JP2017506622A5 - - Google Patents
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- JP2017506622A5 JP2017506622A5 JP2016549241A JP2016549241A JP2017506622A5 JP 2017506622 A5 JP2017506622 A5 JP 2017506622A5 JP 2016549241 A JP2016549241 A JP 2016549241A JP 2016549241 A JP2016549241 A JP 2016549241A JP 2017506622 A5 JP2017506622 A5 JP 2017506622A5
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- JP
- Japan
- Prior art keywords
- alkyl
- compound
- formula
- protein
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 C*(CC*(CCC*1CCOCC1)C(OC1=C(Cc2ccc[o]2)*C2=C(Cc3ccccc3)*C(c3ccccc3)=C*12)=O)C(c(cc1)ccc1OC)=O Chemical compound C*(CC*(CCC*1CCOCC1)C(OC1=C(Cc2ccc[o]2)*C2=C(Cc3ccccc3)*C(c3ccccc3)=C*12)=O)C(c(cc1)ccc1OC)=O 0.000 description 5
- BUFSEVFXVCFYKY-UHFFFAOYSA-N O=C(C(Cc1ccc[o]1)=N1)N2C1=C(Cc1ccccc1)NC(c1ccccc1)=C2 Chemical compound O=C(C(Cc1ccc[o]1)=N1)N2C1=C(Cc1ccccc1)NC(c1ccccc1)=C2 BUFSEVFXVCFYKY-UHFFFAOYSA-N 0.000 description 2
- MWOYPGFRXPPBOX-UHFFFAOYSA-N O=C(C(Cc1ccccc1)=N1)N2C1=C(Cc1ccccc1)NC(c1ccccc1)=C2 Chemical compound O=C(C(Cc1ccccc1)=N1)N2C1=C(Cc1ccccc1)NC(c1ccccc1)=C2 MWOYPGFRXPPBOX-UHFFFAOYSA-N 0.000 description 2
- LNGUITKMTOZNAL-UHFFFAOYSA-N Oc(cc1)ccc1C1=CN(C(C(Cc2ccc[o]2)=N2)=O)C2=C(Cc2ccccc2)N1 Chemical compound Oc(cc1)ccc1C1=CN(C(C(Cc2ccc[o]2)=N2)=O)C2=C(Cc2ccccc2)N1 LNGUITKMTOZNAL-UHFFFAOYSA-N 0.000 description 2
- KAEGGIFPLJZUOZ-UHFFFAOYSA-N Oc(cc1)ccc1C1=CN(C(C(Cc2ccccc2)=N2)=O)C2=C(Cc2ccccc2)N1 Chemical compound Oc(cc1)ccc1C1=CN(C(C(Cc2ccccc2)=N2)=O)C2=C(Cc2ccccc2)N1 KAEGGIFPLJZUOZ-UHFFFAOYSA-N 0.000 description 2
- YHIPILPTUVMWQT-UHFFFAOYSA-N Oc1ccc(CC2=NC3=C(Cc4ccccc4)NC(c(cc4)ccc4O)=CN3C2=O)cc1 Chemical compound Oc1ccc(CC2=NC3=C(Cc4ccccc4)NC(c(cc4)ccc4O)=CN3C2=O)cc1 YHIPILPTUVMWQT-UHFFFAOYSA-N 0.000 description 2
- LABFYLKLEVXOBL-UHFFFAOYSA-N CC(NC(CC[O]=O)C(NC(CC(O)=O)C(N(C)CCCN(CCCN1CCOCC1)C(Oc1c(Cc2ccc[o]2)nc2[n]1cc(-c1ccccc1)nc2Cc1ccccc1)=O)=O)=O)=O Chemical compound CC(NC(CC[O]=O)C(NC(CC(O)=O)C(N(C)CCCN(CCCN1CCOCC1)C(Oc1c(Cc2ccc[o]2)nc2[n]1cc(-c1ccccc1)nc2Cc1ccccc1)=O)=O)=O)=O LABFYLKLEVXOBL-UHFFFAOYSA-N 0.000 description 1
- NMILGIZTAZXMTM-UHFFFAOYSA-N CCCN1CCOCC1 Chemical compound CCCN1CCOCC1 NMILGIZTAZXMTM-UHFFFAOYSA-N 0.000 description 1
- QEUJTSCVVGEZCB-UHFFFAOYSA-N CN(CCCN(CCCN1CCOCC1)C(Oc1c(Cc2ccc[o]2)nc2[n]1cc(-c1ccccc1)nc2Cc1ccccc1)=O)C1(COCC(O)=O)OC1 Chemical compound CN(CCCN(CCCN1CCOCC1)C(Oc1c(Cc2ccc[o]2)nc2[n]1cc(-c1ccccc1)nc2Cc1ccccc1)=O)C1(COCC(O)=O)OC1 QEUJTSCVVGEZCB-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461933210P | 2014-01-29 | 2014-01-29 | |
| US61/933,210 | 2014-01-29 | ||
| PCT/US2015/013504 WO2015116806A1 (en) | 2014-01-29 | 2015-01-29 | Pro-substrates for live cell applications |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017506622A JP2017506622A (ja) | 2017-03-09 |
| JP2017506622A5 true JP2017506622A5 (enExample) | 2018-03-08 |
| JP6588917B2 JP6588917B2 (ja) | 2019-10-09 |
Family
ID=52462487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016549241A Active JP6588917B2 (ja) | 2014-01-29 | 2015-01-29 | 生細胞への適用のためのプロ基質 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9927430B2 (enExample) |
| EP (1) | EP3099691B1 (enExample) |
| JP (1) | JP6588917B2 (enExample) |
| WO (1) | WO2015116806A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3099691B1 (en) | 2014-01-29 | 2019-11-20 | Promega Corporation | Pro-substrates for live cell applications |
| US9790537B2 (en) | 2014-01-29 | 2017-10-17 | Promega Corporation | Quinone-masked probes as labeling reagents for cell uptake measurements |
| EP3313846B1 (en) | 2015-06-25 | 2020-05-06 | Promega Corporation | Thienopyrrole compounds and uses thereof as inhibitors of oplophorus-derived luciferases |
| JP7092677B2 (ja) | 2016-02-15 | 2022-06-28 | プロメガ コーポレイション | セレンテラジン類似体 |
| US10316070B2 (en) * | 2016-09-09 | 2019-06-11 | Promega Corporation | Dual protected pro-coelenterazine substrates |
| EP3548492B1 (en) | 2016-12-01 | 2023-07-05 | Promega Corporation | Cell impermeable coelenterazine analogues |
| JP7161475B2 (ja) | 2016-12-28 | 2022-10-26 | プロメガ コーポレイション | 官能化ｎａｎｏｌｕｃ阻害剤 |
| EP3395803A1 (en) * | 2017-04-28 | 2018-10-31 | Institut Pasteur | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins |
| EP3788048A1 (en) | 2018-05-01 | 2021-03-10 | Promega Corporation | Coelenterazine compounds as nanoluc suicide substrates |
| EP4140991B1 (en) | 2018-06-01 | 2024-05-15 | Promega Corporation | Inhibitors of oplophorus luciferase-derived bioluminescent complexes |
| IL318819A (en) | 2018-10-03 | 2025-04-01 | Promega Corp | Compounds and methods for stabilizing cholinetyrazine and its derivatives |
| US12371676B2 (en) | 2019-04-16 | 2025-07-29 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Circularly permutated haloalkane transferase fusion molecules |
| EP3816180A1 (en) | 2019-10-31 | 2021-05-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Circularly permutated haloalkane transferase fusion molecules |
| WO2026049942A2 (en) * | 2024-08-02 | 2026-03-05 | Promega Corporation | Bioluminescence pro-substrates |
| WO2026128753A2 (en) | 2024-12-12 | 2026-06-18 | Juno Therapeutics, Inc. | Methods for assessing cell proliferation of cell compositions |
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| EP0134108B1 (en) | 1983-08-17 | 1989-04-05 | AlliedSignal Inc. | Gas generator and method of generating gas |
| US5683888A (en) | 1989-07-22 | 1997-11-04 | University Of Wales College Of Medicine | Modified bioluminescent proteins and their use |
| ES2301160T3 (es) | 1994-01-03 | 2008-06-16 | Promega Corporation | Luciferasas mutantes. |
| US6387675B1 (en) | 1994-01-03 | 2002-05-14 | Promega Corporation | Mutant luciferases |
| GB9501170D0 (en) | 1994-03-23 | 1995-03-08 | Secr Defence | Luciferases |
| JP3648763B2 (ja) | 1994-08-23 | 2005-05-18 | 日本油脂株式会社 | ウミホタルルシフェリン誘導体および糖加水分解酵素の定量方法 |
| GB9417593D0 (en) | 1994-09-01 | 1994-10-19 | Secr Defence | Luciferase labelling method |
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| IN186115B (enExample) | 1995-01-20 | 2001-06-23 | Secr Defence Brit | |
| JPH08294397A (ja) | 1995-04-27 | 1996-11-12 | Nippon Oil & Fats Co Ltd | 免疫学的活性物質の測定方法 |
| US5998204A (en) | 1997-03-14 | 1999-12-07 | The Regents Of The University Of California | Fluorescent protein sensors for detection of analytes |
| GB9707486D0 (en) | 1997-04-11 | 1997-05-28 | Secr Defence | Enzyme assays |
| WO1998046739A1 (fr) | 1997-04-16 | 1998-10-22 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Molecules immunomodulatrices et leur procede de production |
| EP2860252A1 (en) | 1997-09-19 | 2015-04-15 | Promega Corporation | Thermostable luciferases and methods of production |
| US6602677B1 (en) | 1997-09-19 | 2003-08-05 | Promega Corporation | Thermostable luciferases and methods of production |
| GB9823468D0 (en) | 1998-10-28 | 1998-12-23 | Secr Defence | Novel enzyme |
| RU2251571C2 (ru) | 1999-10-26 | 2005-05-10 | Дзе Секретэри Оф Стейт Фор Дефенс | РЕКОМБИНАНТНАЯ ТЕРМОСТАБИЛЬНАЯ ЛЮЦИФЕРАЗА, СПОСОБ ЕЕ ПОЛУЧЕНИЯ, ИЗОЛИРОВАННАЯ НУКЛЕИНОВАЯ КИСЛОТА, ЭКСПРЕССИРУЮЩИЙ ВЕКТОР, НАБОР ДЛЯ ИСПОЛЬЗОВАНИЯ В БИОЛЮМИНЕСЦЕНТНОМ АНАЛИЗЕ, АНАЛИТИЧЕСКИЙ ТЕСТ ДЛЯ ОПРЕДЕЛЕНИЯ ПРИСУТСТВИЯ В ОБРАЗЦЕ СоА |
| GB9925161D0 (en) | 1999-10-26 | 1999-12-22 | Secr Defence | Novel enzyme |
| EP1156103B1 (en) | 2000-04-26 | 2010-08-11 | Chisso Corporation | Oplophorus luciferase |
| US7118878B1 (en) | 2000-06-09 | 2006-10-10 | Promega Corporation | Method for increasing luminescence assay sensitivity |
| US7879540B1 (en) | 2000-08-24 | 2011-02-01 | Promega Corporation | Synthetic nucleic acid molecule compositions and methods of preparation |
| ATE323174T1 (de) | 2000-09-13 | 2006-04-15 | Merck Patent Gmbh | Verfahren zur detektion und messung der biomasse |
| US7268229B2 (en) | 2001-11-02 | 2007-09-11 | Promega Corporation | Compounds to co-localize luminophores with luminescent proteins |
| EP1472238B1 (en) | 2002-02-01 | 2012-07-04 | Promega Corporation | Bioluminescent protease assay |
| EP1546162B1 (en) | 2002-09-20 | 2011-06-22 | Promega Corporation | Luminescence-based methods and probes for measuring cytochrome p450 activity |
| EP1413584B1 (en) | 2002-10-21 | 2005-03-02 | AXXAM S.r.l. | Photoprotein with improved bioluminescence |
| WO2004059294A2 (en) | 2002-12-23 | 2004-07-15 | Promega Corporation | Improved luciferase-based assays |
| DE10303265A1 (de) | 2003-01-28 | 2004-07-29 | Roche Diagnostics Gmbh | Fluorimetrische Bestimmung von Analyten durch ein intramolekulares Quencher-Fluorophor-Konjugat |
| US7429472B2 (en) | 2003-01-31 | 2008-09-30 | Promega Corporation | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule |
| KR20050109934A (ko) | 2003-01-31 | 2005-11-22 | 프로메가 코포레이션 | 관능기의 단백질로의 공유 테더링 |
| JP2006517413A (ja) | 2003-02-12 | 2006-07-27 | プロメガ コーポレイション | 光を発光反応から消失させる二重酵素アッセイの方法及びキット |
| US20040178545A1 (en) | 2003-03-14 | 2004-09-16 | Cates Larry E. | System for optically analyzing a molten metal bath |
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| WO2005038029A2 (en) | 2003-10-10 | 2005-04-28 | Promega Corporation | Luciferase biosensor |
| DE602005016648D1 (de) | 2004-01-08 | 2009-10-29 | Univ Zuerich | Metallkomplexe mit vitamin b12 als ligand |
| US7416854B2 (en) | 2004-01-22 | 2008-08-26 | Promega Corporation | Luminogenic and nonluminogenic multiplex assay |
| US7553632B2 (en) | 2004-01-22 | 2009-06-30 | Promega Corporation | Luminogenic and nonluminogenic multiplex assay |
| US20070087400A1 (en) | 2004-07-30 | 2007-04-19 | Aldis Darzins | Covalent tethering of functional groups to proteins and substrates therefor |
| EP2395358B1 (en) | 2004-07-30 | 2017-03-29 | Promega Corporation | Covalent tethering of functional groups to proteins |
| US7425436B2 (en) | 2004-07-30 | 2008-09-16 | Promega Corporation | Covalent tethering of functional groups to proteins and substrates therefor |
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| US20080248511A1 (en) | 2007-03-26 | 2008-10-09 | Promega Corporation | Methods to quench light from optical reactions |
| CN101849005A (zh) | 2007-11-05 | 2010-09-29 | 普罗梅加公司 | 杂合融合报道子及其应用 |
| ATE542903T1 (de) | 2008-05-19 | 2012-02-15 | Promega Corp | Luciferase-biosensoren für camp |
| US8183007B2 (en) | 2008-07-22 | 2012-05-22 | Promega Corporation | ADP detection based methods using adenylate cyclase and bioluminescence |
| TWI354101B (en) | 2008-08-19 | 2011-12-11 | Univ Nat Taipei Technology | Fluorimetric indicator for biosensing and manufact |
| ES2795287T3 (es) | 2009-05-01 | 2020-11-23 | Promega Corp | Luciferasas de Oplophorus sintéticas con mayor emisión de luz |
| WO2011038219A1 (en) | 2009-09-24 | 2011-03-31 | Promega Corporation | Proteases having improved stability, solubility and activity |
| EP2990479B1 (en) | 2010-05-11 | 2019-03-27 | Promega Corporation | Mutant protease biosensors with enhanced detection characteristics |
| WO2011146390A2 (en) * | 2010-05-17 | 2011-11-24 | The Regents Of The University Of California | Compositions and methods for in vivo imaging |
| US9816127B2 (en) | 2010-09-01 | 2017-11-14 | Promega Corporation | Oxidized glutathione assay |
| US9284188B2 (en) | 2010-09-03 | 2016-03-15 | The Regents Of The University Of California | Cytosolic delivery of materials with endosome-disrupting colloids |
| EP2614059B1 (en) | 2010-09-10 | 2015-11-18 | Promega Corporation | Methods for assaying enzyme activities |
| CN103443121B (zh) | 2010-11-02 | 2016-04-20 | 普罗梅加公司 | 新型腔肠素底物及其使用方法 |
| CA2815381C (en) | 2010-11-02 | 2019-03-19 | Promega Corporation | Coelenterazine derivatives and methods of using same |
| US9273343B2 (en) | 2011-09-02 | 2016-03-01 | Promega Corporation | Compounds and methods for assaying redox state of metabolically active cells and methods for measuring NAD(P)/NAD(P)H |
| EP2900833B1 (en) * | 2012-09-26 | 2018-05-30 | Promega Corporation | Real-time monitoring |
| EP3099691B1 (en) | 2014-01-29 | 2019-11-20 | Promega Corporation | Pro-substrates for live cell applications |
| US9790537B2 (en) | 2014-01-29 | 2017-10-17 | Promega Corporation | Quinone-masked probes as labeling reagents for cell uptake measurements |
-
2015
- 2015-01-29 EP EP15703218.6A patent/EP3099691B1/en active Active
- 2015-01-29 WO PCT/US2015/013504 patent/WO2015116806A1/en not_active Ceased
- 2015-01-29 JP JP2016549241A patent/JP6588917B2/ja active Active
- 2015-01-29 US US14/608,910 patent/US9927430B2/en active Active
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