RU2016137291A - Имплантат, содержащий fgf-18 - Google Patents
Имплантат, содержащий fgf-18 Download PDFInfo
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- RU2016137291A RU2016137291A RU2016137291A RU2016137291A RU2016137291A RU 2016137291 A RU2016137291 A RU 2016137291A RU 2016137291 A RU2016137291 A RU 2016137291A RU 2016137291 A RU2016137291 A RU 2016137291A RU 2016137291 A RU2016137291 A RU 2016137291A
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- Prior art keywords
- delivery system
- substance delivery
- polymer material
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- drug
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factors [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
Claims (16)
1. Система доставки вещества, включающая по меньшей мере один полимерный материал, формирующий матрицу, и анаболическое лекарственное средство, где по меньшей мере один полимерный материал является коллагеном, и где указанное анаболическое лекарственное средство включено по меньшей мере в один полимерный материал, формирующий матрицу.
2. Система доставки вещества по п.1, где матрица является каркасом или мембраной.
3. Система доставки вещества по п.2, где каркас является двухфазным каркасом, или где мембрана является бислойной мембраной.
4. Система доставки вещества по любому из пп.1-3, где по меньшей мере один полимерный материал является комбинацией коллагена и гликозаминогликана (GAG).
5. Система доставки вещества по любому из предыдущих пунктов, которая дополнительно включает хондрогенные клетки.
6. Система доставки вещества по любому из предыдущих пунктов, где анаболическое лекарственное средство является соединением FGF-18.
7. Система доставки вещества по п.6, где соединение FGF-18 выбрано из группы, состоящей из:
a) полипептида, включающего или состоящего из зрелой формы человеческого FGF-18, включающей остатки 28-207 из SEQ ID NO:1, или
b) полипептида, включающего или состоящего из SEQ ID NO:2.
8. Способ получения системы доставки вещества по любому из пп.1-7, который включает следующие этапы: a) получение матрицы, включающей по меньшей мере один полимерный материал, и b) добавление анаболического лекарственного средства в матрицу, полученную в этапе a), где указанное анаболическое лекарственное средство включено по меньшей мере в один полимерный материал, формирующий матрицу.
9. Способ по п.8, который дополнительно включает этап c) добавления хондрогенных клеток в матрицу, полученную в этапе a).
10. Система доставки вещества по любому из пп.1-7 для применения в лечении поражения хряща.
11. Система доставки вещества для применения по п.10, где поражение хряща выбрано из остеоартрита, повреждения хряща и костно-хрящевых дефектов.
12. Система доставки вещества для применения по п.10 или 11, где систему доставки вещества вводят пациенту, нуждающемуся в указанном лечении, посредством процедуры трансплантации.
13. Изделие, включающее систему доставки вещества по любому из пп.1-7.
14. Изделие по п.13, где каждый из компонентов объединены до имплантации или после имплантации.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14000598.4 | 2014-02-20 | ||
| EP14000598 | 2014-02-20 | ||
| PCT/EP2015/053645 WO2015124739A1 (en) | 2014-02-20 | 2015-02-20 | Implant comprising fgf-18 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2016137291A true RU2016137291A (ru) | 2018-03-21 |
| RU2016137291A3 RU2016137291A3 (ru) | 2018-08-28 |
| RU2700414C2 RU2700414C2 (ru) | 2019-09-17 |
Family
ID=50151086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016137291A RU2700414C2 (ru) | 2014-02-20 | 2015-02-20 | Имплантат, содержащий fgf-18 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US10086112B2 (ru) |
| EP (1) | EP3107592B1 (ru) |
| JP (1) | JP6510547B2 (ru) |
| KR (1) | KR102421950B1 (ru) |
| CN (1) | CN106232154A (ru) |
| AR (1) | AR099556A1 (ru) |
| AU (1) | AU2015220785B2 (ru) |
| BR (1) | BR112016018681B1 (ru) |
| CA (1) | CA2938796C (ru) |
| DK (1) | DK3107592T3 (ru) |
| ES (1) | ES2698117T3 (ru) |
| HR (1) | HRP20181573T1 (ru) |
| IL (1) | IL247106B (ru) |
| LT (1) | LT3107592T (ru) |
| MX (1) | MX368946B (ru) |
| NZ (1) | NZ723177A (ru) |
| PL (1) | PL3107592T3 (ru) |
| PT (1) | PT3107592T (ru) |
| RS (1) | RS58138B1 (ru) |
| RU (1) | RU2700414C2 (ru) |
| SG (1) | SG11201606697YA (ru) |
| SI (1) | SI3107592T1 (ru) |
| WO (1) | WO2015124739A1 (ru) |
| ZA (1) | ZA201605667B (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2911888C (en) | 2013-02-14 | 2017-09-19 | Nanopareil, Llc | Hybrid felts of electrospun nanofibers |
| LT3107559T (lt) | 2014-02-20 | 2018-10-25 | Merck Patent Gmbh | Fgf-18 junginio dozavimo režimas |
| CN117187255B (zh) * | 2023-11-07 | 2024-01-30 | 北京大学第三医院（北京大学第三临床医学院） | 编码FGF18或rhFGF18的mRNA及其在骨关节炎治疗中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0896825B1 (en) * | 1997-08-14 | 2002-07-17 | Sulzer Innotec Ag | Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors |
| US6511958B1 (en) * | 1997-08-14 | 2003-01-28 | Sulzer Biologics, Inc. | Compositions for regeneration and repair of cartilage lesions |
| KR100380119B1 (ko) * | 2001-04-19 | 2003-04-11 | 한국항공우주연구원 | 이원화된 통신속도 적응형 베이스 밴드 스위칭 위상시프트 키잉 장치 |
| EP1273365A1 (fr) * | 2001-07-06 | 2003-01-08 | Recherche Et Developpement Du Groupe Cockerill Sambre | Outils rotatifs pour le perçage en ligne de produits profiles |
| EP1551426B1 (en) * | 2002-10-07 | 2014-06-25 | ZymoGenetics, Inc. | Methods of administering fgf18 |
| US8852240B2 (en) | 2004-10-25 | 2014-10-07 | Kieran Murphy, Llc | Methods and compositions for fostering and preserving bone growth |
| CA2592261C (en) * | 2004-12-10 | 2015-11-24 | Zymogenetics Inc. | Fgf18 production in prokaryotic hosts |
| SI2054050T1 (sl) * | 2006-08-25 | 2012-12-31 | Ares Trading S.A. | Zdravljenje hrustanäśnih obolenj z fgf-18 |
| JP2012519556A (ja) * | 2009-03-05 | 2012-08-30 | バイオミメティック セラピューティクス， インコーポレイテッド | 骨軟骨欠損を治療するための血小板由来増殖因子組成物および方法 |
| US8431399B2 (en) * | 2010-03-02 | 2013-04-30 | Taipei Medical University | Method to restore cartilaginous phenotype of chondrocytes after cultured and expanded in vitro |
| WO2012094511A2 (en) * | 2011-01-05 | 2012-07-12 | Rhode Island Hospital | Compositions and methods for the treatment of orthopedic disease or injury |
| US10034737B2 (en) | 2011-02-22 | 2018-07-31 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Nano-reservoirs technology for use in bone and/or cartilage regeneration |
| EP3086822B1 (en) * | 2013-12-24 | 2020-04-15 | Ares Trading SA | Fgf-18 formulation in alginate/collagen hydrogels |
| AU2015220781B2 (en) | 2014-02-20 | 2018-05-24 | Merck Patent Gmbh | FGF-18 in graft transplantation and tissue engineering procedures |
| LT3107559T (lt) | 2014-02-20 | 2018-10-25 | Merck Patent Gmbh | Fgf-18 junginio dozavimo režimas |
-
2015
- 2015-02-20 EP EP15706011.2A patent/EP3107592B1/en active Active
- 2015-02-20 RU RU2016137291A patent/RU2700414C2/ru active
- 2015-02-20 RS RS20181404A patent/RS58138B1/sr unknown
- 2015-02-20 SI SI201530409T patent/SI3107592T1/sl unknown
- 2015-02-20 CN CN201580020527.3A patent/CN106232154A/zh active Pending
- 2015-02-20 NZ NZ723177A patent/NZ723177A/en unknown
- 2015-02-20 US US15/120,137 patent/US10086112B2/en active Active
- 2015-02-20 MX MX2016010874A patent/MX368946B/es active IP Right Grant
- 2015-02-20 AU AU2015220785A patent/AU2015220785B2/en active Active
- 2015-02-20 PT PT15706011T patent/PT3107592T/pt unknown
- 2015-02-20 JP JP2016553402A patent/JP6510547B2/ja active Active
- 2015-02-20 SG SG11201606697YA patent/SG11201606697YA/en unknown
- 2015-02-20 DK DK15706011.2T patent/DK3107592T3/en active
- 2015-02-20 CA CA2938796A patent/CA2938796C/en active Active
- 2015-02-20 WO PCT/EP2015/053645 patent/WO2015124739A1/en active Application Filing
- 2015-02-20 PL PL15706011T patent/PL3107592T3/pl unknown
- 2015-02-20 ES ES15706011T patent/ES2698117T3/es active Active
- 2015-02-20 LT LTEP15706011.2T patent/LT3107592T/lt unknown
- 2015-02-20 AR ARP150100505A patent/AR099556A1/es not_active Application Discontinuation
- 2015-02-20 BR BR112016018681-8A patent/BR112016018681B1/pt active IP Right Grant
- 2015-02-20 KR KR1020167025247A patent/KR102421950B1/ko active IP Right Grant
-
2016
- 2016-08-04 IL IL247106A patent/IL247106B/en active IP Right Grant
- 2016-08-16 ZA ZA2016/05667A patent/ZA201605667B/en unknown
-
2018
- 2018-10-02 HR HRP20181573TT patent/HRP20181573T1/hr unknown
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