PL3107592T3 - Implant zawierający FGF-18 - Google Patents

Implant zawierający FGF-18

Info

Publication number
PL3107592T3
PL3107592T3 PL15706011T PL15706011T PL3107592T3 PL 3107592 T3 PL3107592 T3 PL 3107592T3 PL 15706011 T PL15706011 T PL 15706011T PL 15706011 T PL15706011 T PL 15706011T PL 3107592 T3 PL3107592 T3 PL 3107592T3
Authority
PL
Poland
Prior art keywords
fgf
implant
Prior art date
Application number
PL15706011T
Other languages
English (en)
Inventor
Christoph H. Ladel
Hans Guehring
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PL3107592T3 publication Critical patent/PL3107592T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
PL15706011T 2014-02-20 2015-02-20 Implant zawierający FGF-18 PL3107592T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14000598 2014-02-20
EP15706011.2A EP3107592B1 (en) 2014-02-20 2015-02-20 Implant comprising fgf-18
PCT/EP2015/053645 WO2015124739A1 (en) 2014-02-20 2015-02-20 Implant comprising fgf-18

Publications (1)

Publication Number Publication Date
PL3107592T3 true PL3107592T3 (pl) 2019-02-28

Family

ID=50151086

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15706011T PL3107592T3 (pl) 2014-02-20 2015-02-20 Implant zawierający FGF-18

Country Status (24)

Country Link
US (1) US10086112B2 (pl)
EP (1) EP3107592B1 (pl)
JP (1) JP6510547B2 (pl)
KR (1) KR102421950B1 (pl)
CN (1) CN106232154A (pl)
AR (1) AR099556A1 (pl)
AU (1) AU2015220785B2 (pl)
BR (1) BR112016018681B1 (pl)
CA (1) CA2938796C (pl)
DK (1) DK3107592T3 (pl)
ES (1) ES2698117T3 (pl)
HR (1) HRP20181573T1 (pl)
IL (1) IL247106B (pl)
LT (1) LT3107592T (pl)
MX (1) MX368946B (pl)
NZ (1) NZ723177A (pl)
PL (1) PL3107592T3 (pl)
PT (1) PT3107592T (pl)
RS (1) RS58138B1 (pl)
RU (1) RU2700414C2 (pl)
SG (1) SG11201606697YA (pl)
SI (1) SI3107592T1 (pl)
WO (1) WO2015124739A1 (pl)
ZA (1) ZA201605667B (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2959509T3 (en) 2013-02-14 2018-08-13 Nanopareil Llc Electrospun hybrid nanofiber felt, method of making it and method of purifying biomolecules
US9889179B2 (en) 2014-02-20 2018-02-13 Merck Patent Gmbh FGF-18 compound dosing regimen
EP3250925B1 (en) 2015-01-29 2019-04-10 Ares Trading S.A. Immunoassays for highly positively charged proteins
CN111163791A (zh) 2017-09-29 2020-05-15 默克专利有限公司 预测对fgf-18化合物反应性的代谢生物标志物
LT3688468T (lt) 2017-09-29 2022-06-27 Merck Patent Gmbh Uždegiminiai biožymenys, skirti atsako į fgf-18 junginį numatymui
KR20210057764A (ko) 2018-09-10 2021-05-21 메르크 파텐트 게엠베하 골관절염의 치료를 위한 강화 전략에 유용한 마커
CN117187255B (zh) * 2023-11-07 2024-01-30 北京大学第三医院（北京大学第三临床医学院） 编码FGF18或rhFGF18的mRNA及其在骨关节炎治疗中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6511958B1 (en) * 1997-08-14 2003-01-28 Sulzer Biologics, Inc. Compositions for regeneration and repair of cartilage lesions
EP0896825B1 (en) * 1997-08-14 2002-07-17 Sulzer Innotec Ag Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors
KR100380119B1 (ko) * 2001-04-19 2003-04-11 한국항공우주연구원 이원화된 통신속도 적응형 베이스 밴드 스위칭 위상시프트 키잉 장치
EP1273365A1 (fr) * 2001-07-06 2003-01-08 Recherche Et Developpement Du Groupe Cockerill Sambre Outils rotatifs pour le perçage en ligne de produits profiles
CA2500742C (en) * 2002-10-07 2014-02-18 Zymogenetics, Inc. Compositions of fgf-18 and hyaluronic acid for stimulating cartilage production and treating osteoarthritis
US8852240B2 (en) * 2004-10-25 2014-10-07 Kieran Murphy, Llc Methods and compositions for fostering and preserving bone growth
AU2005314438B2 (en) * 2004-12-10 2012-03-29 Zymogenetics, Inc. FGF18 production in prokaryotic hosts
UA99818C2 (ru) * 2006-08-25 2012-10-10 Эйрэс Трейдинг С.А. Лечение заболеваний хряща
JP2012519556A (ja) * 2009-03-05 2012-08-30 バイオミメティック セラピューティクス， インコーポレイテッド 骨軟骨欠損を治療するための血小板由来増殖因子組成物および方法
US8431399B2 (en) 2010-03-02 2013-04-30 Taipei Medical University Method to restore cartilaginous phenotype of chondrocytes after cultured and expanded in vitro
WO2012094511A2 (en) * 2011-01-05 2012-07-12 Rhode Island Hospital Compositions and methods for the treatment of orthopedic disease or injury
US10034737B2 (en) * 2011-02-22 2018-07-31 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nano-reservoirs technology for use in bone and/or cartilage regeneration
RU2698210C2 (ru) * 2013-12-24 2019-08-23 Арес Трейдинг С.А. Состав fgf-18 в альгинатных/коллагеновых гидрогелях
US9889179B2 (en) 2014-02-20 2018-02-13 Merck Patent Gmbh FGF-18 compound dosing regimen
ES2676318T3 (es) 2014-02-20 2018-07-18 Merck Patent Gmbh FGF-18 en procedimientos de trasplante de injertos y de ingeniería tisular

Also Published As

Publication number Publication date
BR112016018681A2 (pt) 2017-10-17
MX2016010874A (es) 2016-11-17
KR102421950B1 (ko) 2022-07-18
KR20160124806A (ko) 2016-10-28
HRP20181573T1 (hr) 2018-11-30
RU2700414C2 (ru) 2019-09-17
DK3107592T3 (en) 2018-11-12
BR112016018681B1 (pt) 2021-01-05
AU2015220785B2 (en) 2018-07-19
JP2017507145A (ja) 2017-03-16
AU2015220785A1 (en) 2016-09-01
CA2938796A1 (en) 2015-08-27
IL247106B (en) 2020-02-27
US10086112B2 (en) 2018-10-02
EP3107592B1 (en) 2018-08-22
EP3107592A1 (en) 2016-12-28
LT3107592T (lt) 2018-12-10
AR099556A1 (es) 2016-08-03
SG11201606697YA (en) 2016-09-29
CN106232154A (zh) 2016-12-14
RU2016137291A (ru) 2018-03-21
RS58138B1 (sr) 2019-02-28
ZA201605667B (en) 2018-12-19
IL247106A0 (en) 2016-09-29
MX368946B (es) 2019-10-22
WO2015124739A1 (en) 2015-08-27
RU2016137291A3 (pl) 2018-08-28
ES2698117T3 (es) 2019-01-31
JP6510547B2 (ja) 2019-05-08
SI3107592T1 (sl) 2018-11-30
US20170056560A1 (en) 2017-03-02
CA2938796C (en) 2022-08-02
PT3107592T (pt) 2018-12-03
NZ723177A (en) 2021-12-24

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