JP2017502957A5 - - Google Patents

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JP2017502957A5
JP2017502957A5 JP2016543097A JP2016543097A JP2017502957A5 JP 2017502957 A5 JP2017502957 A5 JP 2017502957A5 JP 2016543097 A JP2016543097 A JP 2016543097A JP 2016543097 A JP2016543097 A JP 2016543097A JP 2017502957 A5 JP2017502957 A5 JP 2017502957A5
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JP2016543097A
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JP2017502957A (ja
JP6454349B2 (ja
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Priority claimed from PCT/JP2014/084752 external-priority patent/WO2015099196A1/en
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JP2016543097A 2013-12-26 2014-12-25 モノアシルグリセロールリパーゼ（ｍａｇｌ）阻害剤としての４−（ピペラジン−１−イル）−ピロリジン−２−オン化合物 Active JP6454349B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013269244 2013-12-26
JP2013269244 2013-12-26
PCT/JP2014/084752 WO2015099196A1 (en) 2013-12-26 2014-12-25 4-(piperrazin-1-yl)-pyrrolidin-2-one compounds as monoacylglycerol lipase (magl) inhibitors

Publications (3)

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JP2017502957A JP2017502957A (ja) 2017-01-26
JP2017502957A5 true JP2017502957A5 (enExample) 2017-12-07
JP6454349B2 JP6454349B2 (ja) 2019-01-16

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JP2016543097A Active JP6454349B2 (ja) 2013-12-26 2014-12-25 モノアシルグリセロールリパーゼ（ｍａｇｌ）阻害剤としての４−（ピペラジン−１−イル）−ピロリジン−２−オン化合物

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US (1) US9624170B2 (enExample)
EP (1) EP3087067B1 (enExample)
JP (1) JP6454349B2 (enExample)
WO (1) WO2015099196A1 (enExample)

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US10106556B2 (en) 2015-03-30 2018-10-23 Takeda Pharmaceutical Company Limited Heterocyclic compound
US10975081B2 (en) 2015-07-23 2021-04-13 Glaxosmithkline Intellectual Property Development Limited Substituted fused pyrazole compounds and their use as LRRK2 inhibitors
US10434099B2 (en) * 2016-09-22 2019-10-08 The National Institute for Biotechnology in the Negev Ltd. Methods for treating central nervous system disorders using VDAC inhibitors
US10787423B2 (en) 2015-09-14 2020-09-29 The National Institute For Biotechnolgy In The Negev Ltd. Piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction
WO2017046794A1 (en) * 2015-09-14 2017-03-23 The National Institute for Biotechnology in the Negev Ltd. Novel piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting vdac oligomerization, apoptosis and mitochondria dysfunction
MX2018004256A (es) 2015-10-14 2018-05-16 Squibb Bristol Myers Co Antagonistas de receptor de n-metil-d-aspartato subtipo 2b (nr2b) selectivos.
UY37174A (es) * 2016-03-31 2017-10-31 Takeda Pharmaceuticals Co Un compuesto heterocíclico que tiene una acción inhibidora de monoacilglicerol lipasa
WO2017170830A1 (ja) 2016-03-31 2017-10-05 武田薬品工業株式会社 複素環化合物
JOP20190267A1 (ar) 2017-05-23 2019-11-18 Lundbeck La Jolla Research Center Inc مثبطات بيرازول magl
US10927105B1 (en) 2017-05-23 2021-02-23 Lundbeck La Jolla Research Center, Inc. Pyrazole MAGL inhibitors
MY200738A (en) * 2017-05-23 2024-01-13 H Lundbeck As Pyrazole magl inhibitors
CN107397955A (zh) * 2017-08-23 2017-11-28 上海黛妆国际贸易有限公司 黑色素基因抑制剂
AU2018338855B2 (en) 2017-09-29 2022-04-28 Takeda Pharmaceutical Company Limited Heterocyclic compound
CA3085874A1 (en) * 2017-12-18 2019-06-27 Grunenthal Gmbh Substituted pyrrolidine amides i
TW201927769A (zh) * 2017-12-18 2019-07-16 德商歌林達有限公司 經取代之吡咯啶醯胺ｉｉ
CN112135825A (zh) 2018-03-13 2020-12-25 夏尔人类遗传性治疗公司 血浆激肽释放酶抑制剂及其用途
IL279688B2 (en) * 2018-06-27 2025-01-01 Ptc Therapeutics Inc Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease
TW202028209A (zh) * 2018-09-27 2020-08-01 大陸商重慶複創醫藥研究有限公司 作為RET激酶抑制劑的取代的咪唑[1,2-a]吡啶和[1,2,4]三唑[1,5-a]吡啶化合物
WO2020144375A1 (en) 2019-01-11 2020-07-16 Grünenthal GmbH Substituted pyrrolidine amides iii
WO2021055589A1 (en) 2019-09-18 2021-03-25 Shire Human Genetic Therapies, Inc. Heteroaryl plasma kallikrein inhibitors
CN114728962B (zh) 2019-09-18 2025-09-19 武田药品工业有限公司 血浆激肽释放酶抑制剂及其用途
EP3892614A1 (en) 2020-04-07 2021-10-13 Sanofi (1h-indol-5-yl)acrylamide derivatives as inhibitors of tead proteins and the hippo-yap1/taz signaling cascade for the treatment of cancer
WO2021204823A1 (en) 2020-04-07 2021-10-14 Sanofi (1 h-indol-5-yl)acrylamide derivatives as inhibitors of tead proteins and the hippo-yap1/taz signaling cascade for the treatment of cancer
WO2022197755A1 (en) * 2021-03-17 2022-09-22 Shire Human Genetic Therapies, Inc. Imidazopyridinyl inhibitors of plasma kallikrein
US20240382482A1 (en) * 2021-03-17 2024-11-21 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors
US20240262821A1 (en) * 2021-05-06 2024-08-08 Exscientia Al Limited PKC-Theta Modulators
JP7886402B2 (ja) * 2021-09-03 2026-07-07 エフ． ホフマン－ラ ロシュ アーゲー Ｍａｇｌ阻害剤
IL313987A (en) 2021-12-29 2024-08-01 Psy Therapeutics Inc Inhibiting monoacylglycerol lipase (magl)

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EP2760450A1 (en) 2011-09-30 2014-08-06 Janssen Pharmaceutica, N.V. Monoacylglycerol lipase inhibitors for the treatment of metabolic diseases and related disorders
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