JP2017507320A5 - - Google Patents
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- JP2017507320A5 JP2017507320A5 JP2016538689A JP2016538689A JP2017507320A5 JP 2017507320 A5 JP2017507320 A5 JP 2017507320A5 JP 2016538689 A JP2016538689 A JP 2016538689A JP 2016538689 A JP2016538689 A JP 2016538689A JP 2017507320 A5 JP2017507320 A5 JP 2017507320A5
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- prostate cancer
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- srsf5
- adamts9
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- 238000000034 method Methods 0.000 claims 46
- 206010060862 Prostate cancer Diseases 0.000 claims 32
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 32
- 102000051354 ADAMTS9 Human genes 0.000 claims 20
- 108091005669 ADAMTS9 Proteins 0.000 claims 20
- 101000587438 Homo sapiens Serine/arginine-rich splicing factor 5 Proteins 0.000 claims 20
- 101000734339 Homo sapiens [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial Proteins 0.000 claims 20
- 101000988419 Homo sapiens cAMP-specific 3',5'-cyclic phosphodiesterase 4D Proteins 0.000 claims 20
- 102100029703 Serine/arginine-rich splicing factor 5 Human genes 0.000 claims 20
- 102100034825 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial Human genes 0.000 claims 20
- 102100029170 cAMP-specific 3',5'-cyclic phosphodiesterase 4D Human genes 0.000 claims 20
- 239000000523 sample Substances 0.000 claims 20
- 102100034799 CCAAT/enhancer-binding protein delta Human genes 0.000 claims 19
- 102100023344 Centromere protein F Human genes 0.000 claims 19
- -1 ERRI1 Proteins 0.000 claims 19
- 102100022107 Holliday junction recognition protein Human genes 0.000 claims 19
- 101000945965 Homo sapiens CCAAT/enhancer-binding protein delta Proteins 0.000 claims 19
- 101000907941 Homo sapiens Centromere protein F Proteins 0.000 claims 19
- 101001045907 Homo sapiens Holliday junction recognition protein Proteins 0.000 claims 19
- 101001072152 Homo sapiens p53 and DNA damage-regulated protein 1 Proteins 0.000 claims 19
- 102000003620 TRPM3 Human genes 0.000 claims 19
- 108060008547 TRPM3 Proteins 0.000 claims 19
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- 108091005660 ADAMTS1 Proteins 0.000 claims 18
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 18
- 102100030074 Dickkopf-related protein 1 Human genes 0.000 claims 18
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 18
- 101000864646 Homo sapiens Dickkopf-related protein 1 Proteins 0.000 claims 18
- 101000874532 Homo sapiens Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Proteins 0.000 claims 18
- 101000919269 Homo sapiens cAMP-responsive element modulator Proteins 0.000 claims 18
- 102100035655 Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Human genes 0.000 claims 18
- 102100029387 cAMP-responsive element modulator Human genes 0.000 claims 18
- 102100033183 Epithelial membrane protein 1 Human genes 0.000 claims 17
- 102000000802 Galectin 3 Human genes 0.000 claims 17
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- 101000966782 Homo sapiens Lysophosphatidic acid receptor 1 Proteins 0.000 claims 17
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- 101710148753 Ornithine aminotransferase Proteins 0.000 claims 16
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- 108010037462 Cyclooxygenase 2 Proteins 0.000 claims 15
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- 102100037168 Transcription factor JunB Human genes 0.000 claims 15
- BSFODEXXVBBYOC-UHFFFAOYSA-N 8-[4-(dimethylamino)butan-2-ylamino]quinolin-6-ol Chemical compound C1=CN=C2C(NC(CCN(C)C)C)=CC(O)=CC2=C1 BSFODEXXVBBYOC-UHFFFAOYSA-N 0.000 claims 14
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- LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 claims 2
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- 229960000853 abiraterone Drugs 0.000 claims 2
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- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 2
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- ZBZXYUYUUDZCNB-UHFFFAOYSA-N N-cyclohexa-1,3-dien-1-yl-N-phenyl-4-[4-(N-[4-[4-(N-[4-[4-(N-phenylanilino)phenyl]phenyl]anilino)phenyl]phenyl]anilino)phenyl]aniline Chemical group C1=CCCC(N(C=2C=CC=CC=2)C=2C=CC(=CC=2)C=2C=CC(=CC=2)N(C=2C=CC=CC=2)C=2C=CC(=CC=2)C=2C=CC(=CC=2)N(C=2C=CC=CC=2)C=2C=CC(=CC=2)C=2C=CC(=CC=2)N(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 ZBZXYUYUUDZCNB-UHFFFAOYSA-N 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1322034.8A GB201322034D0 (en) | 2013-12-12 | 2013-12-12 | Prostate cancer classification |
| GB1322034.8 | 2013-12-12 | ||
| PCT/GB2014/053694 WO2015087088A2 (en) | 2013-12-12 | 2014-12-12 | Prostate cancer classification |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017507320A JP2017507320A (ja) | 2017-03-16 |
| JP2017507320A5 true JP2017507320A5 (enExample) | 2018-01-25 |
Family
ID=50030858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016538689A Pending JP2017507320A (ja) | 2013-12-12 | 2014-12-12 | 前立腺癌分類 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10196697B2 (enExample) |
| EP (1) | EP3080293B1 (enExample) |
| JP (1) | JP2017507320A (enExample) |
| KR (1) | KR20160098351A (enExample) |
| CN (1) | CN105940117A (enExample) |
| AU (1) | AU2014363173A1 (enExample) |
| BR (1) | BR112016013182A2 (enExample) |
| CA (1) | CA2932553A1 (enExample) |
| GB (1) | GB201322034D0 (enExample) |
| IL (1) | IL246067A0 (enExample) |
| MX (1) | MX2016007333A (enExample) |
| SG (1) | SG11201604508PA (enExample) |
| WO (1) | WO2015087088A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4219765B1 (en) | 2012-08-16 | 2024-12-18 | Veracyte SD, Inc. | Prostate cancer prognosis using biomarkers |
| EP3359692A4 (en) * | 2015-10-05 | 2019-05-01 | Cedars-Sinai Medical Center | METHOD FOR CLASSIFYING AND TREATING CANCER |
| CN108474041A (zh) * | 2015-12-23 | 2018-08-31 | 弗莱德哈钦森癌症研究中心 | 使用遗传标记的甲基化状态区分转移性-致死性前列腺癌与惰性前列腺癌 |
| CA3011106A1 (en) * | 2016-01-20 | 2017-07-27 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for screening and identifying clinically aggressive prostate cancer |
| AU2017315425B2 (en) | 2016-08-24 | 2023-11-09 | The Regents Of The University Of Michigan | Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy |
| US11873532B2 (en) * | 2017-03-09 | 2024-01-16 | Decipher Biosciences, Inc. | Subtyping prostate cancer to predict response to hormone therapy |
| US11874276B2 (en) | 2018-04-05 | 2024-01-16 | Dana-Farber Cancer Institute, Inc. | STING levels as a biomarker for cancer immunotherapy |
| CN109295208A (zh) * | 2018-10-26 | 2019-02-01 | 德阳市人民医院 | Pi15作为骨关节炎标志物的应用 |
| US20210115517A1 (en) * | 2019-01-30 | 2021-04-22 | Janssen Pharmaceutica Nv | Methods of treating prostate cancer based on molecular subtypes |
| GB201917428D0 (en) * | 2019-11-29 | 2020-01-15 | Univ Newcastle | Prostate cancer diagnostic |
| CN111518908B (zh) * | 2020-05-18 | 2023-10-17 | 奥尔文泰生物科技(杭州)有限公司 | 尿液前列腺癌标志物组合及其在制备精准诊断试剂中的用途 |
| EP3960878A1 (en) * | 2020-08-31 | 2022-03-02 | Koninklijke Philips N.V. | Selection of a dose for radiotherapy of a prostate cancer subject |
| EP3960877A1 (en) * | 2020-08-31 | 2022-03-02 | Koninklijke Philips N.V. | Prediction of a response of a prostate cancer subject to therapy or personalization of therapy of a prostate cancer subject |
| EP3960876A1 (en) * | 2020-08-31 | 2022-03-02 | Koninklijke Philips N.V. | Prediction of a response of a prostate cancer subject to radiotherapy based on pde4d7 correlated genes |
| JP7477872B2 (ja) * | 2020-09-30 | 2024-05-07 | 国立大学法人大阪大学 | 癌に関連する新規バイオマーカー |
| CN113234820A (zh) * | 2021-04-29 | 2021-08-10 | 北京艾克伦医疗科技有限公司 | 鉴定前列腺癌状态的方法和试剂盒 |
| WO2023135485A1 (en) * | 2022-01-13 | 2023-07-20 | Oslo Universitetssykehus Hf | Prostate cancer markers and uses thereof |
| EP4253567A1 (en) * | 2022-03-31 | 2023-10-04 | OncoAssure Limited | A method of predicting risk of an aggressive or recurrent cancer |
| AU2023269274A1 (en) * | 2022-05-12 | 2024-12-05 | Veracyte, Inc. | Prognosis and treatment of molecular subtypes of prostate cancer |
| CN116891523B (zh) * | 2023-05-24 | 2024-05-17 | 深圳晶蛋生物医药科技有限公司 | 一种trpm3截短体、包含其的细胞系及其用途 |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE72468B1 (en) | 1987-07-31 | 1997-04-09 | Univ Leland Stanford Junior | Selective amplification of target polynucleotide sequences |
| BR8907830A (pt) | 1988-12-16 | 1991-10-22 | Siska Diagnostics Inc | Processo para preparar uma dna de filamento duplo que codifica uma sequencia que corresponde a uma sequencia objetivada de acido nucleico e processo util para deteccao de pelo menos uma sequencia de acido nucleico objetivada especifica |
| US5437975A (en) | 1991-02-25 | 1995-08-01 | California Institute Of Biological Research | Consensus sequence primed polymerase chain reaction method for fingerprinting genomes |
| US6017704A (en) | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US7220557B2 (en) | 1997-04-24 | 2007-05-22 | Human Genome Sciences, Inc. | METH1 polynucleotides |
| US8071072B2 (en) * | 1999-10-08 | 2011-12-06 | Hoffmann-La Roche Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
| AU2002214576A1 (en) | 2000-10-13 | 2002-04-22 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Genes related to development of refractory prostate cancer |
| AU2002241524A1 (en) | 2000-11-28 | 2002-06-11 | Wyeth | Expression analysis of FKBP nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer |
| AU2002337657A1 (en) | 2001-07-25 | 2003-02-17 | Millennium Pharmaceuticals, Inc. | Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of prostate cancer |
| US7229774B2 (en) | 2001-08-02 | 2007-06-12 | Regents Of The University Of Michigan | Expression profile of prostate cancer |
| US20040029151A1 (en) | 2002-04-09 | 2004-02-12 | Affymetrix, Inc. | Molecular genetic profiling of gleason grades 3 and 4/5 prostate cancer |
| US20050032065A1 (en) | 2002-06-24 | 2005-02-10 | Afar Daniel E. H. | Methods of prognosis of prostate cancer |
| EP1382969A1 (en) | 2002-07-17 | 2004-01-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Diagnosis and prevention of cancer cell invasion |
| US20050259483A1 (en) | 2002-09-30 | 2005-11-24 | Oncotherapy Science, Inc. | Genes and polypeptides relating to prostate cancers |
| WO2004067726A2 (en) | 2003-01-29 | 2004-08-12 | Keck Graduate Institute | Isothermal reactions for the amplification of oligonucleotides |
| US20040223970A1 (en) | 2003-02-28 | 2004-11-11 | Daniel Afar | Antibodies against SLC15A2 and uses thereof |
| WO2005007830A2 (en) | 2003-07-14 | 2005-01-27 | Mayo Foundation For Medical Education And Research | Methods and compositions for diagnosis, staging and prognosis of prostate cancer |
| WO2005083118A2 (en) * | 2004-02-27 | 2005-09-09 | Oncotherapy Science, Inc. | Pin-prc transition genes |
| WO2006091776A2 (en) | 2005-02-25 | 2006-08-31 | The Brigham And Women's Hospital, Inc. | Biomarkers for predicting prostate cancer progression |
| AU2006234897A1 (en) | 2005-03-16 | 2006-10-19 | Sidney Kimmel Cancer Center | Methods and compositions for predicting death from cancer and prostate cancer survival using gene expression signatures |
| CA2605143A1 (en) | 2005-04-15 | 2006-10-26 | Becton, Dickinson And Company | Diagnosis of sepsis |
| EP1717320A1 (en) | 2005-04-26 | 2006-11-02 | TopoTarget Germany AG | Identification of human gene sequences of cancer antigens expressed in metastatic carcinoma and involved in metastasis formation, and their use in cancer diagnosis, prognosis and therapy |
| CA2622440A1 (en) | 2005-09-14 | 2007-03-22 | National Research Council Of Canada | Molecular method for diagnosis of prostate cancer |
| US20070059753A1 (en) | 2005-09-15 | 2007-03-15 | Tatiana Vener | Detecting gene methylation |
| EP2186912A3 (en) | 2005-11-08 | 2011-01-19 | Euclid Diagnostics LLC | Materials and methods for assaying for methylation of CpG islands associated with genes in the evaluation of cancer |
| WO2008067065A2 (en) | 2006-10-19 | 2008-06-05 | Shiv Srivastava | Methods, kits, and systems for diagnosing and prognosing prostate cancer using secreted biomarkers |
| WO2008058018A2 (en) | 2006-11-02 | 2008-05-15 | Mayo Foundation For Medical Education And Research | Predicting cancer outcome |
| WO2008086478A2 (en) | 2007-01-10 | 2008-07-17 | Henry Ford Health System | Methods and compositions for identification of prostate cancer markers |
| EP2155897A2 (en) | 2007-03-30 | 2010-02-24 | Source Precision Medicine, Inc. d/b/a Source MDX. | Gene expression profiling for identification, monitoring, and treatment of prostate cancer |
| WO2009028158A1 (en) | 2007-08-24 | 2009-03-05 | Oncotherapy Science, Inc. | Dkk1 oncogene as therapeutic target for cancer and a diagnosing marker |
| WO2009151503A2 (en) | 2008-04-10 | 2009-12-17 | University Of Florida Research Foundation, Inc. | Compositions and methods for the treatment of a neoplasia |
| AU2009234444A1 (en) | 2008-04-11 | 2009-10-15 | China Synthetic Rubber Corporation | Methods, agents and kits for the detection of cancer |
| AU2009253675A1 (en) | 2008-05-28 | 2009-12-03 | Genomedx Biosciences, Inc. | Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer |
| US20090298082A1 (en) | 2008-05-30 | 2009-12-03 | Klee George G | Biomarker panels for predicting prostate cancer outcomes |
| CA2730277A1 (en) | 2008-07-08 | 2010-01-14 | Source Precision Medicine, Inc. D/B/A Source Mdx | Gene expression profiling for predicting the survivability of prostate cancer subjects |
| EP2318543A2 (en) | 2008-07-16 | 2011-05-11 | Dana-Farber Cancer Institute Inc. | Signatures and pcdeterminants associated with prostate cancer and methods of use thereof |
| US20100055705A1 (en) | 2008-08-29 | 2010-03-04 | Wilson Gerald M | Compositions and methods for diagnosing and treating cancer |
| WO2010062706A2 (en) | 2008-10-30 | 2010-06-03 | Caris Mpi, Inc. | Methods for assessing rna patterns |
| WO2010065940A1 (en) | 2008-12-04 | 2010-06-10 | The Regents Of The University Of California | Materials and methods for determining diagnosis and prognosis of prostate cancer |
| US20120041274A1 (en) | 2010-01-07 | 2012-02-16 | Myriad Genetics, Incorporated | Cancer biomarkers |
| WO2010131195A1 (en) | 2009-05-12 | 2010-11-18 | Koninklijke Philips Electronics N.V. | Phosphodiesterase 4d7 as prostate cancer marker |
| KR20120036842A (ko) | 2009-05-12 | 2012-04-18 | 코닌클리케 필립스 일렉트로닉스 엔.브이. | 악성의 호르몬 민감성 전립선 암에 대한 마커로서의 포스포디에스테라제 4ｄ7 |
| DE112010002253T5 (de) | 2009-06-04 | 2013-01-03 | Charité - Universitätsmedizin Berlin | Mittel und Verfahren zur Diagnostizierung von Prostatakarzinomen |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| EP2309273B1 (en) | 2009-09-16 | 2016-05-18 | ZEILLINGER, Robert | Novel tumor marker determination |
| AU2010326066A1 (en) | 2009-12-01 | 2012-06-21 | Compendia Bioscience, Inc. | Classification of cancers |
| WO2011094233A1 (en) * | 2010-01-26 | 2011-08-04 | The Johns Hopkins University | Methods of disease classification or prognosis for prostate cancer based on expression of cancer/testis antigens |
| US20130058925A1 (en) * | 2010-02-26 | 2013-03-07 | Board Of Regents, The University Of Texas System | Epithelial biomarkers for cancer prognosis |
| CN105601727B (zh) * | 2010-03-11 | 2020-01-10 | 肿瘤疗法科学股份有限公司 | Hjurp肽及包含它们的疫苗 |
| CA2836725A1 (en) * | 2010-06-01 | 2011-12-08 | Indiana University Research And Technology Corporation | Materials and methods for diagnosing and predicting the course of prostate cancer |
| EP3812469A1 (en) | 2010-07-07 | 2021-04-28 | Myriad Genetics, Inc. | Gene signatures for cancer prognosis |
| US20130190310A1 (en) * | 2010-07-26 | 2013-07-25 | The Johns Hopkins University | Mig6 and therapeutic efficacy |
| WO2012015765A2 (en) | 2010-07-27 | 2012-02-02 | Genomic Health, Inc. | Method for using gene expression to determine prognosis of prostate cancer |
| EP2611941A4 (en) | 2010-08-30 | 2014-01-22 | Myriad Genetics Inc | GENESIS OF CANCER DIAGNOSIS AND PROGNOSIS |
| US10519505B2 (en) | 2011-04-28 | 2019-12-31 | Harry Ostrer | Genomic signatures of metastasis in prostate cancer |
| EP2723905A1 (en) | 2011-06-27 | 2014-04-30 | Dana-Farber Cancer Institute, Inc. | Signatures and determinants associated with prostate cancer progression and methods of use thereof |
| US20130079241A1 (en) * | 2011-09-15 | 2013-03-28 | Jianhua Luo | Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse |
| GB201206209D0 (en) | 2012-04-06 | 2012-05-23 | Univ Leuven Kath | Marker gene based diagnosis, staging and prognosis of prostate caner |
| US9546368B2 (en) | 2011-12-22 | 2017-01-17 | Ionis Pharmaceuticals, Inc. | Methods for modulating metastasis-associated-in-lung-adenocarcinoma-transcript-1 (MALAT-1) expression |
| HK1201881A1 (en) | 2012-01-31 | 2015-09-11 | Genomic Health, Inc. | Gene expression profile algorithm and test for determining prognosis of prostate cancer |
| TW201343920A (zh) | 2012-03-29 | 2013-11-01 | Nat Health Research Institutes | 預測前列腺癌預後之分子標記、方法與套組 |
| BR102012007246A2 (pt) * | 2012-03-30 | 2016-02-10 | Fundação Antonio Prudente | métodos para prognóstico e classificação de resultados de um evento |
| US20130288967A1 (en) | 2012-04-25 | 2013-10-31 | Euclid Diagnostics Llc | Materials and methods for cancer diagnosis by evaluation of the methylation status of cpg islands on chromosomes 6 and 8 |
| CN103146688B (zh) | 2012-09-12 | 2015-05-13 | 上海长海医院 | 长链非编码rna作为疾病诊断血液分子标志物的应用 |
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- 2014-12-12 JP JP2016538689A patent/JP2017507320A/ja active Pending
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