JP2017502699A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017502699A5 JP2017502699A5 JP2016562064A JP2016562064A JP2017502699A5 JP 2017502699 A5 JP2017502699 A5 JP 2017502699A5 JP 2016562064 A JP2016562064 A JP 2016562064A JP 2016562064 A JP2016562064 A JP 2016562064A JP 2017502699 A5 JP2017502699 A5 JP 2017502699A5
- Authority
- JP
- Japan
- Prior art keywords
- mirna
- ratio
- expression
- pairs
- mir
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091070501 miRNA Proteins 0.000 claims description 146
- 239000002679 microRNA Substances 0.000 claims description 146
- 238000000034 method Methods 0.000 claims description 103
- 208000020816 lung neoplasm Diseases 0.000 claims description 50
- 208000037841 lung tumor Diseases 0.000 claims description 44
- 206010018910 Haemolysis Diseases 0.000 claims description 24
- 230000008588 hemolysis Effects 0.000 claims description 24
- 239000012472 biological sample Substances 0.000 claims description 20
- 239000000523 sample Substances 0.000 claims description 12
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 10
- 201000005202 lung cancer Diseases 0.000 claims description 10
- 238000011282 treatment Methods 0.000 claims description 8
- 239000013060 biological fluid Substances 0.000 claims description 6
- 108091027943 miR-16 stem-loop Proteins 0.000 claims description 6
- 108091039994 miR-486 stem-loop Proteins 0.000 claims description 6
- 108091034121 miR-92a stem-loop Proteins 0.000 claims description 6
- 108091041519 miR-92a-3 stem-loop Proteins 0.000 claims description 6
- 108091028066 Mir-126 Proteins 0.000 claims description 4
- 108091028049 Mir-221 microRNA Proteins 0.000 claims description 4
- 238000010240 RT-PCR analysis Methods 0.000 claims description 4
- 238000002591 computed tomography Methods 0.000 claims description 4
- 108091031326 miR-15b stem-loop Proteins 0.000 claims description 4
- 108091061917 miR-221 stem-loop Proteins 0.000 claims description 4
- 108091063489 miR-221-1 stem-loop Proteins 0.000 claims description 4
- 108091055391 miR-221-2 stem-loop Proteins 0.000 claims description 4
- 108091031076 miR-221-3 stem-loop Proteins 0.000 claims description 4
- 108091063344 miR-30b stem-loop Proteins 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 238000004458 analytical method Methods 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 238000009534 blood test Methods 0.000 claims description 2
- 238000013276 bronchoscopy Methods 0.000 claims description 2
- 239000002299 complementary DNA Substances 0.000 claims description 2
- 238000010195 expression analysis Methods 0.000 claims description 2
- 108091060382 miR-140 stem-loop Proteins 0.000 claims description 2
- 108091030617 miR-140-1 stem-loop Proteins 0.000 claims description 2
- 108091023370 miR-140-2 stem-loop Proteins 0.000 claims description 2
- -1 miR-451 Proteins 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 claims description 2
- 238000002600 positron emission tomography Methods 0.000 claims description 2
- 238000003753 real-time PCR Methods 0.000 claims description 2
- 210000002700 urine Anatomy 0.000 claims description 2
- 238000007689 inspection Methods 0.000 claims 1
- 238000010606 normalization Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461923758P | 2014-01-05 | 2014-01-05 | |
| US61/923,758 | 2014-01-05 | ||
| US201461926323P | 2014-01-12 | 2014-01-12 | |
| US61/926,323 | 2014-01-12 | ||
| PCT/EP2014/079499 WO2015101653A1 (en) | 2014-01-05 | 2014-12-31 | Lung cancer determinations using mirna ratios |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019087056A Division JP2019122412A (ja) | 2014-01-05 | 2019-04-30 | Ｍｉｒｎａ比率を使用する肺がん決定 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017502699A JP2017502699A (ja) | 2017-01-26 |
| JP2017502699A5 true JP2017502699A5 (enExample) | 2018-02-08 |
| JP6706208B2 JP6706208B2 (ja) | 2020-06-03 |
Family
ID=52347306
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016562064A Expired - Fee Related JP6706208B2 (ja) | 2014-01-05 | 2014-12-31 | Ｍｉｒｎａ比率を使用する肺がん決定 |
| JP2019087056A Pending JP2019122412A (ja) | 2014-01-05 | 2019-04-30 | Ｍｉｒｎａ比率を使用する肺がん決定 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019087056A Pending JP2019122412A (ja) | 2014-01-05 | 2019-04-30 | Ｍｉｒｎａ比率を使用する肺がん決定 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US20150191794A1 (enExample) |
| EP (2) | EP3425066A1 (enExample) |
| JP (2) | JP6706208B2 (enExample) |
| CN (1) | CN106164290A (enExample) |
| AU (1) | AU2014375224A1 (enExample) |
| BR (1) | BR112016015595A2 (enExample) |
| CA (1) | CA2935789A1 (enExample) |
| ES (1) | ES2686631T3 (enExample) |
| IL (1) | IL246580B (enExample) |
| WO (1) | WO2015101653A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3607066A4 (en) * | 2017-04-06 | 2021-05-19 | The United States Government as Represented by the Department of Veterans Affairs | PROCEDURE FOR DETECTION OF LUNG CANCER |
| JP6884810B2 (ja) * | 2019-05-08 | 2021-06-09 | キユーピー株式会社 | 情報提供装置、情報提供方法及びｍｉＲＮＡ重要度テーブル生成方法 |
| IT202100008798A1 (it) * | 2021-04-08 | 2022-10-08 | Univ Degli Studi Di Ferrara | Uso del microrna hsa-mir-197-3p come marcatore di esposizione all’amianto e di mesotelioma maligno della pleura |
| CN113278692A (zh) * | 2021-05-19 | 2021-08-20 | 北京艾克伦医疗科技有限公司 | 鉴定肺结节状态的方法和试剂盒 |
| US20250059603A1 (en) * | 2021-12-15 | 2025-02-20 | Sera Prognastics, Inc. | Expanded panels of nucleic acid biomarkers for placental dysfunction |
| WO2025089028A1 (ja) * | 2023-10-24 | 2025-05-01 | アークレイ株式会社 | 検査方法、検査装置、検査システム、検査プログラム、記録媒体、及び溶血程度学習済モデルの生成方法 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5366860A (en) | 1989-09-29 | 1994-11-22 | Applied Biosystems, Inc. | Spectrally resolvable rhodamine dyes for nucleic acid sequence determination |
| US5188934A (en) | 1989-11-14 | 1993-02-23 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
| DK0515506T3 (da) | 1990-02-16 | 2000-05-08 | Hoffmann La Roche | Fremgangsmåde til påvisning af carcinogene humane papillomavirus |
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| US5965364A (en) | 1990-10-09 | 1999-10-12 | Benner; Steven Albert | Method for selecting functional deoxyribonucleotide derivatives |
| US5413924A (en) | 1992-02-13 | 1995-05-09 | Kosak; Kenneth M. | Preparation of wax beads containing a reagent for release by heating |
| US5767259A (en) | 1994-12-27 | 1998-06-16 | Naxcor | Oligonucleotides containing base-free linking groups with photoactivatable side chains |
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| CA2168712A1 (en) | 1995-02-07 | 1996-08-08 | John William Henderson Sutherland | Use of exonuclease and/or glycosylase as supplements to anti-polymerase antibody to increase specificity in polymerase chain reaction |
| US6020481A (en) | 1996-04-01 | 2000-02-01 | The Perkin-Elmer Corporation | Asymmetric benzoxanthene dyes |
| AU713667B2 (en) | 1996-04-12 | 1999-12-09 | Phri Properties, Inc. | Detection probes, kits and assays |
| US5863727A (en) | 1996-05-03 | 1999-01-26 | The Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
| US5847162A (en) | 1996-06-27 | 1998-12-08 | The Perkin Elmer Corporation | 4, 7-Dichlororhodamine dyes |
| US5945526A (en) | 1996-05-03 | 1999-08-31 | Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
| US5800996A (en) | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
| SE506700C2 (sv) | 1996-05-31 | 1998-02-02 | Mikael Kubista | Sond och förfaranden för analys av nukleinsyra |
| US6008379A (en) | 1997-10-01 | 1999-12-28 | The Perkin-Elmer Corporation | Aromatic-substituted xanthene dyes |
| ATE478090T1 (de) | 1997-10-27 | 2010-09-15 | Boston Probes Inc | SICH AUF ßPNA MOLECULAR BEACONSß BEZIEHENDE VERFAHREN, TESTSÄTZE UND ZUSAMMENSETZUNGEN |
| US6485901B1 (en) | 1997-10-27 | 2002-11-26 | Boston Probes, Inc. | Methods, kits and compositions pertaining to linear beacons |
| US5936087A (en) | 1997-11-25 | 1999-08-10 | The Perkin-Elmer Corporation | Dibenzorhodamine dyes |
| US6140054A (en) | 1998-09-30 | 2000-10-31 | University Of Utah Research Foundation | Multiplex genotyping using fluorescent hybridization probes |
| US6383752B1 (en) | 1999-03-31 | 2002-05-07 | Hybridon, Inc. | Pseudo-cyclic oligonucleobases |
| EA005140B1 (ru) * | 1999-04-02 | 2004-12-30 | Корикса Корпорейшн | Соединения и способы для лечения и диагностики рака легкого |
| JP2004500029A (ja) * | 1999-06-30 | 2004-01-08 | コリクサ コーポレイション | 肺癌の治療および診断のための組成物および方法 |
| CN101284873A (zh) * | 1999-06-30 | 2008-10-15 | 科里克萨有限公司 | 用于肺癌治疗和诊断的组合物和方法 |
| US6140500A (en) | 1999-09-03 | 2000-10-31 | Pe Corporation | Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use |
| US6528254B1 (en) | 1999-10-29 | 2003-03-04 | Stratagene | Methods for detection of a target nucleic acid sequence |
| US6191278B1 (en) | 1999-11-03 | 2001-02-20 | Pe Corporation | Water-soluble rhodamine dyes and conjugates thereof |
| US6596490B2 (en) | 2000-07-14 | 2003-07-22 | Applied Gene Technologies, Inc. | Nucleic acid hairpin probes and uses thereof |
| US6350580B1 (en) | 2000-10-11 | 2002-02-26 | Stratagene | Methods for detection of a target nucleic acid using a probe comprising secondary structure |
| US6403341B1 (en) | 2001-08-02 | 2002-06-11 | Wayne M. Barnes | Magnesium precipitate hot start method for PCR |
| CA2459347C (en) | 2001-09-04 | 2012-10-09 | Exiqon A/S | Locked nucleic acid (lna) compositions and uses thereof |
| US6593091B2 (en) | 2001-09-24 | 2003-07-15 | Beckman Coulter, Inc. | Oligonucleotide probes for detecting nucleic acids through changes in flourescence resonance energy transfer |
| US20060078894A1 (en) | 2004-10-12 | 2006-04-13 | Winkler Matthew M | Methods and compositions for analyzing nucleic acids |
| US7993831B2 (en) * | 2007-09-14 | 2011-08-09 | Asuragen, Inc. | Methods of normalization in microRNA detection assays |
| CN101918594A (zh) * | 2007-11-30 | 2010-12-15 | 俄亥俄州立大学研究基金会 | 肺癌中外周血中的微rna表达特征谱和靶向 |
| CN102725632A (zh) * | 2009-08-28 | 2012-10-10 | 奥斯瑞根公司 | 肺病的miRNA生物标志物 |
| WO2011053257A2 (en) * | 2009-11-02 | 2011-05-05 | Agency For Science, Technology And Research (A*Star) | Methods of monitoring cellular states |
| DK2734636T3 (da) * | 2011-02-07 | 2019-08-26 | Gabriella Sozzi | Mikro-rna-biomarkører til identificering af risikoen for og/eller til diagnosticering af en lungetumor |
| WO2013063519A1 (en) * | 2011-10-26 | 2013-05-02 | Asuragen, Inc. | Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts |
-
2014
- 2014-12-31 ES ES14827245.3T patent/ES2686631T3/es active Active
- 2014-12-31 EP EP18175641.2A patent/EP3425066A1/en not_active Withdrawn
- 2014-12-31 JP JP2016562064A patent/JP6706208B2/ja not_active Expired - Fee Related
- 2014-12-31 US US14/587,281 patent/US20150191794A1/en not_active Abandoned
- 2014-12-31 BR BR112016015595A patent/BR112016015595A2/pt not_active IP Right Cessation
- 2014-12-31 WO PCT/EP2014/079499 patent/WO2015101653A1/en not_active Ceased
- 2014-12-31 CA CA2935789A patent/CA2935789A1/en not_active Abandoned
- 2014-12-31 EP EP14827245.3A patent/EP3090059B1/en active Active
- 2014-12-31 CN CN201480076735.0A patent/CN106164290A/zh active Pending
- 2014-12-31 AU AU2014375224A patent/AU2014375224A1/en not_active Abandoned
-
2016
- 2016-07-03 IL IL246580A patent/IL246580B/en active IP Right Grant
- 2016-12-19 US US15/383,932 patent/US20170204467A1/en not_active Abandoned
-
2018
- 2018-05-16 US US15/981,640 patent/US20190119756A1/en not_active Abandoned
-
2019
- 2019-04-30 JP JP2019087056A patent/JP2019122412A/ja active Pending
-
2020
- 2020-11-13 US US17/097,408 patent/US20210301350A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017502699A5 (enExample) | ||
| Khare et al. | Plasma microRNA profiling: Exploring better biomarkers for lymphoma surveillance | |
| Schrauder et al. | Circulating micro-RNAs as potential blood-based markers for early stage breast cancer detection | |
| Murakami et al. | Comprehensive miRNA expression analysis in peripheral blood can diagnose liver disease | |
| Lian et al. | Identification of a plasma four-microRNA panel as potential noninvasive biomarker for osteosarcoma | |
| Keller et al. | Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controls | |
| Chundong et al. | Molecular diagnosis of MACC1 status in lung adenocarcinoma by immunohistochemical analysis | |
| Vignier et al. | Distinctive serum miRNA profile in mouse models of striated muscular pathologies | |
| Silakit et al. | Circulating mi R‐192 in liver fluke‐associated cholangiocarcinoma patients: a prospective prognostic indicator | |
| Svaton et al. | The prognostic role of KRAS mutation in patients with advanced NSCLC treated with second-or third-line chemotherapy | |
| Ludwig et al. | Circulating serum miRNAs as potential biomarkers for nephroblastoma | |
| Schou et al. | miR-345 in metastatic colorectal cancer: a non-invasive biomarker for clinical outcome in non-KRAS mutant patients treated with 3rd line cetuximab and irinotecan | |
| Webster et al. | Impact of genomics platform and statistical filtering on transcriptional benchmark doses (BMD) and multiple approaches for selection of chemical point of departure (PoD) | |
| JP2016507233A5 (enExample) | ||
| Zhong et al. | Discovery and validation of extracellular vesicle‐associated miRNAs as noninvasive detection biomarkers for early‐stage non‐small‐cell lung cancer | |
| US20180142303A1 (en) | Methods and compositions for diagnosing or detecting lung cancers | |
| RU2016138766A (ru) | Способ диагностики колоректального рака из образца кала человека с помощью количественной пцр, праймеров и набора | |
| Umu et al. | Serum RNAs can predict lung cancer up to 10 years prior to diagnosis | |
| JP2017507320A5 (enExample) | ||
| Mosakhani et al. | MicroRNA expression profiles in metastatic and non-metastatic giant cell tumor of bone | |
| WO2017041746A9 (en) | Methods for histological diagnosis and treatment of diseases | |
| WO2017136662A4 (en) | Circulating serum microrna biomarkers and methods for determining parkinson's disease | |
| CN103484550B (zh) | 一组肺癌早期诊断用microRNA生物标志物及其应用 | |
| Xu et al. | Plasma miR-32 levels in non-small cell lung cancer patients receiving platinum-based chemotherapy can predict the effectiveness and prognosis of chemotherapy | |
| Tao et al. | Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection |