JP2017505104A - インビボにおける薬剤送達のための核酸ナノ構造体 - Google Patents

インビボにおける薬剤送達のための核酸ナノ構造体 Download PDF

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JP2017505104A
JP2017505104A JP2016520077A JP2016520077A JP2017505104A JP 2017505104 A JP2017505104 A JP 2017505104A JP 2016520077 A JP2016520077 A JP 2016520077A JP 2016520077 A JP2016520077 A JP 2016520077A JP 2017505104 A JP2017505104 A JP 2017505104A
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nucleic acid
optionally substituted
nanostructure
acid nanostructure
nanocapsule
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JP2017505104A5 (cg-RX-API-DMAC7.html
Inventor
シー，ウィリアム，エム．
ポヌスワミー，ナンディニ
バスティングズ，マールテ，エム．
Original Assignee
デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド
デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド
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Publication of JP2017505104A publication Critical patent/JP2017505104A/ja
Publication of JP2017505104A5 publication Critical patent/JP2017505104A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6025—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
JP2016520077A 2013-11-08 2014-11-07 インビボにおける薬剤送達のための核酸ナノ構造体 Ceased JP2017505104A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361901820P 2013-11-08 2013-11-08
US61/901,820 2013-11-08
US201462021256P 2014-07-07 2014-07-07
US201462021257P 2014-07-07 2014-07-07
US62/021,256 2014-07-07
US62/021,257 2014-07-07
PCT/US2014/064659 WO2015070080A2 (en) 2013-11-08 2014-11-07 Nucleic acid nanostructures for in vivo agent delivery

Related Child Applications (1)

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JP2019177043A Division JP2020022465A (ja) 2013-11-08 2019-09-27 インビボにおける薬剤送達のための核酸ナノ構造体

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JP2017505104A true JP2017505104A (ja) 2017-02-16
JP2017505104A5 JP2017505104A5 (cg-RX-API-DMAC7.html) 2017-12-07

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JP2016520077A Ceased JP2017505104A (ja) 2013-11-08 2014-11-07 インビボにおける薬剤送達のための核酸ナノ構造体
JP2019177043A Pending JP2020022465A (ja) 2013-11-08 2019-09-27 インビボにおける薬剤送達のための核酸ナノ構造体

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Country Status (5)

Country Link
US (1) US20160271268A1 (cg-RX-API-DMAC7.html)
EP (1) EP3065722A4 (cg-RX-API-DMAC7.html)
JP (2) JP2017505104A (cg-RX-API-DMAC7.html)
CN (1) CN105705143A (cg-RX-API-DMAC7.html)
WO (1) WO2015070080A2 (cg-RX-API-DMAC7.html)

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JP2020191806A (ja) * 2019-05-27 2020-12-03 国立研究開発法人理化学研究所 ナノデバイス、フォースセンサ、力の測定方法、および試薬キット

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MA39970A (fr) 2014-05-14 2015-11-19 Alex Levitzki Man And Holdings Ltd Vecteurs améliorés a base de polyéthylèneimine polyéthylèneglycol
WO2017024239A1 (en) * 2015-08-06 2017-02-09 City Of Hope Therapeutic cell internalizing conjugates
US20190083522A1 (en) * 2016-03-10 2019-03-21 President And Fellows Of Harvard College Biosynthetic modules
EP3967651A1 (en) 2016-03-11 2022-03-16 Children's Medical Center Corporation Nucleic acid nanoswitch catenanes
US11513076B2 (en) * 2016-06-15 2022-11-29 Ludwig-Maximilians-Universität München Single molecule detection or quantification using DNA nanotechnology
CN115948505B (zh) 2016-08-02 2025-07-25 哈佛学院院长及董事 交叉协同自组装体
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
WO2018124423A1 (ko) * 2016-12-30 2018-07-05 주식회사 삼양바이오팜 플라스미드 디엔에이 전달용 고분자 나노입자 조성물 및 그의 제조방법
WO2020210468A1 (en) 2019-04-10 2020-10-15 President And Fellows Of Harvard College Nucleic acid nanostructures crosslinked with oligolysine
WO2020247724A1 (en) * 2019-06-07 2020-12-10 Dana-Farber Cancer Institute, Inc. Dna nanostructure-based vaccines
CN111172146B (zh) * 2020-01-15 2023-09-12 苏州朴衡科技有限公司 纳米级人工抗原呈递细胞αCD3-Origami aAPC及其制备方法和应用
US20210380988A1 (en) * 2020-05-13 2021-12-09 University Of Massachusetts Reducing Prominin2-Mediated Resistance to Ferroptotic Cell Death
EP4019633A1 (en) 2020-12-23 2022-06-29 Technische Universität München Conditional cell connectors
EP4216220A1 (en) * 2022-01-25 2023-07-26 Leica Microsystems CMS GmbH Data storage device and method for storing data
WO2024044663A2 (en) * 2022-08-25 2024-02-29 Ohio State Innovation Foundation Peptide and nucleic acid methods to modulate delivery of nucleic acid structures, polypeptides, and their cargoes
WO2024259439A1 (en) * 2023-06-16 2024-12-19 University Of Connecticut Nucleic acid nanocapsules for drug delivery

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020191806A (ja) * 2019-05-27 2020-12-03 国立研究開発法人理化学研究所 ナノデバイス、フォースセンサ、力の測定方法、および試薬キット
JP7272643B2 (ja) 2019-05-27 2023-05-12 国立研究開発法人理化学研究所 ナノデバイス、フォースセンサ、力の測定方法、および試薬キット

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CN105705143A (zh) 2016-06-22
EP3065722A4 (en) 2017-11-15
EP3065722A2 (en) 2016-09-14
WO2015070080A2 (en) 2015-05-14
JP2020022465A (ja) 2020-02-13
WO2015070080A3 (en) 2015-12-23
US20160271268A1 (en) 2016-09-22

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