withdrawn JP2017507165A (ja) | 2013-12-16 | 2014-12-16 | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| JP2019208044A Pending JP2020055818A (ja) | 2013-12-16 | 2019-11-18 | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| JP2021085890A Active JP7682019B2 (ja) | 2013-12-16 | 2021-05-21 | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| JP2023042995A Pending JP2023075311A (ja) | 2013-12-16 | 2023-03-17 | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019208044A Pending JP2020055818A (ja) | 2013-12-16 | 2019-11-18 | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| JP2021085890A Active JP7682019B2 (ja) | 2013-12-16 | 2021-05-21 | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| JP2023042995A Pending JP2023075311A (ja) | 2013-12-16 | 2023-03-17 | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US10300136B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3082852B1 (cg-RX-API-DMAC7.html) |
| JP (4) | JP2017507165A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2014364930B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2933867A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015095230A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3082852B1 (en) * | 2013-12-16 | 2020-06-17 | Massachusetts Institute of Technology | Micromolded or 3-d printed pulsatile release vaccine formulations |
| EP3302442B1 (en) | 2015-06-03 | 2024-10-16 | Triastek, Inc. | Dosage forms and use thereof |
| WO2018053300A1 (en) * | 2016-09-16 | 2018-03-22 | Auburn University | Biodegradable polymeric particles encapsulating an active agent, pharmaceutical compositions and uses thereof |
| US10150282B2 (en) | 2016-10-14 | 2018-12-11 | Xerox Corporation | System and method for additive manufacture of chemical delivery devices using halftone screening |
| WO2018137686A1 (en) | 2017-01-26 | 2018-08-02 | Triastek, Inc. | Dosage forms of controlled release at specific gastrointestinal sites |
| US10933579B2 (en) | 2017-03-10 | 2021-03-02 | Prellis Biologics, Inc. | Methods and systems for printing biological material |
| US11085018B2 (en) | 2017-03-10 | 2021-08-10 | Prellis Biologics, Inc. | Three-dimensional printed organs, devices, and matrices |
| WO2018218085A2 (en) * | 2017-05-25 | 2018-11-29 | Prellis Biologics, Inc. | Three-dimensional printed organs, devices, and matrices |
| WO2018170132A1 (en) | 2017-03-14 | 2018-09-20 | University Of Connecticut | Biodegradable pressure sensor |
| KR102626745B1 (ko) | 2017-05-26 | 2024-01-17 | 인피니트 머티리얼 솔루션즈, 엘엘씨 | 수용성 중합체 조성물 |
| US20190076631A1 (en) * | 2017-09-13 | 2019-03-14 | Massachusetts Institute Of Technology | Microdevices with complex geometries |
| CN116270513A (zh) | 2018-01-09 | 2023-06-23 | 南京三迭纪医药科技有限公司 | 一种包含固定剂量adhd非兴奋剂和adhd兴奋剂的复方口服药物剂型 |
| WO2019173402A1 (en) | 2018-03-05 | 2019-09-12 | University Of Connecticut | Core-shell microneedle platform for transdermal and pulsatile drug/vaccine delivery and method of manufacturing the same |
| AU2019293579A1 (en) * | 2018-06-29 | 2021-01-07 | The Doshisha | Formulation containing emricasan |
| EP3831879B1 (en) | 2018-07-30 | 2023-07-12 | Mitsubishi Chemical Corporation | Material for fused deposition modeling type additive manufacturing |
| WO2020028436A1 (en) * | 2018-07-31 | 2020-02-06 | Prellis Biologics, Inc. | Optically-induced auto-encapsulation |
| JP7257500B2 (ja) * | 2018-08-20 | 2023-04-13 | 中国科学院過程工程研究所 | マイクロカプセルに基づくワクチン |
| US11826495B2 (en) | 2019-03-01 | 2023-11-28 | University Of Connecticut | Biodegradable piezoelectric ultrasonic transducer system |
| US11678989B2 (en) | 2019-03-01 | 2023-06-20 | University Of Connecticut | Biodegradable piezoelectric nanofiber scaffold for bone or tissue regeneration |
| CN110420324B (zh) * | 2019-08-01 | 2022-07-12 | 临沂大学 | 含兔葡萄球菌抗原的免疫原性组合物及其制备方法和应用 |
| WO2021183626A1 (en) | 2020-03-10 | 2021-09-16 | University Of Connecticut | Therapeutic bandage |
| US12371581B2 (en) | 2020-03-25 | 2025-07-29 | Infinite Material Solutions, Llc | High performance water soluble polymer compositions |
| US20230310710A1 (en) * | 2020-04-20 | 2023-10-05 | Hoffmann-La Roche, Inc. | Method of generating a dried drug formulation |
| IL298019A (en) * | 2020-05-13 | 2023-01-01 | Massachusetts Inst Technology | Compositions of polymeric microdevices and their use in cancer immunotherapy |
| US12491290B2 (en) | 2020-06-08 | 2025-12-09 | University Of Connecticut | Biodegradable piezoelectric composite materials |
| CN112370531B (zh) * | 2020-11-18 | 2022-09-23 | 金宇保灵生物药品有限公司 | 一种犬瘟热、犬细小、犬腺病毒、犬副流感四联活疫苗耐热保护剂及其制备方法和应用 |
| WO2022192361A2 (en) * | 2021-03-09 | 2022-09-15 | Board Of Regents Of The University Of Nebraska | Microparticle compositions and methods use thereof |
| WO2022272247A1 (en) * | 2021-06-21 | 2022-12-29 | William Marsh Rice University | High-throughput preparation of microparticles with pulsatile release |
| CN113521263A (zh) * | 2021-08-03 | 2021-10-22 | 苏州大学 | 一种3d打印的肿瘤疫苗组合物及其制备方法与应用 |
| WO2024026039A2 (en) * | 2022-07-27 | 2024-02-01 | Board Of Regents, The University Of Texas System | Multi-channeled and guided inner controlling (magic) printheads |
| WO2024215759A2 (en) * | 2023-04-11 | 2024-10-17 | The Regents Of The University Of California | Biodegradable scaffolds for enhancing vaccine efficacy |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4450150A (en) | 1973-05-17 | 1984-05-22 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery depots, and method for preparing and using the same |
| US5490962A (en) | 1993-10-18 | 1996-02-13 | Massachusetts Institute Of Technology | Preparation of medical devices by solid free-form fabrication methods |
| ES2184769T3 (es) | 1993-10-22 | 2003-04-16 | Genentech Inc | Metodos y composiciones para microencapsulacion de antigenos para utilizar como vacunas. |
| AU760034B2 (en) | 1997-08-29 | 2003-05-08 | Corixa Corporation | Rapid release encapsulated bioactive agents for inducing or potentiating an immune response and methods of using thereof |
| CA2386151A1 (en) | 1999-10-12 | 2001-04-19 | Marc Madou | Reactive polymeric valve, dispensing devices and methods using same |
| JP2003516343A (ja) | 1999-12-10 | 2003-05-13 | マサチューセッツ インスティテュート オブ テクノロジー | 分子を送達するマイクロチップ素子およびその製作方法 |
| US6565532B1 (en) | 2000-07-12 | 2003-05-20 | The Procter & Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
| US20040033241A1 (en) * | 2000-06-02 | 2004-02-19 | Allergan, Inc. | Controlled release botulinum toxin system |
| ES2310201T3 (es) * | 2001-02-13 | 2009-01-01 | Government Of The United States Of America, As Represented By The Secretary Of The Army | Vacuna para inmunizacion transcutanea contra la diarrea de los viajeros. |
| MXPA04002891A (es) * | 2001-09-28 | 2005-06-20 | Johnson & Johnson | Composicion farmaceutica a base de pasta de azucar. |
| US7122143B2 (en) * | 2001-09-28 | 2006-10-17 | Mcneil-Ppc, Inc. | Methods for manufacturing dosage forms |
| US7285289B2 (en) | 2002-04-12 | 2007-10-23 | Nagy Jon O | Nanoparticle vaccines |
| JP5041663B2 (ja) * | 2002-05-06 | 2012-10-03 | マサチューセッツ インスティテュート オブ テクノロジー | 拡散支配剤形および三次元印刷を含む作製方法 |
| CA2545858A1 (en) | 2003-11-12 | 2005-05-26 | The General Hospital Corporation | Variable appearance tissue markings |
| US9040090B2 (en) | 2003-12-19 | 2015-05-26 | The University Of North Carolina At Chapel Hill | Isolated and fixed micro and nano structures and methods thereof |
| WO2005071088A2 (en) | 2003-12-24 | 2005-08-04 | Cerus Corporation | Recombinant nucleic acid molecules encoding fusion proteins comprising antigens and bacterial secretory signal polypeptides, expression cassettes, and bacteria, and methods of use thereof |
| CN1921884B (zh) | 2003-12-24 | 2012-02-08 | 塞鲁斯公司 | 重组核酸分子,表达盒和细菌,及其使用方法 |
| WO2007001448A2 (en) | 2004-11-04 | 2007-01-04 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
| WO2006121819A1 (en) | 2005-05-06 | 2006-11-16 | Board Of Regents, The University Of Texas System | Methods for fabricating nano and microparticles for drug delivery |
| AU2006285349A1 (en) | 2005-06-20 | 2007-03-08 | Elan Pharma International Limited | Nanoparticulate and controlled release compositions comprising aryl-heterocyclic compounds |
| CN101227940A (zh) | 2005-07-25 | 2008-07-23 | 纳米技术维多利亚有限公司 | 微阵列装置 |
| JP5000652B2 (ja) | 2005-07-28 | 2012-08-15 | エムフォメーション・テクノロジーズ・インコーポレイテッド | ワイヤレス装置のサービス品質管理のためのシステムおよび方法 |
| US20080026040A1 (en) * | 2006-07-31 | 2008-01-31 | Isaac Farr | Active agent-releasing dosage forms |
| US8349326B2 (en) | 2007-02-20 | 2013-01-08 | Tufts University | Methods and systems for multi-antibody therapies |
| CN101809446B (zh) | 2007-09-27 | 2013-11-27 | 株式会社三养生物制药 | 溶胶-凝胶相可逆性水凝胶模板及其应用 |
| EP2394657A1 (en) | 2007-10-12 | 2011-12-14 | Massachusetts Institute Of Technology | Vaccine nanotechnology |
| MX2010009351A (es) | 2008-02-25 | 2011-03-04 | Novavax Inc | Particulas similares a virus cristalizadas con azucar. |
| US10463608B2 (en) | 2008-09-29 | 2019-11-05 | The Corporation Of Mercer University | Microneedle-based transdermal delivery system and method of making same |
| RU2508135C2 (ru) | 2009-07-31 | 2014-02-27 | 3М Инновейтив Пропертиз Компани | Матрица полых микроигл |
| WO2011018753A1 (en) | 2009-08-12 | 2011-02-17 | Koninklijke Philips Electronics N.V. | Drug delivery device with compressible drug reservoir |
| WO2011156641A2 (en) | 2010-06-09 | 2011-12-15 | Kaspar Roger L | Microneedle arrays for active agent delivery |
| CA2819246C (en) * | 2010-12-02 | 2023-04-25 | Oncolytics Biotech Inc. | Liquid viral formulations |
| US20130046182A1 (en) | 2011-08-16 | 2013-02-21 | Elwha LLC, a limited liability company of the State of Delaware | Devices and Methods for Recording Information on a Subject's Body |
| CN103251941A (zh) | 2012-02-16 | 2013-08-21 | 海南大学 | 动物病毒性疫苗脉冲释放系统、其制备方法及用途 |
| US9878137B2 (en) | 2012-05-30 | 2018-01-30 | The Regents Of The University Of California | Bioactive agent delivery devices and methods of making and using the same |
| TWI554289B (zh) | 2012-06-29 | 2016-10-21 | 國立成功大學 | 鑲嵌式經皮藥物釋放貼片及其製造方法 |
| US20140200508A1 (en) | 2012-06-29 | 2014-07-17 | Isaac D. Cohen | Microneedles Comprising One Or More Cosmetic Ingredients |
| ITTO20130284A1 (it) | 2013-04-09 | 2014-10-10 | Fond Istituto Italiano Di Tecnologia | Procedimento per la produzione di microparticelle polimeriche sagomate |
| EP3021930B1 (en) | 2013-07-16 | 2020-10-07 | 3M Innovative Properties Company | Hollow microneedle with beveled tip |
| EP3082852B1 (en) * | 2013-12-16 | 2020-06-17 | Massachusetts Institute of Technology | Micromolded or 3-d printed pulsatile release vaccine formulations |
-
2014
- 2014-12-16 EP EP14830756.4A patent/EP3082852B1/en active Active
- 2014-12-16 CA CA2933867A patent/CA2933867A1/en active Pending
- 2014-12-16 US US14/572,631 patent/US10300136B2/en active Active
- 2014-12-16 EP EP20177222.5A patent/EP3763383A1/en active Pending
- 2014-12-16 WO PCT/US2014/070664 patent/WO2015095230A1/en not_active Ceased
- 2014-12-16 JP JP2016558550A patent/JP2017507165A/ja not_active Withdrawn
- 2014-12-16 AU AU2014364930A patent/AU2014364930B2/en active Active
-
2019
- 2019-05-02 US US16/401,476 patent/US10960073B2/en active Active
- 2019-11-18 JP JP2019208044A patent/JP2020055818A/ja active Pending
-
2021
- 2021-01-07 US US17/143,871 patent/US11975069B2/en active Active
- 2021-05-21 JP JP2021085890A patent/JP7682019B2/ja active Active
-
2023
- 2023-03-17 JP JP2023042995A patent/JP2023075311A/ja active Pending
- 2023-12-29 US US18/400,533 patent/US20240181047A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017507165A5 (cg-RX-API-DMAC7.html) | ||
| Vassilieva et al. | Improved immunogenicity of individual influenza vaccine components delivered with a novel dissolving microneedle patch stable at room temperature | |
| Mansoor et al. | Microneedle-based vaccine delivery: Review of an emerging technology | |
| Kersten et al. | Needle-free vaccine delivery | |
| Lin et al. | Biodegradable polymeric microsphere-based vaccines and their applications in infectious diseases | |
| US20150112250A1 (en) | Soluble microneedle arrays for buccal delivery of vaccines | |
| Kocourkova et al. | Vaccine ingredients: components that influence vaccine efficacy | |
| CN101657188A (zh) | 固体药物和疫苗剂 | |
| Kang et al. | Microneedle and mucosal delivery of influenza vaccines | |
| Tian et al. | Intradermal administration of influenza vaccine with trehalose and pullulan-based dissolving microneedle arrays | |
| Nguyen et al. | Skin immunization with third-generation hepatitis B surface antigen using microneedles | |
| Joyce et al. | Extended delivery of vaccines to the skin improves immune responses | |
| O'Hagan et al. | Novel approaches to pediatric vaccine delivery | |
| CN103957934A (zh) | 包含tlr-5作为佐剂的用于经皮肤免疫的疫苗 | |
| US20190105387A1 (en) | Peptide particle formulation | |
| O’Hagan | New generation vaccine adjuvants | |
| CN104043119B (zh) | 一种新型疫苗佐剂及其制备方法 | |
| Li et al. | Microneedle arrays delivery of the conventional vaccines based on nonvirulent viruses | |
| Bonanni et al. | Vaccine evolution | |
| Chen et al. | Nanotechnologies applied in biomedical vaccines | |
| Mansoor et al. | Intranasal delivery of nanoparticles encapsulating BPI3V proteins induces an early humoral immune response in mice | |
| Simerska et al. | Oral vaccine delivery-new strategies and technologies | |
| Depelsenaire et al. | Introduction to vaccines and vaccination | |
| Andrianov et al. | Intradermal immunization using coated microneedles containing an immunoadjuvant | |
| Saman et al. | Vaccines: An important tool for infectious disease |