JP2017505116A5 - - Google Patents
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- Publication number
- JP2017505116A5 JP2017505116A5 JP2016542739A JP2016542739A JP2017505116A5 JP 2017505116 A5 JP2017505116 A5 JP 2017505116A5 JP 2016542739 A JP2016542739 A JP 2016542739A JP 2016542739 A JP2016542739 A JP 2016542739A JP 2017505116 A5 JP2017505116 A5 JP 2017505116A5
- Authority
- JP
- Japan
- Prior art keywords
- modified oligonucleotide
- compound
- wing segment
- modified
- linked nucleosides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 46
- 229920000272 Oligonucleotide Polymers 0.000 claims description 44
- 239000002777 nucleoside Substances 0.000 claims description 40
- 125000003835 nucleoside group Chemical group 0.000 claims description 29
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 11
- 230000000295 complement Effects 0.000 claims description 10
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims description 9
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-Methylcytosine Chemical group CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 7
- OPTASPLRGRRNAP-UHFFFAOYSA-N Cytosine Chemical group NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims description 5
- RWQNBRDOKXIBIV-UHFFFAOYSA-N Thymine Chemical group CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims description 4
- 208000008787 Cardiovascular Disease Diseases 0.000 claims description 3
- 208000008466 Metabolic Disease Diseases 0.000 claims description 3
- 201000010870 diseases of metabolism Diseases 0.000 claims description 3
- 102100011247 ANGPTL3 Human genes 0.000 claims description 2
- 101710043744 ANGPTL3 Proteins 0.000 claims description 2
- 229960000643 Adenine Drugs 0.000 claims description 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Natural products NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims description 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N Guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims description 2
- 229940113082 Thymine Drugs 0.000 claims description 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims description 2
- 125000002619 bicyclic group Chemical group 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 208000009576 Hypercholesterolemia Diseases 0.000 claims 2
- 208000008338 Non-alcoholic Fatty Liver Disease Diseases 0.000 claims 2
- 206010053219 Non-alcoholic steatohepatitis Diseases 0.000 claims 2
- 108009000135 Nonalcoholic fatty liver disease Proteins 0.000 claims 2
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 208000004981 Coronary Disease Diseases 0.000 claims 1
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- 206010058108 Dyslipidaemia Diseases 0.000 claims 1
- 206010062060 Hyperlipidaemia Diseases 0.000 claims 1
- 206010061227 Lipid metabolism disease Diseases 0.000 claims 1
- 208000006132 Lipodystrophy Diseases 0.000 claims 1
- 206010024606 Lipodystrophy Diseases 0.000 claims 1
- 206010049287 Lipodystrophy acquired Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 201000001320 atherosclerosis Diseases 0.000 claims 1
- 201000008739 coronary artery disease Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361920652P | 2013-12-24 | 2013-12-24 | |
US61/920,652 | 2013-12-24 | ||
PCT/US2014/072303 WO2015100394A1 (en) | 2013-12-24 | 2014-12-24 | Modulation of angiopoietin-like 3 expression |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020000628A Division JP2020072713A (ja) | 2013-12-24 | 2020-01-07 | アンジオポエチン様3発現の調節 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2017505116A JP2017505116A (ja) | 2017-02-16 |
JP2017505116A5 true JP2017505116A5 (es) | 2018-02-08 |
JP6643996B2 JP6643996B2 (ja) | 2020-02-12 |
Family
ID=53479686
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016542739A Expired - Fee Related JP6643996B2 (ja) | 2013-12-24 | 2014-12-24 | アンジオポエチン様3発現の調節 |
JP2020000628A Pending JP2020072713A (ja) | 2013-12-24 | 2020-01-07 | アンジオポエチン様3発現の調節 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020000628A Pending JP2020072713A (ja) | 2013-12-24 | 2020-01-07 | アンジオポエチン様3発現の調節 |
Country Status (19)
Country | Link |
---|---|
US (3) | US20170037409A1 (es) |
EP (2) | EP3087183B1 (es) |
JP (2) | JP6643996B2 (es) |
KR (2) | KR102198082B1 (es) |
CN (3) | CN111394355A (es) |
AU (2) | AU2014369900B2 (es) |
BR (1) | BR112016013473A2 (es) |
CA (1) | CA2931510A1 (es) |
DK (1) | DK3087183T3 (es) |
ES (1) | ES2830257T3 (es) |
HU (1) | HUE052243T2 (es) |
IL (2) | IL245707B (es) |
MX (1) | MX2016008462A (es) |
NZ (1) | NZ720286A (es) |
PL (1) | PL3087183T3 (es) |
PT (1) | PT3087183T (es) |
RU (1) | RU2706964C2 (es) |
SI (1) | SI3087183T1 (es) |
WO (1) | WO2015100394A1 (es) |
Families Citing this family (24)
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AR087329A1 (es) | 2011-06-17 | 2014-03-19 | Regeneron Pharma | Anticuerpos humanos contra proteina 3 de tipo angiopoietina humana |
PT3087183T (pt) | 2013-12-24 | 2020-10-08 | Ionis Pharmaceuticals Inc | Modulação da expressão da proteína relacionada com angiopoietina 3 |
PT3416684T (pt) * | 2016-02-17 | 2023-07-04 | Regeneron Pharma | Métodos para tratamento ou prevenção da aterosclerose por administração de um inibidor da angptl3 |
CA3021884A1 (en) * | 2016-04-28 | 2017-11-02 | Regeneron Pharmaceuticals, Inc. | Methods for treating patients with familial hypercholesterolemia |
EP4035659A1 (en) | 2016-11-29 | 2022-08-03 | PureTech LYT, Inc. | Exosomes for delivery of therapeutic agents |
US10225273B2 (en) * | 2017-01-27 | 2019-03-05 | International Business Machines Corporation | Secured event monitoring leveraging blockchain |
JP2020508056A (ja) * | 2017-02-22 | 2020-03-19 | クリスパー・セラピューティクス・アクチェンゲゼルシャフトCRISPR Therapeutics AG | 遺伝子編集のための組成物および方法 |
BR112020003126A2 (pt) | 2017-09-14 | 2020-10-13 | Arrowhead Pharmaceuticals, Inc. | agentes de rnai e composições para inibição da expressão de angiopoietina tipo 3 (angptl3), e métodos de uso |
JP2021504415A (ja) | 2017-12-01 | 2021-02-15 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッドSuzhou Ribo Life Science Co., Ltd. | 二本鎖オリゴヌクレオチド、二本鎖オリゴヌクレオチドを含む組成物および複合体ならびに調製方法と使用 |
EP3719126A4 (en) * | 2017-12-01 | 2021-10-20 | Suzhou Ribo Life Science Co., Ltd. | NUCLEIC ACID, COMPOSITION AND CONJUGATE CONTAINING NUCLEIC ACID, ASSOCIATED PREPARATION PROCESS AND USE |
WO2019105419A1 (zh) | 2017-12-01 | 2019-06-06 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
CN116375774A (zh) | 2017-12-29 | 2023-07-04 | 苏州瑞博生物技术股份有限公司 | 缀合物及其制备方法和用途 |
US11918600B2 (en) | 2018-08-21 | 2024-03-05 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition and conjugate containing nucleic acid, and use thereof |
EP3862024A4 (en) | 2018-09-30 | 2022-08-17 | Suzhou Ribo Life Science Co., Ltd. | SHORT INTERFERENT RNA CONJUGATE, METHOD FOR PREPARATION AND USE THEREOF |
WO2020099482A2 (en) * | 2018-11-13 | 2020-05-22 | Lipigon Pharmaceuticals Ab | Angptl 3 oligonucleotides influencing the regulation of the fatty acid metabolism |
WO2020099525A2 (en) * | 2018-11-13 | 2020-05-22 | Lipigon Pharmaceuticals Ab | Oligonucleotides influencing the regulation of the fatty acid metabolism |
CN111973617A (zh) * | 2019-05-23 | 2020-11-24 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
CN116096883A (zh) * | 2020-04-09 | 2023-05-09 | 维乎医疗有限公司 | Angptl3的碱基编辑和使用其治疗疾病的方法 |
US20230383294A1 (en) * | 2020-10-16 | 2023-11-30 | Sanofi | Novel rna compositions and methods for inhibiting angptl3 |
CN113956345B (zh) * | 2021-09-10 | 2024-04-23 | 北京大学 | Angpt4蛋白及其编码基因在调控心脏损伤后的修复与再生能力中的应用 |
US20230193271A1 (en) | 2021-12-22 | 2023-06-22 | Regeneron Pharmaceuticals, Inc. | Treatment Of Kidney Diseases With Angiopoietin Like 3 (ANGPTL3) Inhibitors |
WO2023134705A1 (zh) * | 2022-01-11 | 2023-07-20 | 上海金中锘美生物医药科技有限公司 | 抑制angptl3表达的rna干扰剂及其用途 |
WO2024044542A2 (en) * | 2022-08-22 | 2024-02-29 | Arrowhead Pharmaceuticals, Inc. | Methods for the treatment of angptl3-related diseases and disorders |
WO2024102913A1 (en) | 2022-11-10 | 2024-05-16 | Regeneron Pharmaceuticals, Inc. | Treatment of kidney diseases with a combination of angiopoietin like 3 (angptl3) inhibitors and solute carrier family 5 member 2 (slc5a2) inhibitors |
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- 2014-12-24 CN CN202010264234.2A patent/CN111394355A/zh active Pending
- 2014-12-24 US US15/108,099 patent/US20170037409A1/en not_active Abandoned
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- 2014-12-24 CA CA2931510A patent/CA2931510A1/en active Pending
- 2014-12-24 WO PCT/US2014/072303 patent/WO2015100394A1/en active Application Filing
- 2014-12-24 NZ NZ720286A patent/NZ720286A/en unknown
- 2014-12-24 DK DK14874081.4T patent/DK3087183T3/da active
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- 2014-12-24 KR KR1020167016166A patent/KR102198082B1/ko active IP Right Grant
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