JP2017502092A - ヘテロアリール及びその使用 - Google Patents

ヘテロアリール及びその使用 Download PDF

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Publication number
JP2017502092A
JP2017502092A JP2016563905A JP2016563905A JP2017502092A JP 2017502092 A JP2017502092 A JP 2017502092A JP 2016563905 A JP2016563905 A JP 2016563905A JP 2016563905 A JP2016563905 A JP 2016563905A JP 2017502092 A JP2017502092 A JP 2017502092A
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JP
Japan
Prior art keywords
compound
pharmaceutically acceptable
hydrogen
acceptable salt
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2016563905A
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English (en)
Japanese (ja)
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JP2017502092A5 (enExample
Inventor
インドゥ ティー． バラサン，
インドゥ ティー． バラサン，
クリス ブラックバーン，
クリス ブラックバーン，
ジェフリー ピー． シャバーリ，
ジェフリー ピー． シャバーリ，
ジョーハラ チューター，
ジョーハラ チューター，
コートニー エー． クリス，
コートニー エー． クリス，
ナタリー ダモーレ，
ナタリー ダモーレ，
ポール イー． フレミング，
ポール イー． フレミング，
ケネス エム． ギグスタッド，
ケネス エム． ギグスタッド，
クリスタ イー． ギプソン，
クリスタ イー． ギプソン，
マリオ ジラード，
マリオ ジラード，
ヨンボ フー，
ヨンボ フー，
ジャニス リー，
ジャニス リー，
ギャン リー，
ギャン リー，
マンソレ レザイ，
マンソレ レザイ，
マイケル ディー． シンチャック，
マイケル ディー． シンチャック，
フランソワ ソーシー，
フランソワ ソーシー，
スティーブン ジー． ストラウド，
スティーブン ジー． ストラウド，
トリシア ジェイ． ヴォス，
トリシア ジェイ． ヴォス，
ヒ シュー，
ヒ シュー，
インチュン イエ，
インチュン イエ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Publication of JP2017502092A publication Critical patent/JP2017502092A/ja
Publication of JP2017502092A5 publication Critical patent/JP2017502092A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2016563905A 2014-01-14 2015-01-13 ヘテロアリール及びその使用 Pending JP2017502092A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461927064P 2014-01-14 2014-01-14
US61/927,064 2014-01-14
US201462054757P 2014-09-24 2014-09-24
US62/054,757 2014-09-24
PCT/US2015/011250 WO2015108881A1 (en) 2014-01-14 2015-01-13 Heteroaryls and uses thereof

Publications (2)

Publication Number Publication Date
JP2017502092A true JP2017502092A (ja) 2017-01-19
JP2017502092A5 JP2017502092A5 (enExample) 2018-02-08

Family

ID=53543368

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016563905A Pending JP2017502092A (ja) 2014-01-14 2015-01-13 ヘテロアリール及びその使用

Country Status (4)

Country Link
US (1) US10202373B2 (enExample)
EP (1) EP3094326A4 (enExample)
JP (1) JP2017502092A (enExample)
WO (1) WO2015108881A1 (enExample)

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JP6858984B2 (ja) 2016-02-19 2021-04-14 スプリント バイオサイエンス アクティエボラーグ がんおよび糖尿病の治療に有用な６−ヘテロシクリル−４−モルホリン−４−イルピリジン−２−オン化合物
WO2019038390A1 (en) 2017-08-23 2019-02-28 Sprint Bioscience Ab MORPHOLINYLPYRIDONE COMPOUNDS
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JP7763489B2 (ja) 2019-09-11 2025-11-04 プレリュード・セラピューティクス・インコーポレイテッド Ｃｄｋ阻害剤及び医薬品としてのそれらの使用
JP2024532780A (ja) * 2021-08-13 2024-09-10 デシフェラ・ファーマシューティカルズ，エルエルシー Ｖｐｓ３４阻害剤を使用した併用療法
CN119894905A (zh) * 2022-09-23 2025-04-25 广州威诺森医药科技有限公司 一种骈环吡啶类甾体合成酶抑制剂及其制备方法和应用
KR20250076657A (ko) * 2022-11-10 2025-05-29 ≪타겟 메디컬스≫ 리미티드 라이어빌리티 컴퍼니 인간 알도스테론 합성효소(cyp11b2) 억제제

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Also Published As

Publication number Publication date
US10202373B2 (en) 2019-02-12
EP3094326A4 (en) 2017-07-26
WO2015108881A1 (en) 2015-07-23
EP3094326A1 (en) 2016-11-23
US20160333007A1 (en) 2016-11-17

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