JP2017503835A5 - - Google Patents
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- Publication number
- JP2017503835A5 JP2017503835A5 JP2016548111A JP2016548111A JP2017503835A5 JP 2017503835 A5 JP2017503835 A5 JP 2017503835A5 JP 2016548111 A JP2016548111 A JP 2016548111A JP 2016548111 A JP2016548111 A JP 2016548111A JP 2017503835 A5 JP2017503835 A5 JP 2017503835A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- cycloalkyl
- macular degeneration
- alkyl
- age
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 208000002780 macular degeneration Diseases 0.000 claims 5
- 208000005590 Choroidal Neovascularization Diseases 0.000 claims 4
- 206010060823 Choroidal neovascularisation Diseases 0.000 claims 4
- 206010064930 age-related macular degeneration Diseases 0.000 claims 4
- 206010063381 Polypoidal choroidal vasculopathy Diseases 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 208000001344 Macular Edema Diseases 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000002207 retinal effect Effects 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- 125000006660 (C3-C4) halocycloalkyl group Chemical group 0.000 claims 1
- 206010003226 Arteriovenous fistula Diseases 0.000 claims 1
- 206010003591 Ataxia Diseases 0.000 claims 1
- 206010003694 Atrophy Diseases 0.000 claims 1
- 206010058202 Cystoid macular oedema Diseases 0.000 claims 1
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims 1
- 241001317099 Dystaxia Species 0.000 claims 1
- 206010052139 Eye oedema Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 206010072138 Limbal stem cell deficiency Diseases 0.000 claims 1
- 206010025415 Macular oedema Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010029113 Neovascularisation Diseases 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 206010064714 Radiation retinopathy Diseases 0.000 claims 1
- 208000007135 Retinal Neovascularization Diseases 0.000 claims 1
- 201000001949 Retinal Vasculitis Diseases 0.000 claims 1
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 1
- 206010038935 Retinopathy sickle cell Diseases 0.000 claims 1
- 206010043087 Tachyphylaxis Diseases 0.000 claims 1
- 208000034698 Vitreous haemorrhage Diseases 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 206010003230 arteritis Diseases 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 206010072959 birdshot chorioretinopathy Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 201000010206 cystoid macular edema Diseases 0.000 claims 1
- 201000011190 diabetic macular edema Diseases 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 230000007954 hypoxia Effects 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 208000037818 intermediate age-related macular degeneration Diseases 0.000 claims 1
- 201000010230 macular retinal edema Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000002969 morbid Effects 0.000 claims 1
- 208000001491 myopia Diseases 0.000 claims 1
- 230000004379 myopia Effects 0.000 claims 1
- 201000003142 neovascular glaucoma Diseases 0.000 claims 1
- 230000000414 obstructive effect Effects 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
- 201000007714 retinoschisis Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 238000009736 wetting Methods 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
- 0 *C(IN(*)C(c1c(*)c(I)c(*)cn1)=O)=O Chemical compound *C(IN(*)C(c1c(*)c(I)c(*)cn1)=O)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461930811P | 2014-01-23 | 2014-01-23 | |
| US61/930,811 | 2014-01-23 | ||
| PCT/US2015/012634 WO2015112831A1 (en) | 2014-01-23 | 2015-01-23 | Compositions and methods for treating ocular diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017503835A JP2017503835A (ja) | 2017-02-02 |
| JP2017503835A5 true JP2017503835A5 (enExample) | 2018-03-08 |
Family
ID=53681968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016548111A Pending JP2017503835A (ja) | 2014-01-23 | 2015-01-23 | 眼球疾患治療のための組成物及び方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20160339005A1 (enExample) |
| EP (1) | EP3096617A4 (enExample) |
| JP (1) | JP2017503835A (enExample) |
| KR (1) | KR20160108554A (enExample) |
| CN (1) | CN106132201A (enExample) |
| AU (1) | AU2015209264A1 (enExample) |
| CA (1) | CA2937349A1 (enExample) |
| IL (1) | IL246791A0 (enExample) |
| MX (1) | MX2016009331A (enExample) |
| RU (1) | RU2016133980A (enExample) |
| WO (1) | WO2015112831A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ623002A (en) | 2006-06-26 | 2015-08-28 | Akebia Therapeutics Inc | Prolyl hydroxylase inhibitors and methods of use |
| NO2686520T3 (enExample) | 2011-06-06 | 2018-03-17 | ||
| HUE066123T2 (hu) | 2013-06-13 | 2024-07-28 | Akebia Therapeutics Inc | Készítmények és módszerek anémia kezelésére |
| TWI665190B (zh) | 2013-11-15 | 2019-07-11 | 阿克比治療有限公司 | ｛［５－（３－氯苯基）－３－羥基吡啶－２－羰基］胺基｝乙酸之固體型式，其組合物及用途 |
| CA2974691A1 (en) | 2015-01-23 | 2016-07-28 | Akebia Therapeutics, Inc. | Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof |
| NZ735973A (en) | 2015-04-01 | 2023-06-30 | Akebia Therapeutics Inc | Compositions and methods for treating anemia |
| KR20180036580A (ko) | 2016-09-30 | 2018-04-09 | 주식회사 유스바이오팜 | 수가용화(水加溶化)된 우르소데옥시콜산을 함유하는 염증성 피부질환 또는 중증 소양증 예방 또는 치료용 조성물 |
| KR102252450B1 (ko) | 2017-02-09 | 2021-05-14 | 주식회사 아미코젠파마 | 우르소데옥시콜산을 함유하는 시각장애 예방 또는 치료용 조성물 |
| SG11201907490XA (en) * | 2017-02-27 | 2019-09-27 | Regeneron Pharma | Non-human animal models of retinoschisis |
| JP7216006B2 (ja) * | 2017-03-22 | 2023-01-31 | ジェネンテック， インコーポレイテッド | ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法 |
| ES2870106T3 (es) * | 2017-05-05 | 2021-10-26 | Zealand Pharma As | Moduladores de la comunicación intercelular de uniones comunicantes y su uso para el tratamiento de la enfermedad del ojo diabético |
| US20220409606A1 (en) * | 2017-06-15 | 2022-12-29 | The Trustees Of Columbia University In The City Of New York | Treatment of neurodegeneration via reprogramming metabolism by inhibiting phd |
| KR102050506B1 (ko) | 2017-06-20 | 2019-11-29 | 한국식품연구원 | 망막 질환 예방, 개선, 완화 또는 치료용 조성물 |
| WO2019213326A1 (en) * | 2018-05-01 | 2019-11-07 | Idrop, Inc. | Eye drop formulation and method for sustained delivery of medicament to the retina |
| US11713298B2 (en) | 2018-05-09 | 2023-08-01 | Akebia Therapeutics, Inc. | Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid |
| JP2021533148A (ja) * | 2018-08-21 | 2021-12-02 | カリフォルニア インスティチュート オブ テクノロジー | 非漏出性または最小漏出性の脈絡膜または網膜脈管再生 |
| JP7280353B2 (ja) * | 2018-11-02 | 2023-05-23 | キョンブク ナショナル ユニバーシティ インダストリー－アカデミック コーオペレーション ファウンデーション | 黄斑変性予防又は治療用組成物 |
| EP3875092B1 (en) | 2018-11-02 | 2025-11-19 | Kyungpook National University Industry-Academic Cooperation Foundation | Composition for prevention or treatment of macular degeneration |
| IL283127B2 (en) * | 2018-11-14 | 2026-06-01 | Smilebiotek Zhuhai Ltd | Animal models, screening methods, and treatment methods for intraocular diseases or disorders |
| CN111308001B (zh) * | 2018-12-11 | 2024-11-29 | 上海市第一人民医院 | 人黄斑新生血管性疾病的代谢标记物及其应用 |
| TWI859339B (zh) | 2019-09-24 | 2024-10-21 | 德商百靈佳殷格翰國際股份有限公司 | 抗nrp1a抗體及其用於治療眼或眼部疾病之用途 |
| US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
| US12612367B2 (en) | 2019-12-10 | 2026-04-28 | Akebia Therapeutics, Inc. | Method for producing nitrogen-containing heteroarylcarboxamide acetic acid derivative |
| CA3168810A1 (en) * | 2020-02-06 | 2021-08-12 | Perfuse Therapeutics, Inc. | Compositions for treatment of ocular diseases |
| WO2021216530A1 (en) | 2020-04-20 | 2021-10-28 | Akebia Therapeutics, Inc. | Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer |
| WO2022221315A1 (en) * | 2021-04-13 | 2022-10-20 | Unity Biotechnology, Inc. | Methods of treating retinal vasculopathies |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19650215A1 (de) * | 1996-12-04 | 1998-06-10 | Hoechst Ag | 3-Hydroxypyridin-2-carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US7625927B2 (en) * | 2006-02-27 | 2009-12-01 | Alcon Research, Ltd. | Method of treating glaucoma |
| NZ623002A (en) * | 2006-06-26 | 2015-08-28 | Akebia Therapeutics Inc | Prolyl hydroxylase inhibitors and methods of use |
| WO2009035534A2 (en) * | 2007-09-07 | 2009-03-19 | The Cleveland Clinic Foundation | Treatment of ischemic eye disease by the systematic pharmaceutical activation of hypoxia inducible factor (hif) |
| CN103717214A (zh) * | 2011-06-06 | 2014-04-09 | 阿克比治疗有限公司 | 用于稳定低氧诱导因子-2α作为治疗癌症的方法的化合物和组合物 |
| TWI665190B (zh) * | 2013-11-15 | 2019-07-11 | 阿克比治療有限公司 | ｛［５－（３－氯苯基）－３－羥基吡啶－２－羰基］胺基｝乙酸之固體型式，其組合物及用途 |
-
2015
- 2015-01-23 RU RU2016133980A patent/RU2016133980A/ru not_active Application Discontinuation
- 2015-01-23 KR KR1020167022741A patent/KR20160108554A/ko not_active Withdrawn
- 2015-01-23 WO PCT/US2015/012634 patent/WO2015112831A1/en not_active Ceased
- 2015-01-23 JP JP2016548111A patent/JP2017503835A/ja active Pending
- 2015-01-23 US US15/112,954 patent/US20160339005A1/en not_active Abandoned
- 2015-01-23 CA CA2937349A patent/CA2937349A1/en not_active Abandoned
- 2015-01-23 EP EP15740401.3A patent/EP3096617A4/en not_active Withdrawn
- 2015-01-23 MX MX2016009331A patent/MX2016009331A/es unknown
- 2015-01-23 CN CN201580015037.4A patent/CN106132201A/zh active Pending
- 2015-01-23 AU AU2015209264A patent/AU2015209264A1/en not_active Abandoned
-
2016
- 2016-07-14 IL IL246791A patent/IL246791A0/en unknown