JP2017503024A5 - - Google Patents
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- Publication number
- JP2017503024A5 JP2017503024A5 JP2016562455A JP2016562455A JP2017503024A5 JP 2017503024 A5 JP2017503024 A5 JP 2017503024A5 JP 2016562455 A JP2016562455 A JP 2016562455A JP 2016562455 A JP2016562455 A JP 2016562455A JP 2017503024 A5 JP2017503024 A5 JP 2017503024A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- formula
- member selected
- cyano
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C[C@](CCC1CC1)CCC=C(C1)[C@]1C(C1)C1[C@@](C1)[C@@]1(C)C1=CC[C@@](*)C1 Chemical compound C[C@](CCC1CC1)CCC=C(C1)[C@]1C(C1)C1[C@@](C1)[C@@]1(C)C1=CC[C@@](*)C1 0.000 description 9
- KYUDTBPIZLFHNU-UHFFFAOYSA-N CC(C)c(cc1)cnc1F Chemical compound CC(C)c(cc1)cnc1F KYUDTBPIZLFHNU-UHFFFAOYSA-N 0.000 description 1
- NWEJXSNMXOLSTN-UHFFFAOYSA-N CC1=CCC(C(F)(F)F)C(F)=C1 Chemical compound CC1=CCC(C(F)(F)F)C(F)=C1 NWEJXSNMXOLSTN-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461924119P | 2014-01-06 | 2014-01-06 | |
| US61/924,119 | 2014-01-06 | ||
| PCT/US2014/072291 WO2015103060A1 (en) | 2014-01-06 | 2014-12-23 | Trpa1 modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017503024A JP2017503024A (ja) | 2017-01-26 |
| JP2017503024A5 true JP2017503024A5 (OSRAM) | 2018-02-08 |
| JP6626454B2 JP6626454B2 (ja) | 2019-12-25 |
Family
ID=53493929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016562455A Active JP6626454B2 (ja) | 2014-01-06 | 2014-12-23 | Ｔｒｐａ１モジュレーター |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9951046B2 (OSRAM) |
| EP (1) | EP3092228A4 (OSRAM) |
| JP (1) | JP6626454B2 (OSRAM) |
| CN (1) | CN106061969B (OSRAM) |
| AU (1) | AU2014374043B2 (OSRAM) |
| CA (1) | CA2936111C (OSRAM) |
| IL (1) | IL246625B (OSRAM) |
| SG (1) | SG11201605559VA (OSRAM) |
| WO (1) | WO2015103060A1 (OSRAM) |
| ZA (1) | ZA201605332B (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2936111C (en) | 2014-01-06 | 2023-03-14 | Algomedix, Inc. | Trpa1 modulators |
| CA3006434C (en) * | 2015-11-27 | 2021-03-16 | Taiho Pharmaceutical Co., Ltd. | Biphenyl compound or salt thereof |
| EP3481808A4 (en) * | 2016-07-06 | 2020-07-15 | Algomedix, Inc. | TRPA1 ANTAGONISTS FOR THE TREATMENT OF DRY EYE SYNDROME, EYE PAIN AND INFLAMMATION |
| CN106580984A (zh) * | 2016-12-12 | 2017-04-26 | 高群 | 一种治疗高血脂症的药物组合物 |
| JP7178357B2 (ja) * | 2017-03-07 | 2022-11-25 | エフ．ホフマン－ラ ロシュ アーゲー | オキサジアゾール一過性受容器電位チャネル阻害剤 |
| HUE062769T2 (hu) | 2017-05-26 | 2023-12-28 | Taiho Pharmaceutical Co Ltd | Antitumor potenciátor bifenil vegyület felhasználásával |
| CN110740991B (zh) | 2017-05-26 | 2023-07-04 | 大鹏药品工业株式会社 | 新型联苯化合物或其盐 |
| EP3633380A4 (en) | 2017-05-31 | 2021-02-24 | Taiho Pharmaceutical Co., Ltd. | METHOD OF PREDICTING THE THERAPEUTIC EFFECT OF LSD1 INHIBITORS ON THE BASIS OF THE EXPRESSION OF INSM1 |
| CN109596818B (zh) * | 2018-12-13 | 2024-03-19 | 丁蓉 | 一种基于电生理学分析当归四逆汤预防奥沙利铂神经毒性机制的研究方法 |
| WO2021095840A1 (en) | 2019-11-13 | 2021-05-20 | Taiho Pharmaceutical Co., Ltd. | METHODS OF TREATING LSD1-RELATED DISEASES and Disorders WITH LSD1 INHIBITORS |
| JP7688339B2 (ja) * | 2020-01-22 | 2025-06-04 | 国立研究開発法人理化学研究所 | 新規化合物、およびその利用 |
| FR3114235A1 (fr) | 2020-09-18 | 2022-03-25 | Université Grenoble Alpes | Inhibition du canal trpa1 astrocytaire comme nouvelle cible therapeutique neuroprotectrice dans les phases prodromales de la maladie d’alzheimer |
| CN112694436B (zh) * | 2020-12-30 | 2022-07-08 | 济南周行医药科技有限公司 | 一种槟榔碱的合成方法 |
| IT202100015098A1 (it) | 2021-06-09 | 2022-12-09 | Flonext S R L | Composto antagonista del canale trpa1 per uso in patologie degenerative della retina |
| WO2024099404A1 (zh) * | 2022-11-10 | 2024-05-16 | 北京普祺医药科技股份有限公司 | 一种含氮螺环类化合物、药物组合物以及其用途 |
| CN121735827A (zh) * | 2026-02-27 | 2026-03-27 | 泰励生物科技（上海）有限公司 | 哌啶酮类化合物的制备方法 |
| CN121735881A (zh) * | 2026-02-27 | 2026-03-27 | 泰励生物科技（上海）有限公司 | 砜类化合物的制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8429128D0 (en) * | 1984-11-17 | 1984-12-27 | Fisons Plc | Heterocyclic compounds |
| EP0178035B1 (en) * | 1984-05-12 | 1990-01-03 | FISONS plc | Anti-inflammatory 1,n-diarylpyrazol-3-amines, compositions containing them and processes for their preparation |
| JP2002502380A (ja) * | 1997-05-22 | 2002-01-22 | ジー．ディー．サール アンド カンパニー | ｐ３８キナーゼ阻害剤としてのピラゾール誘導体 |
| JP2002514640A (ja) * | 1998-05-14 | 2002-05-21 | ジー・ディー・サール・アンド・カンパニー | ｐ３８キナーゼ阻害剤としての１，５−ジアリール置換ピラゾール類 |
| AU2004200420A1 (en) * | 2003-03-11 | 2004-09-30 | Astellas Pharma Inc. | Inhibitor of cyclooxygenase |
| CN1809351A (zh) * | 2003-04-24 | 2006-07-26 | 麦克公司 | Akt活性抑制剂 |
| ES2297502T3 (es) | 2003-10-23 | 2008-05-01 | F. Hoffmann-La Roche Ag | Derivados de triaza-espiropiperidinas para uso como inhibidores de glyt-1 en el tratamiento de trastornos neurologicos y neuropsiquiatricos. |
| ZA200605252B (en) * | 2003-12-26 | 2007-11-28 | Daiichi Seiyaku Co | Amidopyrazole derivative |
| TW200526641A (en) * | 2003-12-26 | 2005-08-16 | Daiichi Seiyaku Co | Amidopyrazole derivatives |
| GB0417910D0 (en) * | 2004-08-11 | 2004-09-15 | Novartis Ag | Organic compounds |
| WO2007002563A1 (en) | 2005-06-27 | 2007-01-04 | Exelixis, Inc. | Imidazole based lxr modulators |
| AU2006327181A1 (en) | 2005-12-22 | 2007-06-28 | Hydra Biosciences, Inc. | TRPA1 inhibitors for treating pain |
| US7977358B2 (en) | 2007-07-26 | 2011-07-12 | Hoffmann-La Roche Inc. | Pyrazol derivatives |
| CN101959861A (zh) | 2008-01-04 | 2011-01-26 | 雅培制药有限公司 | Trpa1拮抗剂 |
| EP2300440B1 (en) | 2008-06-02 | 2013-02-27 | Janssen Pharmaceutica, N.V. | 3,4-dihydropyrimidine trpa1 antagonists |
| WO2010125469A1 (en) * | 2009-04-29 | 2010-11-04 | Glenmark Pharmaceuticals, S.A. | Pyrimidinedione-fused heterocyclic compounds as trpa1 modulators |
| EP2485737B1 (en) | 2009-10-07 | 2014-06-25 | Merck Sharp & Dohme Corp. | Novel trpa1 antagonists |
| WO2012174362A1 (en) | 2011-06-17 | 2012-12-20 | Research Triangle Institute | Pyrazole derivatives as cannabinoid receptor 1 antagonists |
| DE102011055815A1 (de) | 2011-11-29 | 2013-05-29 | Aicuris Gmbh & Co. Kg | Carboxamid-substituierte Heteroaryl-Pyrazole und ihre Verwendung |
| SI2903965T1 (sl) | 2012-10-01 | 2017-07-31 | Orion Corporation | Derivati n-prop-2-inil karboksamida in njihova uporaba kot antagonisti trpa1 |
| CA2936111C (en) | 2014-01-06 | 2023-03-14 | Algomedix, Inc. | Trpa1 modulators |
| EP3481808A4 (en) | 2016-07-06 | 2020-07-15 | Algomedix, Inc. | TRPA1 ANTAGONISTS FOR THE TREATMENT OF DRY EYE SYNDROME, EYE PAIN AND INFLAMMATION |
-
2014
- 2014-12-23 CA CA2936111A patent/CA2936111C/en active Active
- 2014-12-23 WO PCT/US2014/072291 patent/WO2015103060A1/en not_active Ceased
- 2014-12-23 SG SG11201605559VA patent/SG11201605559VA/en unknown
- 2014-12-23 JP JP2016562455A patent/JP6626454B2/ja active Active
- 2014-12-23 CN CN201480076547.8A patent/CN106061969B/zh not_active Expired - Fee Related
- 2014-12-23 AU AU2014374043A patent/AU2014374043B2/en not_active Ceased
- 2014-12-23 EP EP14876732.0A patent/EP3092228A4/en not_active Withdrawn
-
2016
- 2016-07-06 US US15/203,774 patent/US9951046B2/en not_active Expired - Fee Related
- 2016-07-06 IL IL246625A patent/IL246625B/en active IP Right Grant
- 2016-08-02 ZA ZA2016/05332A patent/ZA201605332B/en unknown
-
2018
- 2018-03-01 US US15/909,652 patent/US10428049B2/en not_active Expired - Fee Related
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