JP2017507145A5 - - Google Patents
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- Publication number
- JP2017507145A5 JP2017507145A5 JP2016553402A JP2016553402A JP2017507145A5 JP 2017507145 A5 JP2017507145 A5 JP 2017507145A5 JP 2016553402 A JP2016553402 A JP 2016553402A JP 2016553402 A JP2016553402 A JP 2016553402A JP 2017507145 A5 JP2017507145 A5 JP 2017507145A5
- Authority
- JP
- Japan
- Prior art keywords
- delivery system
- substance delivery
- matrix
- polymeric material
- anabolic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000126 substance Substances 0.000 claims 12
- 239000011159 matrix material Substances 0.000 claims 7
- 239000000463 material Substances 0.000 claims 6
- 229940124325 anabolic agent Drugs 0.000 claims 5
- 239000003263 anabolic agent Substances 0.000 claims 5
- 102000003977 fibroblast growth factor 18 Human genes 0.000 claims 3
- 108090000370 fibroblast growth factor 18 Proteins 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 2
- 230000002051 biphasic effect Effects 0.000 claims 2
- 208000015100 cartilage disease Diseases 0.000 claims 2
- 230000002648 chondrogenic effect Effects 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000002513 implantation Methods 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010007710 Cartilage injury Diseases 0.000 claims 1
- 206010061762 Chondropathy Diseases 0.000 claims 1
- 201000009859 Osteochondrosis Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14000598.4 | 2014-02-20 | ||
| EP14000598 | 2014-02-20 | ||
| PCT/EP2015/053645 WO2015124739A1 (en) | 2014-02-20 | 2015-02-20 | Implant comprising fgf-18 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017507145A JP2017507145A (ja) | 2017-03-16 |
| JP2017507145A5 true JP2017507145A5 (enExample) | 2018-02-22 |
| JP6510547B2 JP6510547B2 (ja) | 2019-05-08 |
Family
ID=50151086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553402A Active JP6510547B2 (ja) | 2014-02-20 | 2015-02-20 | Ｆｇｆ−１８を含むインプラント |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US10086112B2 (enExample) |
| EP (1) | EP3107592B1 (enExample) |
| JP (1) | JP6510547B2 (enExample) |
| KR (1) | KR102421950B1 (enExample) |
| CN (1) | CN106232154A (enExample) |
| AR (1) | AR099556A1 (enExample) |
| AU (1) | AU2015220785B2 (enExample) |
| BR (1) | BR112016018681B1 (enExample) |
| CA (1) | CA2938796C (enExample) |
| DK (1) | DK3107592T3 (enExample) |
| ES (1) | ES2698117T3 (enExample) |
| HR (1) | HRP20181573T1 (enExample) |
| IL (1) | IL247106B (enExample) |
| LT (1) | LT3107592T (enExample) |
| MX (1) | MX368946B (enExample) |
| NZ (1) | NZ723177A (enExample) |
| PL (1) | PL3107592T3 (enExample) |
| PT (1) | PT3107592T (enExample) |
| RS (1) | RS58138B1 (enExample) |
| RU (1) | RU2700414C2 (enExample) |
| SG (1) | SG11201606697YA (enExample) |
| SI (1) | SI3107592T1 (enExample) |
| WO (1) | WO2015124739A1 (enExample) |
| ZA (1) | ZA201605667B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9604168B2 (en) | 2013-02-14 | 2017-03-28 | Nanopareil, Llc | Hybrid felts of electrospun nanofibers |
| EP3119417B1 (en) | 2014-02-20 | 2018-07-11 | Merck Patent GmbH | Fgf-18 compound dosing regimen |
| WO2016120387A1 (en) | 2015-01-29 | 2016-08-04 | Ares Trading S.A. | Immunoassays for high positively charged proteins |
| RS63292B1 (sr) | 2017-09-29 | 2022-06-30 | Merck Patent Gmbh | Inflamatorni biomarkeri za predviđanje responsivnosti na jedinjenje fgf-18 |
| SI3687558T1 (sl) | 2017-09-29 | 2022-08-31 | Merck Patent Gmbh | Presnovni biooznačevalci za napovedovanje odzivnosti na spojino FGF-18 |
| IL281333B2 (en) | 2018-09-10 | 2025-11-01 | Merck Patent Gmbh | A method for reducing risk in a clinical trial |
| CN117187255B (zh) * | 2023-11-07 | 2024-01-30 | 北京大学第三医院（北京大学第三临床医学院） | 编码FGF18或rhFGF18的mRNA及其在骨关节炎治疗中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0896825B1 (en) * | 1997-08-14 | 2002-07-17 | Sulzer Innotec Ag | Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors |
| US6511958B1 (en) * | 1997-08-14 | 2003-01-28 | Sulzer Biologics, Inc. | Compositions for regeneration and repair of cartilage lesions |
| KR100380119B1 (ko) * | 2001-04-19 | 2003-04-11 | 한국항공우주연구원 | 이원화된 통신속도 적응형 베이스 밴드 스위칭 위상시프트 키잉 장치 |
| EP1273365A1 (fr) * | 2001-07-06 | 2003-01-08 | Recherche Et Developpement Du Groupe Cockerill Sambre | Outils rotatifs pour le perçage en ligne de produits profiles |
| AU2003279835B2 (en) * | 2002-10-07 | 2009-09-10 | Zymogenetics, Inc. | Methods of administering FGF18 |
| US8852240B2 (en) * | 2004-10-25 | 2014-10-07 | Kieran Murphy, Llc | Methods and compositions for fostering and preserving bone growth |
| CA2592261C (en) * | 2004-12-10 | 2015-11-24 | Zymogenetics Inc. | Fgf18 production in prokaryotic hosts |
| ES2392883T3 (es) * | 2006-08-25 | 2012-12-14 | Ares Trading S.A. | Tratamiento de trastornos de cartílagos con FGF-18 |
| EP2403514A4 (en) * | 2009-03-05 | 2012-11-14 | Biomimetic Therapeutics Inc | Platelet-derived growth factor compositions and methods of treating osteocartilaginous defects |
| US8431399B2 (en) * | 2010-03-02 | 2013-04-30 | Taipei Medical University | Method to restore cartilaginous phenotype of chondrocytes after cultured and expanded in vitro |
| WO2012094511A2 (en) * | 2011-01-05 | 2012-07-12 | Rhode Island Hospital | Compositions and methods for the treatment of orthopedic disease or injury |
| EP2678048B1 (en) * | 2011-02-22 | 2018-11-21 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Nano-reservoirs technology for use in bone and/or cartilage regeneration |
| AU2014372578B2 (en) * | 2013-12-24 | 2018-03-01 | Ares Trading S.A | FGF-18 formulation in alginate/collagen hydrogels |
| ES2676318T3 (es) | 2014-02-20 | 2018-07-18 | Merck Patent Gmbh | FGF-18 en procedimientos de trasplante de injertos y de ingeniería tisular |
| EP3119417B1 (en) | 2014-02-20 | 2018-07-11 | Merck Patent GmbH | Fgf-18 compound dosing regimen |
-
2015
- 2015-02-20 BR BR112016018681-8A patent/BR112016018681B1/pt active IP Right Grant
- 2015-02-20 KR KR1020167025247A patent/KR102421950B1/ko active Active
- 2015-02-20 RU RU2016137291A patent/RU2700414C2/ru active
- 2015-02-20 LT LTEP15706011.2T patent/LT3107592T/lt unknown
- 2015-02-20 AR ARP150100505A patent/AR099556A1/es not_active Application Discontinuation
- 2015-02-20 US US15/120,137 patent/US10086112B2/en active Active
- 2015-02-20 WO PCT/EP2015/053645 patent/WO2015124739A1/en not_active Ceased
- 2015-02-20 AU AU2015220785A patent/AU2015220785B2/en active Active
- 2015-02-20 DK DK15706011.2T patent/DK3107592T3/en active
- 2015-02-20 SI SI201530409T patent/SI3107592T1/sl unknown
- 2015-02-20 CA CA2938796A patent/CA2938796C/en active Active
- 2015-02-20 NZ NZ723177A patent/NZ723177A/en unknown
- 2015-02-20 JP JP2016553402A patent/JP6510547B2/ja active Active
- 2015-02-20 ES ES15706011T patent/ES2698117T3/es active Active
- 2015-02-20 PT PT15706011T patent/PT3107592T/pt unknown
- 2015-02-20 RS RS20181404A patent/RS58138B1/sr unknown
- 2015-02-20 CN CN201580020527.3A patent/CN106232154A/zh active Pending
- 2015-02-20 HR HRP20181573TT patent/HRP20181573T1/hr unknown
- 2015-02-20 SG SG11201606697YA patent/SG11201606697YA/en unknown
- 2015-02-20 PL PL15706011T patent/PL3107592T3/pl unknown
- 2015-02-20 EP EP15706011.2A patent/EP3107592B1/en active Active
- 2015-02-20 MX MX2016010874A patent/MX368946B/es active IP Right Grant
-
2016
- 2016-08-04 IL IL247106A patent/IL247106B/en active IP Right Grant
- 2016-08-16 ZA ZA2016/05667A patent/ZA201605667B/en unknown
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