JP2017503803A - Ｅｇｆｒ発現腫瘍を処置するための化合物及び組成物 - Google Patents

Ｅｇｆｒ発現腫瘍を処置するための化合物及び組成物 Download PDF

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JP2017503803A
JP2017503803A JP2016545802A JP2016545802A JP2017503803A JP 2017503803 A JP2017503803 A JP 2017503803A JP 2016545802 A JP2016545802 A JP 2016545802A JP 2016545802 A JP2016545802 A JP 2016545802A JP 2017503803 A JP2017503803 A JP 2017503803A
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alkyl
imidazo
amino
quinolin
ethoxymethyl
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JP2017503803A5 (https=
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リ、リシン
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シャンハイ バーディー バイオテック インコーポレイテッド
シャンハイ バーディー バイオテック インコーポレイテッド
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Priority claimed from CN201410011362.0A external-priority patent/CN104861064A/zh
Priority claimed from CN201410011324.5A external-priority patent/CN104861067A/zh
Priority claimed from CN201410011262.8A external-priority patent/CN104861063A/zh
Application filed by シャンハイ バーディー バイオテック インコーポレイテッド, シャンハイ バーディー バイオテック インコーポレイテッド filed Critical シャンハイ バーディー バイオテック インコーポレイテッド
Publication of JP2017503803A publication Critical patent/JP2017503803A/ja
Publication of JP2017503803A5 publication Critical patent/JP2017503803A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2016545802A 2014-01-10 2015-01-08 Ｅｇｆｒ発現腫瘍を処置するための化合物及び組成物 Withdrawn JP2017503803A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN201410011262.8 2014-01-10
CN201410011324.5 2014-01-10
CN201410011362.0A CN104861064A (zh) 2014-01-10 2014-01-10 靶向表达egfr的肿瘤的化合物和组合物
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