JP2017506570A - 組織治癒のためのシステム及び方法 - Google Patents
組織治癒のためのシステム及び方法 Download PDFInfo
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- JP2017506570A JP2017506570A JP2016569568A JP2016569568A JP2017506570A JP 2017506570 A JP2017506570 A JP 2017506570A JP 2016569568 A JP2016569568 A JP 2016569568A JP 2016569568 A JP2016569568 A JP 2016569568A JP 2017506570 A JP2017506570 A JP 2017506570A
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Abstract
Description
本開示は、2014年2月14日に出願された米国仮特許出願第61/940,245号の利益を主張するものであり、その内容を全体として参照によって本明細書中に援用する。
本発明は、機能的ブロック成分と様々な処理ステップの観点から記載し得る。斯かる機能的ブロックは指定された機能を実施し、様々な結果を得るように構成されたいろいろな成分によって実現され得る。例えば、本発明は、様々な処理ステップ、装置、システム、方法などを利用し得る。加えて、本発明は、開放創を治療するためのいろいろなシステムや方法に関連して実施され得る。更に、本発明は、創傷部の処置、創傷床の準備、創感染の治療又は予防、炎症の軽減、創傷部からの体液抽出、創傷ドレッシングの変更、及び創縁の前進予防のためのいろいろな従来の手法を利用し得る。
胆管接合部に3つの腸皮瘻孔を有しているクローン病と診断された女性患者を入院させた。様々な在来の治療法を試みたが、1日あたり1000〜2000mlの液体漏出速度を有する彼女の瘻孔は残った。患者に彼女の体ではこの瘻孔が自然治癒しないことを説明し、そして末期であることを宣告した。患者は、エステル系フォームを直接瘻孔に配置する実験手順に同意した。エステル系フォームを、V.A.C.VeraFlo Cleanse(商標)Dressingという商品名でKinetic Concepts, Inc.から販売されている133〜600μmの細孔サイズを有する網状ポリウレタンエステルフォームで構成した。細孔のサイズがフォーム内で方向性をもって変化するように、エステル系フォームをフェルト状にしたが、ここで、細孔サイズは、フェルト形成の方向(すなわち、厚さ)に沿ってよりもフォームの全長に沿った方が大きかった。図1で例示したように、瘻孔に対して垂直なエステル系フォームの幅及び瘻孔と直接接触状態にあるエステルフォーム平面を有するフォームを瘻孔に直接配置し、閉塞材料で覆い、そして真空チューブを介して真空ポンプに取り付けた。第二の真空チューブ及びポンプを、瘻孔と反対側の創傷端部に配置して、第一の真空ポンプによって回収されなかった排出排液を回収した。エステル系フォームを3日間毎に交換した。実験手順の約12時間以内に、液体排出は約500ml/日の速度まで低下した。日が進むにつれ、液体排出は約200ml/日まで低下した。加えて、創傷部の全体的な色合い、質感、及び臭いが3日以内に改善した。創傷床の組織が、黄色がかった壊死塊で覆われた組織から赤色の肉のような肉芽組織に改善された。加えて、液体排出の減少よると思われるが、創傷部位の胆汁の臭いが実験手順の初めの3日以内に減少した。
Claims (21)
- 陰圧処置システムにおける、平滑筋瘻孔を含む創傷床の処置のための吸収性ドレッシングであって:
約0.1μm〜約50μmの幅を有する細孔を含む第1の構造的特徴;及び
創傷床からの創傷液の流れを方向づけるように構成される第2の構造的特徴、
を備えたエステル系フォームを含む吸収性ドレッシング。 - 前記エステル系フォームが第一層であり、そして、第2の構造的特徴が、第一層の平均細孔サイズより小さい平均細孔サイズを有する細孔を有するエステル系フォームの第二層を含む、請求項1に記載の吸収性ドレッシング。
- 前記第2の構造的特徴が、エステル系フォーム内に1又は複数のあらかじめ形成された流路を含み、かつ、エステル系フォームの平均細孔サイズより大きな平均細孔サイズを有する、請求項1に記載の吸収性ドレッシング。
- 前記1又は複数のあらかじめ形成された流路が、砂時計様形状に配置される、請求項3に記載の吸収性ドレッシング。
- 前記第2の構造的特徴が、エステル系フォーム内に1又は複数の翼様形状の障壁を含む、請求項1に記載の吸収性ドレッシング。
- 前記1又は複数の翼様形状の障壁が、概して円形に配置される、請求項5に記載の吸収性ドレッシング。
- 前記第2の構造的特徴が、複数の注入ポートを通じて創傷床の上方の領域に液体を送達するように構成された送達チューブを含む放射状ハウジングを含む、請求項1に記載の吸収性ドレッシング。
- 前記放射状ハウジングが砂時計様形状を有する、請求項7に記載の吸収性ドレッシング。
- 前記細孔の幅が約0.2μm〜約2μmである、請求項1に記載の吸収性ドレッシング。
- 前記細孔が、創傷液が細孔間で拡散できるようなオープンセル構造を有する、請求項1に記載の吸収性ドレッシング。
- 前記細孔の幅が、細胞の幅又は滲出液の材料と相関するように構成される、請求項1に記載の吸収性ドレッシング。
- 平滑筋瘻孔を含む創傷床を処置する方法であって:
約0.1μm〜約80μmの幅を有する細孔を持つエステル系フォームを含む吸収性ドレッシングを、平滑筋瘻孔を含む創傷床に直接適用し;そして、
該吸収性ドレッシングに陰圧をかけ、それによって、該創傷床から創傷液を吸い出すこと、
を含む方法。 - 前記吸収性ドレッシングの上を覆う閉塞材料を適用し、創傷床においてシールを形成することを更に含む、請求項12に記載の方法。
- 前記吸収性ドレッシングが、エステル系フォーム内に存在しかつ創傷床から吸い出される創傷液に流動パターンを示すのに適合させた第2の構造的特徴を含む、請求項12に記載の方法。
- 前記エステル系フォームが、少なくとも2つの層を含み、そして、第一層が、第二層の平均細孔サイズより大きな平均細孔サイズを有する、請求項12に記載の方法。
- 平滑筋瘻孔を含む創傷床の処置のための陰圧処置システムであって:
約0.1μm〜約50μmの幅を有する細孔を含む第1の構造的特徴及び創傷床からの創傷液の流れを方向づけるように構成される第2の構造的特徴を備えたエステル系フォームを含む吸収性ドレッシング;及び
該吸収性ドレッシングに陰圧をかけ、それによって、創傷床から創傷液を吸い出すように構成された真空ポンプ、
を含む陰圧処置システム。 - 前記吸収性ドレッシング上に適用され、創傷床においてシールを形成し、かつ、該吸収性ドレッシングに対する真空ポンプに接続するための開口部を有するように構成された閉塞材料を更に含む、請求項16に記載の陰圧処置システム。
- 前記エステル系フォームが第一層であり、かつ、第2の構造的特徴が、第一層の平均細孔サイズより小さい平均細孔サイズを有する細孔を有するエステル系フォームの第二層を含む、請求項16に記載の陰圧処置システム。
- 前記吸収性ドレッシングと前記創傷床との間に配置されるように適合させた界面層を更に含む、請求項16に記載の陰圧処置システム。
- 前記界面層がエステル系材料を含む、請求項19に記載の陰圧処置システム。
- 前記界面層が、約0.1μm〜約50μmの幅を有する細孔を有するフィルムを含む、請求項20に記載の陰圧処置システム。
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JP2020157073A (ja) | 2020-10-01 |
RU2710345C2 (ru) | 2019-12-25 |
RU2016136672A (ru) | 2018-03-19 |
AU2015218302B2 (en) | 2019-11-07 |
AU2015218302A1 (en) | 2016-09-01 |
JP7449160B2 (ja) | 2024-03-13 |
CN106456379A (zh) | 2017-02-22 |
EP3104817B1 (en) | 2023-10-04 |
ES2966671T3 (es) | 2024-04-23 |
CA2939338A1 (en) | 2015-08-20 |
EP3104817C0 (en) | 2023-10-04 |
US10485707B2 (en) | 2019-11-26 |
KR102304753B1 (ko) | 2021-09-23 |
BR112016018549B1 (pt) | 2021-12-28 |
US20170049627A1 (en) | 2017-02-23 |
NZ723205A (en) | 2021-09-24 |
BR112016018549A2 (pt) | 2018-05-02 |
EP3104817A1 (en) | 2016-12-21 |
WO2015123609A1 (en) | 2015-08-20 |
RU2016136672A3 (ja) | 2018-09-07 |
US20200046568A1 (en) | 2020-02-13 |
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