JP2017503749A - 安定化されたポリペプチドおよびその使用 - Google Patents

安定化されたポリペプチドおよびその使用 Download PDF

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Publication number
JP2017503749A
JP2017503749A JP2016519779A JP2016519779A JP2017503749A JP 2017503749 A JP2017503749 A JP 2017503749A JP 2016519779 A JP2016519779 A JP 2016519779A JP 2016519779 A JP2016519779 A JP 2016519779A JP 2017503749 A JP2017503749 A JP 2017503749A
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Japan
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substituted
unsubstituted
cyclic
acyclic
branched
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English (en)
Japanese (ja)
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JP2017503749A5 (enExample
Inventor
ヴァーダイン，グレゴリー，エル．
ナーゲル，イボンヌ，アリス
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Harvard University
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Harvard University
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Publication of JP2017503749A publication Critical patent/JP2017503749A/ja
Publication of JP2017503749A5 publication Critical patent/JP2017503749A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016519779A 2013-10-01 2014-10-01 安定化されたポリペプチドおよびその使用 Pending JP2017503749A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361885384P 2013-10-01 2013-10-01
US61/885,384 2013-10-01
US201461934618P 2014-01-31 2014-01-31
US61/934,618 2014-01-31
PCT/US2014/058680 WO2015051030A2 (en) 2013-10-01 2014-10-01 Stabilized polypeptides and uses thereof

Publications (2)

Publication Number Publication Date
JP2017503749A true JP2017503749A (ja) 2017-02-02
JP2017503749A5 JP2017503749A5 (enExample) 2018-08-30

Family

ID=52779285

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016519779A Pending JP2017503749A (ja) 2013-10-01 2014-10-01 安定化されたポリペプチドおよびその使用

Country Status (6)

Country Link
US (1) US20160244494A1 (enExample)
EP (1) EP3052520A4 (enExample)
JP (1) JP2017503749A (enExample)
CN (1) CN106103472A (enExample)
IL (1) IL244810A0 (enExample)
WO (1) WO2015051030A2 (enExample)

Cited By (1)

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JPWO2022092295A1 (enExample) * 2020-10-30 2022-05-05

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US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
PL2118123T3 (pl) 2007-01-31 2016-06-30 Dana Farber Cancer Inst Inc Stabilizowane peptydy p53 i ich zastosowania
JP5631201B2 (ja) 2007-03-28 2014-11-26 プレジデント アンド フェローズ オブ ハーバード カレッジ ステッチングされたポリペプチド
KR102104762B1 (ko) 2010-08-13 2020-04-24 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
EP2768518A4 (en) 2011-10-18 2015-05-27 Aileron Therapeutics Inc PEPTIDOMIMETIC MACROCYCLES
RU2642299C2 (ru) 2012-02-15 2018-01-24 Эйлерон Терапьютикс, Инк. P53 пептидомиметические макроциклы
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
WO2014138429A2 (en) 2013-03-06 2014-09-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and use thereof in regulating hif1alpha
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
EP3197478A4 (en) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN107106642B (zh) 2014-09-24 2021-02-26 艾瑞朗医疗公司 拟肽大环化合物及其制剂
JP2018516844A (ja) 2015-03-20 2018-06-28 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその使用
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2018089648A2 (en) 2016-11-09 2018-05-17 Ohio State Innovation Foundation Di-sulfide containing cell penetrating peptides and methods of making and using thereof
US10913773B2 (en) 2016-11-22 2021-02-09 Ohio State Innovation Foundation Bicyclic peptidyl inhibitor of tumor necrosis factor-alpha
US11352394B2 (en) 2016-11-22 2022-06-07 Ohio State Innovation Foundation Cyclic cell penetrating peptides comprising beta-hairpin motifs and methods of making and using thereof
EA202090513A1 (ru) 2017-09-07 2020-08-24 Фог Фармасьютикалз, Инк. Агенты, модулирующие функции бета-катенина, и связанные способы
WO2019070962A1 (en) 2017-10-04 2019-04-11 Ohio State Innovation Foundation BICYCLIC PEPTIDE INHIBITORS
WO2019118893A1 (en) 2017-12-15 2019-06-20 Dana-Farber Cancer Institute, Inc. Stabilized peptide-mediated targeted protein degradation
WO2019136209A1 (en) * 2018-01-05 2019-07-11 President And Fellows Of Harvard College Stabilized polypeptides and uses thereof
US11793884B2 (en) 2018-01-29 2023-10-24 Ohio State Innovation Foundation Cyclic peptidyl inhibitors of CAL-PDZ binding domain
WO2019157131A1 (en) 2018-02-07 2019-08-15 Dana-Farber Cancer Institute, Inc. Cell-permeable stapled peptide modules for cellular delivery
WO2019217682A1 (en) 2018-05-09 2019-11-14 Ohio State Innovation Foundation Cyclic cell-penetrating peptides with one or more hydrophobic residues
WO2020023502A1 (en) 2018-07-23 2020-01-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
EP3838924A4 (en) * 2018-07-31 2022-06-22 Lemonex Inc. POLYPEPTIDE DELIVERY COMPOSITION
BR112021003113A2 (pt) 2018-08-20 2021-05-11 Fog Pharmaceuticals, Inc. coleções de peptídeos, agentes de peptídeos e métodos de uso dos mesmos

Citations (5)

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WO2005118620A2 (en) * 2004-05-27 2005-12-15 New York University Methods for preparing internally constraied peptides and peptidomimetics
JP2008500260A (ja) * 2003-11-15 2008-01-10 ポリファー リミテッド テンプレート固定β−ヘアピンループ模倣体とそのファージディスプレイにおける使用
JP2010522769A (ja) * 2007-03-28 2010-07-08 プレジデント アンド フェロウズ オブ ハーバード カレッジ ステッチングされたポリペプチド
JP2012532929A (ja) * 2009-07-13 2012-12-20 プレジデント アンド フェロウズ オブ ハーバード カレッジ 二機能性のステープリングされたポリペプチドおよびそれらの使用
US20130177979A1 (en) * 2010-06-22 2013-07-11 University Of Central Florida Research Foundation, Inc. Methods and compositions for cell permeable stat3 inhibitor

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WO2001029247A1 (en) * 1999-10-15 2001-04-26 Avatar Medical, Llc Stabilized proteins
WO2005044839A2 (en) * 2003-11-05 2005-05-19 Dana-Farber Cancer Institute, Inc. Stabilized alpha helical peptides and uses thereof
WO2006069001A2 (en) * 2004-12-20 2006-06-29 Baylor College Of Medicine Structural requirements for stat3 binding and recruitment to phosphototyrosine ligands
US20110144306A1 (en) * 2008-07-23 2011-06-16 President And Fellows Of Harvard College Ligation of stapled polypeptides

Patent Citations (5)

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JP2008500260A (ja) * 2003-11-15 2008-01-10 ポリファー リミテッド テンプレート固定β−ヘアピンループ模倣体とそのファージディスプレイにおける使用
WO2005118620A2 (en) * 2004-05-27 2005-12-15 New York University Methods for preparing internally constraied peptides and peptidomimetics
JP2010522769A (ja) * 2007-03-28 2010-07-08 プレジデント アンド フェロウズ オブ ハーバード カレッジ ステッチングされたポリペプチド
JP2012532929A (ja) * 2009-07-13 2012-12-20 プレジデント アンド フェロウズ オブ ハーバード カレッジ 二機能性のステープリングされたポリペプチドおよびそれらの使用
US20130177979A1 (en) * 2010-06-22 2013-07-11 University Of Central Florida Research Foundation, Inc. Methods and compositions for cell permeable stat3 inhibitor

Non-Patent Citations (2)

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Title
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NATURE, vol. 394, JPN6019028604, 1998, pages 145 - 151, ISSN: 0004241557 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2022092295A1 (enExample) * 2020-10-30 2022-05-05
WO2022092295A1 (ja) * 2020-10-30 2022-05-05 Ｘｅｎｏ－Ｉｎｔｅｒｆａｃｅ株式会社 βストランド型架橋ペプチド

Also Published As

Publication number Publication date
IL244810A0 (en) 2016-05-31
WO2015051030A2 (en) 2015-04-09
CN106103472A (zh) 2016-11-09
WO2015051030A3 (en) 2015-06-25
EP3052520A4 (en) 2017-12-06
EP3052520A2 (en) 2016-08-10
US20160244494A1 (en) 2016-08-25
WO2015051030A8 (en) 2015-05-07

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