JP2017503749A5 - - Google Patents
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- Publication number
- JP2017503749A5 JP2017503749A5 JP2016519779A JP2016519779A JP2017503749A5 JP 2017503749 A5 JP2017503749 A5 JP 2017503749A5 JP 2016519779 A JP2016519779 A JP 2016519779A JP 2016519779 A JP2016519779 A JP 2016519779A JP 2017503749 A5 JP2017503749 A5 JP 2017503749A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- cyclic
- acyclic
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361885384P | 2013-10-01 | 2013-10-01 | |
| US61/885,384 | 2013-10-01 | ||
| US201461934618P | 2014-01-31 | 2014-01-31 | |
| US61/934,618 | 2014-01-31 | ||
| PCT/US2014/058680 WO2015051030A2 (en) | 2013-10-01 | 2014-10-01 | Stabilized polypeptides and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017503749A JP2017503749A (ja) | 2017-02-02 |
| JP2017503749A5 true JP2017503749A5 (enExample) | 2018-08-30 |
Family
ID=52779285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016519779A Pending JP2017503749A (ja) | 2013-10-01 | 2014-10-01 | 安定化されたポリペプチドおよびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20160244494A1 (enExample) |
| EP (1) | EP3052520A4 (enExample) |
| JP (1) | JP2017503749A (enExample) |
| CN (1) | CN106103472A (enExample) |
| IL (1) | IL244810A0 (enExample) |
| WO (1) | WO2015051030A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| EP2118123B1 (en) | 2007-01-31 | 2015-10-14 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| EP3159352B1 (en) | 2007-03-28 | 2023-08-02 | President and Fellows of Harvard College | Stitched polypeptides |
| KR102104762B1 (ko) | 2010-08-13 | 2020-04-24 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| NZ627528A (en) | 2012-02-15 | 2016-05-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles |
| CA2864120A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| WO2014138429A2 (en) | 2013-03-06 | 2014-09-12 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and use thereof in regulating hif1alpha |
| CN105764491A (zh) | 2013-12-09 | 2016-07-13 | 度瑞公司 | 药物活性剂复合物、聚合物复合物，以及包括其的组合物和方法 |
| KR20170058424A (ko) | 2014-09-24 | 2017-05-26 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방 거대고리 및 이의 용도 |
| MX389354B (es) | 2014-09-24 | 2025-03-20 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos y formulaciones de los mismos. |
| SG11201707750YA (en) | 2015-03-20 | 2017-10-30 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
| WO2017004548A1 (en) | 2015-07-01 | 2017-01-05 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| CN110114075B (zh) | 2016-11-09 | 2024-01-12 | 俄亥俄州国家创新基金会 | 含有二硫化物的细胞穿透肽及其制备和使用方法 |
| WO2018098282A2 (en) | 2016-11-22 | 2018-05-31 | Ohio State Innovation Foundation | Cyclic cell penetrating peptides comprising beta-hairpin motifs and methods of making and using thereof |
| WO2018098226A1 (en) | 2016-11-22 | 2018-05-31 | Ohio State Innovation Foundation | Bicyclic peptidyl inhibitor of tumor necrosis factor-alpha |
| KR20200064075A (ko) | 2017-09-07 | 2020-06-05 | 포그 파마슈티컬스 인코포레이티드 | 베타-카테닌 기능을 조절하는 제제 및 이의 방법 |
| US11339192B2 (en) | 2017-10-04 | 2022-05-24 | Ohio State Innovation Foundation | Bicyclic peptidyl inhibitors |
| CA3078682A1 (en) | 2017-12-15 | 2019-06-20 | Dana-Farber Cancer Institute, Inc. | Stabilized peptide-mediated targeted protein degradation |
| WO2019136209A1 (en) * | 2018-01-05 | 2019-07-11 | President And Fellows Of Harvard College | Stabilized polypeptides and uses thereof |
| EP3749678A1 (en) | 2018-02-07 | 2020-12-16 | Dana Farber Cancer Institute, Inc. | Cell-permeable stapled peptide modules for cellular delivery |
| EP3790890A4 (en) | 2018-05-09 | 2022-03-02 | Ohio State Innovation Foundation | CYCLIC PEPTIDES OF CELL PENETRATION WITH ONE OR MORE HYDROPHOBIC RESIDUES |
| WO2020023502A1 (en) | 2018-07-23 | 2020-01-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| CN113039195A (zh) | 2018-08-20 | 2021-06-25 | 弗格制药有限公司 | 肽集合、肽试剂及其使用方法 |
| WO2022092295A1 (ja) * | 2020-10-30 | 2022-05-05 | Ｘｅｎｏ－Ｉｎｔｅｒｆａｃｅ株式会社 | βストランド型架橋ペプチド |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2367475T3 (es) * | 1999-10-15 | 2011-11-03 | Avatar Medical, L.L.C. | Proteínas estabilizadas. |
| PT2332968T (pt) * | 2003-11-05 | 2016-08-17 | Harvard College | Péptidos alfa-helicoidais adequados para a activação ou inibição da morte celular |
| DK1689863T3 (da) * | 2003-11-15 | 2014-08-25 | Polyphor Ltd | Template-fikserede beta-hairpinloopmimetika og deres anvendelse i fag-display |
| WO2005118620A2 (en) * | 2004-05-27 | 2005-12-15 | New York University | Methods for preparing internally constraied peptides and peptidomimetics |
| WO2006069001A2 (en) * | 2004-12-20 | 2006-06-29 | Baylor College Of Medicine | Structural requirements for stat3 binding and recruitment to phosphototyrosine ligands |
| EP3159352B1 (en) * | 2007-03-28 | 2023-08-02 | President and Fellows of Harvard College | Stitched polypeptides |
| WO2010011313A2 (en) * | 2008-07-23 | 2010-01-28 | President And Fellows Of Harvard College | Ligation of stapled polypeptides |
| WO2011008260A2 (en) * | 2009-07-13 | 2011-01-20 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
| WO2011163423A2 (en) * | 2010-06-22 | 2011-12-29 | University Of Central Florida Research Foundation, Inc. | Methods and compositions for cell permeable stat3 inhibitor |
-
2014
- 2014-10-01 EP EP14850442.6A patent/EP3052520A4/en not_active Withdrawn
- 2014-10-01 JP JP2016519779A patent/JP2017503749A/ja active Pending
- 2014-10-01 CN CN201480065507.3A patent/CN106103472A/zh active Pending
- 2014-10-01 WO PCT/US2014/058680 patent/WO2015051030A2/en not_active Ceased
- 2014-10-01 US US15/026,473 patent/US20160244494A1/en not_active Abandoned
-
2016
- 2016-03-29 IL IL244810A patent/IL244810A0/en unknown
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